This Pathways to Enable Open-Source Ecosystems (POSE) project creating an open-source ecosystem (OSE) around software for cyber-physical systems (CPS), which integrate software with physical-world processes. CPS applications have great societal and national importance; They include manufacturing, robotics, transportation, energy systems, and healthcare. Achieving the required levels of safety and reliability in these systems is increasingly challenging. Since the intelligence and network connectivity required for the software adds to system complexity, system designers must become experts in concurrent software, distributed computing, real-time software, and virtualization technologies, on top of their domain expertise. To address these challenges, this project focuses on developing an open-source software framework that provides developers with an intuitive programming model for managing complex system demands that is tightly matched to the requirements of CPS applications. This project provides the framework to strengthen the OSE, expand its community of users, and apply the results in real-world industrial applications. This POSE project replaces traditional embedded software running on bare metal or a real-time operating system (RTOS) with containerized applications mixing edge computing, specialized hardware for machine learning (ML)-based artificial intelligence (AI), and cloud computing. The project has four primary objectives: 1) strengthening the OSE infrastructur