# Enzyme Preparations From Animal and Plant Sources; Affirmation of Gras Status as Direct Food Ingredients
> **US Department of Health and Human Services** · Final rule. · Published 1995-06-26 · Effective 1995-06-26 · 60 FR 32904
## Document
- **Document number:** 95-15239
- **Category:** other
- **Sub-agency:** US Department of Health and Human Services
- **Federal Register citation:** 60 FR 32904
- **CFR reference:** 21 CFR 184
- **Publication date:** 1995-06-26
- **Effective date:** 1995-06-26
- **HHS docket:** Docket No. 84G-0257
## Abstract

The Food and Drug Administration (FDA) is affirming that certain enzyme preparations derived from animal and plant sources are generally recognized as safe (GRAS) for use as direct food ingredients. This action is a partial response to a petition filed by the Ad Hoc Enzyme Technical Committee (now the Enzyme Technical Association). The following enzyme preparations derived from animal sources are affirmed as GRAS in this final rule: Catalase (bovine liver), animal lipase, pepsin, trypsin, and pancreatin (as a source of protease activity). The following enzyme preparations derived from plant sources are affirmed as GRAS in this final rule: Bromelain, ficin, and malt.

## Source
- [Federal Register document](https://www.federalregister.gov/documents/1995/06/26/95-15239/enzyme-preparations-from-animal-and-plant-sources-affirmation-of-gras-status-as-direct-food)
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