The U.S. Consumer Product Safety Commission (CPSC or Commission) amends it regulations to revise the supplemental definition of "strong sensitizer" under the Federal Hazardous Substances Act (FHSA). The revised definition of "strong sensitizer" eliminates redundancy, removes certain subjective factors, incorporates new and anticipated technology, places the criteria for classification of strong sensitizers in the order of importance, defines criteria for "severity of reaction," and provides for the use of a weight-of- evidence approach to determine whether a substance is a strong sensitizer.