Exploring Routes to Homochirality in the Synthesis of Biological Polymers

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $602,976 · view on nsf.gov ↗

Abstract

With the support of the Chemistry of Life Processes program in the Division of Chemistry, Professor Donna G. Blackmond from Scripps Research is studying how exclusively homochiral biological polymers emerged from the chiral building blocks of life. Homochiral molecules exist in only one of two possible mirror-image forms, analogous to our right and left hands. Understanding how homochirality emerged will help us understand the origin of life on Earth. Homochirality is also a critical feature of many modern pharmaceuticals, where administering the incorrect “hand” of a drug may result in unintended biological effects. The current research intends to study how molecular building blocks assemble into homochiral chains of proteins and nucleic acids. The results of this work will shed light on chemical processes that occurred billions of years ago, provide insights into the production of modern pharmaceuticals, and underlie key science teaching moments. The concept of mirror image molecules is fascinating to students and laymen alike because the two molecules that are mirror images of each other can exhibit different properties, such as taste and smell. Demonstrations of homochirality – ranging from the shapes of seashells and the smells of spearmint and rye bread to the search for life in interstellar space – represent an exciting means of bringing fundamental and practical chemistry concepts into the lives of young scientists. A key current challenge is to combine the finding

Key facts

NSF award ID
2515406
Awardee
The Scripps Research Institute (CA)
SAM.gov UEI
PHZJFZ32NKH4
PI
Donna G Blackmond
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
Estimated total
$602,976
Funds obligated
$602,976
Transaction type
Standard Grant
Period
09/01/2025 → 08/31/2028