# CREST Phase I: Center for Circadian Rhythmicity and Sleep Homeostasis

> **NSF 04002526DB NSF STEM Education** · Morehouse School of Medicine (GA) · $7,394,696

## Abstract

With support from the Centers for Research Excellence in Science and Technology (CREST), this project aims to study sleep and internal circadian clocks that regulate sleep-wake cycles. These investigations are significant because lack of sleep has been associated with individuals whose occupations require shift-work. How circadian disruptions affect sleep is unknown. This project will identify how circadian disruptions affect the body.

The goal of the project is to establish a world-class research center for circadian system biology. The research questions will focus on understanding how circadian rhythms adapt/resynchronize in response to frequently disrupted and ever-changing stimuli.  The Center aims to: identify the neuronal network mechanisms by which light-dark signals are integrated by the circadian clock in the brain; probe the molecular mechanisms for the synchronization of circadian clocks outside of the brain; and  determine the neurocircuitry underlying sleep. Research methods will include spatial transcriptomics, proteomics, computational neurobiology, and in vivo brain imaging. The project’s scope will engage collaborators to leverage additional cutting-edge technologies. The expected results are the identification of cellular and molecular mechanisms responsible for circadian disruptions.  Results will be disseminated at meetings and in publications for the scientific and lay communities. Broader impacts include understanding and mitigating the adverse impac

## Key facts

- **NSF award ID:** 2514598
- **Awardee organization:** Morehouse School of Medicine (GA)
- **SAM.gov UEI:** X5S7PNXMJMC7
- **PI:** Gianluca Tosini
- **Primary program:** 04002526DB NSF STEM Education
- **All programs:** CENTERS FOR RSCH EXCELL IN S&T
- **Estimated total:** $7,394,696
- **Funds obligated:** $7,394,696
- **Transaction type:** Standard Grant
- **Period:** 09/01/2025 → 08/31/2030

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2514598

## Citation

> US National Science Foundation, Award 2514598, CREST Phase I: Center for Circadian Rhythmicity and Sleep Homeostasis. Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/grant/nsf/2514598. Licensed CC0.

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