This Major Research Instrumentation Program (MRI) award supports the acquisition of an advanced thermal scanning probe lithography (t-SPL) instrument, the NanoFrazor (NF) Explore, by the University of Mississippi (UM). The NF Explore uses a unique lithography method that directly creates micro- and nano-scale structures and patterns by precisely heating a material sensitive to temperature changes, eliminating the need for photomasks used in traditional methods such as photolithography and electron-beam lithography. This acquisition will significantly enhance multidisciplinary research capabilities at UM and for collaborating institutions across the Mid-South region, including Mississippi State University, Jackson State University, and the University of Southern Mississippi. Researchers in fields spanning chemistry, biology, materials science, and engineering will benefit from this state-of-the-art technology. Currently, Mississippi lacks a dedicated nanofabrication facility, making this instrument essential for introducing nanofabrication capabilities to the state. Furthermore, this acquisition will offer invaluable hands-on training for undergraduate and graduate students, advancing their research and educational experience. The project will also include educational outreach activities aimed at promoting nanotechnology and nanoscience awareness among K-12 students and the broader public. The NanoFrazor (NF) Explore, a cutting-edge thermal scanning probe lithography (t-SPL