# Carbohydrase and Protease Enzyme Preparations Derived From Bacillus Subtilis or Bacillus Amyloliquefaciens; Affirmation of GRAS Status as Direct Food Ingredients
> **Food and Drug Administration** · Final rule. · Published 1999-04-23 · Effective 1999-04-23 · 64 FR 19887
## Document
- **Document number:** 99-10011
- **Category:** other
- **Sub-agency:** Food and Drug Administration
- **Federal Register citation:** 64 FR 19887
- **CFR reference:** 21 CFR 184
- **Publication date:** 1999-04-23
- **Effective date:** 1999-04-23
- **HHS docket:** Docket No. 84G-0257
## Abstract

The Food and Drug Administration (FDA) is affirming that carbohydrase enzyme preparations derived from either Bacillus subtilis or B. amyloliquefaciens and protease enzyme preparations derived from either B. subtilis or B. amyloliquefaciens are generally recognized as safe (GRAS) for use as direct food ingredients. This action is a partial response to a petition filed by the Ad Hoc Enzyme Technical Committee (now the Enzyme Technical Association).

## Source
- [Federal Register document](https://www.federalregister.gov/documents/1999/04/23/99-10011/carbohydrase-and-protease-enzyme-preparations-derived-from-bacillus-subtilis-or-bacillus)
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