Natural history collections provide strategic biological data assets that document biodiversity across space and time, underpinning discovery and innovation. However, their scientific value depends on making specimen data accessible to researchers, decision-makers, industry, educators and the public. The American Museum of Natural History (AMNH) Malacology collection is one of seven largest mollusk collections in the United States and holds an estimated 188,000 specimens from the Atlantic and Gulf Coasts of the United States, spanning 150 years of collecting. However, only 18–20% of the collection has been digitized. This project will integrate AMNH's Eastern Seaboard mollusk holdings into the Eastern Seaboard (ESB) Thematic Collections Network (TCN), bringing the total proportion of digitized U.S. ESB mollusk records to over 90%. Making these standardized and structured data publicly available will directly support research on marine and coastal biological systems, while advancing biotechnology innovation by enabling bioinformatic analyses, genomic resource development and data-driven discovery relevant to U.S. coastal communities and economies. The project will also build partnerships between academia, industry and others to develop a competitive STEM workforce. This project will engage broad public audiences through web content and social media outreach tied to AMNH's existing exhibits. This project is aligned with the NSF priorities in Biotechnology. Over a three-year period, AMNH will database approximately 40,000 uncatalogued lots (~160,000 specimens) of mollusks from the Atlantic and Gulf Coasts, georeference associated collecting localities, and produce high-resolution images of 93 type lots representing 50 significant Eastern Seaboard species. Digitization will combine Optical Character Recognition (OCR)-assisted label transcription with direct data entry into AMNH's Axiell EMu collection management system, following the established ESB TCN workflow. Spe