# Bond-Forming Methods for Strained Cycloalkyl Groups in Organic and Main-Group Compounds: Applications in Catalyst Design

> **NSF 01002526DB NSF RESEARCH & RELATED ACTIVIT** · Vanderbilt University (TN) · $380,000

## Abstract

With the support of the Chemical Catalysis Program in the Division of Chemistry, Professor Schley at Vanderbilt University is developing new synthetic methods for the synthesis of organic molecules containing bicyclic groups. These methods will equip synthetic chemists with the means to craft molecules of increasingly complex three-dimensional shape and structure, contributing techniques to enhance innovation in the US fine chemical and specialty chemical industries. Members in Prof. Schley’s team will receive training in advanced chemistry techniques necessary to become part of a skilled and competitive workforce. Researchers at Vanderbilt University will partner with local community colleges in the greater Nashville area to establish undergraduate research and training opportunities for local Tennessee community college students to conduct research at Vanderbilt University.

With the support of the Chemical Catalysis Program in the Division of Chemistry, Professor Schley at Vanderbilt University is developing methods for the synthesis of organometallic compounds of strained bicyclic groups via radical hydrometalation of the corresponding propellanes. The resulting bicycloalkyl organometallics will be applied as nucleophilic coupling partners in palladium-catalyzed cross-coupling chemistry, and as reagents in 1,2-hydrometalation chemistry of carbonyl derivatives. Whereas existing methods primarily allow for difunctionalization of propellanes via radical reactions, the prop

## Key facts

- **NSF award ID:** 2453672
- **Awardee organization:** Vanderbilt University (TN)
- **SAM.gov UEI:** GTNBNWXJ12D5
- **PI:** Nathan D Schley
- **Primary program:** 01002526DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** Advanced Manufacturing, REU SUPP-Res Exp for Ugrd Supp
- **Estimated total:** $380,000
- **Funds obligated:** $380,000
- **Transaction type:** Standard Grant
- **Period:** 09/01/2025 → 08/31/2027

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2453672

## Citation

> US National Science Foundation, Award 2453672, Bond-Forming Methods for Strained Cycloalkyl Groups in Organic and Main-Group Compounds: Applications in Catalyst Design. Retrieved via AI Analytics 2026-06-07 from https://api.ai-analytics.org/grant/nsf/2453672. Licensed CC0.

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