With the support of the Chemical Synthesis Program of the Division of Chemistry, Professor Alison Frontier of the Department of Chemistry at the University of Rochester is studying anomalous forms of known cyclization reactions. Some of the reactions chosen for exploration in this project lie at the interface between two well-defined reaction classes that are understood by the community to operate according to different sets of rules. These rules are not well understood. A central goal of the program is to learn more about these ambiguous, underexplored reactions, and understand the behavior of systems designed to occur at the “edges” of an accepted paradigm of reactivity. Other anomalous reactions slated for investigation are expected to enable the Frontier lab to build three-dimensional molecules with unique spatial arrays of carbon, nitrogen and oxygen atoms. These structural features are critical to the behavior of small molecules, and new arrays could uncover new possibilities for chemical reactivity or biological activity. The research conducted by Professor Frontier and her students will expand the range of three-dimensional molecules that can be assembled using chemical methods. Professor Frontier also continues to develop and maintain the “Not Voodoo” website, an educational resource she created in 2004. The site is designed to help students demystify laboratory protocols and procedures. It serves hundreds of organic experimental chemists each day, from students ju