This Faculty Early Career Development Program (CAREER) award will support the development of new methods for simulation-driven regional-scale risk and recovery assessment of civil infrastructure systems subjected to extreme and cascading natural hazards. Evaluating the vulnerability of infrastructure to extreme event scenarios is crucial for protecting lives, preserving economic security, and accelerating post-event community recovery. However, designing informative regional-scale computer simulations of such scenarios is challenged by the spatial and temporal variability of extreme events and their cascading threats to infrastructure. These challenges are compounded by the computational costs of high-resolution regional simulations and lack of scientific mechanisms to identify the most informative simulation scenarios. This project will address these challenges by developing a computational paradigm for designing uncertainty-informed regional-scale simulations, which will enable engineers to understand the consequences of cascading natural hazards and optimize the allocation of computational resources toward reliable infrastructure risk and recovery assessment. The project outcomes will advance national welfare and contribute to the National Science Foundation’s role in supporting the National Earthquake Hazards Reduction Program by improving earthquake risk assessment and recovery planning methods and understanding of the consequences of earthquake sequences on infrastructu