# New Methods for Scalable and Robust Simulation-Based Inference

> **NSF 01002526DB NSF RESEARCH & RELATED ACTIVIT** · University of Illinois at Urbana-Champaign (IL) · $155,000

## Abstract

In fields like genetics, ecology, biology, economics, and psychology, scientists use complex structural models to better understand how the world works. These models aim to mimic real systems, such as how species interact, how crops grow, or how diseases spread, and often rely on key input values, or parameters, that need to be estimated from data. However, many of these models involve high-dimensional, richly structured parameter spaces, making traditional likelihood-based inference methods infeasible, especially for large and complicated datasets. Simulation-based inference (SBI) offers a powerful alternative by exploring these models using simulations rather than direct likelihood evaluation. Within this framework, Bayesian methods provide a natural way to combine expert knowledge with data. This project will develop new simulation-based inference (SBI) methods. These innovations will empower scientists make better use of complex models across diverse domains, supporting more scalable, efficient and reliable decision-making.

Current SBI methods face serious limitations when models involve many parameters or when the models do not fully align with the real-world systems that they are meant to represent.  This project will address two core challenges limiting the broader applicability of Bayesian inference in complex scientific models: scalability to high-dimensional parameter spaces and robustness to model misspecification. To improve scalability, this project introduces

## Key facts

- **NSF award ID:** 2515542
- **Awardee organization:** University of Illinois at Urbana-Champaign (IL)
- **SAM.gov UEI:** Y8CWNJRCNN91
- **PI:** Yuexi Wang
- **Primary program:** 01002526DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** Artificial Intelligence (AI)
- **Estimated total:** $155,000
- **Funds obligated:** $155,000
- **Transaction type:** Standard Grant
- **Period:** 09/01/2025 → 08/31/2028

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2515542

## Citation

> US National Science Foundation, Award 2515542, New Methods for Scalable and Robust Simulation-Based Inference. Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/grant/nsf/2515542. Licensed CC0.

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*[NSF Awards dataset](/datasets/nsf-awards) · CC0 1.0*