ISS: Effects of curvature and inertia on the hydrodynamics of complex fluid interfaces

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $400,000 · view on nsf.gov ↗

Abstract

Proteins are large, flexible macromolecules that perform a vast range of functions in all living organisms. Their functions span from copying genetic material to providing structural integrity to cells and organisms. Because of their size, flexibility, and chemistry, proteins can undergo structural changes that dictate their function and sometimes cause disease. The ability to understand and predict how the conditions that proteins experience affect their structure and conformation, and in turn their functioning in solution, is essential for science and technology. This award will be used for the development of predictive models for both fundamental physics of complex fluids and some industrial applications, including the development of first-principle models in manufacturing of biologics, pharmaceutical products composed of proteins, nucleic acids, or cells. Microgravity makes it possible to study how protein solutions flow, without complications associated with the interaction of protein solutions and solid walls. This project utilizes the microgravity environment of the International Space Station (ISS), where surface tension becomes a dominant force, this allows the study of protein solutions in the ring-sheared drop module, a container-less biochemical reactor. In this research, fluid dynamics will be used as a probe to gain fundamental insight on protein structure and function, especially at interfaces with fluidity. Simultaneously, proteins are used to gain fundame

Key facts

NSF award ID
2532121
Awardee
Rensselaer Polytechnic Institute (NY)
SAM.gov UEI
U5WBFKEBLMX3
PI
Amir H Hirsa
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
Estimated total
$400,000
Funds obligated
$400,000
Transaction type
Standard Grant
Period
07/01/2025 → 06/30/2028