Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals, and certain legacy PFAS may pose health and environmental risks due to the strong chemical bonds. This project addresses the challenge of PFAS removal and conversion by integrating expertise in materials science, separations, reaction engineering, electrochemistry, process systems, multiscale modeling, artificial intelligence, and social science. Spanning Delaware, Alabama, and South Carolina, the project aims to build regional research capacity and infrastructure to support PFAS mitigation within a circular economy framework. Led by the University of Delaware, in collaboration with Delaware State University, University of Alabama at Huntsville, Alabama A&M University, University of South Carolina, Clemson University, and Benedict College, the project has the potential to revolutionize defluorination technologies across water, air, and soil, impacting medical, agricultural, and industrial sectors. Education and outreach efforts will train skilled educators, scientists, and engineers to tackle PFAS challenges and advance national health, prosperity, and economic growth. The project will employ a multi-scale research framework, integrating experiments and modeling, to create innovative knowledge and robust technologies for PFAS separation and conversion, aiming for near-zero fluoro-pollution. It will address critical knowledge gaps in PFAS concentration and defluorination within a circular economy context, w