With the support of the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Lane A. Baker of Texas A&M University will develop new instrumentation and tools for measuring chemical and biological species at electrode surfaces. Specifically, reactions and processes where ions or electrons are involved in electrochemical reactions will be studied at nanometer length scales. To meet this challenge, new instrumentation will be constructed that enables the combination of multiple imaging modalities to be carried out at the same time. Specifically, hardware and protocols to enable integrated electrochemical imaging and optical imaging (e.g., bright field, dark field, fluorescence) will be developed. Methods to efficiently analyze and process data from newly developed instruments with statistical and machine learning approaches will also be pursued. This research project will help to advance the fundamental understanding of chemical and biochemical processes related to neuronal communication, wound healing. This research advances the understanding of molecular biology, and in turn informs efforts to improve human health and the treatment of disease. Additionally, this research project will study catalytic reactions at nanoparticle catalysts, which will aid in developing efficient and selective chemical transformations of interest in applications related to energy and materials. Students trained in this project will learn state-of-the-art fabrication, m