With support from the Chemical Structure and Dynamics (CSD) program in the Division of Chemistry, Professor John Wright at the University of Wisconsin-Madison is developing a new technology called Floquet state spectroscopy. It will allow synthetic chemists to use lasers to discover the vibrational modes and electronic states that control their chemical reactions. Floquet state spectroscopy fulfils a dream for creating an optical analogue of NMR that can also coherently control chemical reactions. NMR itself is based on controlling Floquet states. Floquet states are a non-equilibrium, non-adiabatic entanglements of multiple quantum states where the couplings between states changes the states. NMR uses the entangled and coupled nuclear spins of 1H, 13C, etc. to control the spin states, so flipping the spin on a 13C will change the frequency of the neighboring 1H. In the same way, Floquet state spectroscopy uses entangled molecular vibrational and electronic states where the coupling is much stronger and even controls the molecular structure. Professor Wright and his students will employ higher order Floquet state spectroscopy to investigate the multidimensional potential energy surfaces of cobalamin and methyl-cobalamin including their Co-C and Co-N axial ligand stretch motions that are involved in both the photodissociation, and the 12 orders of magnitude increase in the enzymatic rate of the Co-C bond scission. Their work will have a Broad Impact on, not only the field of sy