# Intermediary Arene Dearomatization as an Approach for meta-Selective Functionalization of Arenols and Heteroarenols

> **NSF 01002526DB NSF RESEARCH & RELATED ACTIVIT** · University of Tulsa (OK) · $500,000

## Abstract

With the support of the Chemical Synthesis program in the Division of Chemistry, Professors Angus Lamar and Gordon Purser of the University of Tulsa are investigating new methods for the modification of arenols and heteroarenols, which are compounds commonly found in medicines, agricultural products, and advanced materials. The predictable decoration of an aromatic framework is a cornerstone of chemical synthesis, and significant effort has been devoted toward the expansion of a synthetic toolkit to allow for installation of molecular complexity. Despite the intense synthetic focus, access to certain substitution patterns of polysubstituted aromatics is largely restricted by intrinsic substituent effects. Due to this inherent activity, 1,2- and 1,4-substituent patterns dominate marketed drugs and chemical catalogs. The planned studies will provide direct architectural access to rarely observed polysubstituted bicyclic frameworks with 1,3-substituent patterns which will open the chemical landscape for the rapid construction of potentially bioactive frameworks that have thus far gone unexplored. During the funding period, the planned studies will provide Ph.D. students and undergraduate researchers with the opportunity to develop laboratory skills in chemical synthesis and computational chemistry, which will prepare them for careers in pharmaceutical, agrochemical, and materials industries. In addition, the researchers involved in this project will participate in STEM-related o

## Key facts

- **NSF award ID:** 2452746
- **Awardee organization:** University of Tulsa (OK)
- **SAM.gov UEI:** P23YK1EKPS51
- **PI:** Angus A Lamar
- **Primary program:** 01002526DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** EXP PROG TO STIM COMP RES
- **Estimated total:** $500,000
- **Funds obligated:** $500,000
- **Transaction type:** Standard Grant
- **Period:** 09/01/2025 → 08/31/2028

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2452746

## Citation

> US National Science Foundation, Award 2452746, Intermediary Arene Dearomatization as an Approach for meta-Selective Functionalization of Arenols and Heteroarenols. Retrieved via AI Analytics 2026-06-07 from https://api.ai-analytics.org/grant/nsf/2452746. Licensed CC0.

---

*[NSF Awards dataset](/datasets/nsf-awards) · CC0 1.0*