The Computer Science Alliance and Data Science 4 Everyone (DS4E), in collaboration with aiEDU, Bootstrap, Introduction to Data Science (IDS), CourseKata, and Youcubed, will launch a multi-subject Data Science (DS) + Artificial Intelligence (AI) Professional Development (PD) Week for high school teachers. U.S. students must be prepared to compete in a global economy increasingly dominated by artificial intelligence, big data, computing, and other emerging technology, collectively defined here as “the Digital Frontier.” Skill demands in manufacturing, healthcare, agriculture, and energy management are increasingly data-centric as workers increasingly perform tasks in-tandem with AI and other digital tools. What are high-priority skills and teaching strategies to ensure students graduate prepared for an AI economy, and how can these be integrated across traditional school subjects, including but beyond K-12 Computer Science? The DS + AI National PD Week project will engage, train, and equip a cohort of “master teachers” to serve as national experts in these emerging topics, and investigate the strategies best suited to scale educator training and preparation across existing core school subjects to adapt to a fast-changing landscape. With AI’s potential to serve as a force-multiplier technology, students who are ready to customize AI-models for specific industry use-cases and research questions with domain-relevant digital data will unlock accelerated scientific progress. As othe