The Great Plains region faces an ever-increasing need to conserve dwindling water reserves from the Ogallala aquifer. The same region also annually generates more than 80% of the country’s total livestock wastes (dairy, beef, swine), raising concerns about the impact on water quality and living conditions. About 12– 35% of the water used annually for production-intensive agriculture in Kansas, Nebraska, and Oklahoma combined (8 M acre-ft/yr) can potentially be derived by recovering and treating water contained in livestock waste. A team of interdisciplinary researchers from Kansas State University (KSU), Seward County Community College (SCCC), Oklahoma State University (OSU), and the University of Nebraska-Lincoln (UNL), representing three contiguous EPSCoR jurisdictions, will synergize their complementary research capacities to enable adoption of circular waste resource recovery and water reuse technology platforms. This research will enhance economic resiliency, environmental sustainability, and quality of life in Great Plains micropolitan communities. The overall project objective is to build regional research capacity and develop an economically viable, socially accepted, and efficient circular resource recovery platform integrated with water reuse from livestock wastes that are copiously generated in the region. The proposed work would build capacity for use-inspired research to be demonstrated for adoption by livestock operations in southwest Kansas first (Liberal, KS),