CAREER: Mechanisms of Hidden Microbes: Secretion System Usage by Endofungal Bacteria

NSF Award Search · 01003031DB NSF RESEARCH & RELATED ACTIVIT · $1,222,376 · view on nsf.gov ↗

Abstract

Fungi pose challenges and opportunities in both the field and hospital, where they can cause devastating diseases, create useful compounds, and promote the well-being of other organisms. The roles of fungi as pathogens, beneficial species, and nutrient cyclers within ecosystems are dramatically affected by their relationship with other microbes present in the same place. Bacteria can even directly inhabit fungi, living internally within their cells and communicating with them through unknown molecules. This project seeks to understand how endofungal bacteria communicate with and control the fungi that they inhabit. The long-term goal of this research is to inform new biotechnology applications to control fungi causing disease and promote fungi providing benefits. Complementary educational goals will integrate undergraduate students in course-based and laboratory-based research experiences early in their college journeys, to improve their training as new scientists. Additionally, visitors to the campus botanical gardens will learn through short courses, informational booths, and new signage about the role of microbes in nature and biotechnology. Though bacteria and fungi interact everywhere from soils to hosts, a lack of understanding how bacterial secretion systems facilitate cross-kingdom microbial interactions with fungi represents a barrier to our ability to predict and alter emergent properties of microbial communities. To gain a framework-level perspective, this proj

Key facts

NSF award ID
2541782
Awardee
University of North Carolina at Charlotte (NC)
SAM.gov UEI
JB33DT84JNA5
PI
Morgan E Carter
Primary program
01003031DB NSF RESEARCH & RELATED ACTIVIT
All programs
CAREER-Faculty Erly Career Dev, Biotechnology
Estimated total
$1,222,376
Funds obligated
$1,004,780
Transaction type
Continuing Grant
Period
07/01/2026 → 06/30/2031