This Pathways to Enable Open-Source Ecosystems (POSE) project centers on opening access to quantum computing through the development and formalization of the qBraid-SDK—a hardware-agnostic, open-source runtime and middleware framework. In an industry fragmented by proprietary software and siloed development stacks, the qBraid-SDK introduces a unifying layer that simplifies and standardizes how developers interface with quantum devices. By reducing technical barriers and promoting interoperability across vendor platforms, the project addresses a critical gap in the quantum software ecosystem, providing the foundation for experimentation, reproducibility, and accelerated innovation. The open-source model promotes transparency and community ownership, empowering its contributors—particularly from academic, startup and others, to participate in shaping the field’s trajectory. Rather than aligning with any single hardware standard, the SDK is designed to adapt alongside a heterogeneous quantum landscape. This project positions the U.S. to maintain leadership in quantum technologies by enabling sustainable, collaborative infrastructure. This initiative will not only support a quantum ecosystem but also accelerate the development of robust software infrastructure, enabling faster innovation cycles, and more agile responses to advances in quantum hardware. This POSE project will formalize the governance, community practices, and technical roadmap for the qBraid-SDK, positioning it