# Listing of Color Additives Exempt From Certification; Titanium Dioxide and Listing of Color Additives Subject to Certification; [Phthalocyaninato (2-)] Copper
> **Food and Drug Administration** · Final rule. · Published 2016-11-01 · Effective 2016-12-02 · 81 FR 75689
## Document
- **Document number:** 2016-26310
- **Category:** fda-food
- **Sub-agency:** Food and Drug Administration
- **Federal Register citation:** 81 FR 75689
- **CFR reference:** 21 CFR 73
- **Publication date:** 2016-11-01
- **Effective date:** 2016-12-02
- **HHS docket:** Docket No. FDA-2016-F-0821
## Abstract

The Food and Drug Administration (FDA or we) is amending the color additive regulations to provide for the safe use of titanium dioxide and [phthalocyaninato (2-)] copper to color orientation marks for intraocular lenses. This action is in response to a petition filed by Milton W. Chu, M.D.

## Source
- [Federal Register document](https://www.federalregister.gov/documents/2016/11/01/2016-26310/listing-of-color-additives-exempt-from-certification-titanium-dioxide-and-listing-of-color-additives)
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