This project funds construction of IceCore, a graphics processing unit (GPU)-focused, high-performance computing (HPC), enhancing critically needed research computing capacity in Northern New England (NNE). IceCore will enable research of national significance conducted by scientists across NNE, including projects enhancing the explainability of machine learning, infectious disease simulation, hi-resolution mapping of neural circuitry, and the computational design of living robots. Managed by the Vermont Advanced Computing Center (VACC) at the University of Vermont (UVM), IceCore fulfills the unique needs of smaller institutions while catalyzing continued growth in research infrastructure. Access to IceCore will improve the ability of NNE institutions to recruit and retain new faculty, staff, researchers, and students, building their institutional capacity. IceCore will also serve as a powerful educational platform that will train the next generation science and technology workforce for a region whose growth has been critically limited by a shortage of workers with the necessary skills for a digital and computational economy. IceCore will increase the computational capacity of UVM’s GPU cluster by nearly two orders of magnitude to over 100-petaflops, accelerating large-scale computing research and facilitating a broad set of important scientific investigations. Crucially, it will also offer improved HPC access for rural health network research spanning Vermont and Upstate