# Role of type III interferons in promoting barrier formation at mucosal surfaces

> **NSF 01002526DB NSF RESEARCH & RELATED ACTIVIT** · University of Florida (FL) · $1,261,546

## Abstract

Our body's surfaces that come into contact with the outside world (the lining of our nose, mouth, and gut) are protected by a layer of cells called epithelial cells. These cells form tight connections with each other to keep harmful pathogens like bacteria, viruses, and parasites from getting inside our body. These cells also produce special proteins called interferons, which help fight off infections. Recently, interferons were shown not only to fight pathogens but also to function when there's no infection. The interferons appear to be essential for creation of the tight connections in the cellular protective layer. This study will investigate how cells control the production of interferons and how these proteins help cells build their wall against the outside environment. Understanding this process could lead to new treatments for diseases that arise when this protective barrier breaks down. The project will provide education and training opportunities for high school students and teachers and for graduate students.

Epithelial cells at mucosal surfaces form the primary barrier against environmental threats through tight junctions that regulate molecular diffusion and prevent pathogen access to subepithelial tissues. Type III interferons (IFNλs) primarily function at these surfaces as key protective cytokines against pathogens. Recently, the investigators discovered that basal IFNλ expression increases as epithelial cells polarize, and this increase is fundamental for 

## Key facts

- **NSF award ID:** 2528816
- **Awardee organization:** University of Florida (FL)
- **SAM.gov UEI:** NNFQH1JAPEP3
- **PI:** Megan L Stanifer
- **Primary program:** 01002526DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** NANOSCALE BIO CORE
- **Estimated total:** $1,261,546
- **Funds obligated:** $1,261,546
- **Transaction type:** Standard Grant
- **Period:** 09/01/2025 → 08/31/2029

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2528816

## Citation

> US National Science Foundation, Award 2528816, Role of type III interferons in promoting barrier formation at mucosal surfaces. Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/grant/nsf/2528816. Licensed CC0.

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