# Over-the-Counter Drug Products Containing Colloidal Silver Ingredients or Silver Salts
> **Food and Drug Administration** · Final rule. · Published 1999-08-17 · Effective 1999-09-16 · 64 FR 44653
## Document
- **Document number:** 99-21253
- **Category:** other
- **Sub-agency:** Food and Drug Administration
- **Federal Register citation:** 64 FR 44653
- **CFR reference:** 21 CFR 310
- **Publication date:** 1999-08-17
- **Effective date:** 1999-09-16
- **HHS docket:** Docket No. 96N-0144
## Abstract

The Food and Drug Administration (FDA) is issuing a final rule establishing that all over-the-counter (OTC) drug products containing colloidal silver ingredients or silver salts for internal or external use are not generally recognized as safe and effective and are misbranded. FDA is issuing this final rule because many OTC drug products containing colloidal silver ingredients or silver salts are being marketed for numerous serious disease conditions and FDA is not aware of any substantial scientific evidence that supports the use of OTC colloidal silver ingredients or silver salts for these disease conditions.

## Source
- [Federal Register document](https://www.federalregister.gov/documents/1999/08/17/99-21253/over-the-counter-drug-products-containing-colloidal-silver-ingredients-or-silver-salts)
---
*AI Analytics · CC0 1.0*