# Select Agent: Determination That Vaccine Strain, TC-83(A3G) of Venezuelan Equine Encephalitis Virus (VEEV) Is a Regulated Strain of VEEV
> **Centers for Disease Control and Prevention** · Regulatory determination. · Published 2022-09-01 · Effective 2022-09-01 · 87 FR 53679
## Document
- **Document number:** 2022-18973
- **Category:** public-health
- **Sub-agency:** Centers for Disease Control and Prevention
- **Federal Register citation:** 87 FR 53679
- **CFR reference:** 42 CFR 73
- **Publication date:** 2022-09-01
- **Effective date:** 2022-09-01
## Abstract

The Centers for Disease Control and Prevention (CDC), located within the Department of Health and Human Services (HHS), has determined that a modification to the attenuated, excluded strain Venezuelan Equine Encephalitis Virus (VEEV) TC-83 has been shown to increase its virulence. The modified VEEV strain TC-83(A3G) demonstrated increased pathogenicity and lethality. Therefore, the modified VEEV strain TC-83(A3G) is not an excluded strain but is a select agent and is subject to regulation.

## Source
- [Federal Register document](https://www.federalregister.gov/documents/2022/09/01/2022-18973/select-agent-determination-that-vaccine-strain-tc-83a3g-of-venezuelan-equine-encephalitis-virus-veev)
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