The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the production and manufacture of the first user-friendly, high-throughput, and low-cost Differential Scanning Calorimeter (DSC) instrument. This DSC instrument is an advancement for label free analytical instruments with broad commercial and industrial potential. DSC analysis can provide extremely powerful tools for drug discovery that have low adoption due to high costs and low throughput of only one sample every two hours. The power of DSC is the thermodynamic measurements which do not require any prior specific knowledge of the molecules being studied and does not require any labels. Innovations from this project will also reduce the cost of producing DSC instruments, making them widely available for research and educational purposes. Reducing the complexity of experiments and costs of instruments will lead to lower drug development costs. An additional benefit of these advancements is the potential to also serve as an effective tool for teaching thermodynamics. The combination of unique knowledge provided by DSC analysis with a low-cost instrument will serve to reduce the costs associated with discovering and analyzing potential new drug molecules and provide an effective tool for teaching thermodynamics. The Small Business Innovation Research (SBIR) Phase II project comprises the research and development activities that are necessary to translate the successf