# New Hypervalent Iodine Agents for N-N Bond Coupling

> **NSF 01002526DB NSF RESEARCH & RELATED ACTIVIT** · Cornell University (NY) · $600,000

## Abstract

With the support of the Chemical Synthesis (SYN) program in the Division of Chemistry Professor Song Lin of Cornell University is developing new chemical reactions that form nitrogen–nitrogen (N–N) bonds. N–N bonds are frequently present in useful organic compounds such as bioactive natural products, medicines, agrochemicals, and polymer materials. However, traditional approaches to construct N–N bonds are significantly limited by the types of products that they can provide. The Lin lab aims to develop a new reagent that can selectively couple two molecules containing amines, which are readily available species from feedstock chemicals and naturally occurring compounds. The long-term objective of this research program is to facilitate the development of new medicines, agrochemicals, and light-responsive materials. The project lies at the interface of organic synthesis, medicinal chemistry, and physical organic chemistry. Therefore, it is also well suited for the education of trainees including graduate and undergraduate students. In addition to contributing to the advancement of scientific knowledge and improving fine chemical preparation, the project will also exert broader impacts on the training of students through collaboration with other laboratories with complementary expertise.

Professor Song Lin is studying the development of reaction methodologies using novel hypervalent iodine agents for the selective coupling of amines. N–N bonds are prevalent in bioactive natur

## Key facts

- **NSF award ID:** 2453722
- **Awardee organization:** Cornell University (NY)
- **SAM.gov UEI:** G56PUALJ3KT5
- **PI:** Song Lin
- **Primary program:** 01002526DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** —
- **Estimated total:** $600,000
- **Funds obligated:** $600,000
- **Transaction type:** Standard Grant
- **Period:** 06/15/2025 → 05/31/2028

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2453722

## Citation

> US National Science Foundation, Award 2453722, New Hypervalent Iodine Agents for N-N Bond Coupling. Retrieved via AI Analytics 2026-06-07 from https://api.ai-analytics.org/grant/nsf/2453722. Licensed CC0.

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