The renewal of the Institute for Student-AI Teaming will continue to directly address the urgent national need to develop a world-leading, next-generation artificial intelligence (AI) workforce. The Institute will pursue a transformative new vision for 21st century K-12 classrooms that uses AI to promote student success in STEM--where all students experience authentic learning by co-constructing knowledge, making discoveries through inquiry, and developing their interests. This work reframes the role of AI in education, pioneering a future where AI serves as a social, collaborative partner that helps students and teachers make learning more effective and engaging. The Institute will push the capabilities of AI to support small groups with knowledge sharing and uptake, collaboratively solving complex problems, and working through uncertainty and differences in ideas to engender "mental leaps" during STEM learning. The broad research agenda will focus on developing, testing, and scaling AI Partners and their integration in innovative STEM curricula supporting AI education through hands-on student-centered investigations. Research will be situated in authentic school contexts and developed in close partnerships with students, teachers, and school districts to examine the impacts of AI-enhanced pedagogies on learners' collaboration skills as well as their STEM knowledge and capabilities. A dedicated Nexus Hub will work with more than 25 organizations to amplify the Institute's