# CAREER: Chronically Stable, High-Precision, Multimodal Bioelectronic Platform  for Longitudinal In-Situ Interrogation of Peripheral Nerve Injury

> **NSF 01002627DB NSF RESEARCH & RELATED ACTIVIT** · University of Pennsylvania (PA) · $637,912

## Abstract

Peripheral nerve injuries (PNI) are a leading cause of chronic disability that affects millions of people in the U.S.  Understanding long term effects of PNI is challenging because most diagnostic tools, such as advanced imaging, only provide a snapshot in time.  The field of bioelectronics may provide new tools to monitor PNI continuously over long times, if certain challenges can be overcome.  This CAREER project will design and fabricate bioelectronic devices that integrate into tissue and continuously monitor the progression of chronic PNI over long times.  The outcomes of the project could lead to new personalized treatments of PNI.  The research team will partner with the Franklin Institute in Philadelphia to launch "Engineering in Medicine" that will engage high school students in biosensor fabrication. Additionally, the project will establish a new  bioelectronics curriculum. Overall, this project will develop novel biotechnologies to better understand nerve injury and will inspire a workforce capable of solving challenges in materials science and healthcare engineering.

This CAREER project will support fundamental engineering research to overcome critical barriers of bioelectronics for PNI applications. First, this project will address challenges preventing long-term tissue integration of bioelectronic devices in dynamic nerve environments. An engineered interface will be fabricated to overcome the trade-off between wet adhesion and stability. This design is expec

## Key facts

- **NSF award ID:** 2543715
- **Awardee organization:** University of Pennsylvania (PA)
- **SAM.gov UEI:** GM1XX56LEP58
- **PI:** Yuanwen Jiang
- **Primary program:** 01002627DB NSF RESEARCH & RELATED ACTIVIT
- **All programs:** CAREER-Faculty Erly Career Dev
- **Estimated total:** $637,912
- **Funds obligated:** $637,912
- **Transaction type:** Standard Grant
- **Period:** 07/01/2026 → 06/30/2031

## Primary source

NSF Award Search: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2543715

## Citation

> US National Science Foundation, Award 2543715, CAREER: Chronically Stable, High-Precision, Multimodal Bioelectronic Platform  for Longitudinal In-Situ Interrogation of Peripheral Nerve Injury. Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/grant/nsf/2543715. Licensed CC0.

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