Massive stars are born in thick clouds of gas and dust. Within these environments, radio telescopes have revealed compounds known as “complex organic molecules” (COMs). These carbon-based molecules are precursors of larger molecules that are needed for life. Understanding how COMs form and evolve in space is key to uncovering the origin of complex chemical species on Earth and on planets orbiting other stars. Led by a team at the University of Virginia, this project combines cutting-edge astronomical observations and computational chemical simulations to investigate how and why the chemical content varies across different star-forming environments. This research will help astronomers to understand the chemistry of our galaxy and to trace the building blocks of life across the universe. In addition to expanding our knowledge of space chemistry, the project also focuses on training future scientists. It will support students at every level, from elementary school through graduate school, and increase learning opportunities for students with limited exposure to astronomy and space science. Public events will help bring science education and excitement to local communities. Understanding the origin and evolution of space chemistry, particularly the disparities in chemical content observed between star-forming regions, requires a comprehensive study of a large sample of star-forming objects spanning a wide range of masses, ages, and environments. This project combines (i) multi