This research will advance community priorities in the areas of safety, security, and human health and wellness pertaining to existing and future neural implant devices. The team includes computer scientists, electrical engineers, MDs, neuroscientists, neural implant community groups, and manufacturers. The partner community groups include patients and their supporting families and caregivers from whom the team will understand the personal impact of neural implant technologies. Expanding engagement with partnered companies who manufacture and medical doctors who use neural implants, the team will address these community challenges and collaboratively deliver a neural implant hardware/software co-design solution that empowers the use and facilitates the safe adoption of emerging neural implant technologies. The research techniques developed for chip security will have applicability to other security related chip-based devices. This project will advance the scientific and technical security and chip hardware design by modeling the operations from a secure and dependable control perspective and developing innovative defense mechanisms that can be applied to emerging smart healthcare devices. Finally, by adding low-resource chip design, the team will advance manufacturing techniques for chip-based devices adding additional security features without impact to overall performance or lifetime. Researchers have demonstrated the impact of “brain-jacking” in mouse models but have no