# Total Synthesis of Complex Alkaloid Natural Products

> **NSF 01002526DB NSF RESEARCH & RELATED ACTIVIT** · Yale University (CT) · $500,000

## Abstract

With the support of the Chemical Synthesis (SYN) program in the Division of Chemistry, Professor Seth B. Herzon of Yale University develops novel synthetic routes toward bioactive complex molecules derived from living organisms known as natural products. The syntheses and structural analyses of natural products play an essential role in the chemical industries as well as in the development of new chemical methods.  Moreover, natural products form the basis for a large proportion of pharmaceuticals.  Access to natural products by synthetic chemistry allows for systematic evaluation of their molecular properties, including bioactivity, thereby providing the foundation for new medicines.  Until now, the marine natural products known as chartellamides have remained relatively inaccessible, limiting our understanding of the properties of these molecules.

During the last funding period, a synthesis of the related isolates known as securamines and securines was developed, and this will form the foundation of the approach to chartellamides.  To access chartellamides, the development of novel synthetic transformations, which may be of general utility, will be required.  To access chartellamide, a biomimetic strategy based upon direct introduction of the indolenine–imidazole bond, peripheral oxidative cyclization, and alkene bromoamination will be pursued.  The total synthesis of chartellamide B will permit rigorous structural analysis and potential structural revision using computa

## Key facts

- **NSF award ID:** 2452274
- **Awardee organization:** Yale University (CT)
- **SAM.gov UEI:** FL6GV84CKN57
- **PI:** Seth B Herzon
- **Primary program:** 01002526DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** —
- **Estimated total:** $500,000
- **Funds obligated:** $500,000
- **Transaction type:** Standard Grant
- **Period:** 07/15/2025 → 06/30/2028

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2452274

## Citation

> US National Science Foundation, Award 2452274, Total Synthesis of Complex Alkaloid Natural Products. Retrieved via AI Analytics 2026-06-07 from https://api.ai-analytics.org/grant/nsf/2452274. Licensed CC0.

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