The primary objective of this project between Montclair State University (US) and Bar-Ilan University (Israel) is the design, testing, and deployment of a low-latency alert infrastructure that will address the needs of the upcoming fifth observing run. Multi-messenger astronomy has exploded with the detection of gravitational and electromagnetic waves from the mergers of binary systems of neutron stars and black holes. With the growing data sets of gravitational waves and their electromagnetic signatures and the astrophysical detectors that create them, the need for improving the software contributing to this ecosystem of technologies to exploit these data sets has rapidly grown. For this reason, multi-messenger follow-up networks have realized a need for open-source software toolkits that address the technical and scientific challenges they face. They include enabling transformational insights on the nature of extreme matter found inside the neutron stars and physics of relativistic ejecta produced as a result of colliding neutron stars, the origins of element formation in the universe, and measurements of the Hubble Constant. As the rates of detections by gravitational-wave networks increase during the lifetime of this award, the toolkits employed to study these sources must grow with them to understand the physics of one of the most energetic phenomena of the Universe. This award also facilitates collaboration between the US scientific lead and the Israeli Science lead fro