This REU Site award to the University of Pittsburgh, located in Pittsburgh, PA, will support the training of 10 students for 10 weeks during the Summers of 2025-2027. The program, entitled Training and Experimentation in Computational Biology (TECBio), will immerse students in a mentored research project in interdisciplinary areas of computational, quantitative, and systems biology. Students will gain independence and confidence as researchers working on real-world research projects, with some students having the opportunity to do research with a local biotechnology company. Student contributions will advance the ongoing research of faculty at the host institution and help drive innovation at the forefront of discovery. Students will also learn the essential skills needed to pursue additional training and careers in these emerging fields in both the academic and biotechnology sectors. Students will present their results at a regional symposium and will be encouraged to also present at other scientific conferences. Program assessment will be done using a Qualtrics version of the Undergraduate Research Student Self-Assessment (URSSA) Survey. Students should apply to the REU site using the NSF ETAP (Education and Training Application: https://etap.nsf.gov). The TECBio REU has the scientific theme of “Multiscale Modeling, Simulation, and Systems-level Analyses for Biological Discovery” and leverages the expertise of the host institution’s Computational and Systems Biology Dep