Postdoctoral Fellowship: MPS-Ascend: Controlling Radical Trifluoromethylation from Abundant CF3 Sources via Tandem Catalysis

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $300,000 · view on nsf.gov ↗

Abstract

Deiaa Harraz is awarded an NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broadening participation in STEM. This fellowship to Dr. Harraz supports the research project entitled “Postdoctoral Fellowship: MPS-Ascend: Controlling radical trifluoromethylation from abundant CF3 sources via tandem catalysis” under the mentorship of a sponsoring scientist. The host institution for the fellowship is Harvard University, and the sponsoring scientist is Dr. Daniel G. Nocera. The objective of the proposed research is to develop a new approach to trifluoromethylation chemistry to provide more cost-effective trifluoromethylation routes desirable for the large-scale synthesis of pharmaceutical compounds needed for the manufacture of commonly prescribed drugs in the United States. The research will interface radical cross-coupling catalysis with electro-photochemical catalysis for the generation of CF3 radicals from the abundant and inexpensive trifluoroacetic acid to achieve regioselective C(sp3) trifluoromethylation. Successful implementation of this work will enable novel and more cost-effective routes for the manufacture of trifluoromethyl containing compounds, with a focus on pharmaceutical compounds. The PI intends to increase the participation of undergraduate students in research by launching a graduate application mentorship program to assist prospective applicants wi

Key facts

NSF award ID
2503283
Awardee
Harraz, Deiaa (MA)
PI
Deiaa Harraz
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
POSTDOCTORAL FELLOWSHIPS, SusChEM
Estimated total
$300,000
Funds obligated
$300,000
Transaction type
Fellowship Award
Period
09/01/2025 → 08/31/2028