# Possession, Use, and Transfer of Select Agents and Toxins-Addition of SARS-CoV/SARS-CoV-2 Chimeric Viruses Resulting From Any Deliberate Manipulation of SARS-CoV-2 To Incorporate Nucleic Acids Coding for SARS-CoV Virulence Factors to the HHS List of Select Agents and Toxins
> **Centers for Disease Control and Prevention** · Interim final rule. · Published 2021-11-17 · Effective 2021-11-17 · 86 FR 64075
## Document
- **Document number:** 2021-25204
- **Category:** public-health
- **Sub-agency:** Centers for Disease Control and Prevention
- **Federal Register citation:** 86 FR 64075
- **CFR reference:** 42 CFR 73
- **Publication date:** 2021-11-17
- **Effective date:** 2021-11-17
- **HHS docket:** Docket No. CDC-2021-0119
## Abstract

The Centers for Disease Control and Prevention (CDC) located within the Department of Health and Human Services (HHS) is amending its select agents and toxins regulations to add SARS-CoV/SARS-CoV-2 chimeric viruses resulting from any deliberate manipulation of SARS- CoV-2 to incorporate nucleic acids coding for SARS-CoV virulence factors to the list of HHS select agents and toxins. HHS/CDC intends to regulate this agent and to require the regulated entity to obtain prior approval from CDC to conduct deliberate manipulation of SARS-CoV-2 to incorporate nucleic acids coding for SARS-CoV virulence factors because these chimeric viruses have the potential to pose a severe threat to public health and safety.

## Source
- [Federal Register document](https://www.federalregister.gov/documents/2021/11/17/2021-25204/possession-use-and-transfer-of-select-agents-and-toxins-addition-of-sars-covsars-cov-2-chimeric)
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