{"url_path":"/sec/cdna/proxy/2026-04-27/000121723426000028","section_key":"body","section_title":"DEF 14A body","topic":"sec","document":{"doc_type":"DEF 14A","doc_date":"2026-04-27","source_url":"https://www.sec.gov/Archives/edgar/data/1217234/0001217234-26-000028-index.html","accession_number":"0001217234-26-000028","cik":"0001217234","ticker":"CDNA","issuer_name":"CareDx, Inc.","edgar_url":"https://www.sec.gov/Archives/edgar/data/1217234/0001217234-26-000028-index.html","primary_entity_key":"0001217234","primary_entity_name":"CareDx, Inc."},"word_count":68904,"has_tables":true,"body_markdown":"cdna-20260427\n0001217234falseDEF 14Aiso4217:USD00012172342025-01-012025-12-3100012172342026-04-272026-04-270001217234cdna:Mr.JohnW.HannaMember2025-01-012025-12-310001217234cdna:Mr.JohnsonMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMember2024-01-012024-12-310001217234cdna:Mr.JohnsonMember2024-01-012024-12-310001217234cdna:DrSeetoMember2024-01-012024-12-3100012172342024-01-012024-12-310001217234cdna:Mr.JohnsonMember2023-01-012023-12-310001217234cdna:DrSeetoMember2023-01-012023-12-3100012172342023-01-012023-12-310001217234cdna:DrSeetoMember2022-01-012022-12-3100012172342022-01-012022-12-310001217234cdna:DrSeetoMember2021-01-012021-12-3100012172342021-01-012021-12-310001217234cdna:Mr.JohnW.HannaMemberecd:EqtyAwrdsInSummryCompstnTblForAplblYrMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMemberecd:PeoMember2025-01-012025-12-310001217234cdna:Mr.JohnW.HannaMemberecd:EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMemberecd:PeoMember2025-01-012025-12-310001217234ecd:EqtyAwrdsInSummryCompstnTblForAplblYrMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMemberecd:NonPeoNeoMember2025-01-012025-12-310001217234ecd:EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMemberecd:NonPeoNeoMember2025-01-012025-12-31000121723412025-01-012025-12-31000121723422025-01-012025-12-31000121723432025-01-012025-12-31\n\nUNITED STATES\n\nSECURITIES AND EXCHANGE COMMISSION\n\nWashington, D.C. 20549\n\nSCHEDULE 14A\n\nProxy Statement Pursuant to Section 14(a) of the\n\nSecurities Exchange Act of 1934\n\nFiled by the Registrant Filed by a Party other than the Registrant\n\nCheck the appropriate box:\n\n☐\n\nPreliminary Proxy Statement\n\n☐\n\nConfidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))\n\n☒\n\nDefinitive Proxy Statement\n\n☐\n\nDefinitive Additional Materials\n\n☐\n\nSoliciting Material under §240.14a-12\n\nCareDx, Inc.\n\n(Name of Registrant as Specified In Its Charter)\n\n(Name of Person(s) Filing Proxy Statement, if other than the Registrant)\n\nPayment of Filing Fee (Check all boxes that apply):\n\n☒\n\nNo fee required.\n\n☐\n\nFee paid previously with preliminary materials.\n\n☐\n\nFee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.\n\nMessage from the\n\nCompany’s Management\n\nApril 27, 2026\n\nDear CareDx Stockholder,\n\n2025 was a year of strong execution for CareDx, as we advanced the long‑term strategy we outlined at our Investor Day\n\nin October 2024.\n\nOver the past year, we sharpened our focus, strengthened our operating foundation, and made deliberate investments to\n\nsupport sustainable growth and long‑term value creation. Our progress reflects a disciplined approach to building a\n\ndurable, best‑in‑class financial profile while remaining firmly anchored to our mission to create life‑changing solutions that\n\nenable transplant patients to thrive.\n\nI am proud of what our team accomplished in 2025 and grateful for the continued confidence of our stockholders. We\n\nremain focused on executing our strategy and advancing our vision of a world where every patient receives the care they\n\nneed to live longer, fuller lives.\n\nSincerely,\n\n \n\nJohn W. Hanna | President and CEO\n\n8000 Marina Boulevard,\n\n4th Floor Brisbane, CA 94005\n\nNotice of Annual Meeting\n\nof Stockholders\n\nDear Stockholder:\n\nYou are cordially invited to attend the 2026 annual meeting of stockholders (the “Annual Meeting”) of CareDx, Inc., a Delaware\n\ncorporation (“CareDx,” “we”, “us”, “our”, or the “Company”). The Annual Meeting will be held on Thursday, June 11, 2026 at 10:00\n\na.m. Pacific Time, virtually via live webcast at http://www.virtualshareholdermeeting.com/CDNA2026.\n\nMeeting Details\n\nDate & Time\n\nThursday, June 11, 2026\n\nat 10:00 a.m. Pacific Time\n\nLocation\n\nVirtually via live webcast at\n\nhttp://www.virtualshareholder\n\nmeeting.com/CDNA2026\n\nRecord Date\n\nApril 15, 2026\n\nThe Annual Meeting will be held for the following purposes, as more fully described in the accompanying proxy statement:\n\n1\n\nTo elect five directors to serve until the 2027 annual meeting of stockholders or until their successors are duly elected and qualified;\n\n2\n\nTo ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending\n\nDecember 31, 2026;\n\n3\n\nTo approve, on an advisory basis, the compensation of our named executive officers;\n\n4\n\nTo approve, on an advisory basis, the frequency of advisory votes on the compensation of our named executive officers;\n\n5\n\nTo approve an amendment to our 2024 Equity Incentive Plan to increase the available shares reserved thereunder; and\n\n6\n\nTo conduct any other business properly brought before the Annual Meeting and any adjournments or postponements thereof.\n\nOur Board of Directors has fixed the close of business on April 15, 2026 as the record date for the Annual Meeting. Only\n\nstockholders of record on April 15, 2026 are entitled to notice of and to vote at the Annual Meeting. Further information regarding\n\nvoting rights and the matters to be voted upon are more fully described in the accompanying proxy statement.\n\nOn or about April 27, 2026 we expect to mail our stockholders a Notice of Internet Availability of Proxy Materials (the “Notice”)\n\ncontaining instructions on how to access our proxy statement and our annual report. The Notice provides instructions on how to\n\nvote via the Internet or by telephone and includes instructions on how to receive a paper copy of our proxy materials by mail. The\n\naccompanying proxy statement and our annual report can be accessed directly at http://investors.CareDxinc.com/financial-\n\ninformation/annual-reports.\n\nYOUR VOTE IS IMPORTANT. Whether or not you plan to attend the Annual Meeting, we urge you to submit your vote via\n\nthe Internet, telephone or mail as soon as possible so that your shares can be voted at the Annual Meeting in accordance\n\nwith your instructions.\n\nThank you for your continued support of CareDx.\n\nBy order of the Board of Directors,\n\n/s/ Michael D. Goldberg\n\nChairman of the Board of Directors\n\nBrisbane, California | April 27, 2026\n\nTable of Contents\n\n[Proxy Statement for 2026 Annual Meeting of Stockholders](#i905f78cfb2ec4d6ba9e65cdd610942a5_19)\n\n[1](#i905f78cfb2ec4d6ba9e65cdd610942a5_19)\n\n[Questions and Answers about the Annual Meeting](#i905f78cfb2ec4d6ba9e65cdd610942a5_22) . . . . . . . .\n\n[1](#i905f78cfb2ec4d6ba9e65cdd610942a5_22)\n\nProposal No. 1 Election Of Directors . . . . . . . . . . . . . . . . . . . . .\n\n[9](#i905f78cfb2ec4d6ba9e65cdd610942a5_19791209301252)\n\nNominees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[9](#i905f78cfb2ec4d6ba9e65cdd610942a5_19791209301261)\n\nVote Required; Board Recommendation . . . . . . . . . . . . . . . . .\n\n[9](#i905f78cfb2ec4d6ba9e65cdd610942a5_19791209301270)\n\nBoard of Directors and Corporate Governance . . . . . . . . . . .\n\n[10](#i905f78cfb2ec4d6ba9e65cdd610942a5_19241453487452)\n\nDirectors with Terms Expiring at the Annual Meeting-\n\nNominees for Director . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[11](#i905f78cfb2ec4d6ba9e65cdd610942a5_19241453487462)\n\n[Continuing Directors](#i905f78cfb2ec4d6ba9e65cdd610942a5_1513) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[16](#i905f78cfb2ec4d6ba9e65cdd610942a5_1513)\n\n[Considerations in Evaluating Director Nominees](#i905f78cfb2ec4d6ba9e65cdd610942a5_1528) . . . . . . . . . .\n\n[21](#i905f78cfb2ec4d6ba9e65cdd610942a5_1528)\n\n[Director Independence](#i905f78cfb2ec4d6ba9e65cdd610942a5_1535) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[21](#i905f78cfb2ec4d6ba9e65cdd610942a5_1535)\n\n[Board Leadership Structure](#i905f78cfb2ec4d6ba9e65cdd610942a5_1541) . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[22](#i905f78cfb2ec4d6ba9e65cdd610942a5_1541)\n\n[Board Diversity of Skills and Expertise](#i905f78cfb2ec4d6ba9e65cdd610942a5_1547) . . . . . . . . . . . . . . . . . . .\n\n[22](#i905f78cfb2ec4d6ba9e65cdd610942a5_1547)\n\n[Legal Proceedings with Directors](#i905f78cfb2ec4d6ba9e65cdd610942a5_1554) . . . . . . . . . . . . . . . . . . . . . . . .\n\n[23](#i905f78cfb2ec4d6ba9e65cdd610942a5_1554)\n\n[Agreements with Directors](#i905f78cfb2ec4d6ba9e65cdd610942a5_1561) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[23](#i905f78cfb2ec4d6ba9e65cdd610942a5_1561)\n\n[Board and Committee Meetings](#i905f78cfb2ec4d6ba9e65cdd610942a5_1569) . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[23](#i905f78cfb2ec4d6ba9e65cdd610942a5_1569)\n\n[Compensation Committee Interlocks and Insider](#i905f78cfb2ec4d6ba9e65cdd610942a5_1575)\n\n[Participation](#i905f78cfb2ec4d6ba9e65cdd610942a5_1575) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[26](#i905f78cfb2ec4d6ba9e65cdd610942a5_1575)\n\n[Stockholder Recommendations for Nominations to the](#i905f78cfb2ec4d6ba9e65cdd610942a5_1581)\n\n[Board of Directors](#i905f78cfb2ec4d6ba9e65cdd610942a5_1581) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[27](#i905f78cfb2ec4d6ba9e65cdd610942a5_1581)\n\n[Communications with the Board of Directors](#i905f78cfb2ec4d6ba9e65cdd610942a5_1587) . . . . . . . . . . . . . .\n\n[28](#i905f78cfb2ec4d6ba9e65cdd610942a5_1587)\n\n[Corporate Governance Guidelines and Code of Business](#i905f78cfb2ec4d6ba9e65cdd610942a5_1593)\n\n[Conduct and Ethics](#i905f78cfb2ec4d6ba9e65cdd610942a5_1593) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[28](#i905f78cfb2ec4d6ba9e65cdd610942a5_1593)\n\n[Clawback Policy](#i905f78cfb2ec4d6ba9e65cdd610942a5_1599) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[28](#i905f78cfb2ec4d6ba9e65cdd610942a5_1599)\n\n[Insider Trading Policy](#i905f78cfb2ec4d6ba9e65cdd610942a5_1605) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[29](#i905f78cfb2ec4d6ba9e65cdd610942a5_1605)\n\n[Non-Employee Director Stock Ownership Policy](#i905f78cfb2ec4d6ba9e65cdd610942a5_1609) . . . . . . . . . .\n\n[29](#i905f78cfb2ec4d6ba9e65cdd610942a5_1609)\n\n[Executive Officer Stock Ownership Policy](#i905f78cfb2ec4d6ba9e65cdd610942a5_1615) . . . . . . . . . . . . . . . .\n\n[29](#i905f78cfb2ec4d6ba9e65cdd610942a5_1615)\n\n[Board of Directors’ Role in Risk Oversight](#i905f78cfb2ec4d6ba9e65cdd610942a5_1621) . . . . . . . . . . . . . . . .\n\n[30](#i905f78cfb2ec4d6ba9e65cdd610942a5_1621)\n\n[Director Compensation](#i905f78cfb2ec4d6ba9e65cdd610942a5_1627) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[31](#i905f78cfb2ec4d6ba9e65cdd610942a5_1627)\n\n[Director Compensation Table](#i905f78cfb2ec4d6ba9e65cdd610942a5_1633) . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[32](#i905f78cfb2ec4d6ba9e65cdd610942a5_1633)\n\n[Proposal No. 2 Ratification of Appointment of](#i905f78cfb2ec4d6ba9e65cdd610942a5_100)\n\n[Independent Registered Public Accounting Firm](#i905f78cfb2ec4d6ba9e65cdd610942a5_100) . . . . . . . . .\n\n[34](#i905f78cfb2ec4d6ba9e65cdd610942a5_100)\n\n[Fees Paid to the Independent Registered Public Accounting](#i905f78cfb2ec4d6ba9e65cdd610942a5_103)\n\n[Firm](#i905f78cfb2ec4d6ba9e65cdd610942a5_103) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[34](#i905f78cfb2ec4d6ba9e65cdd610942a5_103)\n\n[Auditor Independence](#i905f78cfb2ec4d6ba9e65cdd610942a5_106) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[35](#i905f78cfb2ec4d6ba9e65cdd610942a5_106)\n\n[Audit and Finance Committee Policy on Pre-Approval of](#i905f78cfb2ec4d6ba9e65cdd610942a5_109)\n\n[Audit and Permissible Non-Audit Services of Independent](#i905f78cfb2ec4d6ba9e65cdd610942a5_109)\n\n[Registered Public Accounting Firm](#i905f78cfb2ec4d6ba9e65cdd610942a5_109) . . . . . . . . . . . . . . . . . . . . . .\n\n[35](#i905f78cfb2ec4d6ba9e65cdd610942a5_109)\n\n[Vote Required; Board Recommendation](#i905f78cfb2ec4d6ba9e65cdd610942a5_112) . . . . . . . . . . . . . . . . .\n\n[35](#i905f78cfb2ec4d6ba9e65cdd610942a5_112)\n\n[Audit and Finance Committee Report](#i905f78cfb2ec4d6ba9e65cdd610942a5_115) . . . . . . . . . . . . . . . . . . . .\n\n[36](#i905f78cfb2ec4d6ba9e65cdd610942a5_115)\n\n[Proposal No. 3 Advisory Vote on Executive Compensation](#i905f78cfb2ec4d6ba9e65cdd610942a5_118)\n\n[37](#i905f78cfb2ec4d6ba9e65cdd610942a5_118)\n\n[Vote Required; Board Recommendation](#i905f78cfb2ec4d6ba9e65cdd610942a5_121) . . . . . . . . . . . . . . . . .\n\n[37](#i905f78cfb2ec4d6ba9e65cdd610942a5_121)\n\nProposal No. 4 Advisory Vote on Frequency of Advisory\n\nVotes on Executive Compensation . . . . . . . . . . . . . . . . . . . . . .\n\n[38](#i905f78cfb2ec4d6ba9e65cdd610942a5_6597069767843)\n\n[Vote Required; Board Recommendation](#i905f78cfb2ec4d6ba9e65cdd610942a5_1199) . . . . . . . . . . . . . . . . .\n\n[38](#i905f78cfb2ec4d6ba9e65cdd610942a5_1199)\n\n[Proposal No. 5 Approval of an Amendment to 2024 Equity](#i905f78cfb2ec4d6ba9e65cdd610942a5_124)\n\n[Incentive Plan](#i905f78cfb2ec4d6ba9e65cdd610942a5_124) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[39](#i905f78cfb2ec4d6ba9e65cdd610942a5_124)\n\n[Information on Equity Compensation Plans as of March 31,](#i905f78cfb2ec4d6ba9e65cdd610942a5_133)\n\n[202](#i905f78cfb2ec4d6ba9e65cdd610942a5_133)6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[40](#i905f78cfb2ec4d6ba9e65cdd610942a5_133)\n\n[Taking Action to Reduce Burn Rate and Dilution](#i905f78cfb2ec4d6ba9e65cdd610942a5_136) . . . . . . . . . .\n\n[40](#i905f78cfb2ec4d6ba9e65cdd610942a5_136)\n\n[Key Features and Governance Practices](#i905f78cfb2ec4d6ba9e65cdd610942a5_145) . . . . . . . . . . . . . . . . .\n\n[43](#i905f78cfb2ec4d6ba9e65cdd610942a5_145)\n\n[Summary of the 2024 Plan](#i905f78cfb2ec4d6ba9e65cdd610942a5_148) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[44](#i905f78cfb2ec4d6ba9e65cdd610942a5_148)\n\n[Form S-8 Registration Statement](#i905f78cfb2ec4d6ba9e65cdd610942a5_151) . . . . . . . . . . . . . . . . . . . . . . . .\n\n[51](#i905f78cfb2ec4d6ba9e65cdd610942a5_151)\n\n[New Plan Benefits](#i905f78cfb2ec4d6ba9e65cdd610942a5_154) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[51](#i905f78cfb2ec4d6ba9e65cdd610942a5_154)\n\n[Federal Income Tax Consequences](#i905f78cfb2ec4d6ba9e65cdd610942a5_157) . . . . . . . . . . . . . . . . . . . . .\n\n[52](#i905f78cfb2ec4d6ba9e65cdd610942a5_157)\n\n[Vote Required; Board Recommendation](#i905f78cfb2ec4d6ba9e65cdd610942a5_160) . . . . . . . . . . . . . . . . .\n\n[54](#i905f78cfb2ec4d6ba9e65cdd610942a5_160)\n\n[Executive Officers](#i905f78cfb2ec4d6ba9e65cdd610942a5_163) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[55](#i905f78cfb2ec4d6ba9e65cdd610942a5_163)\n\n[Legal Proceedings with Executive Officers](#i905f78cfb2ec4d6ba9e65cdd610942a5_166) . . . . . . . . . . . . . . .\n\n[56](#i905f78cfb2ec4d6ba9e65cdd610942a5_166)\n\n[Executive Compensation](#i905f78cfb2ec4d6ba9e65cdd610942a5_169) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[57](#i905f78cfb2ec4d6ba9e65cdd610942a5_169)\n\n[Compensation Discussion and Analysis](#i905f78cfb2ec4d6ba9e65cdd610942a5_172) . . . . . . . . . . . . . . . . . .\n\n[57](#i905f78cfb2ec4d6ba9e65cdd610942a5_172)\n\n[I. Executive Summary](#i905f78cfb2ec4d6ba9e65cdd610942a5_175) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[57](#i905f78cfb2ec4d6ba9e65cdd610942a5_175)\n\n[II. Compensation Philosophy](#i905f78cfb2ec4d6ba9e65cdd610942a5_178) . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[59](#i905f78cfb2ec4d6ba9e65cdd610942a5_178)\n\n[III. Compensation Determination Process](#i905f78cfb2ec4d6ba9e65cdd610942a5_181) . . . . . . . . . . . . . . . .\n\n[60](#i905f78cfb2ec4d6ba9e65cdd610942a5_181)\n\n[IV. Pay Components](#i905f78cfb2ec4d6ba9e65cdd610942a5_184) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[62](#i905f78cfb2ec4d6ba9e65cdd610942a5_184)\n\n[Compensation and Human Capital Committee Report](#i905f78cfb2ec4d6ba9e65cdd610942a5_190) . . . . .\n\n[70](#i905f78cfb2ec4d6ba9e65cdd610942a5_190)\n\n[Summary Compensation Table](#i905f78cfb2ec4d6ba9e65cdd610942a5_193) . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[71](#i905f78cfb2ec4d6ba9e65cdd610942a5_193)\n\n[Grants of Plan-Based Awards](#i905f78cfb2ec4d6ba9e65cdd610942a5_196) . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[73](#i905f78cfb2ec4d6ba9e65cdd610942a5_196)\n\n[Outstanding Equity Awards at Fiscal Year-End](#i905f78cfb2ec4d6ba9e65cdd610942a5_199) . . . . . . . . . . . .\n\n[74](#i905f78cfb2ec4d6ba9e65cdd610942a5_199)\n\n[Option Exercises and Stock Vested](#i905f78cfb2ec4d6ba9e65cdd610942a5_202) . . . . . . . . . . . . . . . . . . . . .\n\n[78](#i905f78cfb2ec4d6ba9e65cdd610942a5_202)\n\n[Pension Benefits](#i905f78cfb2ec4d6ba9e65cdd610942a5_205) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[78](#i905f78cfb2ec4d6ba9e65cdd610942a5_205)\n\n[Pay Ratio Disclosure](#i905f78cfb2ec4d6ba9e65cdd610942a5_208) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[82](#i905f78cfb2ec4d6ba9e65cdd610942a5_208)\n\n[Pay Versus Performance](#i905f78cfb2ec4d6ba9e65cdd610942a5_211) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[83](#i905f78cfb2ec4d6ba9e65cdd610942a5_211)\n\n[Equity Compensation Plan Information](#i905f78cfb2ec4d6ba9e65cdd610942a5_214) . . . . . . . . . . . . . . . . . . .\n\n[87](#i905f78cfb2ec4d6ba9e65cdd610942a5_214)\n\n[Security Ownership of Certain Beneficial Owners and](#i905f78cfb2ec4d6ba9e65cdd610942a5_217)\n\n[Management](#i905f78cfb2ec4d6ba9e65cdd610942a5_217) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[88](#i905f78cfb2ec4d6ba9e65cdd610942a5_217)\n\n[Related Party Transactions](#i905f78cfb2ec4d6ba9e65cdd610942a5_220) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[91](#i905f78cfb2ec4d6ba9e65cdd610942a5_220)\n\n[Indemnification Agreements](#i905f78cfb2ec4d6ba9e65cdd610942a5_223) . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[91](#i905f78cfb2ec4d6ba9e65cdd610942a5_223)\n\n[Rule 10b5-1 Sales Plans](#i905f78cfb2ec4d6ba9e65cdd610942a5_226) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[91](#i905f78cfb2ec4d6ba9e65cdd610942a5_226)\n\n[Policies and Procedures for Related Party Transactions](#i905f78cfb2ec4d6ba9e65cdd610942a5_229) . . . .\n\n[91](#i905f78cfb2ec4d6ba9e65cdd610942a5_229)\n\n[Other Matters](#i905f78cfb2ec4d6ba9e65cdd610942a5_232) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[92](#i905f78cfb2ec4d6ba9e65cdd610942a5_232)\n\n[Delinquent Section 16(a) Reports](#i905f78cfb2ec4d6ba9e65cdd610942a5_235) . . . . . . . . . . . . . . . . . . . . . . .\n\n[92](#i905f78cfb2ec4d6ba9e65cdd610942a5_235)\n\n[Available Information](#i905f78cfb2ec4d6ba9e65cdd610942a5_238) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[92](#i905f78cfb2ec4d6ba9e65cdd610942a5_238)\n\n[Note About Forward-Looking Statements](#i905f78cfb2ec4d6ba9e65cdd610942a5_241) . . . . . . . . . . . . . . . . .\n\n[92](#i905f78cfb2ec4d6ba9e65cdd610942a5_241)\n\n[Householding](#i905f78cfb2ec4d6ba9e65cdd610942a5_244) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[92](#i905f78cfb2ec4d6ba9e65cdd610942a5_244)\n\n[Company Website](#i905f78cfb2ec4d6ba9e65cdd610942a5_247) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\n[93](#i905f78cfb2ec4d6ba9e65cdd610942a5_247)\n\n[Appendix A – 2024 Equity Incentive Plan](#i905f78cfb2ec4d6ba9e65cdd610942a5_250) (including\n\nAmendment No. 1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\nA-[1](#i905f78cfb2ec4d6ba9e65cdd610942a5_250)\n\n[Appendix B – Amendment No. 2 to the 2024 Equity](#i905f78cfb2ec4d6ba9e65cdd610942a5_253)\n\n[Incentive Plan](#i905f78cfb2ec4d6ba9e65cdd610942a5_253) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\n\nB-[1](#i905f78cfb2ec4d6ba9e65cdd610942a5_253)\n\nCareDx Inc.\n\n2026 Proxy Statement  |  1\n\nProxy Statement for 2026\n\nAnnual Meeting of Stockholders\n\nDate & Time\n\nThursday, June 11, 2026\n\nat 10:00 a.m. Pacific Time\n\nLocation\n\nVirtually via live webcast at\n\nhttp://www.virtualshareholder\n\nmeeting.com/CDNA2026\n\nRecord Date\n\nApril 15, 2026\n\nWe sent you this proxy statement and the enclosed proxy card because the Board of Directors (“Board of Directors”) of CareDx,\n\nInc. (sometimes referred to as “we”, “CareDx” or the “Company”) is soliciting your proxy to vote at the Company’s 2026 annual\n\nmeeting of stockholders (the “Annual Meeting”) and any postponements, adjournments or continuations thereof. The Annual\n\nMeeting will be held on Thursday, June 11, 2026 at 10:00 a.m. Pacific Time, virtually via live webcast at http://\n\nwww.virtualshareholdermeeting.com/CDNA2026. You are invited to attend the Annual Meeting and we request that you vote on the\n\nproposals described in this proxy statement. However, you do not need to attend the Annual Meeting to vote your shares. Instead,\n\nyou may complete, sign and return the enclosed proxy card or submit your proxy through the Internet or by telephone according to\n\nthe instructions contained in the enclosed proxy card.\n\nThe Notice of Internet Availability of Proxy Materials (the “Notice”) containing instructions on how to access this proxy statement\n\nand our annual report is first being mailed on or about April 27, 2026 to all stockholders entitled to receive notice of and to vote at\n\nthe Annual Meeting. A list of stockholders entitled to vote at the Annual Meeting will be available upon request for inspection by any\n\nstockholder, during ordinary business hours at our principal executive offices, for any purpose relating to the Annual Meeting for a\n\nperiod of at least 10 days before the Annual Meeting.\n\nQuestions and Answers About the Annual Meeting\n\nThe information provided in the “question and answer” format below addresses certain frequently asked questions but is not\n\nintended to be a summary of all matters contained in this proxy statement. Please read the entire proxy statement carefully before\n\nvoting your shares.\n\nWhat matters am I voting on?\n\nYou will be voting on:\n\n•the election of five directors to hold office until the 2027 annual meeting of stockholders or until their successors are duly\n\nelected and qualified;\n\n•a proposal to ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our\n\nfiscal year ending December 31, 2026;\n\n•a proposal to approve, on an advisory basis, the compensation of our named executive officers;\n\n•a proposal to approve, on an advisory basis, the frequency of advisory votes on the compensation of our named executive\n\nofficers;\n\n•a proposal to approve an amendment to our 2024 Equity Incentive Plan (as previously amended by Amendment No. 1,\n\nthe \"2024 Plan\") to increase the available shares reserved thereunder; and\n\n•any other business properly brought before the Annual Meeting or any adjournments or postponements thereof.\n\n2  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nHow does our Board of Directors recommend that I vote?\n\nOur Board of Directors recommends that you vote:\n\n•FOR the election of each of the five directors nominated by our Board of Directors and named in this proxy statement to\n\nserve for a one-year term;\n\n•FOR the ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for\n\nour fiscal year ending December 31, 2026;\n\n•FOR the approval of the compensation paid to our named executive officers as disclosed in this proxy statement;\n\n•FOR \"1 Year\" (annual vote) regarding the frequency of future advisory votes on the compensation of our named executive\n\nofficers; and\n\n•FOR the approval of an amendment to our 2024 Plan to increase the available shares reserved thereunder.\n\nWill there be any other items of business on the agenda?\n\nIf any other items of business or other matters are properly brought before the Annual Meeting, your proxy gives discretionary\n\nauthority to the persons named on the proxy card concerning those items of business or other matters. The persons named on the\n\nproxy card intend to vote the proxy in accordance with their best judgment. Our Board of Directors does not intend to bring any\n\nother matters to be voted on at the Annual Meeting, and we are not currently aware of any matters that may be properly presented\n\nby others for consideration at the Annual Meeting.\n\nWho is entitled to vote at the Annual Meeting?\n\nHolders of our common stock at the close of business on April 15, 2026, the record date for the Annual Meeting (the “Record\n\nDate”), are entitled to notice of and to vote at the Annual Meeting. Each stockholder is entitled to one vote for each share of our\n\ncommon stock held as of the Record Date. Stockholders are not permitted to cumulate votes with respect to the election of\n\ndirectors.\n\nAs of the Record Date, there were 51,547,801 shares of common stock outstanding and entitled to vote.\n\nWhat is the difference between holding shares as a stockholder of record and as a beneficial owner?\n\nStockholder of Record: Shares Registered in Your Name. If, at the close of business on the Record Date, your shares were\n\nregistered directly in your name with Computershare Trust Company, N.A., our transfer agent, then you are the stockholder of\n\nrecord for such shares. As the stockholder of record, you may vote either electronically at the Annual Meeting or by proxy.\n\nBeneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If, at the close of business on the\n\nRecord Date, your shares were held, not in your name, but rather in a stock brokerage account or by a bank or other nominee on\n\nyour behalf, then you are considered the beneficial owner of shares held in “street name.” As the beneficial owner, you have the\n\nright to direct your broker, bank or other nominee how to vote your shares by following the voting instructions your broker, bank or\n\nother nominee provides. If you do not provide your broker, bank or other nominee with instructions on how to vote your shares,\n\nyour broker, bank or other nominee may, in its discretion, vote your shares with respect to routine matters but may not vote your\n\nshares with respect to any non-routine matters. Please see “What if I do not specify how my shares are to be voted?” for\n\nadditional information.\n\nDo I have to do anything in advance if I plan to attend the Annual Meeting?\n\nThe Annual Meeting will be a virtual audio meeting of stockholders, which will be conducted via live audio webcast. You are entitled\n\nto participate in the Annual Meeting only if you were a holder of our common stock as of the close of business on the Record Date\n\nor if you hold a valid proxy for the Annual Meeting.\n\nTo participate in the Annual Meeting, you will need the control number included on your proxy card or the Notice. The live audio\n\nwebcast will begin promptly at 10:00 a.m. Pacific Time. We encourage you to access the meeting prior to the start time. Online\n\ncheck-in will begin at 9:45 a.m. Pacific Time and you should allow ample time for the check-in procedures.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  3\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nHow can I get help if I have trouble checking in or listening to the meeting online?\n\nIf you encounter any difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support\n\nnumber that will be posted on the log-in page at http://www.virtualshareholdermeeting.com/CDNA2026.\n\nHow do I vote and what are the voting deadlines?\n\nStockholder of Record: Shares Registered in Your Name. If you are a stockholder of record, you can vote in one of the following\n\nways:\n\n•You may vote via the Internet or by telephone. To vote via the Internet or by telephone, follow the instructions provided\n\nin the Notice. If you vote via the Internet or by telephone, you do not need to return a proxy card by mail. Internet and\n\ntelephone voting are available 24 hours a day. Votes submitted through the Internet or by telephone must be received\n\nby 11:59 p.m. Eastern Time on June 10, 2026 at 1-800-690-6903, or the Internet at www.proxyvote.com.\n\n•You may vote by mail. If you have received printed proxy materials by mail and would like to vote by mail, you need to\n\ncomplete, date and sign the proxy card that accompanies this proxy statement and promptly mail it to the tabulation agent\n\nin the enclosed postage-paid envelope so that it is received no later than June 10, 2026. You do not need to put a stamp\n\non the enclosed envelope if you mail it from within the United States. The persons named in the proxy card will vote the\n\nshares you own in accordance with your instructions on the proxy card you mail.\n\n•You may vote electronically at the Annual Meeting. If you plan to attend the Annual Meeting, please log into http://\n\nwww.virtualshareholdermeeting.com/CDNA2026 as a “Stockholder” using the control number available on your proxy card\n\nor the Notice, and vote during the Annual Meeting following the instructions at http://www.virtualshareholdermeeting.com/\n\nCDNA2026.\n\n•Note: If you vote via the Internet, return a proxy card by mail or vote electronically at the Annual Meeting, but do not give\n\nany instructions on a particular matter to be voted on at the Annual Meeting. John W. Hanna and Keith Kennedy, the\n\npersons who have been designated as proxy holders by our Board of Directors, will vote the shares you own in\n\naccordance with the recommendations of our Board of Directors. Our Board of Directors recommends that you vote FOR\n\nthe election of each of the five directors nominated by our Board of Directors and named in this proxy statement directors\n\nto serve for a one-year term (Proposal No. 1), FOR the ratification of the appointment of Deloitte & Touche LLP as our\n\nindependent registered public accounting firm for our fiscal year ending December 31, 2026 (Proposal No. 2), FOR the\n\napproval of the compensation paid to our named executive officers as disclosed in this proxy statement (Proposal No. 3),\n\nFOR \"1 Year\" (annual vote) regarding the frequency of future advisory votes on the compensation of our named executive\n\nofficers (Proposal No. 4), and FOR the approval of an amendment to our 2024 Equity Incentive Plan (Proposal No. 5) to\n\nincrease the available shares reserved thereunder.\n\nBeneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you are the beneficial owner of\n\nshares held of record by a broker, bank or other nominee, you will receive voting instructions from your broker, bank or other\n\nnominee. You must follow the voting instructions provided by your broker, bank or other nominee in order to instruct your broker,\n\nbank or other nominee how to vote your shares. The availability of Internet and telephone voting options will depend on the voting\n\nprocess of your broker, bank or other nominee. As discussed above, if you are a beneficial owner, you may not vote your shares\n\nelectronically at the Annual Meeting unless you obtain a legal proxy from your broker, bank or other nominee.\n\nCan I change my vote or revoke my proxy?\n\nStockholder of Record: Shares Registered in Your Name. If you are a stockholder of record, you may revoke your proxy or\n\nchange your proxy instructions at any time before your proxy is voted at the Annual Meeting by:\n\n•entering a new vote by Internet or telephone;\n\n•signing and returning a new proxy card with a later date;\n\n•delivering a written notice of revocation to our Corporate Secretary prior to the Annual Meeting; or\n\n•attending the Annual Meeting and voting electronically.\n\n4  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nBeneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you are the beneficial owner of your\n\nshares, you must contact the broker, bank or other nominee holding your shares and follow their instructions to change your vote or\n\nrevoke your proxy.\n\nWhat is the effect of giving a proxy?\n\nProxies are solicited by and on behalf of our Board of Directors. John W. Hanna and Keith Kennedy have been designated as\n\nproxy holders by our Board of Directors. When a proxy is properly dated, executed and returned, the shares represented by the\n\nproxy will be voted at the Annual Meeting in accordance with the instructions of the stockholder. If no specific instructions are\n\ngiven, however, the shares will be voted in accordance with the recommendations of our Board of Directors. If any matters not\n\ndescribed in this proxy statement are properly presented at the Annual Meeting, the proxy holders will use their own judgment to\n\ndetermine how to vote your shares. If the Annual Meeting is postponed or adjourned, the proxy holders can vote your shares on the\n\nnew meeting date, unless you have properly revoked your proxy, as described above.\n\nWhat if I do not specify how my shares are to be voted?\n\nStockholder of Record: Shares Registered in Your Name. If you are a stockholder of record and you submit a proxy but you do\n\nnot provide voting instructions, your shares will be voted:\n\n•FOR the election of each of the directors nominated by our Board of Directors and named in this proxy statement to serve\n\nfor a one-year term (Proposal No. 1);\n\n•FOR the ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for\n\nour fiscal year ending December 31, 2026 (Proposal No. 2);\n\n•FOR the approval of the compensation paid to our named executive officers as disclosed in this proxy\n\nstatement (Proposal No. 3);\n\n•FOR \"ONE YEAR\" (annual vote) regarding the frequency of future advisory votes on the compensation of our named\n\nexecutive officers (Proposal No. 4);\n\n•FOR the approval of an amendment to our 2024 Equity Incentive Plan (Proposal No. 5) to increase the available shares\n\nreserved thereunder; and\n\n•In the discretion of the named proxy holders regarding any other matters properly presented for a vote at the Annual\n\nMeeting.\n\nBeneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you are a beneficial owner and you\n\ndo not provide your broker, bank or other nominee that holds your shares with voting instructions, then your broker, bank or other\n\nnominee will determine if it has discretion to vote on each matter. Brokers do not have discretion to vote on non-routine matters.\n\nProposal No. 1 (election of directors), Proposal No. 3 (approval of the compensation of our named executive officers), Proposal No.\n\n4 (approval of the frequency of advisory votes on executive compensation) and Proposal No. 5 (approval of an amendment to our\n\n2024 Equity Incentive Plan to increase the available shares reserved thereunder) are non-routine matters, while Proposal No. 2\n\n(ratification of appointment of independent registered public accounting firm) is a routine matter. As a result, if you do not provide\n\nvoting instructions to your broker, bank or other nominee, then your broker, bank or other nominee may not vote your shares with\n\nrespect to Proposal No. 1, Proposal No. 3, or Proposal No. 4, or Proposal No. 5, which would result in a “broker non-vote,” but\n\nmay, in its discretion, vote your shares with respect to Proposal No. 2. For additional information regarding broker non-votes, see\n\n“What are the effects of abstentions and broker non-votes?” below.\n\nWhat is a quorum?\n\nA quorum is the minimum number of shares required to be present at the Annual Meeting for the meeting to be properly held under\n\nour amended and restated bylaws (the “Bylaws”) and Delaware law. A majority of the shares of common stock outstanding and\n\nentitled to vote, at the Annual Meeting or by proxy, constitutes a quorum for the transaction of business at the Annual Meeting. As\n\nnoted above, as of the Record Date, there were a total of 51,547,801 shares of common stock outstanding, which means that\n\n25,773,901 shares of common stock must be represented virtually or by proxy at the Annual Meeting to have a quorum. If there is\n\nno quorum, either the chairman or chairwoman of the meeting or a majority of the shares present at the Annual Meeting may\n\nadjourn the meeting to a later date.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  5\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nWhat are the effects of abstentions and broker non-votes?\n\nAn abstention represents a stockholder’s affirmative choice to decline to vote on a proposal. If a stockholder indicates on its proxy\n\ncard or vote over the Internet or by telephone that such stockholder wishes to abstain from voting such stockholder’s shares, or if a\n\nbroker, bank or other nominee holding its customers’ shares of record causes abstentions to be recorded for shares, these shares\n\nwill be considered present and entitled to vote at the Annual Meeting. As a result, abstentions will be counted for purposes of\n\ndetermining the presence or absence of a quorum and will also count as votes against a proposal in cases where approval of the\n\nproposal requires the affirmative vote of a majority of the shares present and entitled to vote at the Annual Meeting (e.g., Proposal\n\nNo. 2, Proposal No. 3, and Proposal No. 5). However, abstentions will have no impact on the outcome of Proposal No. 1 and No. 5\n\nbecause they are not considered votes cast for such purposes.\n\nA broker non-vote occurs when a broker, bank or other nominee holding shares for a beneficial owner does not vote on a particular\n\nproposal because the broker, bank or other nominee does not have discretionary voting power with respect to such proposal and\n\nhas not received voting instructions from the beneficial owner of the shares. Broker non-votes are not considered votes cast or\n\nentitled to vote on a proposal and therefore will be counted for purposes of calculating whether a quorum is present at the Annual\n\nMeeting, but will not have any effect on the results of Proposals Nos. 1 through 4.\n\nHow many votes are needed for approval of each proposal and how are votes counted?\n\n•Proposal No. 1: We have a majority voting standard for uncontested elections of directors, which means that to be\n\nelected, a director nominee must receive a majority of the votes cast, i.e. the number of shares voted FOR a director\n\nnominee must exceed the votes cast AGAINST that nominee. You may (i) vote FOR each of the nominees, (ii)\n\nWITHHOLD your vote as to each of the nominees, or (iii) vote FOR each of the nominees except for those specific\n\nnominees from whom you WITHHOLD your vote. Abstentions and broker non-votes will have no impact on this proposal\n\nas they are not considered votes cast for the foregoing purpose and will not be counted as a FOR or AGAINST vote for\n\nthis proposal. If you WITHHOLD your vote as to all nominees, you will be deemed to have abstained from voting on\n\nProposal No. 1, and such abstention will have no effect on the outcome of the proposal.\n\n•Proposal No. 2: The ratification of the appointment of Deloitte & Touche LLP requires an affirmative vote of a majority of\n\nthe shares of our common stock present virtually or by proxy at the Annual Meeting and entitled to vote thereon to be\n\napproved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on Proposal No. 2, the abstention will\n\nhave the same effect as a vote AGAINST the proposal.\n\n•Proposal No. 3: The approval, on an advisory basis, of the compensation of our named executive officers requires an\n\naffirmative vote of a majority of the shares of our common stock present virtually or by proxy at the Annual Meeting and\n\nentitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on\n\nProposal No. 3, the abstention will have the same effect as a vote AGAINST the proposal. As an advisory vote, this\n\nproposal is not binding. However, our Board of Directors and Compensation and Human Capital Committee will consider\n\nthe outcome of the vote when making future compensation decisions for our named executive officers.\n\n•Proposal No. 4: The approval, on an advisory basis, of the frequency of advisory votes on the compensation of our\n\nnamed executive officers will be determined by a plurality vote of the shares of our common stock present virtually or by\n\nproxy at the Annual Meeting and entitled to vote thereon to be approved. The option receiving the highest number of\n\naffirmative votes will be determined to be the preferred frequency. You may vote for \"ONE YEAR,\" \"TWO YEARS,\" or\n\n\"THREE YEARS\", or you may ABSTAIN. If you ABSTAIN from voting on Proposal No. 4, the abstention will have no effect\n\non the outcome of the proposal. As an advisory vote, this proposal is not binding. However, our Board of Directors and\n\nCompensation and Human Capital Committee will consider the choice that receives the most votes in making future\n\ndecisions regarding the frequency of future votes on the compensation program for our named executive officers.\n\n•Proposal No. 5: The approval of an amendment to our 2024 Equity Incentive Plan to increase the available shares\n\nreserved thereunder requires an affirmative vote of a majority of the shares of our common stock present virtually or by\n\nproxy at the Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If\n\nyou ABSTAIN from voting on Proposal No. 5, the abstention will have the same effect as a vote AGAINST the proposal.\n\n6  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nHow are proxies solicited for the Annual Meeting and who is paying for such solicitation?\n\nOur Board of Directors is soliciting proxies for use at the Annual Meeting by means of the proxy materials. We will bear the entire\n\ncost of proxy solicitation, including the preparation, assembly, printing, mailing and distribution of the proxy materials. Copies of\n\nsolicitation materials will also be made available upon request to brokers, banks and other nominees to forward to the beneficial\n\nowners of the shares held of record by such brokers, banks or other nominees. The original solicitation of proxies may be\n\nsupplemented by solicitation by telephone, electronic communication, or other means by our directors, officers, employees or\n\nagents. No additional compensation will be paid to these individuals for any such services, although we may reimburse such\n\nindividuals for their reasonable out-of-pocket expenses in connection with such solicitation. We have retained Innisfree M&A\n\nIncorporated to help us solicit proxies. We will pay Innisfree M&A Incorporated $25,000 plus reasonable expenses for its services.\n\nIf you choose to access the proxy materials and/or vote over the Internet, you are responsible for Internet access charges you may\n\nincur. If you choose to vote by telephone, you are responsible for telephone charges you may incur.\n\nWhy did I receive the Notice instead of a full set of proxy materials?\n\nIn accordance with the rules of the Securities and Exchange Commission (the “SEC”), we have elected to furnish our proxy\n\nmaterials, including this proxy statement and our annual report, primarily via the Internet. Stockholders may request to receive\n\nproxy materials in printed form by mail or electronically by e-mail by following the instructions contained in the Notice. We\n\nencourage stockholders to take advantage of the availability of our proxy materials on the Internet to help reduce the environmental\n\nimpact of our annual meetings of stockholders.\n\nWhat does it mean if I received more than one Notice?\n\nIf you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow\n\nthe voting instructions on each Notice to ensure that all of your shares are voted.\n\nWho will count the votes?\n\nThe votes will be counted, tabulated and certified by Broadridge Financial Solutions, Inc.\n\nIs my vote confidential?\n\nProxies, ballots and voting tabulations are handled on a confidential basis to protect your voting privacy. This information will not be\n\ndisclosed either within CareDx or to third parties, except as necessary to meet applicable legal requirements, to allow for the\n\ntabulation of votes and certification of the vote, or to facilitate a successful proxy solicitation.\n\nDo CareDx’s executive officers and directors have an interest in any of the matters to be acted upon at the\n\nAnnual Meeting?\n\nDr. Cohen, Mr. Riggsbee, Mr. Gunasekaran, Mr. Goldberg and Mr. Hanna each have an interest in Proposal No. 1 (election of\n\ndirectors), as each nominee is currently a member of our Board of Directors. Members of our Board of Directors and our executive\n\nofficers do not have any interest in Proposal No. 2 (ratification of appointment of independent registered public accounting firm).\n\nOur executive officers have an interest in Proposal No. 3 (approval of the compensation of our named executive officers), as\n\ncompensation for our current and former executive officers is subject to this vote. Additionally, our executive officers have an\n\ninterest in Proposal No. 4 (approval of the frequency of advisory votes on executive compensation), as the outcome of this vote\n\nimpacts how frequently we will conduct advisory votes on executive compensation. Members of our Board of Directors and our\n\nexecutive officers have an interest in Proposal No. 5 (approval of an amendment to our 2024 Equity Incentive Plan to increase the\n\navailable shares reserved thereunder), as each would be eligible to receive equity awards under the plan.\n\nWill members of the Board of Directors attend the Annual Meeting?\n\nWe encourage, but do not require, the members of our Board of Directors to attend the Annual Meeting. Those who do attend will\n\nbe available to answer appropriate questions from stockholders.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  7\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nI share an address with another stockholder, and we received only one paper copy of the proxy materials.\n\nHow may I obtain an additional copy of the proxy materials?\n\nWe are sending only one annual report and proxy materials to multiple stockholders who share the same address unless we\n\nreceived contrary instructions from one or more of the stockholders. This practice, known as “householding,” reduces our printing\n\nand mailing costs. Stockholders who participate in householding will continue to be able to access and receive separate proxy\n\ncards. Upon written or oral request, we will promptly deliver a separate copy of the proxy materials and annual report to any\n\nstockholder at a shared address to which we delivered a single copy of any of these documents. To receive a separate copy, or, if\n\nyou are receiving multiple copies, to request that we only send a single copy of next year’s proxy materials and annual report, you\n\nmay contact us as follows:\n\nCareDx, Inc.\n\nAttention: Corporate Secretary\n\n8000 Marina Boulevard, 4th Floor\n\nBrisbane, CA 94005\n\n(415) 287-2300\n\nStockholders who hold shares in street name may contact their broker, bank or other nominee to request information about\n\nhouseholding.\n\nHow can I find out the results of the voting at the Annual Meeting?\n\nPreliminary voting results will be announced at the Annual Meeting. In addition, final voting results will be published in a Current\n\nReport on Form 8-K (“Form 8-K”) that we expect to file within four business days after the Annual Meeting. If final voting results are\n\nnot available to us by such date, we intend to file a Form 8-K to publish preliminary results and, within four business days after the\n\nfinal results are known to us, file an amendment to the Form 8-K to publish the final results.\n\nWhat is the deadline to propose actions for consideration at next year’s annual meeting of stockholders or to\n\nnominate individuals to serve as directors?\n\nStockholder Proposals\n\nStockholders may present proper proposals for inclusion in our proxy statement and for consideration at the next annual meeting of\n\nstockholders by submitting their proposals in writing to our Corporate Secretary in a timely manner. For a stockholder proposal to\n\nbe considered for inclusion in our proxy statement for our 2027 annual meeting of stockholders, our Corporate Secretary must\n\nreceive the written proposal at our principal executive offices no later than December 30, 2026. In addition, stockholder proposals\n\nmust comply with the requirements of Rule 14a-8 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”),\n\nregarding the inclusion of stockholder proposals in company-sponsored proxy materials. Stockholder proposals should be\n\naddressed to:\n\nCareDx, Inc.\n\nAttention: Corporate Secretary\n\n8000 Marina Boulevard, 4th Floor\n\nBrisbane, CA 94005\n\nOur Bylaws also establish an advance notice procedure for stockholders who wish to present a proposal before an annual meeting\n\nof stockholders but do not intend for the proposal to be included in our proxy statement. Our Bylaws provide that the only business\n\nthat may be conducted at an annual meeting is business that is brought (i) pursuant to our proxy materials with respect to the\n\nannual meeting specified in the notice of meeting (or any supplement thereto), (ii) by or at the direction of our Board of Directors, or\n\n(iii) properly before the annual meeting by a stockholder of record entitled to vote at the annual meeting who has delivered timely\n\nwritten notice to our Corporate Secretary, which notice must contain the information specified in our Bylaws.\n\n8  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProxy Statement for 2026 Annual Meeting of Stockholders\n\nTo be timely for our 2027 annual meeting of stockholders, our Corporate Secretary must receive the written notice at our principal\n\nexecutive offices:\n\n•not earlier than February 13, 2027; and\n\n•not later than March 15, 2027.\n\nIn the event that we hold our 2027 annual meeting of stockholders more than 30 days before or after the first anniversary of the\n\ndate of the Annual Meeting, then notice of a stockholder proposal that is not intended to be included in our proxy statement must\n\nbe received no earlier than the close of business on the 120th day before such annual meeting and no later than the close of\n\nbusiness on the later of the following two dates:\n\n•the 90th day prior to such annual meeting; or\n\n•the 10th day following the day on which public announcement of the date of such annual meeting is first made.\n\nIf a stockholder who has notified us of such stockholder’s intention to present a proposal at an annual meeting does not appear to\n\npresent such stockholder’s proposal at such annual meeting, we are not required to present the proposal for a vote at such annual\n\nmeeting.\n\nIn addition, pursuant to Rule 14a-19 of the Exchange Act (“Rule 14a-19”), the SEC’s universal proxy rule, notices of a solicitation of\n\nproxies in support of director nominees other than our own nominees must be postmarked or electronically submitted no later than\n\nApril 12, 2027, and each nomination must comply with the SEC regulations under Rule 14a-19, which requires, among other\n\nthings, that such notice include a statement that such person intends to solicit the holders of shares representing at least 67% of\n\nthe voting power of shares entitled to vote on the election of directors. If, however, the date of the 2027 annual meeting of\n\nstockholders is more than 30 days before or after June 11, 2027, then the Rule 14a-19 deadline shall be the later of 60 calendar\n\ndays prior to the date of the 2027 annual meeting of stockholders or the 10th calendar day following the day on which we first make\n\na public announcement of the date of our 2027 annual meeting of stockholders. A nomination that does not comply with the\n\nrequirements set forth in the Certificate of Incorporation and Bylaws will not be considered for presentation at the annual meeting.\n\nWe intend to file our proxy statement and white proxy card with the SEC in connection with our solicitation of proxies for our 2027\n\nannual meeting of stockholders.\n\nNomination of Director Candidates\n\nYou may propose director candidates for consideration by our Governance and Nominating Committee. Any such\n\nrecommendations should include the nominee’s name and qualifications for membership on our Board of Directors and should be\n\ndirected to our Corporate Secretary at the address set forth above. For additional information regarding stockholder\n\nrecommendations for director candidates, see “Board of Directors and Corporate Governance - Stockholder Recommendations for\n\nNominations to the Board of Directors.”\n\nIn addition, our Bylaws permit stockholders to nominate directors for election at an annual meeting of stockholders. To nominate a\n\ndirector, the stockholder must provide the information required by our Bylaws. The stockholder must also give timely notice to our\n\nCorporate Secretary in accordance with our Bylaws, which, in general, require that the notice be received by our Corporate\n\nSecretary within the time period described above under “Stockholder Proposals” for stockholder proposals that are not intended to\n\nbe included in a proxy statement.\n\nAvailability of Bylaws\n\nA copy of our Bylaws may be obtained by accessing our public filings on the SEC’s website at www.sec.gov. You may also contact\n\nour Corporate Secretary at our principal executive office for a copy of the relevant Bylaw provisions regarding the requirements for\n\nmaking stockholder proposals and nominating director candidates.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  9\n\nProposal No. 1\n\nElection of Directors\n\nOur Board of Directors is currently composed of ten members. In accordance with our amended and restated certificate of\n\nincorporation (the “Certificate of Incorporation”), our Board of Directors is currently divided into three classes with staggered three-\n\nyear terms. At the Annual Meeting, three Class II directors and two Class III directors will be elected for a one-year term to succeed\n\nthe same classes whose term is then expiring. Following the Annual Meeting, our Board of Directors will be composed of eight\n\nmembers.\n\nEach director’s term continues until the election and qualification of such director’s successor, or such director’s earlier death,\n\nresignation, or removal. Any increase or decrease in the number of directors will be distributed among the three classes so that, as\n\nnearly as possible, each class will consist of one-third of our directors. The current classification of our Board of Directors may have\n\nthe effect of delaying or preventing changes in control of our company. However, our Certificate of Incorporation provides for the\n\ngradual elimination of the classification of our Board of Directors and provides for the annual election of all directors beginning at\n\nour 2027 annual meeting of stockholders.\n\nPeter Maag, Ph.D. and Arthur A. Torres are not standing for re-election at the Annual Meeting and therefore, effective as of\n\nimmediately following the Annual Meeting, the number of authorized directors on our Board of Directors will be decreased to eight.\n\nThe Board of Directors thanks Dr. Maag for his more than thirteen years of service to CareDx and his invaluable contributions to\n\nthe Board of Directors. The Board of Directors also thanks Mr. Torres for his more than four years of service to CareDx and his\n\ninvaluable contributions to the Board of Directors.\n\nNominees\n\nOur Governance and Nominating Committee has recommended, and our Board of Directors has approved, Fred E. Cohen, M.D.,\n\nD. Phil, R. Bryan Riggsbee and Suresh Gunasekaran as nominees for election as Class II directors, and Michael D. Goldberg and\n\nJohn W. Hanna as nominees for election as Class III directors, at the Annual Meeting. If elected, each nominee will serve until the\n\n2027 annual meeting of stockholders or until their successors are duly elected and qualified. Each of the nominees is currently a\n\ndirector of our company. For information concerning the nominees, please see the section titled “Board of Directors and Corporate\n\nGovernance.”\n\nIf you are a stockholder of record and you sign your proxy card or vote over the Internet or by telephone but do not give instructions\n\nwith respect to the voting of directors, your shares will be voted FOR the re-election of Dr. Cohen, Mr. Riggsbee, Mr. Gunasekaran,\n\nMr. Goldberg and Mr. Hanna.  We expect that each nominee will each accept such nomination; however, in the event that a\n\ndirector nominee is unable or declines to serve as a director at the time of the Annual Meeting, the proxies will be voted for any\n\nnominee who shall be designated by our Board of Directors to fill such vacancy. If you are a beneficial owner of shares of our\n\ncommon stock and you do not give voting instructions to your broker, bank or other nominee, then your broker, bank or other\n\nnominee will leave your shares unvoted on this matter.\n\nVote Required; Board Recommendation\n\nThe election of directors requires the affirmative vote of a majority of the votes cast by stockholders present virtually or by proxy at\n\nthe Annual Meeting and entitled to vote thereon. Abstentions and broker non-votes will have no effect on this proposal.\n\nOur Board of Directors recommends a vote “FOR” the election of each of the five directors\n\nnominated by our Board of Directors and named in this Proxy Statement to serve for a one-year\n\nterm.\n\n10  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors\n\nand Corporate Governance\n\nOur business affairs are managed under the direction of our Board of Directors, which is currently composed of 10 members. As\n\nnoted above, our Certificate of Incorporation provides for the gradual elimination of the classification of our Board of Directors and\n\nprovides for the annual election of all directors beginning at our 2027 annual meeting of stockholders. Consistent with this, at the\n\nAnnual Meeting, five directors will be elected for a one-year term.\n\nThe following table sets forth the name, age as of April 15, 2026 and certain other information of each of our directors:\n\nDirectors with Terms Expiring at the\n\nAnnual Meeting\n\nClass\n\nAge\n\nPosition\n\nDirector\n\nSince\n\nCurrent Term\n\nExpires\n\nExpiration of\n\nTerm For Which\n\nNominated\n\nDirector Nominees\n\nFred E. Cohen, M.D., D. Phil(4)\n\nII\n\n69\n\nDirector\n\n2003\n\n2026\n\n2027\n\nR. Bryan Riggsbee(2)\n\nII\n\n55\n\nDirector\n\n2024\n\n2026\n\n2027\n\nSuresh Gunasekaran\n\nII\n\n50\n\nDirector\n\n2025\n\n2026\n\n2027\n\nMichael D. Goldberg\n\nIII\n\n68\n\nChairman of the\n\nBoard of Directors\n\n2011\n\n2026\n\n2027\n\nJohn W. Hanna\n\nIII\n\n46\n\nDirector\n\n2024\n\n2026\n\n2027\n\nDeparting Directors\n\nPeter Maag, Ph.D.(4)\n\nIII\n\n59\n\nDirector\n\n2012\n\n2026\n\n—\n\nArthur A. Torres(3)\n\nIII\n\n79\n\nDirector\n\n2021\n\n2026\n\n—\n\nContinuing Directors\n\nGeorge W. Bickerstaff, III(1)(2)(3)\n\nI\n\n70\n\nDirector\n\n2014\n\n2027\n\n—\n\nChristine M. Cournoyer(1)(2)\n\nI\n\n74\n\nDirector\n\n2019\n\n2027\n\n—\n\nHannah A. Valantine, M.D.(3)(4)\n\nI\n\n74\n\nDirector\n\n2021\n\n2027\n\n—\n\n(1)Member of our Compensation and Human Capital Committee\n\n(2)Member of our Audit and Finance Committee\n\n(3)Member of our Governance and Nominating Committee\n\n(4)Member of our Technology and Innovation Committee\n\nCareDx Inc.\n\n2026 Proxy Statement  |  11\n\nBoard of Directors and Corporate Governance\n\nDirector Nominees with Terms Expiring at the Annual Meeting\n\nFred E. Cohen,\n\nM.D., D. Phil\n\nIndependent Director\n\nAge: 69\n\nIndependent Director\n\nsince: 2014\n\nCommittees:\n\n•Technology and\n\nInnovation Committee\n\nProfessional Experience\n\n•Founder & Chairman, Monograph Capital Partners (2021 - Present)\n\n•Founder & Senior Managing Director, Vida Ventures (2017 - Present)\n\n•Senior Advisor & Retired Partner, TPG (2001 - Present)\n\n•Professor (Cellular and Molecular Pharmacology), University of California, San Francisco (UCSF)\n\n(1988 - 2016)\n\nKey Skills & Qualifications\n\n•Relevant Industry Experience: Dr. Cohen’s thought leadership in biotechnology as an elected\n\nmember of the National Academy of Medicine of the National Academy of Sciences and fellow of the\n\nAmerican College of Physicians, among other organizations, and experience as Professor of Cellular\n\nand Molecular Pharmacology at UCSF, is an asset to the Board in assessing the firm’s strategy.\n\n•Investment, Finance or Accounting Experience: As founder and Senior Managing Director of Vida\n\nVentures and as a Partner and more recently a Senior Advisor at TPG, Dr. Cohen is well-versed in\n\ninvestment and financial matters specific to biotechnology companies.\n\n•Public Company Board or Governance Experience: Dr. Cohen has served on multiple public boards\n\nand committees including most recently at Progyny, Intellia Therapeutics and Urogen Pharma.\n\nOther Boards\n\n•Director, Kyverna Therapeutics (2020 - Present)\n\n•Director, Progyny (Nasdaq: PGNY) (2019 - 2025)\n\n•Director, Intellia Therapeutics (Nasdaq: NTLA) (2019 - Present)\n\n•Director, Urogen Pharma (Nasdaq: URGN) (2017 - 2024)\n\n•Director, Novotech (2017 - Present)\n\n•Director, Tandem Diabetes (Nasdaq: TNDM) (2013 - 2019)\n\n•Director, Biocryst (Nasdaq: BCRX) (2013 - 2019)\n\n•Director, Five Prime Therapeutics (Nasdaq: FPRX) (2013 - 2018)\n\n•Director, Veracyte (Nasdaq: VCYT) (2013 - 2019)\n\n•Director, Roka Biosciences (Nasdaq: ROKA) (2014 - 2017)\n\n•Director, Quintiles (NYSE: Q) (merged with IQVIA Holdings) (2013 - 2015)\n\n•Director, Genomic Health (Nasdaq: GHDX) (acquired by Exact Sciences) (2005 - 2019)\n\n•Director, Matrix Laboratories (2004 - 2009)\n\nCurrent Organizations\n\n•Member, American Academy of Arts and Sciences\n\n•Fellow, National Academy of Medicine\n\n•Fellow, American Medical Informatics Association\n\nPrevious Organizations\n\n•Trustee, Autistica\n\n•Fellow, American College of Physicians\n\n•Member, Association of American Physicians\n\n•Fellow, Western Association of Physicians\n\n•Member, American Society for Clinical Investigation\n\nEducation\n\n•Ph.D., Oxford University\n\n•M.D., Stanford University\n\n•B.S., Yale University\n\n12  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nR. Bryan\n\nRiggsbee\n\nIndependent Director\n\nAge: 55\n\nIndependent Director\n\nsince: 2024\n\nCommittees:\n\n•Audit & Finance\n\nCommittee (Chairman)\n\nProfessional Experience\n\n•Senior Vice President, CFO - Neogen Corporation (Nasdaq: NEOG) (2025-present)\n\n•Independent Director, Member of the Audit Committee, Member of the Remuneration Committee -\n\nImmunovia AB (2025 - present)\n\n•Senior Vice President, CFO - North America, BioMerieux (2025)\n\n•CFO, Myriad Genetics (Nasdaq: MYGN) (2014 – 2024)\n\n•Interim President and CEO, Myriad Genetics (Nasdaq: MYGN) (2020)\n\n•Senior Vice President, Corporate Finance, Laboratory Corporation of America (LabCorp) (NYSE: LH)\n\n(2004-2014)\n\nKey Skills & Qualifications\n\n•Financial Planning and Analysis\n\n•Strategic Planning\n\n•Risk Management\n\n•Compliance and Regulatory Standards\n\n•Treasury\n\n•Certified Public Accountant licensed in the state of North Carolina\n\nCurrent Organizations\n\n•Neogen Corporation\n\nPrevious Organizations\n\n•BioMerieux\n\n•Myriad Genetics\n\n•Laboratory Corporation of America (LabCorp)\n\n•General Electric\n\n•KPMG\n\nEducation\n\n•M.B.A., Northwestern University\n\n•B.A. (Political Science), University of North Carolina at Chapel Hill\n\n•B.A. (Accounting), North Carolina State University\n\nCareDx Inc.\n\n2026 Proxy Statement  |  13\n\nBoard of Directors and Corporate Governance\n\nSuresh\n\nGunasekaran\n\nIndependent Director\n\nAge: 50\n\nIndependent Director\n\nsince 2025\n\nProfessional Experience\n\n•President and CEO, UCSF Health (2022 - Present)\n\n•CEO and the Associate Vice President, University of Iowa Hospitals & Clinics (2018 - 2022)\n\n•Senior Executive Officer, Southwestern Health Resources Population Health Services Company\n\n(2017 - 2018)\n\n•Associate Vice President, Health System Affairs & CIO, Southwestern Medical Center (2004 - 2014)\n\n•Chief Operations Officer, UT Southwestern Medical Center (2015 - 2018)\n\nKey Skills & Qualifications\n\n•Relevant Industry Experience: Mr. Gunasekaran brings more than 20 years of executive leadership\n\nexperience in healthcare administration and information technology, including as President and Chief\n\nExecutive Officer of UCSF Health and previously as Chief Executive Officer of University of Iowa\n\nHospitals & Clinics. His track record leading large, complex academic medical centers—along with\n\nprior roles as Chief Information Officer and Chief Operations Officer at UT Southwestern and\n\nleadership experience at Vanderbilt Children’s Hospital—provides the Board with valuable\n\nperspective on healthcare delivery, operational excellence, technology-enabled innovation, and\n\ngrowth strategy.\n\nCurrent Organization\n\n•CEO, UCSF Health\n\nPrevious Organizations\n\n•University of Iowa Hospitals & Clinics\n\n•Southwestern Health Resources Population Health Services Company\n\n•Southwestern Medical Center\n\nEducation\n\n•M.B.A., Southern Methodist University\n\n14  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nMichael\n\nGoldberg\n\nChairman of the Board of\n\nDirectors\n\nAge: 68\n\nIndependent Director\n\nsince 2011\n\nProfessional Experience\n\n•Partner, Mohr Davidow Ventures (2005 - 2011)\n\n•Founder & CEO, Axion (1987 - 1995) (acquired by Bristol-Myers Squibb, NYSE: BMS)\n\n•Partner, Sevin Rosen Management Company (1985 - 1987)\n\n•Director (Corporate Development), Cetus Corporation (1981 - 1985)\n\nKey Skills & Qualifications\n\n•Relevant Industry Knowledge: Mr. Goldberg has a track record of leadership in healthcare, as the\n\nformer CEO of Axion and a founding and a former Board member of the California Institute for\n\nRegenerative Medicine. Mr. Goldberg is also a former director of Cetus Corporation, which developed\n\nthe foundational PCR technology for precision medicine.\n\n•Public Company Board or Governance Experience: As a director at multiple public companies, Mr.\n\nGoldberg has extensive experience working with management teams and Board members on\n\nbusiness matters and governance policies.\n\n•Business and Operations Leadership Experience: Mr. Goldberg’s experience as founder and CEO of\n\nAxion, as well as Executive Chair at DNAnexus and Senior Executive and Venture Capital Investor\n\nwith numerous companies in the Life Sciences industry, helps the Board develop and oversee our\n\noperations and business strategy.\n\nOther Boards\n\n•Executive Chairman & Director, DNAnexus (2013 - Present)\n\n•Chairman, YorLabs (2018 - Present)\n\n•Chairman, iRhythm Technologies (Nasdaq: IRTC) (2007 - 2010)\n\n•Chairman, Crescendo Biosciences (2007 - 2010) (acquired by Myriad Genetics, Nasdaq: MYGN)\n\n•Director, eHealth (Nasdaq: EHTH) (1999 - 2021)\n\n•Director, Genomic Health (acquired by Exact Sciences, Nasdaq: EXAS) (2001 - 2007)\n\nPrevious Organizations\n\n•Founding Board Member, California Institute for Regenerative Medicine\n\n•Board Member, Western Association of Venture Capitalists\n\n•Advisory Board Member, Harvard Center for Genetics and Genomics\n\n•Advisory Board Member, Berkeley Center for Law and Technology\n\n•Advisory Board Member, UCSF Center for Translational and Policy Research on Personalized\n\nMedicine\n\n•Advisory Board Member, Stanford Distinguished Careers Institute\n\n•Trustee, National Childhood Cancer Foundation\n\nEducation\n\n•M.B.A., Stanford Graduate School of Business\n\n•B.A., Brandeis University\n\nCareDx Inc.\n\n2026 Proxy Statement  |  15\n\nBoard of Directors and Corporate Governance\n\nJohn W.\n\nHanna\n\nDirector, President and\n\nChief Executive Officer of\n\nCareDx\n\nAge: 46\n\nDirector since 2024\n\nProfessional Experience\n\n•President and Chief Executive Officer, CareDx, Inc. (2024 - Present)\n\n•Vice President, Corporate Development (Pacific Biosciences of California, Inc. (2023 – 2024)\n\n•CEO, Apton Biosystem, Inc. (2021 – 2023)\n\n•Chief Commercial Officer, Veracyte, Inc. (2011 – 2021)\n\nKey Skills & Qualifications\n\n•Relevant Industry Knowledge: Mr. Hanna has over two decades of experience in the molecular\n\ndiagnostics and life sciences tools industries.\n\n•Business and Operations Leadership Experience: Mr. Hanna previously served as CEO of Apton\n\nBiosystems, Inc. where he led the development of a high throughput next-generation sequencing\n\n(NGS) platform for liquid biopsy and other clinical applications. The company was acquired by Pacific\n\nBiosciences of California, Inc. in August 2023, where he served as Vice President of Corporate\n\nDevelopment. Mr. Hanna previously spent ten years at Veracyte, Inc., an oncology diagnostics\n\ncompany in the fields of thyroid, lung, breast, and prostate cancer, where he held numerous roles\n\nincluding Chief Commercial Office and Vice President of Marketing. Prior to Veracyte, Mr. Hanna\n\nheld leadership roles at Humana and IBM.\n\nCurrent Organization\n\n•CareDx, Inc.\n\nPrevious Organizations\n\n•Pacific Biosciences of California, Inc.\n\n•Apton Biosystem, Inc.\n\n•Veracyte, Inc.\n\nEducation\n\n•M.B.A., University of Miami\n\n•B.S. (Political Science), Hampden Sydney College\n\n16  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nContinuing Directors\n\nGeorge W.\n\nBickerstaff, III\n\nIndependent Director\n\nAge: 70\n\nIndependent Director\n\nsince 2014\n\nCommittees:\n\n•Audit & Finance\n\nCommittee\n\n•Governance & Nominating\n\nCommittee\n\n•Compensation  & Human\n\nCapital Committee\n\nProfessional Experience\n\n•Partner & MD, M.M. Dillon & Co. (2005 - Present)\n\n•CFO, Novartis Pharma AG (2000 - 2005)\n\n•EVP & CFO, Workspace (1999 - 2000)\n\n•EVP & CFO, Uniscribe Professional Services (1998 - 1999)\n\n•EVP & CFO, Intellisource Group (1998)\n\n•Vice President (Finance), Cognizant (1997)\n\n•CFO, IMS Health (1990 - 1997)\n\n•Senior Vice President (Finance), Dun & Bradstreet (NYSE: DNB) (1985 – 1989)\n\n•Auditor & Engineer, General Electric (1978 - 1984)\n\nKey Skills & Qualifications\n\nMr. Bickerstaff was selected to serve on the Board based on his extensive experience in financial\n\nleadership, healthcare operations, and public company governance. He has served as Chief Financial\n\nOfficer for multiple global healthcare and life sciences organizations and has significant expertise in\n\nfinancial reporting, capital markets, mergers and acquisitions, and risk management. Mr. Bickerstaff\n\nalso brings substantial experience in public company board service, including audit, finance, and\n\ngovernance oversight at publicly traded biotechnology and healthcare companies.\n\nThe Board believes his background provides valuable perspective in overseeing financial integrity,\n\nstrategic transactions, and regulatory risk.\n\nOther Boards\n\n•Director, InCarda Therapeutics (2020 - 2023)\n\n•Director, Innoviva (Nasdaq: INVA) (2017 - 2023)\n\n•Director, RoosterBio (2017 - 2020)\n\n•Chairman, Optical Academy (2017 - 2019)\n\n•Independent Chairman, Cardax (2016 - 2021)\n\n•Director, Aegis Health Analytics (2014 - 2016)\n\n•Director, Sio Gene Therapies (Nasdaq: SIOX) (2018 - 2020)\n\n•Director, Inovio Pharmaceuticals (Nasdaq: INO) (2017 - 2018)\n\n•Director, Ariad Pharmaceuticals (Nasdaq: ARIA) (2016 - 2017)\n\n•Director, Viventia Bio Inc. (2015 - 2017)\n\n•Director, Cyclica Inc. (2010 - 2014)\n\n•Director, BMP Sunstone (Nasdaq: BJGP) (2008 - 2009)\n\n•Director, Vion Pharmaceuticals (Nasdaq: VION) (2005 - 2008)\n\n•Director, Amazys Holding (2005 - 2006)\n\nCurrent Organizations\n\n•Founding Member, The Global Leaders\n\n•Chairman, International Vaccine Institute\n\nPrevious Organizations\n\n•Vice Chairman, International Centre for Missing & Exploited Children\n\n•Chairman, Global Oncology\n\n•Director, Center for Disease Dynamics, Economics & Policy Inc.\n\n•Director, Gavi, the Vaccine Alliance\n\nEducation\n\n•B.S., Rutgers University\n\n•B.A., Rutgers University\n\nCareDx Inc.\n\n2026 Proxy Statement  |  17\n\nBoard of Directors and Corporate Governance\n\nChristine M.\n\nCournoyer\n\nIndependent Director\n\nAge: 74\n\nIndependent Director\n\nsince 2019\n\nCommittees:\n\n•Audit & Finance\n\n•Compensation & Human\n\nCapital (Chairwoman)\n\nProfessional Experience\n\n•Chairman & CEO, N-of-One (2012 - 2019)\n\n•Vice President (Clinical Analytics), Optum (part of UnitedHealth Group) (2010 - 2011)\n\n•President & COO, Picis (acquired by UnitedHealth Group) (2006 - 2010)\n\n•Managing Director (Solutions), Harte-Hanks (2005 - 2006)\n\n•CIO & Division Vice President, IBM (NYSE: IBM) (1995 - 2002)\n\n•SVP, CIO, Lotus Development (1994 - 1995)\n\nKey Skills & Qualifications\n\n•Relevant Industry Knowledge: Ms. Cournoyer has extensive experience as an executive in the life\n\nsciences industry and healthcare technology, including at N-of-One, Optum and Picis.\n\n•M&A or Corporate Development Experience: Ms. Cournoyer has led or contributed to two\n\ntransformative M&A transactions - while CEO at N-of-One, Ms. Cournoyer led the strategic sales\n\nprocess and successful sale to QIAGEN, and while at Picis, she contributed to Picis’ sale to\n\nUnitedHealth Group in an executive capacity.\n\n•Investment, Finance or Accounting Experience: Ms. Cournoyer managed P&L, raised capital and\n\nmanaged cash operations for different organizations including N-of-One, Picis and IBM, among\n\nothers.\n\n•Risk Management: As a former CIO, Ms. Cournoyer has a deep understanding of IT controls and\n\ncyber security.\n\nOther Boards\n\n•Chairman, Spok Holdings (Nasdaq: SPOK) (2022 - Present)\n\n•Director, Emerson Hospital (2012 - 2018)\n\n•Director, BJ’s Wholesale Club (NYSE: BJ) (2008 - 2011)\n\n•Director, GTEC (2003 - 2006)\n\n•Director, Lightbridge (Nasdaq: LTBR) (2002 - 2003)\n\n•Director, Stride Rite (Nasdaq: LRN) (2001 - 2007)\n\nCurrent Organizations\n\n•Editorial Board Member, Clinical OMICs\n\n•Board of Advisors, Manning School of Business\n\n•Member, Madam Chair\n\nEducation\n\n•M.A., Northeastern University\n\n•B.S., University of Massachusetts Lowell\n\n18  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nHannah A.\n\nValantine, M.D.\n\nIndependent Director\n\nAge: 74\n\nIndependent Director\n\nsince 2021\n\nCommittees:\n\n•Governance & Nominating\n\nCommittee\n\n•Technology and\n\nInnovation Committee\n\n(Chairwoman)\n\nProfessional Experience\n\n•Professor of Medicine, Stanford School of Medicine (2000 - Present)\n\n•Chief Officer (Scientific Workforce Diversity), National Institutes of Health (2014 - 2020)\n\n•Senior Associate Dean for Diversity and Leadership, Stanford School of Medicine (2005 - 2014)\n\n•Assistant Professor of Medicine, Stanford School of Medicine (1987 - 2000)\n\n•Registrar, Hammersmith Hospitals NHS Trust\n\nKey Skills & Qualifications\n\n•Relevant Industry Knowledge: Dr. Valantine has more than thirty-five years of expertise in transplant\n\nmedicine. She is an international leader in the development and application of genomic-based\n\ndiagnostics for acute rejection, having led the first ever randomized controlled trial of gene-\n\nexpression profiling published in the New England Journal of Medicine, setting the stage for FDA\n\napproval. She further advanced the field by publishing the first application of donor-derived cell-free\n\nDNA as a sensitive and specific biomarker for heart transplant rejection, an approach that has\n\nbecome widely adopted across all other solid organ transplants. Her pioneering work across several\n\nplatforms has enabled the advancement of a multi-modality approach to molecular diagnostics\n\nservices.\n\n•ESG: Dr. Valantine’s experience in ESG matters spans more than two decades. She is nationally\n\nrecognized for her transformative approaches to enhancing both gender and racial diversity among\n\nfaculty. As the inaugural Senior Associate Dean for Diversity and Leadership at Stanford University\n\nSchool of Medicine, and then as the inaugural NIH Chief Officer for scientific workforce diversity, she\n\nhas built and disseminated successful national programs to ensure both workforce diversity and\n\nhealth equity across the NIH research ecosystem.\n\nOther Boards\n\n•Director, BridgeBio Pharma (Nasdaq: BBIO) (2021 - Present)\n\n•Director, Pacific Biosciences (Nasdaq: PACB) (2021 - Present)\n\nCurrent Organizations\n\n•Founder & Principal, HAV\n\n•Member, National Academy of Medicine\n\n•Member, Stanford Cardiovascular Institute\n\nPrevious Organizations\n\n•President (Western State Affiliation), American Heart Association\n\nEducation\n\n•M.D., London University\n\n•Fellowship, Stanford University\n\n•M.B.B.S., London University\n\nCareDx Inc.\n\n2026 Proxy Statement  |  19\n\nBoard of Directors and Corporate Governance\n\nNon-Continuing Directors\n\nPeter K. Maag,\n\nPh.D.\n\nIndependent Director\n\nAge: 59\n\nIndependent Director\n\nsince 2024\n\nCommittees:\n\n•Technology and\n\nInnovation Committee\n\nProfessional Experience\n\n•CEO, Kyverna Therapeutics (Nasdaq: KYTX) (2022 - 2024)\n\n•Executive Chairman, CareDx (Nasdaq: CDNA) (2020 - 2021)\n\n•CEO & President, CareDx (Nasdaq: CDNA) (2012 - 2020)\n\n•Division President, Novartis Diagnostics AG (NYSE: NVS) (2009 - 2012)\n\n•CEO & Country President, Novartis AG, Germany (NYSE: NVS) (2006 - 2008)\n\n•CEO & Country President, Novartis AG, Korea (2003 - 2005)\n\n•Head of Division (Franchise Infectious Diseases), Novartis AG (2002 - 2003)\n\n•Head of Strategy (Pharma Division), Novartis AG (2001 - 2002)\n\n•Associate Principal, McKinsey & Company (1994 - 2001)\n\nKey Skills & Qualifications\n\n•Business and Operations Leadership Experience: Dr. Maag’s 20+ years of executive management\n\nexperience in the pharmaceutical and diagnostic industry including as former CEO of CareDx and as\n\nPresident of Diagnostics qualify him to advise the Board on matters specific to CareDx’s business\n\nand strategy.\n\n•Risk Management: Dr. Maag has deep expertise in risk management as he has served as a director\n\nof multiple healthcare companies, including Novartis, MiroMatrix Medical, and as the former\n\nChairman and CEO of CareDx.\n\n•M&A or Corporate Development Experience: Dr. Maag served in positions at Novartis Pharma and\n\nNovartis Diagnostics including as Head of Strategy where he was instrumental in the global growth of\n\nthe organization. During his tenure at CareDx, he has led multiple acquisitions and financial\n\ntransactions.\n\nOther Boards\n\n•Director, Kyverna Therapeutics (2022 - 2024)\n\n•Director, MiroMatrix Medical (2021 - 2023), MiroMatrix was acquired by United Therapeutics\n\n(Nasdaq: UTHR) in December 2023\n\n•Director, Phoenix Pharmahandel (2012 - Present)\n\n•Director, MolecularMD (2012 - 2020)\n\n•Director, Chiron France (2009 - 2012)\n\n•Director, Novartis AG, Germany (2006 - 2008)\n\n•Director, Zuellig Pharma (2003 - 2005)\n\n•Director, Novartis, Korea (2003 - 2005)\n\nCurrent Organizations\n\n•Director, Personalized Medicine Coalition\n\n•Director, BluLake Ventures LLC\n\nEducation\n\n•Ph.D., University of Berlin\n\n•MSc, University of Heidelberg, University of London\n\n20  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nArthur A.\n\nTorres\n\nIndependent Director\n\nAge: 79\n\nIndependent Director\n\nsince 2021\n\nCommittees:\n\n•Governance & Nominating\n\nCommittee (Chairman)\n\nProfessional Experience\n\n•Regent Emeritus University of California Board of Regents\n\n•Vice Chair Emeritus, California Institute for Regenerative Medicine\n\n•Director, San Francisco Municipal Transportation Agency (2017 - 2020)\n\n•President & Member, San Francisco Public Utilities Commission (2010 - 2014)\n\n•Member Covered California Board of Directors\n\n•Chairman, California Democratic Party (1996 - 2009)\n\n•Senator, California State Senate (1982 - 1994)\n\n•Chair, California Senate Insurance Committee\n\n•Chair, California Senate Toxics Committee\n\n•Assembly Member, California State Assembly ( 1974 - 1982)\n\n•Chair, California Assembly Health Committee (1978 - 1994)\n\nKey Skills & Qualifications\n\n•Regulatory and Legal Experience: Mr. Torres’ extensive career in politics and government and\n\nbackground in law qualifies him to advise on regulatory and legal matters.\n\n•Relevant Industry Knowledge: As Chair of the California Assembly Health Committee and California\n\nSenate Insurance Committee and the Vice Chair of One Legacy, an organ transplant foundation, Mr.\n\nTorres has the experience necessary to set strategy for our organization.\n\n•ESG: During his tenure in the California state legislature, Mr. Torres worked to provide a voice for his\n\nconstituents as co-author of the California Clean Water Act and consultant on immigration reform,\n\namong other initiatives.\n\nCurrent Organization\n\n•Lifeguard Health Networks, Member, Board of Directors\n\n•PFM, Board Member, Member Audit Committee\n\nPrevious Organizations\n\n•Vice Chair Emeritus, California Institute for Regenerative Medicine\n\n•Vice Chair, Emeritus, One Legacy, an Organ Transplant Foundation\n\n•Alumni Regent & President Emeritus, University of California Alumni Association\n\n•Alumni Regent Emeritus, University of California\n\n•Board Member Emeritus, Covered California\n\n•Fellow, German Marshal Fund\n\n•JFK Teaching Fellow, Harvard University\n\n•Visiting Professor, University of San Francisco School of Nursing\n\nEducation\n\n•J.D., University of California Davis School of Law\n\n•B.A. (Government), University of California Santa Cruz\n\nCareDx Inc.\n\n2026 Proxy Statement  |  21\n\nBoard of Directors and Corporate Governance\n\nConsiderations in Evaluating Director Nominees\n\nOur Governance and Nominating Committee uses a variety of methods for identifying and evaluating director nominees. In its\n\nevaluation of director candidates, our Governance and Nominating Committee will consider the composition of our Board of\n\nDirectors, including, without limitation, issues of character, integrity, judgment, diversity, age, independence, skills, education,\n\nexpertise, business acumen, business experience, length of service, understanding of our business and other commitments.\n\nMembers of our Board of Directors are expected to prepare for, attend, and participate in all Board of Directors and applicable\n\ncommittee meetings. Our Governance and Nominating Committee requires the following minimum qualifications to be satisfied by\n\nany nominee for a position on our Board of Directors: (i) the highest personal and professional ethics and integrity, (ii) proven\n\nachievement and competence in the nominee’s field and the ability to exercise sound business judgment, (iii) skills that are\n\ncomplementary to those of the existing Board of Directors, (iv) the ability to assist and support management and make significant\n\ncontributions to our success, and (v) an understanding of the fiduciary responsibilities that are required of a member of our Board\n\nof Directors and the commitment of time and energy necessary to diligently carry out those responsibilities. Other than the\n\nforegoing, there are no stated minimum criteria for director nominees, although our Governance and Nominating Committee may\n\nalso consider such other factors as it may deem, from time to time, are in our and our stockholders’ best interests.\n\nAlthough our Board of Directors does not maintain a specific policy with respect to board diversity, our Board of Directors believes\n\nthat our Board of Directors should be a diverse body in terms of experiences and backgrounds, and our Governance and\n\nNominating Committee considers a broad range of factors in identifying new nominees. In determining nominations of directors, our\n\nGovernance and Nominating Committee may take into account the benefits of varying viewpoints, industry experience, academic\n\nexperience, and educational backgrounds. Our Governance and Nominating Committee also considers these and other factors as\n\nit oversees the annual Board of Directors and committee evaluations. After completing its review and evaluation of director\n\ncandidates, our Governance and Nominating Committee recommends to our full Board of Directors the director nominees for\n\nselection.\n\nDirector Independence\n\nOur common stock is listed on the Nasdaq Global Market. Under the rules of The Nasdaq Stock Market LLC (the “Nasdaq Rules”),\n\nindependent directors must comprise a majority of a listed company’s Board of Directors. In addition, the Nasdaq Rules require\n\nthat, subject to specified exceptions, each member of a listed company’s audit, compensation, and nominating and corporate\n\ngovernance committees be independent. Under the Nasdaq Rules, a director will only qualify as an “independent director” if, in the\n\nopinion of the listed company’s Board of Directors, the director does not have a relationship that would interfere with the exercise of\n\nindependent judgment in carrying out the responsibilities of a director.\n\nAudit and Finance Committee members must also satisfy the independence criteria set forth in Rule 10A-3 under the Exchange Act\n\nand the Nasdaq Rules. In addition, Compensation and Human Capital Committee members must satisfy the independence criteria\n\nset forth in Rule 10C-1 under the Exchange Act and the Nasdaq Rules.\n\nOur Board of Directors has undertaken a review of the independence of each director and considered whether such director has a\n\nmaterial relationship with us that could compromise the director’s ability to exercise independent judgment in carrying out the\n\ndirector’s responsibilities. As a result of this review, our Board of Directors has determined that Mr. Goldberg, Mr. Bickerstaff, Dr.\n\nCohen, Dr. Maag, Ms. Cournoyer, Mr. Gunasekaran, Mr. Riggsbee, Senator Torres and Dr. Valantine are “independent directors”\n\nas defined under the applicable rules and regulations of the SEC and the Nasdaq Rules. Accordingly, all of the members, including\n\nthe chairman or chairwoman, of each of the Audit and Finance Committee, the Compensation and Human Capital Committee, and\n\nthe Governance and Nominating Committee are independent directors.\n\n22  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nBoard Leadership Structure\n\nOur Board of Directors has an independent Chairman, Mr. Goldberg, and we believe that having independent leadership is an\n\nimportant component of our governance structure. Our independent Chairman has authority, among other things, to preside over\n\nBoard of Directors meetings, including meetings of the independent directors, and to call special meetings of our Board of\n\nDirectors. Accordingly, the independent Chairman has substantial ability to shape the work of our Board of Directors. We currently\n\nbelieve that having an independent Chairman creates an environment that is more conducive to objective evaluation and oversight\n\nof management’s performance, increasing management accountability and improving the ability of our Board of Directors to\n\nmonitor whether management’s actions are in the best interests of our Company and our stockholders.\n\nIn addition, we believe that separation of the roles of Chairman and Chief Executive Officer enhances the accountability of our\n\nChief Executive Officer to our Board of Directors and encourages balanced decision making. While our Chief Executive Officer is\n\nresponsible for our day-to-day leadership and operations, our independent Chairman provides guidance to our Board of Directors\n\nand sets the agenda for the meetings of the Board of Directors.\n\nHowever, no single leadership model is right for all companies and at all times. Our Board of Directors recognizes that, depending\n\non the circumstances, other leadership models, such as combining the role of Chairman with the role of Chief Executive Officer,\n\nmight be appropriate. Accordingly, our Board of Directors periodically reviews its leadership structure and will continue to evaluate\n\nand implement the leadership structure that it concludes most effectively supports our Board of Directors in fulfilling its\n\nresponsibilities.\n\nBoard Diversity of Skills and Expertise\n\nThe Board of Directors believes its current composition provides an appropriate balance of industry expertise, financial experience,\n\nand operational leadership, enabling effective oversight of the Company’s strategy, risk management, and long-term value\n\ncreation.\n\nThe following is an overview of the collective experiences, qualifications and attributes of our Board of Directors. Please see the\n\nsections titled “Directors with Terms Expiring at the Annual Meeting-Nominees for Director” and “Continuing Directors” for individual\n\ndetails regarding the experience and expertise of each of our directors.\n\nDirector Skills /\n\nQualifications\n\nGoldberg\n\nBickerstaff\n\nCohen\n\nCournoyer\n\nGunasekaran\n\nHanna\n\nMaag\n\nRiggsbee\n\nTorres\n\nValantine\n\nBoard\n\nComposition\n\nRelevant Industry Knowledge\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n10 of 10\n\nBusiness and Operations Leadership\n\nExperience\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n8 of 10\n\nInvestment, Finance or Accounting\n\nExperience\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n9 of 10\n\nPublic Company Board or Governance\n\nExperience\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n9 of 10\n\nRisk Management\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n8 of 10\n\nM&A or Corporate Development\n\nExperience\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n8 of 10\n\nRegulatory and Legal Experience\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n9 of 10\n\nFemale\n\nl\n\nl\n\n2 of 10\n\nIndependent\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\nl\n\n9 of 10\n\nCareDx Inc.\n\n2026 Proxy Statement  |  23\n\nBoard of Directors and Corporate Governance\n\nLegal Proceedings with Directors\n\nThere are no legal proceedings related to any of the directors or director nominees that require disclosure pursuant to Items 103\n\nor 401(f) of Regulation S-K.\n\nAgreements with Directors\n\nNone of the directors or nominees for director was selected pursuant to any arrangement or understanding, other than\n\ncompensation arrangements in the ordinary course of business.\n\nBoard and Committee Meetings\n\nDuring fiscal year 2025, our Board of Directors held six meetings (including regularly scheduled and special meetings), and took\n\naction by written consent. Each director attended at least 97% of the aggregate of (i) the total number of meetings of our Board of\n\nDirectors held during the period for which he or she served as a director, and (ii) the total number of meetings held by the Audit and\n\nFinance Committee, Compensation and Human Capital Committee, and Governance and Nomination Committee of our Board of\n\nDirectors on which he or she served during the periods that he or she served.\n\nIt is the policy of our Board of Directors to regularly have separate meeting times for independent directors without management.\n\nAlthough we do not have a formal policy regarding attendance by members of our Board of Directors at annual meetings of\n\nstockholders, we encourage, but do not require, our directors to attend.\n\nOur Board of Directors has four standing committees: the Audit and Finance Committee, the Compensation and Human Capital\n\nCommittee, the Governance and Nominating Committee and the Technology and Innovation Committee. The composition and\n\nresponsibilities of each of the committees of our Board of Directors following the Annual Meeting are described below. Members\n\nwill serve on these committees until their resignation or until otherwise determined by our Board of Directors.\n\nAudit and\n\nFinance Committee\n\nGovernance and\n\nNominating Committee\n\nCompensation and\n\nHuman Capital Committee\n\nTechnology and\n\nInnovation Committee\n\nGeorge W. Bickerstaff, III\n\nl\n\nl\n\nl\n\nFred E. Cohen, M.D., D. Phil\n\nl\n\nl\n\nChristine M. Cournoyer\n\nl\n\nC\n\nMichael D. Goldberg\n\nC\n\nSuresh Gunasekaran\n\nl\n\nR. Bryan Riggsbee\n\nC\n\nHannah A. Valantine, M.D.\n\nl\n\nC\n\nlCommittee Member\n\nCCommittee Chairman or Chairwoman\n\n24  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nAudit and Finance Committee\n\nWe have a separately-designated standing audit and finance committee established in accordance with Section 3(a)(58)(A) of the\n\nExchange Act. Our Audit and Finance Committee is currently comprised of R. Bryan Riggsbee, George W. Bickerstaff, III and\n\nChristine M. Cournoyer, each of whom is a non-employee member of our Board of Directors. Mr. Riggsbee has served as the\n\nChairman of our Audit and Finance Committee since his appointment to our Board of Directors in March 2024. Our Board of\n\nDirectors has determined that each of the members of our Audit and Finance Committee satisfies the requirements for\n\nindependence and financial literacy under the rules and regulations of the SEC, including Rule 10A-3 under the Exchange Act and\n\nthe Nasdaq Rules. Our Board of Directors has determined that each of Messrs. Riggsbee, Bickerstaff, and Ms. Cournoyer qualifies\n\nas an “audit committee financial expert” as defined by the applicable SEC rules and satisfies the financial sophistication\n\nrequirements of the Nasdaq Rules. This designation does not impose on Messrs. Riggsbee, Bickerstaff and Ms. Cournoyer any\n\nduties, obligations or liabilities that are greater than those generally imposed on them as members of our Audit and Finance\n\nCommittee and our Board of Directors. Our Audit and Finance Committee is responsible for, among other things:\n\n•appointing, compensating and overseeing the work of our independent registered public accounting firm;\n\n•reviewing the qualifications, performance and independence of our independent registered public accounting firm;\n\n•pre-approving any audit and permissible non-audit services to be performed by our independent registered public\n\naccounting firm;\n\n•overseeing our internal accounting and financial controls, including procedures for the treatment of complaints on\n\naccounting controls, internal accounting controls or auditing matters and procedures for the submission of confidential,\n\nanonymous employee comments about questionable accounting or auditing matters;\n\n•providing to our Board of Directors such information and materials as it may deem necessary to make our Board of\n\nDirectors aware of significant financial matters that require the attention of our Board of Directors;\n\n•overseeing our financial and treasury policies and strategies, including our cash position, capital structure and strategies,\n\nand insurance coverage;\n\n•reviewing the terms and conditions of material financing plans and making recommendations to our Board of Directors on\n\nsuch plans;\n\n•reviewing our Board of Directors’ delegated authority to our officers and related spending and transaction authority\n\nguidelines, matrices or policies;\n\n•reviewing with our management and independent registered public accounting firm the organization and performance of\n\nour internal audit function;\n\n•reviewing and discussing with our management and the independent registered public accounting firm the results of our\n\nannual audit, our quarterly financial statements and financial statements included in our publicly filed reports;\n\n•reviewing and approving related party transactions;\n\n•preparing and providing the report of the Audit and Finance Committee that the SEC requires in our annual proxy\n\nstatements;\n\n•reviewing our guidelines and policies with respect to risk assessment and risk management, including risks relating to our\n\naccounting matters, financial reporting, legal and regulatory compliance and general business risks and the steps taken by\n\nmanagement to monitor and control these exposures;\n\n•assisting with the resolution of any actual or potential conflicts of interest with respect to members of our Board of\n\nDirectors; and\n\n•reviewing and evaluating, at least annually, the performance of the Audit and Finance Committee and its members.\n\nOur Audit and Finance Committee operates under a written charter that satisfies the applicable rules and regulations of the SEC\n\nand the Nasdaq Rules. A copy of the charter of our Audit and Finance Committee is available on our website at www.caredx.com in\n\nthe Corporate Governance section of our Investors webpage. During fiscal year 2025, our Audit and Finance Committee held\n\nseven standalone meetings.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  25\n\nBoard of Directors and Corporate Governance\n\nCompensation and Human Capital Committee\n\nOur Compensation and Human Capital Committee is comprised of Christine M. Cournoyer and George W. Bickerstaff, III, each of\n\nwhom is a non-employee member of our Board of Directors. Ms. Cournoyer serves as the Chairwoman of our Compensation and\n\nHuman Capital Committee. Our Board of Directors has determined that each member of our Compensation and Human Capital\n\nCommittee meets the requirements for independence under the rules and regulations of the SEC, including Rule 10C-1 under the\n\nExchange Act, and the Nasdaq Rules and is a “non-employee director” within the meaning of Rule 16b-3 under the Exchange Act.\n\nOur Compensation and Human Capital Committee is responsible for, among other things:\n\n•reviewing and approving all salaries, incentive awards and bonuses, equity awards, severance arrangements, change in\n\ncontrol agreements and any other compensation and benefit plans for our Chief Executive Officer and all other executive\n\nofficers;\n\n•administering our equity compensation plans and the issuance of stock options and other stock-related awards not\n\ngranted pursuant to a plan;\n\n•reviewing, at least annually, our stock plans, performance goals, incentive awards and the overall composition and\n\ncoverage of its compensation plans;\n\n•preparing and providing the annual report on executive compensation that the SEC requires in our annual proxy\n\nstatements;\n\n•reviewing the results of any stockholder advisory vote on executive compensation and considering whether to recommend\n\nadjustments to our executive compensation policies and practices as a result of such vote;\n\n•reviewing and recommending to our Board of Directors for approval the frequency with which we will conduct the\n\nstockholder advisory vote on named executive officer compensation, taking into account the results of the most recent\n\nstockholder advisory vote;\n\n•evaluating risks arising from our compensation plans, policies and programs for our employees;\n\n•developing and implementing policies with respect to the recovery of any excess compensation paid to our executive\n\nofficers based on erroneous data;\n\n•evaluating and making recommendations to our Board of Directors about director compensation;\n\n•overseeing our overall compensation philosophy, compensation plans and benefits programs;\n\n•overseeing and reviewing our human capital management practices, including talent management and diversity, equity\n\nand inclusion considerations in the context of our compensation plans, programs and pay equity practices; and\n\n•reviewing and evaluating, at least annually, the performance of the Compensation and Human Capital Committee and its\n\nmembers.\n\nOur Compensation and Human Capital Committee operates under a written charter that satisfies the applicable rules and\n\nregulations of the SEC and the Nasdaq Rules. A copy of the charter of our Compensation and Human Capital Committee is\n\navailable on our website at www.caredx.com in the Corporate Governance section of our Investors webpage. During fiscal year\n\n2025, our Compensation and Human Capital Committee held five standalone meetings.\n\nOur Compensation and Human Capital Committee adopted an Equity Award Grant Policy, pursuant to which our Compensation\n\nand Human Capital Committee delegated our Chief Executive Officer the power and authority, separately but concurrently with the\n\npower and authority of our Compensation and Human Capital Committee, to grant stock options, restricted stock awards and stock-\n\nsettled stock appreciation rights under our 2024 Equity Incentive Plan to our employees (other than executives and directors),\n\nconsultants or advisors of our company that are natural persons.\n\n26  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nCompensation Committee Interlocks and Insider Participation\n\nNo member of our Compensation and Human Capital Committee in fiscal year 2025 was at any time during 2025 or at any other\n\ntime an officer or employee of ours, and none had or have any relationships with us that are required to be disclosed under\n\nItem 404 of Regulation S-K. None of our executive officers has served as a member of the board of directors, or as a member of\n\nthe compensation or similar committee, of any entity that has one or more executive officers who served on our Board of Directors\n\nor Compensation and Human Capital Committee during fiscal year 2025.\n\nGovernance and Nominating Committee\n\nOur Governance and Nominating Committee is comprised of Arthur A. Torres, George W. Bickerstaff, III and Hannah A. Valantine,\n\nM.D., each of whom is a non-employee member of our Board of Directors. Senator Torres serves as the Chairman of our\n\nGovernance and Nominating Committee. Following the Annual Meeting, Michael Goldberg will serve as the Chairman of the\n\nGovernance and Nominating Committee. Our Board of Directors has determined that each member of our Governance and\n\nNominating Committee meets the requirements for independence under the Nasdaq Rules. Our Governance and Nominating\n\nCommittee is responsible for, among other things:\n\n•reviewing and making recommendations regarding the composition and size of our Board of Directors and determine the\n\nrelevant criteria (including any minimum qualifications) for membership on our Board of Directors;\n\n•overseeing our Board of Directors’ evaluation process, including conducting periodic evaluations of the performance of our\n\nBoard of Directors as a whole and each committee of our Board of Directors, and evaluating the performance of members\n\nof our Board of Directors eligible for re-election;\n\n•reviewing and recommending candidates for election to our Board of Directors (including candidates proposed by our\n\nstockholders) at the annual meeting of stockholders in compliance with our policies and procedures for consideration of\n\nBoard of Directors candidates;\n\n•reviewing disclosures about our nomination process in our annual proxy statement;\n\n•reviewing and making recommendations about our corporate governance guidelines and overseeing compliance with laws\n\nand regulations by our Board of Directors and its committees;\n\n•overseeing and providing input to management on our risks, policies, strategies and programs related to matters of\n\nsustainability, corporate social responsibility, corporate culture, corporate governance, and other important governance\n\nmatters that impact the Company’s workforce, patients, and the broader community;\n\n•overseeing our compliance program, including policies and practices designed to ensure our compliance with applicable\n\nlegal, regulatory and ethical requirements, except with respect to matters of financial compliance, which are the\n\nresponsibility of the Audit and Finance Committee;\n\n•overseeing our response to regulatory actions and investigations (except for financial, accounting and internal control\n\nmatters, which are responsibilities of the Audit and Finance Committee) and investigating any matter within the scope of\n\nits responsibilities that it determines appropriate;\n\n•determining the manner in which stockholders may send communications to our Board of Directors, as well as the process\n\nby which stockholder communications will be relayed to our Board of Directors and what our Board of Directors’ response,\n\nif any, should be;\n\n•reviewing governance-related stockholder proposals and recommending our Board of Directors’ responses;\n\n•reviewing and approving conflicts of interest of our directors and corporate officers, other than related party transactions\n\nreviewed by the Audit and Finance Committee; and\n\n•reviewing and evaluating, at least annually, the performance of the Governance and Nominating Committee and its\n\nmembers.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  27\n\nBoard of Directors and Corporate Governance\n\nOur Governance and Nominating Committee operates under a written charter that satisfies the Nasdaq Rules. A copy of the\n\ncharter of our Governance and Nominating Committee is available on our website at www.caredx.com in the Corporate\n\nGovernance section of our Investors webpage. During fiscal year 2025, our Governance and Nominating Committee held six\n\nstandalone meetings.\n\nTechnology and Innovation Committee\n\nOur Technology and Innovation Committee is comprised of Hannah A. Valantine, M.D., Fred E. Cohen, M.D., D. Phil and Peter\n\nMaag, Ph.D., each of whom is a non-employee member of our Board of Directors. Dr. Valantine serves as the Chairwoman of our\n\nTechnology and Innovation Committee. Our Technology and Innovation Committee is responsible for, among other things:\n\n•meeting with our science and technology leaders to review our internal research and technology development activities\n\nand providing input as it deems appropriate;\n\n•reviewing technologies that we consider for licensing or acquisition and providing input as it deems appropriate;\n\n•reviewing our development of our technical goals and research and development strategies and providing input as it\n\ndeems appropriate;\n\n•periodically reporting to our Board of Directors regarding the Technology and Innovation Committee’s review and\n\nassessment of our internal technology development, technology assessment, technology review and technical goals and\n\nresearch and development strategies and any other matters as it deems appropriate; and\n\n•reviewing and evaluating, at least annually, the performance of the Technology and Innovation Committee and its\n\nmembers.\n\nOur Technology and Innovation Committee operates under a written charter. During fiscal year 2025, our Technology and\n\nInnovation Committee held two standalone meetings.\n\nStockholder Recommendations for Nominations to the Board of Directors\n\nOur Governance and Nominating Committee will consider candidates for director recommended by stockholders holding at least\n\none percent of our fully diluted capitalization continuously for at least 12 months prior to the date of the submission of the\n\nrecommendation. Our Governance and Nominating Committee will evaluate such recommendations in accordance with its charter,\n\nour Bylaws, our policies and procedures for director candidates, as well as the regular director nominee criteria described above.\n\nThis process is designed to ensure that our Board of Directors includes members with diversity of experience, skills and expertise,\n\nincluding appropriate financial and other expertise relevant to our business. Stockholders wishing to recommend a candidate for\n\nnomination should contact our Corporate Secretary in writing. Such recommendations must include:\n\n•the candidate’s name;\n\n•home and business contact information;\n\n•detailed biographical data;\n\n•relevant qualifications;\n\n•a signed letter from the candidate confirming willingness to serve on our Board of Directors;\n\n•information regarding any relationships between the candidate and CareDx; and,\n\n•evidence of the recommending stockholder’s ownership of our common stock.\n\nSuch recommendations must also include a statement from the recommending stockholder in support of the candidate, particularly\n\nwithin the context of the criteria for Board of Directors’ membership. Our Governance and Nominating Committee has discretion to\n\ndecide which individuals to recommend for nomination as directors.\n\n28  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nA stockholder can nominate a candidate directly for election to our Board of Directors by complying with the procedures in\n\nSection 2.4(ii) of our Bylaws and the rules and regulations of the SEC. Any eligible stockholder who wishes to submit a nomination\n\nshould review the requirements in our Bylaws on nominations by stockholders. Any nomination should be sent in writing to our\n\nCorporate Secretary at CareDx, Inc., 8000 Marina Boulevard, 4th Floor, Brisbane, California 94005. To be timely for our 2027\n\nannual meeting of stockholders, our Corporate Secretary must receive the nomination no earlier than February 13, 2027 and no\n\nlater than March 15, 2027. The notice must state the information required by Section 2.4(ii) of our Bylaws and otherwise must\n\ncomply with applicable federal and state law.\n\nIn addition, pursuant to Rule 14a-19, the SEC’s universal proxy rule, notices of a solicitation of proxies in support of director\n\nnominees other than our own nominees must be postmarked or electronically submitted no later than April 12, 2027, and each\n\nnomination must comply with the SEC regulations under Rule 14a-19, which requires, among other things, that such notice include\n\na statement that such person intends to solicit the holders of shares representing at least 67% of the voting power of shares\n\nentitled to vote on the election of directors. If, however, the date of the 2027 annual meeting of stockholders is more than 30 days\n\nbefore or after June 11, 2027, then the Rule 14a-19 deadline shall be the later of 60 calendar days prior to the date of the 2027\n\nannual meeting of stockholders or the 10th calendar day following the day on which we first make a public announcement of the\n\ndate of our 2027 annual meeting of stockholders. A nomination that does not comply with the requirements set forth in the\n\nCertificate of Incorporation and Bylaws will not be considered for presentation at the annual meeting. We intend to file a proxy\n\nstatement and white proxy card with the SEC in connection with our solicitation of proxies for our 2027 annual meeting of\n\nstockholders.\n\nCommunications with the Board of Directors\n\nStockholders wishing to communicate with our Board of Directors or with an individual member of our Board of Directors may do so\n\nby writing to our Board of Directors or to the particular member of our Board of Directors, and mailing the correspondence to our\n\nChief Financial Officer at CareDx, Inc., 8000 Marina Boulevard, 4th Floor, Brisbane, California 94005. Our Chief Financial Officer\n\nwill review all incoming stockholder communications (excluding mass mailings, product complaints or inquiries, job inquiries,\n\nbusiness solicitations and patently offensive or otherwise inappropriate material), and if deemed appropriate, the stockholder\n\ncommunications will be forwarded to the appropriate member or members of our Board of Directors, or if none is specified, to the\n\nChairman of the Board of Directors. This procedure does not apply to stockholder proposals submitted pursuant to Rule 14a-8\n\nunder the Exchange Act.\n\nCorporate Governance Guidelines and Code of Business Conduct and\n\nEthics\n\nOur Board of Directors has adopted Corporate Governance Guidelines. These guidelines address items such as the qualifications\n\nand responsibilities of our directors and director candidates and corporate governance policies and standards applicable to us in\n\ngeneral. In addition, our Board of Directors has adopted a Code of Business Conduct and Ethics that applies to all of our\n\nemployees, officers and directors, including our Chief Executive Officer, Chief Financial Officer, and other executive and senior\n\nfinancial officers. The full text of our Corporate Governance Guidelines and our Code of Business Conduct and Ethics is posted on\n\nour website at www.caredx.com in the Corporate Governance section of our Investors webpage. We intend to post any\n\namendments to our Code of Business Conduct and Ethics, and any waivers of our Code of Business Conduct and Ethics for\n\ndirectors and executive officers, on the same website.\n\nClawback Policy\n\nEffective October 1, 2023, our Board of Directors adopted a restated compensation recovery (“clawback”) policy pursuant to the\n\nlisting standards approved by The Nasdaq Stock Market LLC implementing Rule 10D-1 under the Exchange Act. The clawback\n\npolicy is administered by our Compensation and Human Capital Committee and applies to current and former executive officers of\n\nthe Company as defined in Rule 10D-1 (each an “Affected Officer”). Under the clawback policy, if the Company is required to\n\nprepare an accounting restatement to correct the Company’s material noncompliance with any financial reporting requirement\n\nunder securities laws, including restatements that correct an error in previously issued financial statements that is material to the\n\npreviously issued financial statements or that would result in a material misstatement if the error were corrected in the current\n\nCareDx Inc.\n\n2026 Proxy Statement  |  29\n\nBoard of Directors and Corporate Governance\n\nperiod or left uncorrected in the current period (collectively, a “Restatement”), the Company is obligated to recover erroneously\n\nawarded incentive-based compensation received from the Company by Affected Officers. Incentive-based compensation includes\n\nany compensation that is granted, earned or vested based in whole or in part on the attainment of a financial reporting\n\nmeasure. Erroneously awarded incentive-based compensation is the amount of incentive-based compensation received that\n\nexceeds the amount of incentive-based compensation that otherwise would have been received had it been determined based on\n\nan applicable Restatement.\n\nInsider Trading Policy\n\nOur Board of Directors has adopted an insider trading policy. Our insider trading policy prohibits our directors, officers (including\n\nour executive officers), employees and agents, as well as their immediate family members, from engaging in short sales of our\n\nsecurities and from engaging in transactions in publicly-traded options and other derivative securities with respect to our securities.\n\nThis prohibition extends to any hedging or similar transactions designed to decrease the risks associated with holding our\n\nsecurities. Our insider trading policy also prohibits us from transacting in our securities unless in compliance with U.S. federal\n\nsecurities laws and restricts certain individuals, including our directors and executive officers, from pledging our securities as\n\ncollateral for loans absent pre-clearance and the satisfaction of other conditions. A copy of our Insider Trading Policy is filed as\n\nExhibit 19.1 to our 2025 Annual Report on Form 10-K.\n\nNon-Employee Director Stock Ownership Policy\n\nOur Compensation and Human Capital Committee has adopted a stock ownership policy that is applicable to each of our non-\n\nemployee directors. Our Compensation and Human Capital Committee believes this policy is an important tool in aligning the\n\ninterests of our non-employee directors with the long-term interests of our stockholders.\n\nThis policy requires that our non-employee directors hold shares of our common stock with a value equal to at least three times\n\nsuch director’s annual cash retainer for service on our Board of Directors (excluding service on any committee of our Board of\n\nDirectors). For purposes of calculating ownership under this policy, the following sources are included: shares held in the director’s\n\nname; shares held in trust for the benefit of the director or their family; shares held by the director jointly with, or separately by,\n\ncertain family members of the director; shares held by the director through a profit sharing or savings plan; the “in the money”\n\nportion of vested, but unexercised, stock options or stock-settled stock appreciation rights; shares issued or vested pursuant to the\n\nachievement of the performance conditions of a performance-based equity award even if such shares are subject to additional\n\ntime-based vesting requirements (the “Vested Performance Awards”); vested restricted stock units (“RSU” or “RSUs”) awards;\n\ndeferred share units; shares held by the director under any deferral plan; and restricted stock or phantom stock held by the director.\n\nThe following shares do not count towards the requirements: (i) shares that directors have the right to acquire through the exercise\n\nof stock options or stock appreciation rights that are not “in the money”, (ii) shares underlying stock options or stock appreciation\n\nrights that have not yet vested or (iii) shares that may be issued pursuant to unvested performance-based restricted stock units\n\n(“PRSUs”) or other performance-based equity awards (other than Vested Performance Awards).\n\nFor purposes of these requirements, a director’s annual cash retainer shall be deemed to be the director’s annual cash retainer\n\nearned by such director for the calendar year immediately preceding the applicable date of calculation. To give our non-employee\n\ndirectors time to comply with our stock ownership policy, the policy provides that our non-employee directors have until the first\n\nannual meeting of stockholders held after the date that is six years following their appointment as a director to comply with the\n\nstock ownership provisions in the policy.\n\nExecutive Officer Stock Ownership Policy\n\nOur Compensation and Human Capital Committee adopted a stock ownership policy that is applicable to each of our executive\n\nofficers. Our Compensation and Human Capital Committee believes this policy is an important tool in aligning the interests of our\n\nexecutive officers with the long-term interests of our stockholders.\n\n30  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nThis policy requires that our executive officers hold shares of our common stock with a value equal to a multiple of their base\n\nsalary, as follows: 3X in the case of our Chief Executive Officer and 1X in the case of each of our other executive officers. For\n\npurposes of calculating ownership under this policy, the following sources are included: shares held in the executive officer’s name;\n\nshares held in trust for the benefit of the executive officer or their family; shares held by the executive officer jointly with, or\n\nseparately by, certain family members of the executive officer; shares held by the executive officer through a profit sharing or\n\nsavings plan; the “in the money” portion of vested, but unexercised, stock options or stock-settled stock appreciation rights; Vested\n\nPerformance Awards; vested RSU awards; deferred share units; shares held by the executive officer under any deferral plan; and\n\nrestricted stock or phantom stock held by the executive officer.\n\nThe following shares do not count towards the requirements: (i) shares that the executive officers have the right to acquire through\n\nthe exercise of stock options or stock appreciation rights that are not “in the money”, (ii) shares underlying stock options or stock\n\nappreciation rights that have not yet vested or (iii) shares that may be issued pursuant to unvested PRSUs or other performance-\n\nbased equity awards (other than Vested Performance Awards).\n\nFor purposes of these requirements, an executive officer’s base salary during any calendar year is deemed to be their base salary\n\nas of 5:00 p.m. PT on December 31st of the immediately preceding year. To give our executive officers time to comply with our\n\nstock ownership policy, the policy provides that our executive officers have until the first annual meeting of stockholders held after\n\nthe date that is six years following the date such individual first becomes an executive officer to comply with the stock ownership\n\nprovisions in the policy.\n\nBoard of Directors’ Role in Risk Oversight\n\nRisk is inherent with every business, and we face a number of risks, including strategic, financial, business and operational, legal\n\nand compliance, and reputational risks. We have designed and implemented processes to manage risk in our operations.\n\nManagement is responsible for the day-to-day management of risks we face, while our Board of Directors, as a whole and assisted\n\nby its committees, has responsibility for the oversight of risk management.\n\nOur Board of Directors believes that open communication between management and our Board of Directors is essential for\n\neffective risk management and oversight. Our Board of Directors meets with our Chief Executive Officer and other members of the\n\nsenior management team at quarterly meetings of our Board of Directors, where, among other topics, they discuss strategy,\n\noperational performance and risks facing us. While our Board of Directors is ultimately responsible for risk oversight, our board\n\ncommittees assist our Board of Directors in fulfilling its oversight responsibilities in certain areas of risk as follows:\n\nAudit and Finance Committee - It assists our Board of Directors in fulfilling its oversight responsibilities with respect to risk\n\nmanagement in the areas of internal control over financial reporting and disclosure controls and procedures, legal and regulatory\n\ncompliance, and discusses with management and the independent auditor guidelines and policies with respect to risk assessment\n\nand risk management. The Committee also reviews our major financial risk exposures, including liquidity risks, and the steps\n\nmanagement has taken to monitor and control these exposures. In addition, the Committee monitors certain key risks on a regular\n\nbasis throughout the fiscal year, such as risk associated with internal control over financial reporting and liquidity risk, as well as\n\ncybersecurity risks as further described below.\n\nGovernance and Nominating Committee - assists our Board of Directors in fulfilling its oversight responsibilities with respect to\n\nthe management of risk associated with board organization, membership and structure and corporate governance.\n\nCompensation and Human Capital Committee - assesses risks created by the incentives inherent in our compensation and\n\nhuman capital policies.\n\nFinally, our full Board of Directors reviews strategic and operational risk in the context of reports from the management team,\n\nreceives reports on all significant committee activities at each regular meeting, and evaluates the risks inherent in significant\n\ntransactions.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  31\n\nBoard of Directors and Corporate Governance\n\nWith respect to cybersecurity risks, our Board of Directors and Audit and Finance Committee each receive regular presentations\n\nand reports on developments in the cybersecurity space, including risk management practices, recent developments, evolving\n\nstandards, vulnerability assessments, third-party and independent reviews, the threat environment, technological trends, and\n\ninformation security issues encountered by our peers and third parties. Our Board of Directors and Audit and Finance Committee\n\nalso receive prompt and timely information regarding any cybersecurity risk that meets pre-established reporting thresholds.\n\nAnnually, our Board of Directors and Audit and Finance Committee discuss our approach to overseeing cybersecurity threats with\n\nour Chief Technology Officer and other senior management members. We also conduct periodic assessments and testing of our\n\npolicies, standards, processes, and practices in a manner designed to address cybersecurity threats and events. The results of\n\nsuch assessments, audits, and reviews are evaluated by management and reported to our Audit and Finance Committee, and we\n\nadjust our cybersecurity policies, standards, processes, and practices as necessary based on the information provided by these\n\nassessments, audits, and reviews. For further information regarding our oversight of cybersecurity risks, please see the\n\n“Cybersecurity” section of our Annual Report on Form 10-K for the year ended December 31, 2025 that was filed with the SEC on\n\nFebruary 25, 2026.\n\nWorkforce Diversity\n\nWe are a global company with employees from numerous countries around the world. We aim to hire the best talent which includes\n\nindividuals with varying educational, demographic, and geographic backgrounds. Our senior leadership team includes leaders with\n\ndiverse skills, academic training, industry experience, racial backgrounds and genders. We aim to assemble a workforce that is\n\nreflective of the patients and caregivers we serve so we may better understand their perspectives and needs. We have a zero-\n\ntolerance policy for discrimination.\n\nDirector Compensation\n\nCompensation Policy\n\nDirectors who are employees do not receive any additional compensation for their service on our Board of Directors. We reimburse\n\nour non-employee directors for their reasonable out-of-pocket costs and travel expenses in connection with their attendance at\n\nBoard of Directors and committee meetings in accordance with our travel policy. In fiscal year 2025, our non-employee directors\n\nreceived cash compensation and RSU awards pursuant to our outside director compensation policy in effect during 2025 as set\n\nforth below.\n\nEffective January 6, 2025, our Compensation and Human Capital Committee approved an amendment and restatement of our\n\noutside director compensation policy, which amended the vesting schedules with respect to annual grants of options (if any) and\n\nRSUs to provide that: (i) any then-unvested options fully vest on the day immediately before the first annual meeting of our\n\nstockholders that occurs after the grant date, and (ii) RSUs vest on the earlier of the first anniversary of the grant date and the day\n\nimmediately before the first annual meeting of stockholders that occurs after such grant date. The amended and restated policy\n\nalso removed quarterly retainers previously provided to Mr. Goldberg for his additional efforts and services while serving as a\n\nmember of the Office of the Chief Executive Officer.\n\nEffective June 13, 2025, our Compensation and Human Capital Committee approved a further amendment and restatement of our\n\noutside director compensation policy, pursuant to which, during fiscal year 2025, the independent Chairman of our Board of\n\nDirectors received an annual retainer of $100,000, our other non-employee directors received an annual retainer of $50,000 for\n\ntheir service on our Board of Directors, members of our Audit and Finance Committee, Compensation and Human Capital\n\nCommittee, Governance and Nominating Committee and Technology and Innovation Committee, other than the chairman or\n\nchairwoman of each such committee, received an additional annual retainer of $10,000, $7,500, $5,000 and $5,000, respectively,\n\nand the chairman or chairwoman of our Audit and Finance Committee, Compensation and Human Capital Committee, Governance\n\nand Nominating Committee and Technology and Innovation Committee each received an additional annual retainer of $20,000,\n\n$15,000, $10,000 and $10,000, respectively. All annual retainers were paid quarterly and pro-rated for partial service in any year.\n\nOur non-employee directors are entitled to elect the ratio of shares of our common stock to cash issuable or payable to the non-\n\nemployee director for the payment of the annual retainers.\n\n32  |  2026 Proxy Statement\n\nCareDx Inc.\n\nBoard of Directors and Corporate Governance\n\nPursuant to our amended outside director compensation policy, any director first appointed to our Board going forward is\n\nautomatically granted, on a nondiscretionary basis, an award of RSUs having a grant date fair value of $400,000, rounded down to\n\nthe nearest whole share. The RSUs vest at a rate of one-third on each one-year anniversary of the grant date. In addition, on the\n\nfirst business day after the annual meeting of our stockholders, each non-employee director who continues to serve on our Board\n\nof Directors is automatically granted, on a nondiscretionary basis, an award of RSUs having a grant date fair value of $225,000,\n\nrounded down to the nearest whole share. These annual RSUs vest in full on the earlier of the first anniversary of the grant date\n\nand the day immediately before the first annual meeting our stockholders that occurs after such grant date. The vesting of the\n\noptions and the RSUs described above will accelerate in full upon a “change in control,” as defined in our 2024 Plan.\n\nNotwithstanding any provisions in our outside director compensation policy, pursuant to the terms of our 2024 Plan, (a) no outside\n\ndirector may be granted, in any fiscal year, cash and equity-based compensation having a value of greater than $1,500,000 in the\n\nfiscal year of such director’s initial service as an outside director, and (b) no outside director may be granted, in any fiscal year,\n\ncash and equity-based compensation having a value greater than $750,000.\n\nDirector Compensation Table\n\nThe following table sets forth the compensation accrued or paid by us to our non-employee directors during the year ended\n\nDecember 31, 2025 for service on our Board of Directors and its committees.\n\nName\n\nFees Earned or\n\nPaid in Cash\n\n($)\n\nStock Awards\n\n($)(1)(2)\n\nTotal\n\n($)\n\nMichael D. Goldberg\n\n138,736\n\n(3)\n\n224,995\n\n363,731\n\nGeorge W. Bickerstaff, III\n\n70,247\n\n224,995\n\n295,242\n\nFred E. Cohen, M.D., D. Phil\n\n52,747\n\n224,995\n\n277,742\n\nChristine M. Cournoyer\n\n72,747\n\n224,995\n\n297,742\n\nWilliam A. Hagstrom\n\n24,025\n\n(4)\n\n—\n\n24,025\n\nPeter Maag, Ph.D.\n\n52,747\n\n224,995\n\n277,742\n\nR. Bryan Riggsbee\n\n67,747\n\n224,995\n\n292,742\n\nArthur A. Torres\n\n57,747\n\n224,995\n\n282,742\n\nHannah A. Valantine, M.D.\n\n62,747\n\n224,995\n\n287,742\n\nSuresh Gunasekaran\n\n9,647\n\n399,990\n\n409,637\n\n(1)Amounts represent the aggregate fair value of the stock awards computed as of the grant date of each stock award in accordance with\n\nFinancial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) Topic 718. Our assumptions with respect to the\n\ncalculation of these values are set forth in Note 11 of the consolidated financial statements included in our Annual Report on Form 10-K for the\n\nyear ended December 31, 2025 that was filed with the SEC on February 25, 2026.\n\n(2)As of December 31, 2025, each of our then-current non-employee directors held the following number of unvested RSUs granted in 2025: Mr.\n\nGoldberg: 12,103; Mr. Bickerstaff: 12,103; Dr. Cohen: 12,103; Ms. Cournoyer: 12,103; Mr. Gunasekaran: 27,453; Dr. Maag: 12,103; Mr.\n\nRiggsbee: 12,103; Mr. Torres: 12,103 and Dr. Valantine: 12,103.\n\n(3)Amount includes (i) $46,284 representing the portion of Mr. Goldberg’s annual retainer paid in cash and $92,452 representing the aggregate\n\nfair value of the stock award granted to Mr. Goldberg in lieu of the remaining portion of his annual cash retainer fee computed as of the grant\n\ndate of each stock award in accordance with FASB ASC Topic 718. Mr. Goldberg elected to receive such portion of his annual cash retainer\n\nfee in the form of shares of our common stock pursuant to our outside director compensation policy. Our assumptions with respect to the\n\ncalculation of these values are set forth in Note 11 of the consolidated financial statements included in our Annual Report on Form 10-K for the\n\nyear ended December 31, 2025 that was filed with the SEC on February 25, 2026.\n\n(4)William A. Hagstrom stepped down from the Board when his term expired at the 2025 Annual Meeting.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  33\n\nBoard of Directors and Corporate Governance\n\nDeferral Election Program\n\nIn December 2018, our Compensation and Human Capital Committee approved an RSU and performance restricted stock unit, or\n\nPRSU, deferral election program, which is still in effect, pursuant to which our non-employee directors, executive officers and\n\ncertain other employees may elect, on an annual basis, to defer the settlement of all RSU and performance unit awards granted to\n\nsuch individuals until the first to occur of (i) a “change in control,” as defined in our 2014 Equity Incentive Plan (the “2014 Plan”),\n\n(ii) the individual’s death, or (iii) a specified number of years following the individual’s separation of service with us, in which case\n\nthe shares will settle in a number of substantially equal annual installments selected by the individual, on every June 30 starting in\n\nthe calendar year immediately following the year in which the individual incurs a separation of service.\n\nNon-employee directors who elect to defer the settlement of RSU and performance units must make these deferral elections by the\n\nend of the calendar year preceding the date of the grant of the stock award (or on such earlier date as specified by us). As of\n\nDecember 31, 2025, none of our non-employee directors held any deferred stock awards, except for Mr. Goldberg, who previously\n\nelected to defer the settlement of RSUs, with an aggregate value of $49,229 as of December 31, 2025, and Dr. Maag, who elected\n\nto defer the settlement of RSUs, with an aggregate value of $ 3,902,781 as of December 31, 2025. Not only does the RSU and\n\nperformance unit deferral election program allow our eligible participants to defer the federal income taxes otherwise payable upon\n\nthe delivery of RSUs, but our Compensation and Human Capital Committee also believes that with respect to non-employee\n\ndirectors and executives who avail themselves of the deferral features, such persons will necessarily hold our common stock for a\n\nlonger period of time. Accordingly, any deferred RSUs will continue to align such portion of our non-employee directors’ and named\n\nexecutive officers’ compensation with the interests of our stockholders for a longer period of time than would be provided by typical\n\nvesting periods.\n\n34  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal No. 2\n\nRatification of Appointment of\n\nIndependent Registered Public\n\nAccounting Firm\n\nOur Audit and Finance Committee has appointed Deloitte & Touche LLP (“Deloitte”) as our independent registered public\n\naccounting firm to audit our consolidated financial statements for our fiscal year ending December 31, 2026. Deloitte also served as\n\nour independent registered public accounting firm for our fiscal year ended December 31, 2025. Deloitte was appointed as our\n\nindependent registered public accounting firm on April 10, 2018. In evaluating Deloitte's continued engagement, our Audit and\n\nFinance Committee considered Deloitte's tenure, independence, and qualifications, as well as the benefits of auditor continuity and\n\ninstitutional knowledge. The Audit and Finance Committee confirmed that the lead audit partner has been rotated in accordance\n\nwith Public Company Accounting Oversight Board requirements, which mandate rotation of the lead audit partner at least every five\n\nyears.\n\nAt the Annual Meeting, stockholders are being asked to ratify the appointment of Deloitte as our independent registered public\n\naccounting firm for our fiscal year ending December 31, 2026. Stockholder ratification of the appointment of Deloitte is not required\n\nby our Bylaws or other applicable legal requirements. However, our Board of Directors is submitting the appointment of Deloitte to\n\nour stockholders for ratification as a matter of good corporate governance. In the event that this appointment is not ratified by the\n\naffirmative vote of a majority of the shares present virtually or by proxy at the Annual Meeting and entitled to vote, such\n\nappointment will be reconsidered by our Audit and Finance Committee. Even if the appointment is ratified, our Audit and Finance\n\nCommittee, in its sole discretion, may appoint another independent registered public accounting firm at any time during our fiscal\n\nyear ending December 31, 2026 our Audit and Finance Committee believes that such a change would be in the best interests of\n\nCareDx and its stockholders. A representative of Deloitte is expected to be present at the Annual Meeting. Such representative will\n\nhave an opportunity to make a statement if they wish to do so and is expected to be available to respond to appropriate questions\n\nfrom stockholders.\n\nFees Paid to the Independent Registered Public Accounting Firm\n\nThe following table sets forth fees in connection with services rendered by Deloitte, our independent registered public accounting\n\nfirm, for our fiscal years ended December 31, 2025 and 2024.\n\n2025\n\n2024\n\nAudit Fees(1)\n\n$2,428,400\n\n$2,422,838\n\nAudit-Related Fees\n\n—\n\n—\n\nTax Fees\n\n—\n\n—\n\nAll Other Fees(2)\n\n3,790\n\n3,790\n\nTotal\n\n$2,432,190\n\n$2,426,628\n\n(1)Audit Fees include fees and out-of-pocket expenses, whether or not yet invoiced, for professional services associated with the annual audit of\n\nour financial statements, the reviews of our interim financial statements, statutory audits, and the issuance of consents in connection with\n\nregistration statement filings with the SEC.\n\n(2)All Other Fees include any fees billed that are not audit, audit-related or tax fees. All other fees include fees for a subscription service to a\n\ntechnical accounting research tool.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  35\n\nProposal 2\n\nAuditor Independence\n\nIn 2025, there were no other professional services provided by Deloitte that would have required our Audit and Finance Committee\n\nto consider their compatibility with maintaining the independence of Deloitte.\n\nAudit and Finance Committee Policy on Pre-Approval of Audit and\n\nPermissible Non-Audit Services of Independent Registered Public\n\nAccounting Firm\n\nOur Audit and Finance Committee has established a policy governing our use of the services of our independent registered public\n\naccounting firm. Under the policy, our Audit and Finance Committee is required to pre-approve all audit and permissible non-audit\n\nservices performed by our independent registered public accounting firm to ensure that the provision of such services does not\n\nimpair such accounting firm’s independence. The policy generally pre-approves specified services in the defined categories of audit\n\nservices, audit-related services, tax services and other services up to specified amounts. The pre-approval of services may be\n\ndelegated to one or more of the Audit and Finance Committee’s members, but the decision must be reported to the full Audit and\n\nFinance Committee at its next scheduled meeting. In the fiscal years ended December 31, 2025, and 2024, services and related\n\nfees identified above under the captions “Audit Fees” and “All Other Fees” that were billed by Deloitte were approved by the Audit\n\nand Finance Committee in accordance with SEC requirements.\n\nVote Required; Board Recommendation\n\nThe ratification of the appointment of Deloitte requires the affirmative vote of a majority of the shares of our common stock present\n\nvirtually or by proxy at the Annual Meeting and entitled to vote thereon. Abstentions will have the effect of a vote AGAINST the\n\nproposal. We do not expect any broker non-votes on this proposal.\n\nOur Board of Directors recommends a vote “FOR” the ratification of the appointment of Deloitte\n\n& Touche LLP as our independent registered public accounting firm for our fiscal year ending\n\nDecember 31, 2026.\n\n36  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAudit and Finance Committee\n\nReport\n\nThe information contained in the following Audit and Finance Committee Report shall not be deemed to be soliciting material or to\n\nbe filed with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future\n\nfiling under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent\n\nthat CareDx, Inc. (the “Company”) specifically incorporates it by reference in such filing.\n\nThe Audit and Finance Committee has reviewed and discussed the Company’s audited consolidated financial statements with\n\nmanagement and Deloitte & Touche LLP (“Deloitte”), the Company’s independent registered public accounting firm. The Audit and\n\nFinance Committee has discussed with Deloitte the matters required to be discussed by the applicable requirements of the Public\n\nCompany Accounting Oversight Board and the Securities and Exchange Commission (the “SEC”).\n\nThe Audit and Finance Committee has received and reviewed the written disclosures and the letter from Deloitte required by the\n\napplicable requirements of the Public Company Accounting Oversight Board regarding Deloitte’s communications with the Audit\n\nand Finance Committee concerning independence, and has discussed with Deloitte its independence.\n\nBased on the review and discussions referred to above, the Audit and Finance Committee recommended to the Board of Directors\n\nthat the Company’s audited consolidated financial statements be included in the Company’s Annual Report on Form 10-K for the\n\nfiscal year ended December 31, 2025 for filing with the SEC.\n\nRespectfully submitted by the members of the Audit and Finance Committee of the Board of Directors:\n\nR. Bryan Riggsbee\n\nGeorge W. Bickerstaff, III\n\nChristine M. Cournoyer\n\nCareDx Inc.\n\n2026 Proxy Statement  |  37\n\nProposal No. 3\n\nAdvisory Vote on\n\nExecutive Compensation\n\nPursuant to the proxy rules under the Exchange Act and as required by Section 951 of the Dodd-Frank Wall Street Reform and\n\nConsumer Protection Act (the “Dodd-Frank Act”), we are presenting to our stockholders with a non-binding, advisory vote to\n\napprove the compensation of our named executive officers as described in this proxy statement. This proposal is commonly\n\nreferred to as a “Say-on-Pay” proposal. In accordance with the results of the advisory vote held at our 2020 annual meeting of\n\nstockholders on the frequency of future say-on-pay votes, we are conducting say-on-pay votes every year. After the Annual\n\nMeeting, our next say-on-pay vote will be held at our 2027 annual meeting of stockholders.\n\nThe compensation of our named executive officers is designed to attract, motivate and retain talented and experienced executives,\n\nwho are critical to our success. Our executive compensation contains elements of cash and equity-based compensation. Our\n\nBoard of Directors and our Compensation and Human Capital Committee believe that our executive compensation directly and\n\nsubstantially link rewards to measurable corporate performance and are designed to align the interests of our named executive\n\nofficers with those of our stockholders and to reward our named executive officers for the achievement of our near-term and longer-\n\nterm financial and strategic goals. The process for determining compensation packages requires that our Board of Directors and\n\nour Compensation and Human Capital Committee use judgment and experience to determine the optimal components and\n\namounts of compensation for each named executive officer.\n\nThe Say-on-Pay vote gives you as a stockholder the opportunity to express your views regarding the compensation of our named\n\nexecutive officers by voting to approve or not approve such compensation as described in this proxy statement. This vote is\n\nadvisory and will not be binding upon our Board of Directors or our Compensation and Human Capital Committee. However, our\n\nBoard of Directors and our Compensation and Human Capital Committee value the opinion of our stockholders and will take into\n\naccount the outcome of the vote when considering future executive compensation arrangements. The vote on this resolution is not\n\nintended to address any specific element of compensation, but rather relates to the overall compensation of our named executive\n\nofficers, as described in this proxy statement in accordance with the compensation disclosure rules of the SEC.\n\nWe encourage our stockholders to read the “Executive Compensation” section in this proxy statement, including the compensation\n\ntables and the related narrative disclosure, which describes the structure and amounts of the compensation of our named\n\nexecutive officers in fiscal year 2025.\n\nVote Required; Board Recommendation\n\nThe advisory approval of this Proposal No. 3 requires the affirmative vote of a majority of the shares of our common stock present\n\nvirtually or by proxy at the Annual Meeting and entitled to vote thereon. Abstentions will have the effect of a vote AGAINST the\n\nproposal. Broker non-votes will have no effect on this proposal. Although this vote is advisory in nature and does not impose any\n\naction on our Board of Directors or our Compensation and Human Capital Committee, we strongly encourage all stockholders to\n\nvote on this matter.\n\nOur Board of Directors recommends a vote “FOR” the approval, on an advisory basis, of the\n\ncompensation of our named executive officers as disclosed in this proxy statement.\n\n38  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal No. 4\n\nAdvisory Vote on Frequency\n\nof Advisory Votes on Executive\n\nCompensation\n\nUnder the Dodd-Frank Act, we are required, every six years, to provide our stockholders with an opportunity to make a non-\n\nbinding, advisory vote on the frequency of future non-binding advisory votes on the compensation of our named executive officers.\n\nAfter careful consideration, our Board of Directors recommends that future non-binding advisory votes on the compensation of our\n\nnamed executive officers be held every year so that stockholders may express annually their views on our executive compensation\n\nprogram. Our Board of Directors believes that holding the advisory vote to approve named executive officer compensation annually\n\nwill allow for timely and valuable feedback from stockholders on executive compensation matters. Gaining an understanding of the\n\nreasons behind an advisory vote for or against named executive officer compensation in a given year will require engagement with\n\nstockholders, and refining compensation programs warrants thoughtful deliberation and analysis.\n\nStockholders are not voting to approve or disapprove the Board of Directors’ recommendation. Instead, stockholders may indicate\n\ntheir preference regarding the frequency of future non-binding advisory votes on the compensation of our named executive officers\n\nby selecting “ONE YEAR,” “TWO YEARS” or “THREE YEARS.” Stockholders that do not have a preference regarding the\n\nfrequency of future advisory votes may “ABSTAIN” from voting on the proposal.\n\nAs an advisory vote, this proposal is not binding. However, our Board of Directors and Compensation and Human Capital\n\nCommittee value the opinions expressed by stockholders in their vote on this proposal and will consider the outcome of the vote\n\nwhen making future decisions regarding the frequency of holding future non-binding advisory votes on the compensation of our\n\nnamed executive officers.\n\nVote Required; Board Recommendation\n\nYou have four choices for voting on this proposal. You can choose whether future non-binding advisory votes on the compensation\n\nof our named executive officers should be conducted every “ONE YEAR,” “TWO YEARS,” or “THREE YEARS.” Under the rules\n\nissued by the SEC, you may also “ABSTAIN” from voting. The frequency that receives the greatest number of votes cast by\n\nstockholders on this matter at the meeting will be deemed to be the preferred frequency option of our stockholders. Broker\n\nnon‑votes will have no effect on this proposal as they are not considered votes cast for the foregoing purpose. This proposal is\n\nconsidered to be a non-routine proposal on which a broker or other nominee does not have discretionary authority to vote.\n\nAlthough this vote is advisory in nature and does not impose any action on our Board of Directors or our Compensation and Human\n\nCapital Committee, we strongly encourage all stockholders to vote on this matter.\n\nOur Board of Directors recommends a vote “FOR” the selection of “ONE YEAR” as the\n\nfrequency with which we will hold an advisory vote to approve the compensation of our named\n\nexecutive officers.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  39\n\nProposal No. 5\n\nApproval of Amendment to the 2024\n\nEquity Incentive Plan\n\nAlignment of the 2024 Plan with the Interests of the Company and\n\nStockholders\n\nCareDx is a growth company in the biotechnology industry based principally in San Francisco, California. We operate in a highly\n\ncompetitive labor market and believe equity compensation is an important component of our overall compensation program to\n\nattract and retain the talent and skills necessary to execute our long‑term strategy. We use equity compensation as a long‑term\n\nincentive to align the interests of employees and officers with those of stockholders and to motivate sustained performance over\n\ntime.\n\nTo achieve our objective of recruiting the right talent to meet our long-term plan, at the Annual Meeting, the Company’s\n\nstockholders will be asked to approve an amendment to the 2024 Plan to increase the available shares reserved thereunder by\n\n1,600,000 shares, or approximately 3.1% of common shares issued and outstanding, subject to adjustment as provided in the 2024\n\nPlan, and an equivalent increase to the number of shares of stock available for grant pursuant to incentive stock options (“ISOs”).\n\nThe amendment to the 2024 Plan was approved unanimously by the Board of Directors at its meeting on April 21, 2026. No other\n\nchanges are contemplated by the amendment to the 2024 Plan.\n\nThe 2024 Plan was originally adopted by our Board of Directors on April 24, 2024 and became effective June 13, 2024, following\n\napproval by our stockholders at our 2024 Annual Meeting. The 2024 Plan has been an important factor in attracting, retaining,\n\nmotivating, and rewarding certain employees, officers, directors and consultants by closely aligning the interests of such individuals\n\nwith those of our stockholders. We believe the Amendment to the 2024 Plan as proposed aligns the interest of our employees and\n\nexecutive officers with that of stockholders. We also believe that equity compensation is by its very nature performance based.\n\nAs of March 31, 2026, approximately 9 executive officers, 783 employees (excluding executive officers), and 10 non-employee\n\ndirectors were eligible to participate in the 2024 Plan.\n\nAs discussed below, the Board of Directors believes the 2024 Plan is essential to the Company’s continued success as it remains\n\ncommitted to the Company’s historical philosophy of incentivizing employees by tying a significant portion of their compensation to\n\nthe interests of the Company’s stockholders. As of March 31, 2026, there were 1,855,798 shares available for grant under all equity\n\nplans including 1,786,835 shares available for grant under the 2024 Plan. The Company has determined that an increase to the\n\nshares reserved under the 2024 Plan by 1,600,000 shares will allow the Company to continue providing meaningful incentives to its\n\nservice providers under the 2024 Plan. The Board of Directors believes the proposed share reserve appropriately balances the\n\nneed to provide competitive equity incentives with the goal of limiting stockholder dilution over time.\n\nIf the stockholders approve this proposal, the amendment to the 2024 Plan will become effective as of the date of stockholder\n\napproval. If stockholders do not approve this proposal, the amendment to the 2024 Plan described in this proposal will not take\n\neffect.\n\n40  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\nInformation on Equity Compensation Plans as of March 31, 2026\n\nAs of March 31, 2026, a total of 51,274,651 shares of our common stock were outstanding and the fair market value of our\n\ncommon stock was $17.36 per share based on the closing sale price of our common stock on the Nasdaq Global Market. The\n\nfollowing table sets forth information regarding equity awards outstanding under our Equity Plans as of March 31, 2026 other than\n\nthe CareDx, Inc. 2014 Employee Stock Purchase Plan (“2014 ESPP”). As of March 31, 2026, 613,740 shares of our common stock\n\nremained available for future issuance pursuant to the 2014 ESPP.\n\nAs of March 31, 2026\n\nEquity Plans(1)\n\nTotal shares underlying outstanding stock options\n\n2,433,684\n\nWeighted average exercise price of outstanding stock options\n\n$20.62\n\nWeighted average remaining life of outstanding stock options (in years)\n\n1.98\n\nTotal shares underlying outstanding RSUs\n\n4,209,704\n\nTotal shares underlying outstanding PRSUs(2)\n\n627,793\n\nTotal number of shares remaining available for future awards under our equity plans(1)\n\n1,855,798\n\n(1)Comprised of the CareDx, Inc. 2025 Inducement Equity Incentive Plan, the 2024 Plan, the CareDx, Inc. 2019 Inducement Equity Incentive\n\nPlan and CareDx, Inc. 2016 Inducement Equity Incentive Plan (collectively, the “Equity Plans”) and excluding the 2014 ESPP. The number of\n\nshares remaining available for future grant under the 2024 Plan reflects PRSUs that have not yet been earned and remain subject to on-going\n\nperformance periods at the target payout even though a lesser or greater number of shares may be or have been issued. Actual shares\n\ndelivered will be based on the performance results outlined in the specific plan governing the PRSUs.\n\n(2)Assumes performance at the target performance level even though a lesser or greater number of shares may be or have been issued. Actual\n\nshares delivered will be based on the performance results outlined in the specific plan governing the PRSUs.\n\nTaking Action to Reduce Burn Rate and Dilution\n\nAs detailed below, the Company has taken significant action to reduce its burn rate and dilution and anticipates its Gross Burn Rate\n\nin 2026 to be approximately 3 –4% and Net Burn Rate to be approximately 2 – 3%.\n\nHistorical Burn Rate\n\nOur equity plan share usage over 2023, 2024 and 2025 represented a three-year average Gross Burn Rate (as defined below) of\n\n7% and a Net Burn Rate (as defined below) of 5%.\n\nGross Burn Rate is calculated by dividing (x) the number of stock options, RSUs and restricted shares granted to participants\n\nduring a fiscal year, plus (y) the number of PRSUs granted to participants during a fiscal year (with PRSUs included at “target”\n\nlevels), by the sum of the total common stock outstanding plus the number of equity awards outstanding (with PRSUs included at\n\n“target” levels) during such year.\n\nNet Burn Rate excludes expired and forfeited options and RSUs primarily associated with employee turnover.\n\nOver the period of 2023-2025, on average, our Net Burn Rate was more than 40% lower than our Gross Burn Rate due to the\n\nforfeiting of stock, as well as the expiration of options, primarily related to employee turnover. We believe Net Burn Rate is a better\n\nrepresentation of the actual dilution to stockholders because it accounts for shares that are forfeited or expired and not exercised\n\ndue to employee turnover.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  41\n\nProposal 5\n\nIn addition, under our 2024 Plan, we retire shares that are withheld at vesting to satisfy employee tax obligations rather than\n\nrecycling these shares into the share pool. This practice of retiring shares withheld to address employee tax obligations further\n\nreduces the net burn rate and dilution to stockholders. Our 2025 Net Burn Rate was exceptionally low due to forfeiting stock from\n\nformer executives and we anticipate our 2026 Net Burn Rate to be 25% - 30% lower than our Gross Burn Rate in 2026. In 2024,\n\nour Net Burn Rate increased, including because we hired several new executives, including our Chief Executive Officer, Chief\n\nOperating Officer, Chief Commercial Officer, and Chief Data and AI Officer. In addition, our burn rate was impacted by agreements\n\nentered into in connection with the departure of several former executives.\n\nFor purposes of the table below, the number of shares issuable under an award that provides for issuance of a variable number of\n\nshares based on the extent to which performance targets are satisfied, such as PRSUs, is deemed to be the target number of\n\nshares that may be issued on attainment of target performance, even though a lesser or greater number of shares may be or may\n\nhave been issued based on actual performance. Note that our calculation of equity burn rate differs, or may differ, from calculations\n\nof burn rate in 2024 conducted by proxy advisory or other groups.\n\nYear\n\nWeighted\n\nAverage\n\nCommon Stock\n\nOutstanding\n\nTime-based\n\nStock Options\n\nGranted\n\nPerformance-\n\nbased Stock\n\nOptions Granted\n\nRSUs Granted\n\nand PRSUs\n\nGranted at\n\nTarget\n\nGross Burn\n\nRate\n\nExpired and\n\nForfeited\n\nOptions and\n\nRSUs\n\nNet Burn\n\nRate\n\n2023\n\n53,764,705\n\n680,788\n\n—\n\n4,028,424\n\n9%\n\n1,646,333\n\n6%\n\n2024\n\n52,773,247\n\n1,053,285\n\n—\n\n3,726,419\n\n9%\n\n816,550\n\n8%\n\n2025\n\n53,287,546\n\n—\n\n—\n\n2,123,644\n\n4%\n\n1,488,052\n\n1%\n\n2026 Forecasted Net Burn Rate: Approximately 2 - 3%\n\n2026 Expected Burn Rate\n\nIn our 2025 proxy, we requested additional shares from investors and received their feedback concerning the need to continue to\n\nreduce burn rate.\n\nWe took the following actions to significantly reduce our burn rate in 2025 and will continue with this practice in 2026:\n\n•Reduced grant sizes for employees\n\n•Shifted to a more balanced approach of cash compensation (base salary & annual bonus), equity compensation and\n\ndefined contribution (401(k)) benefits.\n\n•Refined the parameters of employees who are eligible for stock awards\n\n•Moved to full-value RSUs and PRSUs and eliminated the use of options\n\n42  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\nThese actions resulted in a gross burn rate below our industry benchmark for 2025 as determined by ISS. We anticipate this trend\n\ncontinuing in 2026. Our 2026 industry benchmark for Pharmaceuticals, Biotechnology & Life Sciences, as determined by ISS, is\n\n6.23%. As shown in the chart below, in 2026 we forecast our Gross Burn Rate to be approximately 3 –4% and our Net Burn Rate to\n\nbe approximately 2 – 3%.\n\nThe Compensation and Human Capital Committee and the Board of Directors determined that the increase to the reserved pool\n\nunder the amendment to the 2024 Plan should be 1,600,000 shares based on projected equity awards to anticipated new hires and\n\nprojected annual equity awards to existing employees and other service providers. We anticipate that our Gross Burn Rate and Net\n\nBurn Rate for 2026 will remain below the industry benchmarks. If our requested additional share reserve is approved by our\n\nstockholders, we believe it will be sufficient to provide equity incentives to attract, retain and motivate employees for the next year.\n\nOur future share usage could be impacted by a number of factors such as award type mix; hiring and promotion activity at the\n\nexecutive level; the rate at which shares are returned to the 2024 Plan’s reserve upon the awards’ expiration, forfeiture or cash\n\nsettlement; the future performance of our stock price; the consequences of acquiring other companies; and other factors.\n\nDilution\n\nDilution is commonly measured by “overhang,” which we calculate as the total number of equity awards outstanding (with PRSUs\n\nincluded at “target” levels) plus the total number of shares available for grant under our equity plans (other than the 2014 ESPP),\n\ndivided by the sum of the total common stock outstanding, the number of equity awards outstanding (with PRSUs included at\n\n“target” levels) and the total number of shares available for grant under our equity plans (other than the 2014 ESPP).\n\nAs of March 31, 2026, our total overhang was 18%. If the amendment to the 2024 Plan to increase the share reserve is approved,\n\nour total overhang (as calculated above) will be approximately 21% (excluding our 2014 ESPP).\n\nCareDx Inc.\n\n2026 Proxy Statement  |  43\n\nProposal 5\n\nOf the 2,433,684 stock options currently outstanding, many relate to underwater stock options. Based on a closing stock price on\n\nMarch 31, 2026, of $17.36, 1,282,713 stock options, with a weighted average strike price of approximately $30, are currently\n\nunderwater and account for 12% of our overhang if the amendment to the 2024 Plan is approved. As we reduce our burn rate, we\n\nexpect overhang to continue to come down in 2026.\n\nKey Features and Governance Practices\n\nWe have incorporated a number of provisions in the 2024 Plan that are designed to protect stockholders and that we believe reflect\n\nstrong governance practices, including the following:\n\n•No Evergreen: The 2024 Plan does not include an automatic share reload or “evergreen” provision. Additional\n\nstockholder approval will be required to increase the maximum number of shares reserved under the 2024 Plan.\n\n•No Repricing: The 2024 Plan prohibits the repricing of stock options and stock appreciation rights (“SARs”) without\n\nstockholder approval, the exchange or substitution of one award for another award that has the effect of reducing the\n\nexercise or purchase price and the cancellation or exchange of underwater awards for cash, another award or other\n\nproperty, except in the event of a capitalization adjustment (described below).\n\n•No Dividends on Unvested Awards: Dividends or dividend equivalents credited or payable in connection with an award\n\nunder the 2024 Plan that is not yet vested will be subject to the same restrictions and risk of forfeiture as the underlying\n\naward.\n\n•No Liberal Share Recycling: The 2024 Plan prohibits liberal share recycling. Shares tendered by a participant or\n\nwithheld by the Company in payment of the purchase price of a stock option or to satisfy any tax withholding obligation\n\nwith respect to any option or SAR do not become available for issuance as future awards under the 2024 Plan.\n\n44  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\n•Limit on Non-Employee Director Compensation: The 2024 Plan contains an annual limit on cash and equity-based\n\ncompensation that may be paid or granted, whether under the 2024 Plan or otherwise, to our non-employee directors of\n\n$750,000 (or $1,500,000 in the calendar year that the non-employee director first joins our Board of Directors).\n\n•Minimum Vesting: The 2024 Plan imposes a one-year minimum vesting requirement on awards granted thereunder,\n\nsubject to certain exceptions set forth in the 2024 Plan.\n\n•Clawback Provision: Awards under the 2024 Plan are subject to our current clawback policy and to any future clawback\n\npolicies that we may adopt. See “—Clawback/Recovery” discussed below.\n\n•No Automatic Single-Trigger Acceleration: In the event of a change in control (described below), the 2024 Plan does\n\nnot provide for automatic single trigger acceleration.\n\n•Term and Exercise Price Limits on Options and SARs: Options and SARs granted under the 2024 Plan are subject to\n\na maximum term of 10 years and, with the exception of certain awards assumed in a corporate transaction, may not be\n\ngranted at a discount to the fair market value of our common stock on the grant date.\n\n•No Change in Control/280G Tax Gross-Ups: We do not provide our employees with tax gross-ups on change in control\n\nbenefits.\n\n•No Liberal Change in Control Definition: The definition of Change in Control in the 2024 Plan does not include events\n\nwhere an actual change in control of the Company may not occur (e.g., commencement or announcement of a tender\n\noffer or stockholder approval of a merger).\n\n•Limited Transferability: Awards are not transferable except by will or by the laws of descent and distribution, or under a\n\ndomestic relations order, subject to limited approvals that may be approved by the plan administrator; provided, unless\n\napproved by stockholders, no award can be transferred for value and no stock option or SAR can be transferred to a third-\n\nparty financial institution.\n\nConsequences if the Amended Plan is not Approved\n\nIf the amendment to the 2024 Plan is not approved, the Company would be at a significant disadvantage relative to its competitors\n\nfor recruiting, retaining and motivating the high caliber individuals critical to our growth and profitability and could be forced to\n\nincrease cash compensation, thereby reducing resources available to meet our business needs. Since our inception, the Board of\n\nDirectors has sought to align the interests of our employees and other service providers with the long-term interests of our\n\nstockholders through, among other things, placing a significant emphasis on equity-based compensation as a component of our\n\ncompensation programs. The Board of Directors believes that equity compensation of the type available for grant under the 2024\n\nPlan, a stock-based incentive plan, furthers the Company’s goal of creating long-term value for the Company’s stockholders by\n\nfostering an ownership culture that encourages a focus on long-term performance, retention, and stockholder value-creation, and\n\nexposes the Company’s employees to economic diminishment if the Company’s share performance lags.\n\nSummary of the 2024 Plan\n\nThe following summary describes the material terms of the 2024 Plan. This summary of the 2024 Plan is not a complete description\n\nof all provisions of the 2024 Plan and is qualified in its entirety by reference to the 2024 Plan, which is attached hereto as Appendix\n\nA. Stockholders are encouraged to read the 2024 Plan in its entirety, including the proposed amendment to the 2024 Plan attached\n\nhereto as Appendix B.\n\nPurpose. The purpose of the 2024 Plan is to provide incentives for our employees, directors and consultants to exert maximum\n\nefforts for the success of the Company and our affiliates and to promote the creation of long-term value for the stockholders of the\n\nCompany by closely aligning the interests of such individuals with those of such stockholders.\n\nAuthorized Shares. As of March 31, 2026, 1,786,835 shares of common stock were available for issuance under the 2024 Plan,\n\nsubject to adjustment as provided in the 2024 Plan. If the proposed amendment to the 2024 Plan is approved by stockholders, an\n\nadditional 1,600,000 shares of our common stock will be available for future issuance under the 2024 Plan.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  45\n\nProposal 5\n\nIf any awards granted under the 2024 Plan are forfeited, expire, terminate, otherwise lapse or are surrendered pursuant to an\n\nexchange program or otherwise settled for cash, in whole or in part, without the delivery of shares, the shares covered by such\n\nforfeited, expired, terminated or lapsed award or award surrendered or settled in cash will be added back to and again become\n\navailable for issuance under the 2024 Plan. Any shares withheld in respect of taxes, any shares tendered or withheld to pay the\n\nexercise price of options and any shares underlying an award of stock appreciation rights will not be added back to or again\n\nbecome available for issuance under the 2024 Plan. For the avoidance of doubt, awards granted under the 2024 Plan that by their\n\nterms settle in cash will not reduce the 2024 Plan’s share reserve.\n\nPlan Administration. Our Board of Directors, or a duly authorized committee of our Board of Directors (referred to collectively as\n\nthe “plan administrator”), will administer the 2024 Plan. The plan administrator may, in accordance with the terms of the 2024 Plan,\n\ndelegate to one or more of our officers the authority to determine (i) award recipients, (ii) how and when each award will be\n\ngranted, (iii) the types of awards to be granted, (iv) grant dates, (v) the number of shares subject to each award, (vi) the fair market\n\nvalue of our common stock, and (vii) the provisions of each award, including the period of exercisability and the vesting schedule\n\napplicable to an award.\n\nUnder the 2024 Plan, (i) the plan administrator will not, without stockholder approval, (A) reduce the exercise or strike price of an\n\noption or stock appreciation right (other than in connection with a capitalization adjustment), (B) at any time when the exercise or\n\nstrike price of an option or stock appreciation right is above the fair market value of a share of our common stock, cancel and re-\n\ngrant or exchange such option or stock appreciation right for a new award with a lower (or no) purchase price or for cash and (C)\n\ninstitute and determine the terms and conditions of an “exchange program” under which outstanding awards are surrendered or\n\ncancelled in exchange for awards of the same type (which may have higher or lower exercise prices and different terms), awards of\n\na different type, and/or cash, participants would have the opportunity to transfer any outstanding awards to a financial institution or\n\nother person or entity selected by the plan administrator, and/or the exercise price of an outstanding award is increased or\n\nreduced, and (ii) a participant’s rights under any award will not be amended to materially adversely affect such participant’s rights\n\nthereunder without the participant’s written consent.\n\nOur Board of Directors is the plan administrator of the 2024 Plan unless and until administration of the plan is delegated to a\n\ncommittee of one or more members of our Board of Directors in accordance with the 2024 Plan. Generally, the administration of\n\nthe 2024 Plan has been delegated to the Compensation and Human Capital Committee and, in connection with the administration\n\nof the 2024 Plan, the Compensation and Human Capital Committee has the administrative powers and authority provided to the\n\nBoard of Directors under the 2024 Plan, concurrently with the authority retained by the Board of Directors to administer the 2024\n\nPlan.\n\nAwards Under the 2024 Plan\n\nThe 2024 Plan provides for the grant of ISOs, within the meaning of Section 422 of the Internal Revenue Code of 1986, as\n\namended (the “Code”), to our employees and our parent and subsidiary corporations’ employees, and for the grant of nonstatutory\n\nstock options (“NSOs”), stock appreciation rights, restricted stock awards, restricted stock unit awards and other forms of awards to\n\nour employees, directors and consultants and any of our affiliates’ employees and consultants.\n\nStock Options. ISOs and NSOs will be granted under stock option agreements adopted by the plan administrator. The plan\n\nadministrator will determine the exercise price for stock options, within the terms and conditions of the 2024 Plan, except the\n\nexercise price of a stock option (other than an option assumed or substituted in connection with a corporate transaction) generally\n\nwill not be less than 100% (or 110% in the case of ISOs granted to a person who owns or is deemed to own stock possessing more\n\nthan 10% of our total combined voting power or that of any of our parent or subsidiary corporations, or a ten percent stockholder) of\n\nthe fair market value of our common stock on the date of grant. Options granted under the 2024 Plan will vest at the rate specified\n\nin the stock option agreement as will be determined by the plan administrator. The terms and conditions of separate options need\n\nnot be identical.\n\nNo option will be exercisable after the expiration of ten years (or five years in the case of ISOs granted to a ten percent\n\nstockholder) or a shorter period specified in the applicable award agreement. Unless otherwise determined by the plan\n\nadministrator or the terms of an option holder’s stock option agreement, or other written agreement between us and the recipient,\n\nprovide otherwise, if an option holder’s service relationship with us or any of our affiliates ceases for any reason other than\n\ndisability, death, or cause, the option holder may generally exercise any vested options for a period of three months following the\n\n46  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\ncessation of service. This period may be extended in the event that exercise of the option is prohibited by applicable securities\n\nlaws. If an option holder’s service relationship with us or any of our affiliates ceases due to death, or an option holder dies within a\n\ncertain period following cessation of service, the option holder or a beneficiary may generally exercise any vested options for a\n\nperiod of 12 months following the date of death. If an option holder’s service relationship with us or any of our affiliates ceases due\n\nto disability, the option holder may generally exercise any vested options for a period of 12 months following the cessation of\n\nservice. In the event of a termination for cause, options generally terminate upon the termination date. If a participant is suspended\n\npending investigation of whether their service relationship with us or any of our affiliates shall be terminated for cause, the\n\nparticipant’s rights to exercise an option will be suspended during the investigation period. An option holder may not exercise an\n\noption at any time that the issuance of shares upon such exercise would violate applicable law. Unless determined by the Board of\n\nDirectors or provided otherwise in the option holder’s stock option agreement or other written agreement between an option holder\n\nand us, if an option holder’s service relationship with us or any of our affiliates ceases for any reason other than for cause and, at\n\nany time during the last thirty days of the applicable post-termination exercise period: (i) the exercise of the option holder’s option\n\nwould be prohibited solely because the issuance of shares upon such exercise would violate applicable law, (ii) the immediate sale\n\nof any shares issued upon such exercise would violate our trading policy or (iii) the plan administrator has suspended exercisability\n\nof such option holder’s option pending investigation of whether their service relationship with us or any of our affiliates shall be\n\nterminated for cause, then the applicable post-termination exercise period will be extended to the last day of the calendar month\n\nthat begins after the date the award would otherwise expire, with an additional extension of the exercise period to the last day of\n\nthe next calendar month to apply if any of the foregoing restrictions apply at any time during such extended exercise period. There\n\nis no limitation as to the maximum permitted number of extensions. However, in no event may an option be exercised beyond the\n\nexpiration of its term.\n\nAcceptable consideration for the purchase of common stock issued upon the exercise of a stock option will be determined by the\n\nplan administrator and may include (i) cash, check, bank draft or money order payable to us; (ii) a broker-assisted cashless\n\nexercise; (iii) subject to certain conditions, the tender of shares of our common stock previously owned by the option holder; (iv) a\n\nnet exercise of the option if it is an NSO; or (v) other legal consideration approved by the plan administrator.\n\nUnless the plan administrator provides otherwise, options or stock appreciation rights generally will not be transferable except by\n\nwill or the laws of descent and distribution. Subject to approval of the plan administrator or a duly authorized officer, an option may\n\nbe transferred pursuant to a domestic relations order.\n\nTax Limitations on ISOs. The aggregate fair market value, determined at the time of grant, of our common stock with respect to\n\nISOs that are exercisable for the first time by any participant during any calendar year under all of our stock plans or plans of our\n\naffiliates may not exceed $100,000. Options or portions thereof that exceed such limit will generally be treated as NSOs. No ISO\n\nmay be granted to any person who, at the time of the grant, is a ten percent stockholder unless (i) the option exercise price is at\n\nleast 110% of the fair market value of the stock subject to the option on the date of grant; and (ii) the term of the ISO does not\n\nexceed five years from the date of grant.\n\nRestricted Stock Unit Awards. Subject to the terms of the 2024 Plan, each restricted stock unit award will have such terms and\n\nconditions as determined by the plan administrator. A restricted stock unit award represents a participant’s right to be issued on a\n\nfuture date the number of shares of our common stock that is equal to the number of restricted stock units subject to the award. A\n\nparticipant will not have voting or any other rights as a stockholder of ours with respect to any restricted stock unit award (unless\n\nand until shares are actually issued in settlement of a vested restricted stock unit award). A restricted stock unit award will\n\ngenerally be granted in consideration for a participant’s services to us or an affiliate, such that the participant will not be required to\n\nmake any payment to us (other than such services) with respect to the grant or vesting of the restricted stock unit award, or the\n\nissuance of any shares pursuant to the restricted stock unit award. If, at the time of grant, the plan administrator determines that a\n\nparticipant must pay consideration upon the issuance of shares pursuant to a restricted stock unit award, such consideration may\n\nbe paid in any form of legal consideration that may be acceptable to the plan administrator and permissible under applicable law. A\n\nrestricted stock unit award may be settled by cash, delivery of stock (or any combination of our common stock and cash), or in any\n\nother form of consideration determined by the plan administrator and set forth in the restricted stock unit award agreement. At the\n\ntime of grant, the plan administrator may impose such restrictions or conditions on the award of restricted stock units that delay\n\ndelivery to a date following the vesting of the award in a manner intended to comply with Section 409A of the Code, as applicable.\n\nAdditionally, dividends or dividend equivalents may be paid or credited in respect of shares covered by a restricted stock unit\n\naward, subject to the same restrictions on transferability and forfeitability as the underlying award with respect to which such\n\nCareDx Inc.\n\n2026 Proxy Statement  |  47\n\nProposal 5\n\ndividends or dividend equivalents are granted and subject to such other terms and conditions as determined by the plan\n\nadministrator and specified in the applicable restricted stock unit award agreement. Except as determined by the plan administrator\n\nor otherwise provided in the applicable award agreement, or other written agreement between us and the recipient, restricted stock\n\nunit awards that have not vested will be forfeited once the participant’s continuous service ends for any reason.\n\nRestricted Stock Awards. Restricted stock awards will be granted under restricted stock award agreements adopted by the plan\n\nadministrator. A restricted stock award may be awarded in consideration for cash, check, bank draft or money order, past or future\n\nservices to us or any of our affiliates, or any other form of legal consideration that may be acceptable to the plan administrator and\n\npermissible under applicable law. The plan administrator will determine the terms and conditions of restricted stock awards,\n\nincluding vesting and forfeiture terms. Dividends or dividend equivalents may be paid or credited with respect to shares subject to a\n\nrestricted stock award, subject to the same restrictions on transferability and forfeitability as the underlying award with respect to\n\nwhich such dividends or dividend equivalents are granted and subject to such other terms and conditions as determined by the\n\nplan administrator and specified in the applicable restricted stock award agreement. If a participant’s service relationship with us\n\nends for any reason, we may receive any or all of the shares of our common stock held by the participant that have not vested as\n\nof the date the participant terminates service with us through a forfeiture condition or a repurchase right.\n\nStock Appreciation Rights. Stock appreciation rights will be granted under stock appreciation right agreements adopted by the\n\nplan administrator and denominated in shares of common stock equivalents. The terms of separation stock appreciation rights\n\nneed not be identical. The plan administrator will determine the purchase price or strike price for a stock appreciation right, which\n\ngenerally will not be less than 100% of the fair market value of our common stock on the date of grant. A stock appreciation right\n\ngranted under the 2024 Plan will vest at the rate specified in the stock appreciation right agreement as will be determined by the\n\nplan administrator. Stock appreciation rights may be settled in cash or shares of our common stock (or any combination of our\n\ncommon stock and cash) or in any other form of payment, as determined by the plan administrator and specified in the stock\n\nappreciation right agreement.\n\nThe plan administrator will determine the term of stock appreciation rights granted under the 2024 Plan, up to a maximum of 10\n\nyears. If a participant’s service relationship with us or any of our affiliates ceases for any reason other than cause, disability, or\n\ndeath, the participant may generally exercise any vested stock appreciation right for a period of three months following the\n\ncessation of service. This period may be further extended in the event that exercise of the stock appreciation right following such a\n\ntermination of service is prohibited by applicable securities laws. If a participant’s service relationship with us or any of our affiliates\n\nceases due to disability or death, or a participant dies within a certain period following cessation of service, the participant or a\n\nbeneficiary may generally exercise any vested stock appreciation rights for a period of 18 months following the date of death. If a\n\nparticipant’s service relationship with us or any of our affiliates ceases due to disability, the participant may generally exercise any\n\nvested stock appreciation rights for a period of 12 months following the cessation of service. In the event of a termination for cause,\n\nstock appreciation rights generally terminate upon the termination date. If a participant is suspended pending investigation of\n\nwhether their service relationship with us or any of our affiliates shall be terminated for cause, the participant’s rights to exercise a\n\nstock appreciation right will be suspended during the investigation period. A holder of a stock appreciation right may not exercise a\n\nstock appreciation right at any time that the issuance of shares upon such exercise would violate applicable law. Unless\n\ndetermined by the plan administrator or provided otherwise in the stock appreciation right agreement or other written agreement\n\nbetween the participant and us, if a participant’s service relationship with us or any of our affiliates ceases for any reason other\n\nthan for cause and, at any time during the last thirty days of the applicable post-termination exercise period: (i) the exercise of the\n\nparticipant’s stock appreciation right would be prohibited solely because the issuance of shares upon such exercise would violate\n\napplicable law, (ii) the immediate sale of any shares issued upon such exercise would violate our trading policy or (iii) the plan\n\nadministrator has suspended exercisability of such option holder’s option pending investigation of whether their service relationship\n\nwith us or any of our affiliates shall be terminated for cause, then the applicable post-termination exercise period will be extended\n\nto the last day of the calendar month that begins after the date the award would otherwise expire, with an additional extension of\n\nthe exercise period to the last day of the next calendar month to apply if any of the foregoing restrictions apply at any time during\n\nsuch extended exercise period. There is no limitation as to the maximum permitted number of extensions. However, in no event\n\nmay a stock appreciation right be exercised beyond the expiration of its term.\n\n48  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\nOther Stock Awards. The plan administrator will be permitted to grant other awards, based in whole or in part by reference to, or\n\notherwise based on, our common stock, either alone or in addition to other awards. The plan administrator will have the sole and\n\ncomplete discretion to determine the persons to whom and the time or times at which other stock awards will be granted, the\n\nnumber of shares under the other stock award (or cash equivalent), the form of payment (for example, shares of stock, cash or\n\nother property) and all other terms and conditions of such awards.\n\nAwards; Performance Criteria\n\nAwards made pursuant to the 2024 Plan may be made subject to the attainment of performance goals relating to one or more\n\nbusiness criteria. For purposes of the 2024 Plan, such business criteria may include (but is not limited to) any one or more of the\n\nfollowing performance criteria, either individually, alternatively, or in any combination: earnings (including earnings per share and\n\nnet earnings); earnings before interest, taxes and depreciation; earnings before interest, taxes, depreciation and amortization; total\n\nstockholder return; return on equity or average stockholder’s equity; return on assets, investment, or capital employed; stock price;\n\nmargin (including gross margin); income (before or after taxes); operating income; operating income after taxes; pre-tax profit;\n\noperating cash flow; sales or revenue targets; increases in revenue or product revenue; expenses and cost reduction goals;\n\nimprovement in or attainment of working capital levels; economic value added (or an equivalent metric); market share; cash flow;\n\ncash flow per share; share price performance; debt reduction; customer satisfaction; stockholders’ equity; capital expenditures;\n\ndebt levels; operating profit or net operating profit; workforce diversity; growth of net income or operating income; billings; pre-\n\nclinical development related compound goals; financing; regulatory milestones, including approval of a compound; stockholder\n\nliquidity; corporate governance and compliance; product commercialization; intellectual property; personnel matters; progress of\n\ninternal research or clinical programs; progress of partnered programs; partner satisfaction; budget management; clinical\n\nachievements; completing phases of a clinical study (including the treatment phase); announcing or presenting preliminary or final\n\ndata from clinical studies; in each case, whether on particular timelines or generally; timely completion of clinical trials; submission\n\nof INDs and NDAs and other regulatory achievements; partner or collaborator achievements; internal controls, including those\n\nrelated to the Sarbanes-Oxley Act of 2002; research progress, including the development of programs; investor relations, analysts\n\nand communication; manufacturing achievements (including obtaining particular yields from manufacturing runs and other\n\nmeasurable objectives related to process development activities); strategic partnerships or transactions (including in-licensing and\n\nout-licensing of intellectual property; establishing relationships with commercial entities with respect to the marketing, distribution\n\nand sale of our products (including with group purchasing organizations, distributors and other vendors)); supply chain\n\nachievements (including establishing relationships with manufacturers or suppliers of active pharmaceutical ingredients and other\n\ncomponent materials and manufacturers of our products); co-development, co-marketing, profit sharing, joint venture or other\n\nsimilar arrangements; individual performance goals; corporate development and planning goals; and other measures of\n\nperformance selected by our Board of Directors or our Compensation and Human Capital Committee.\n\nIn determining performance outcomes related to such measures or criteria, the plan administrator may provide for the exclusion of\n\nthe impact of an event or occurrence which the plan administrator determines should appropriately be excluded, including: (a)\n\nrestructuring and/or other nonrecurring charges, (b) exchange rate effects, (c) the effects of changes to generally accepted\n\naccounting principles, (d) the effects of any statutory adjustments to corporate tax rates, (e) the effects of items that are “unusual”\n\nin nature or occur “infrequently” as determined under generally accepted accounting principles, (f) the dilutive effects of acquisitions\n\nor joint ventures, (g) exclusions to assume that any business divested by us achieved performance objectives at targeted levels\n\nduring the balance of a performance period following such divestiture, (h) the effect of any change in the outstanding shares of our\n\ncommon stock by reason of any stock dividend or split, stock repurchase, reorganization, recapitalization, merger, consolidation,\n\nspin-off, combination or exchange of shares or other similar corporate change, or any distributions to common stockholders other\n\nthan regular cash dividends, (i) the effects of stock based compensation and the award of bonuses under the Company’s bonus\n\nplans, (j) costs incurred in connection with potential acquisitions or divestitures that are required to be expensed under generally\n\naccepted accounting principles and (k) the goodwill and intangible asset impairment charges that are required to be recorded under\n\ngenerally accepted accounting principles.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  49\n\nProposal 5\n\nNon-Employee Director Compensation Limit\n\nThe aggregate value of all compensation granted or paid following the effective date of the 2024 Plan to any individual for service\n\nas a non-employee director with respect to any fiscal year, including awards granted under the 2024 Plan (valued based on the\n\ngrant date fair value for financial reporting purposes) and cash fees paid by us to such non-employee director, will not exceed\n\n$750,000 in total value, except such amount will increase to $1,500,000 for the year in which a non-employee director is first\n\nappointed or elected to our Board. For the avoidance of doubt, any awards granted and cash fees paid to a non-employee director\n\nfor their service as a non-employee director in respect of any fiscal year will count against the annual compensation limits for the\n\nfiscal year to which such awards and fees related, regardless of any deferral of such Awards or fees.\n\nChanges to Capital Structure\n\nIn the event there is a specified type of change in our capital structure, such as a stock split, reverse stock split, or recapitalization,\n\nthe plan administrator will appropriately and proportionately adjust (i) the class and maximum number of shares subject to the 2024\n\nPlan; (ii) the class and maximum number of shares that may be issued on the exercise of ISOs; and (iii) the class and number of\n\nshares and exercise price, strike price, or purchase price, if applicable, of all outstanding awards granted under the 2024 Plan.\n\nChange in Control. In the event of a change in control (as defined below), all outstanding awards as of the date of such change in\n\ncontrol will be treated in the manner described in the definitive agreement evidencing such change in control (or, in the event that\n\nsuch change in control is not effected pursuant to a definitive agreement to which the Company is a party, in the manner\n\ndetermined by our Board of Directors). For the avoidance of doubt, the definitive agreement (or the Board of Directors’\n\ndetermination) does not need to treat all awards outstanding under the 2024 Plan (or portions thereof) in an identical matter.\n\nUnless otherwise provided in a participant’s award agreement or other written agreement with us or one of our affiliates or unless\n\notherwise expressly provided by the plan administrator at the time of grant (and without limiting the prior sentence), any awards\n\noutstanding under the 2024 Plan may be assumed, continued or substituted for, in whole or in part, by any surviving or acquiring\n\ncorporation (or its parent company), and any reacquisition or repurchase rights held by us with respect to our common stock issued\n\npursuant to awards may be assigned to the successor (or its parent company). If the surviving or acquiring corporation (or its\n\nparent company) does not assume, continue or substitute for such awards, then (i) with respect to any such awards that are held\n\nby participants whose continuous service has not terminated prior to the effective time of the change in control, or current\n\nparticipants, the vesting (and exercisability, if applicable) of such awards will be accelerated in full (or, in the case of awards with\n\nperformance-based vesting with multiple vesting levels depending on the level of performance, unless provided otherwise in the\n\napplicable award agreement, vesting will accelerate at 100% of the target level or such greater level as determined by the Board)\n\nto a date prior to the effective time of the change in control (contingent upon the effectiveness of the corporate transaction), and\n\nsuch awards will terminate if not exercised (if applicable) at or prior to the effective time of the change in control, and any\n\nreacquisition or repurchase rights held by us with respect to such awards will lapse (contingent upon the effectiveness of the\n\nchange in control); and (ii) any such awards that are held by persons other than current participants will terminate if not exercised\n\n(if applicable) prior to the occurrence of the change in control, except that any reacquisition or repurchase rights held by us with\n\nrespect to such awards will not terminate and may continue to be exercised notwithstanding the change in control.\n\nIn the event an award will terminate if not exercised prior to the effective time of a change in control, the plan administrator may\n\nprovide, in its sole discretion, that the holder of such award may not exercise such award but instead will receive a payment, in\n\nsuch form as may be determined by the plan administrator, equal in value to the excess (if any) of (i) the value of the property the\n\nparticipant would have received upon the exercise of the award, over (ii) any per share exercise price payable by such holder, if\n\napplicable. As a condition to the receipt of an award, a participant will be deemed to have agreed that the award will be subject to\n\nthe terms of any agreement under the 2024 Plan governing a corporate transaction involving us.\n\nAwards to be granted under the 2024 Plan may be subject to acceleration of vesting and exercisability upon or after a change in\n\ncontrol (as defined below) as may be provided in the applicable stock award agreement or in any other written agreement between\n\nus or any affiliate and the participant, but in the absence of such provision, no such acceleration will automatically occur.\n\n50  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\nUnder the 2024 Plan, a “change in control” generally will be: (i) the acquisition by any person or company of more than 50% of the\n\ncombined voting power of our then outstanding stock; (ii) a merger, consolidation or similar transaction in which our stockholders\n\nimmediately before the transaction do not own, directly or indirectly, more than 50% of the combined voting power of the surviving\n\nentity (or the parent of the surviving entity) in substantially the same proportions as their ownership immediately prior to such\n\ntransaction; (iii) stockholder approval of a complete dissolution or liquidation; (iv) a sale, lease, exclusive license or other\n\ndisposition of all or substantially all of our assets other than to an entity more than 50% of the combined voting power of which is\n\nowned by our stockholders in substantially the same proportions as their ownership of our outstanding voting securities\n\nimmediately prior to such transaction; or (v) when a majority of our Board of Directors becomes comprised of individuals who were\n\nnot serving on our Board of Directors on the date of the underwriting agreement related to this offering, or the incumbent board, or\n\nwhose nomination, appointment, or election was not approved by a majority of the incumbent board still in office.\n\nMinimum Vesting Conditions\n\nSubject to the proviso below, awards granted under the 2024 Plan will vest no earlier than the first anniversary of the date on which\n\nthe award is granted; provided, that the following will not be subject to the foregoing minimum vesting requirement: (i) awards to\n\nnon-employee directors that vest on earlier of the one-year anniversary of the date of grant and the next annual meeting of\n\nstockholders, which is at least 50 weeks after the immediately preceding year’s annual meeting; (ii) additional awards the plan\n\nadministrator may grant, up to a maximum of five percent (5%) of the available share reserve authorized for issuance under the\n\n2024 Plan (subject to the 2024 Plan’s adjustment provisions); and (iii) any decision by our Board to provide for accelerated vesting\n\nof any award in connection with the termination of a participant’s continuous service in exchange of a release of claims. The\n\nforegoing restriction does not apply to the plan administrator’s discretion to provide for accelerated exercisability or vesting of any\n\naward in the event of change in control in which the surviving corporation or acquiring corporation (or its parent company) does not\n\nassume or continue such award or substitute a similar award.\n\nProhibition on Repricing\n\nOther than pursuant to certain equitable adjustments as described in the 2024 Plan, the plan administrator will not, without the\n\napproval of the Company’s stockholders, lower the option price per share of an option (or base price of a SAR) after it is granted,\n\ncancel an option or SAR when the exercise price per share exceeds the fair market value of one share in exchange for cash or\n\nanother award (other than in connection with a change in control), or take any other action with respect to an option or SAR that\n\nwould be treated as a repricing under the rules and regulations of the principal United States (“U.S.”) national securities exchange\n\non which the shares are listed.\n\nDeferral\n\nIn its discretion and subject to such terms and conditions as it may impose, the plan administrator may permit a participant to elect\n\nto defer receipt of shares of common stock issuable pursuant to any equity award granted under the 2024 Plan to a time later than\n\nthe time the shares otherwise would be issued to the participant; provided that such deferral election complies with rules adopted\n\nby the plan administrator, which comply with, or are exempt from, the requirements of Section 409A of the Code. In such event, the\n\nplan administrator may, in its discretion, provide for the payment by the Company of an additional amount representing interest at a\n\nreasonable rate or the actual rate of return on one or more predetermined specific investments, as determined by the plan\n\nadministrator.\n\nForeign Employees and Consultants\n\nAwards may be granted to participants who are foreign nationals or employed or providing services outside the United States, or\n\nboth, on such terms and conditions different from those applicable to awards to employees or consultants providing services in the\n\nUnited States as may, in the judgment of the plan administrator, be necessary or desirable in order to recognize differences in local\n\nlaw or tax policy.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  51\n\nProposal 5\n\nTransferability\n\nExcept as determined by the Board or expressly provided in the 2024 Plan or the form of award agreement, awards granted under\n\nthe 2024 Plan may not be transferred or assigned by a participant. After the vested shares subject to an award have been issued,\n\nor in the case of a restricted stock award and similar awards, after the issued shares have vested, the holder of such shares is free\n\nto assign, hypothecate, donate, encumber or otherwise dispose of any interest in such shares provided that any such actions are in\n\ncompliance with the terms of our trading policy and applicable law.\n\nClawback/Recovery\n\nAll awards granted under the 2024 Plan will be subject to recoupment in accordance with our current clawback policy and as\n\notherwise required by the Dodd-Frank Act or other applicable law, and any clawback policy that we otherwise adopt, to the extent\n\napplicable and permissible under applicable law. See “Board of Directors and Corporate Governance—Clawback Policy”. In\n\naddition, the plan administrator may impose such other clawback, recovery or recoupment provisions in an award agreement as\n\nthe plan administrator determines necessary or appropriate, including but not limited to a reacquisition right in respect of previously\n\nacquired shares of our common stock or other cash or property upon the occurrence of cause.\n\nAmendment or Termination\n\nThe plan administrator may accelerate the time at which an award granted under the 2024 Plan may first be exercised or the time\n\nduring which an award grant under the 2024 Plan or any part thereof will vest, notwithstanding the provisions in the award\n\nagreement stating the time at which it may first be exercised or the time during which it will vest. The plan administrator will have\n\nthe authority to amend, suspend or terminate the 2024 Plan at any time, provided that such action does not materially impair the\n\nexisting rights of any participant without such participant’s written consent. Certain material amendments will also require the\n\napproval of our stockholders. No ISOs may be granted after the tenth anniversary of the effective date of the 2024 Plan. No awards\n\nmay be granted under the 2024 Plan while it is suspended or after it is terminated.\n\nForm S-8 Registration Statement\n\nWe intend to file a registration statement on Form S-8 to register the additional shares of our common stock approved under the\n\namendment to the 2024 Plan.\n\nNew Plan Benefits\n\nAs described above, the selection of participants who will receive awards under the 2024 Plan and the size and types of awards\n\nwill be determined by the plan administrator at its discretion. None of the shares authorized by the amendment to the 2024 Plan\n\nhave been awarded to any of the directors or employees, and no commitment has been made to award any such shares. The plan\n\nadministrator has authority to authorize future awards under the 2024 Plan from time to time. The value of any future equity awards\n\nwill ultimately depend on the nature and size of the awards, the future price of our common stock and the exercise decisions made\n\nby the participants, among other factors, and will be subject to such vesting conditions under the 2024 Plan as the plan\n\nadministrator determines from time to time. Therefore, the amount of any future awards under the 2024 Plan is not yet\n\ndeterminable and it is not possible to predict the benefits or amounts that will be received by, or allocated to, particular individuals\n\nor groups of employees. Currently, our non-employee directors are entitled to receive cash and equity compensation for their\n\nservice as directors as described above under “Board of Directors and Corporate Governance—Director Compensation.” For\n\nfurther details on the awards granted during the fiscal year ended December 31, 2025 under the 2024 Plan, please refer to the\n\nexecutive and director compensation tables beginning on page [68](#i905f78cfb2ec4d6ba9e65cdd610942a5_187) and [32](#i905f78cfb2ec4d6ba9e65cdd610942a5_1633), respectively, of this proxy statement.\n\n52  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\nHistorical Plan Benefits\n\nThe table below shows, for the individuals and groups listed below, all equity awards granted under the 2024 Plan from its\n\ninception through December 31, 2025. Amounts shown represent the total number of shares of our common stock subject to\n\nawards granted under the 2024 Plan, whether or not such awards remain outstanding as of that date.\n\nName and position\n\nNumber of shares\n\n(#)\n\nJohn W. Hanna\n\n286,723\n\nKeith Kennedy\n\n110,278\n\nJessica Meng\n\n88,223\n\nJeffrey Novack\n\n33,083\n\nAbhishek Jain\n\n79,400\n\nNathan Smith\n\n60,000\n\nAll current executive officers as a group excluding the NEOs (6) persons\n\n191,882\n\nAll current directors who are not executive officers as a group\n\n380,443\n\nAll current and former employees (excluding current executive officers as a group)\n\n1,000,020\n\nCertain U.S. Federal Income Tax Consequences\n\nThe following is a summary of the U.S. federal income tax treatment applicable to us and the participants who receive awards\n\nunder the 2024 Plan based on the federal income tax laws in effect on the date of this proxy statement. This summary is not\n\nintended to be exhaustive and does not address all matters relevant to a particular participant based on their specific\n\ncircumstances. The summary expressly does not discuss the income tax laws of any state, municipality or non-U.S. taxing\n\njurisdiction, or the gift, estate, excise or other tax laws other than U.S. federal income tax law. Because individual circumstances\n\nmay vary, we recommend that all participants to consult with their tax advisor concerning the tax implications of awards granted\n\nunder the 2024 Plan.\n\nStock Option Grants\n\nStock options granted under the 2024 Plan may either be ISOs, which satisfy the requirements of Section 422 of the Code, or\n\nNSOs, which are not intended to meet such requirements. The U.S. federal income tax treatment for the two types of options\n\ndiffers as follows:\n\nIncentive Stock Options\n\nNo taxable income is recognized by the participant at the time of the grant of an ISO, and no taxable income is recognized for\n\nordinary income tax purposes at the time the ISO is exercised, although taxable income may arise at that time for alternative\n\nminimum tax purposes. Unless there is a disqualifying disposition, as described below, the participant will recognize long-term\n\ncapital gain in an amount equal to the excess of (i) the amount realized upon the sale or other disposition of the purchased shares\n\nover (ii) the exercise price paid for the shares.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  53\n\nProposal 5\n\nA disqualifying disposition occurs if the disposition is less than two years after the date of grant or less than one year after the\n\nexercise date. If there is a disqualifying disposition of the shares, then the excess of (i) the fair market value of those shares on the\n\nexercise date or (if less) the amount realized upon such sale or disposition over (ii) the exercise price paid for the shares will be\n\ntaxable as ordinary income to the participant. Any additional gain or loss recognized upon the disposition will be a capital gain or\n\nloss.\n\nIf the participant makes a disqualifying disposition of the purchased shares, then we will be entitled to an income tax deduction for\n\nthe taxable year in which such disposition occurs, equal to the amount of ordinary income recognized by the participant as a result\n\nof the disposition. We will not be entitled to any income tax deduction if the participant makes a qualifying disposition of the shares.\n\nNon-Statutory Stock Options\n\nNo taxable income is recognized by a participant upon the grant of an NSO. The participant in general will recognize ordinary\n\nincome, in the year in which the NSO is exercised, equal to the excess of the fair market value of the purchased shares on the\n\nexercise date over the exercise price paid for the shares. We will be entitled to an income tax deduction equal to the amount of\n\nordinary income recognized by the participant with respect to the exercised non-statutory stock option.\n\nSARs\n\nNo taxable income is recognized upon receipt of an SAR. The holder will recognize ordinary income in the year in which the SAR is\n\nexercised, in an amount equal to the excess of (i) the fair market value of the underlying shares of common stock on the exercise\n\ndate over (ii) the base price in effect for the exercised right. We will be entitled to an income tax deduction equal to the amount of\n\nordinary income recognized by the holder in connection with the exercise of the SAR.\n\nStock Awards\n\nParticipants will recognize ordinary income at the time unrestricted stock awards are granted in an amount equal to the excess of\n\n(i) the fair market value of the shares on the grant date over (ii) the cash consideration (if any) paid for the shares.\n\nNo taxable income is recognized at the time restricted stock awards are issued but the participant will have to report as ordinary\n\nincome, as and when those shares subsequently vest, an amount equal to the excess of (i) the fair market value of the shares on\n\nthe vesting date over (ii) the cash consideration (if any) paid for the shares. The participant may, however, elect under Section\n\n83(b) of the Code to include as ordinary income in the year the unvested shares are issued an amount equal to the excess of (a)\n\nthe fair market value of those shares on the issue date over (b) the cash consideration (if any) paid for such shares. If the Section\n\n83(b) election is made, the participant will not recognize any additional income as and when the shares subsequently vest.\n\nWe will be entitled to an income tax deduction equal to the amount of ordinary income recognized by the participant at the time\n\nsuch ordinary income is recognized by the participant.\n\nOther Awards\n\nGenerally, no taxable income is recognized upon receipt of stock units (including RSUs), performance awards or cash awards. The\n\nholder will recognize ordinary income in the year in which the shares subject to the award are actually issued or in the year in which\n\nthe award is settled in cash. The amount of that income will be equal to the fair market value of the shares on the date of issuance\n\nor the amount of the cash paid in settlement of the award.\n\nWe will be entitled to an income tax deduction equal to the amount of ordinary income recognized by the holder at the time the\n\nshares are issued or the cash amount is paid.\n\n54  |  2026 Proxy Statement\n\nCareDx Inc.\n\nProposal 5\n\nWithholding\n\nPrior to the delivery of any shares of our common stock or cash pursuant to a 2024 Plan award (or exercise thereof), the Company\n\nwill have the power and the right to deduct or withhold, or require a participant to remit to the Company, an amount sufficient to\n\nsatisfy federal, state, and local taxes or other amounts (including the participant’s FICA obligation) required to be withheld with\n\nrespect to such award (or exercise thereof). The plan administrator, in its sole discretion and pursuant to such procedures as it may\n\nspecify from time to time, may permit a participant to satisfy such tax withholding obligation, in whole or in part by (a) electing to\n\nhave the Company withhold otherwise deliverable shares of our common stock, or (b) delivering to the Company already-owned\n\nshares of our common stock having a fair market value equal to the minimum amount required to be withheld. If the plan\n\nadministrator permits shares of our common stock to be withheld from the award to satisfy applicable withholding obligations, the\n\nfair market value of the shares of our common stock withheld, as determined as of the date of withholding, will not exceed the\n\namount determined by the applicable minimum statutory withholding rates unless the plan administrator determines an additional\n\namount can be withheld and will not result in adverse accounting consequences, and the plan administrator authorizes such\n\nadditional withholding.\n\nSection 409A of the Code\n\nCertain types of awards under the 2024 Plan may constitute, or provide for, a deferral of compensation subject to Section 409A of\n\nthe Code. Unless certain requirements set forth in Section 409A of the Code are complied with, holders of such awards may be\n\ntaxed earlier than would otherwise be the case (e.g., at the time of vesting instead of the time of payment) and may be subject to\n\nan additional 20% penalty tax (and, potentially, certain interest, penalties and additional state taxes). To the extent applicable, the\n\n2024 Plan and awards granted under the 2024 Plan are intended to be structured and interpreted in a manner intended to either\n\ncomply with or be exempt from Section 409A of the Code and the Department of Treasury regulations and other interpretive\n\nguidance that may be issued under Section 409A of the Code. To the extent determined necessary or appropriate by the plan\n\nadministrator, the 2024 Plan and applicable award agreements may be amended to further comply with Section 409A of the Code\n\nor to exempt the applicable awards from Section 409A of the Code.\n\nDeductibility of Executive Compensation\n\nSection 162(m) of the Code limits the deductibility for federal income tax purposes of certain annual compensation paid to any\n\n“covered employee” in excess of $1 million. For purposes of Section 162(m), the term “covered employee” includes any individual\n\nwho serves or has served as our chief executive officer, chief financial officer or one of the other three most highly compensated\n\nexecutive officers for 2017 or any subsequent calendar year. It is expected that compensation deductions for any covered\n\nemployee with respect to awards under the 2024 Plan will be subject to the $1 million annual deduction limitation.\n\nVote Required; Board Recommendation\n\nApproval of the amendment to the 2024 Plan requires the affirmative vote of a majority of the shares of our common stock present\n\nvirtually or by proxy at the Annual Meeting and entitled to vote thereon. Abstentions will have the effect of a vote AGAINST the\n\nproposal. Broker non-votes will have no effect on this proposal.\n\nOur Board of Directors unanimously recommends that our Stockholders  vote “FOR” the\n\napproval of the amendment to the 2024 Equity Incentive Plan.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  55\n\nExecutive Officers\n\nThe following table identifies certain information about our executive officers as of April 25, 2026. There are no family relationships\n\namong any of our directors or executive officers.\n\nName\n\nAge\n\nPosition(s)\n\nJohn W. Hanna\n\n46\n\nPresident and Chief Executive Officer\n\nKeith Kennedy\n\n56\n\nChief Operating Officer and Chief Financial Officer\n\nJessica Meng\n\n51\n\nChief Commercial Officer\n\nJeffrey Novack\n\n43\n\nGeneral Counsel and Secretary\n\nJohn W. Hanna was appointed as our President and Chief Executive Officer, effective April 15, 2024. Prior to his appointment, Mr.\n\nHanna served as the Chief Executive Officer of Apton Biosystems, Inc., from April 2021 to August 2023. Apton Biosystems, Inc.\n\nwas acquired by Pacific Biosciences of California, Inc. in August 2023, where Mr. Hanna served as Vice President of Corporate\n\nDevelopment from August 2023 to March 2024. Mr. Hanna previously served for ten years with Veracyte, Inc. from September\n\n2011 to March 2021, where his most recent position was Chief Commercial Officer since March 2017. Prior to Veracyte, Mr. Hanna\n\nheld leadership roles at Humana and IBM. Mr. Hanna received a B.S. in Political Science from Hampden-Sydney College in 2001\n\nand an M.B.A. from the University of Miami in 2008.\n\nKeith Kennedy has served as our Chief Operating Officer since September 2024 and, since February 2026, has also served as\n\nour Chief Financial Officer. Prior to joining us, Mr. Kennedy served as the Chief Financial Officer of PharmaLogic Holdings Corp\n\nfrom April 2022 to September 2024. Mr. Kennedy served as Veracyte Inc.’s Chief Operating Officer from July 2019, as well as its\n\nChief Financial Officer from December 2016, until his retirement in May 2021, as well as its Secretary from November 2017 to July\n\n2020. Prior to joining Veracyte, Mr. Kennedy provided strategic counsel and consulting services from his consulting practice from\n\nSeptember 2015 to November 2016, including advisory services to Pennant Park Investment Advisors. Mr. Kennedy served as\n\nPresident, Chief Executive Officer and Director of MCG Capital Corporation, a publicly traded business development company,\n\nfrom April 2014 until its merger with Pennant Park Floating Rate Capital Ltd in August 2015. Mr. Kennedy joined MCG Capital\n\nCorporation in February 2012 as an Executive Vice President and Managing Director, served as its Chief Financial Officer and\n\nTreasurer from May 2012 to March 2014, and its President from March to April 2014. Prior to MCG, Mr. Kennedy served as a\n\nManaging Director at GE Capital, a Manager of Transaction Services at Ernst & Young LLP and as an Officer in the U.S. Air Force.\n\nMr. Kennedy holds a B.S. in Accounting with high distinction from Indiana University and holds an M.B.A. from the College of\n\nWilliam & Mary. Mr. Kennedy is a Chartered Financial Analyst and Certified Public Accountant.\n\nJessica Meng was appointed as our Chief Commercial Officer, effective September 12, 2024. Ms. Meng previously served as\n\nChief Commercial Officer at DELFI Diagnostics from July 2022 to September 2023, where she served first as a consultant\n\nbeginning January 2022. Ms. Meng served as Chief Commercial Officer and General Manager of Women’s Health at Myovant\n\nSciences from May 2020 to December 2021. Ms. Meng previously held roles of increasing responsibility in sales and marketing\n\nleadership at Veracyte from November 2017 to May 2020 and Genentech from 2004 to 2017. Prior to Genentech she worked at\n\nProgress Software and Monitor Company. Ms. Meng received a Bachelor of Science in Finance and Bachelor of Arts in\n\nInternational Relations with a minor in Mathematics from the University of Pennsylvania, and a Master’s in Business Administration,\n\nMarketing, Strategic Management from The Wharton School.\n\n56  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Officers\n\nJeffrey Novack joined CareDx in 2021 and has served as our General Counsel since December 2023 and as our Secretary since\n\nApril 2024. Before joining CareDx, Mr. Novack served as an Assistant Attorney General in the Investor Protection Bureau of the\n\nNew York Attorney General’s Office. Prior to that, Mr. Novack practiced at two international law firms and clerked for The\n\nHonorable Renée Marie Bumb, Chief Judge of the United States District Court for the District of New Jersey. Mr. Novack is a\n\ngraduate of New York University School of Law and Washington University in St. Louis – Olin Business School. Mr. Novack is\n\nadmitted to practice law in New York and New Jersey.\n\nLegal Proceedings with Executive Officers\n\nThere are no legal proceedings related to any of the executive officers that require disclosure pursuant to Items 103 or 401(f) of\n\nRegulation S-K.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  57\n\nExecutive Compensation\n\nCompensation Discussion and Analysis\n\nIn this Compensation Discussion and Analysis (“CD&A”), we provide an overview of our executive compensation philosophy and\n\nobjectives, as well as a description of the material components of our executive compensation program. This CD&A is intended to\n\nbe read in conjunction with the tables that immediately follow this section, which provide further historical compensation\n\ninformation.\n\nDuring fiscal year 2025, the following executive officers constituted our named executive officers (collectively, our “NEOs”):\n\nName\n\nPosition(s)\n\nJohn W. Hanna\n\nPresident and Chief Executive Officer\n\nKeith Kennedy(1)\n\nChief Operating Officer and Chief Financial Officer\n\nJessica Meng\n\nChief Commercial Officer\n\nJeffrey Novack\n\nGeneral Counsel and Secretary\n\nAbhishek Jain(2)\n\nChief Financial Officer\n\nNathan Smith(3)\n\nChief Financial Officer\n\n(1)Mr. Kennedy’s employment with us as our Chief Operating Officer commenced effective September 12, 2024. In addition to his role as Chief\n\nOperating Officer, he was appointed as the Company’s Chief Financial Officer, effective as of February 26, 2026.\n\n(2)Mr. Jain transitioned from his position as the Company’s Chief Financial Officer on August 6, 2025.\n\n(3)Mr. Smith’s employment with us as our Chief Financial Officer commenced effective August 7, 2025. Mr. Smith transitioned from his position as\n\nthe Company’s Chief Financial Officer on February 25, 2026.\n\nI.Executive Summary\n\n2025 Business Highlights\n\nCareDx is a precision medicine company dedicated to improving outcomes for transplant patients and advancing organ health. We\n\ndeliver solutions designed to empower clinicians and improve patient outcomes. Our integrated solutions include non-invasive\n\nmolecular testing for heart, kidney, and lung transplants; laboratory products; digital health technologies; and patient solutions that\n\nsupport care before and after transplant. CareDx is the leading provider of genomics-based information for transplant patients.\n\nWe have initiated several clinical studies to generate data on our existing and planned future testing services. From time to time,\n\nwe partner with pharma and biopharma companies to use our technology and tests, often in clinical trials, to identify or screen for\n\npatients that may be appropriate candidates for their products. We also offer high-quality products in the pre-transplant space that\n\nincrease the chance of successful transplants by facilitating a better match between a donor and a recipient of stem cells and\n\norgans. We also provide digital transplant solutions and various offerings that help transplant centers with patient management,\n\noutcomes quality and operational support.\n\nFiscal year 2025 was an important year for CareDx as we achieved the following:\n\nFinancials and Performance\n\n•Reported full year revenue of $380 million, an increase of 14% year-over-year\n\n•Reported full year testing services revenue of $275 million, an increase of 10% year-over-year, and testing services\n\nvolume of approximately 200,000, an increase of 14% year-over-year\n\n58  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\n•Reported full year patient and digital solutions revenue of $57 million and product revenue of $48 million, representing\n\nyear-over-year growth of 31% and 19%, respectively\n\n•Reported full year net loss of $21 million\n\n•Reported full year cash flow from operations of $42 million\n\n•Ended fiscal year 2025 with cash, cash equivalents and marketable securities of approximately $200 million as of\n\nDecember 31, 2025\n\n•Repurchased 5.8 million shares for $88 million during the year at an average price of $15.16 per share\n\nIn achieving the above, we have continued to execute on our business objectives, improving our products and technologies, and\n\nstrengthening our financial position.\n\nOur total stockholder return for 2025 is outlined below:\n\nKey 2025 Compensation Highlights\n\n•Achieved 91.5% Say-on-Pay support in 2025\n\n•Annual cash bonuses paid at 117%–124% of target, reflecting above-target financial and departmental performance\n\n•Shifted equity mix from 70% RSUs / 30% PRSUs in 2025 to 50% RSUs / 50% PRSUs in 2026, strengthening pay-for-\n\nperformance alignment\n\n•Eliminated stock option grants for NEOs, reducing burn rate\n\n•Adopted revised stock ownership guidelines for executive officers and directors\n\n•2025 gross burn rate below ISS industry benchmark\n\nCareDx Inc.\n\n2026 Proxy Statement  |  59\n\nExecutive Compensation\n\nIn 2025, our Compensation and Human Capital Committee continued to focus on retention, incentivizing our leadership team, and\n\nattracting new employees. The compensation decisions for the 2025 fiscal year reflect the successful retention and incentivization\n\nof the Company’s leadership without compromising the Company’s objective of maintaining and ensuring the long-term growth and\n\nsuccess of the Company and the best interests of our stockholders. Aligned with our accomplishments in 2025 and continued\n\nstrong business and company performance as outlined above, we continued to incentivize our executive officers through a\n\ncompensation program that aligns our executives with the best interests of our stockholders by placing an emphasis on pay for\n\nperformance while balancing retention needs and building share ownership among our executives. Our performance-based\n\nincentives aim to strengthen the pay-for-performance relationship and drive fulfillment of key strategic goals. We continue to\n\nmanage award design, with a goal of delivering value that is aligned with our compensation philosophy and proactively managing\n\nour share usage as well as dilution during a period of rapid growth.\n\nResults of Fiscal Year 2024 Stockholder Advisory Vote\n\nAt our 2025 annual meeting of stockholders, our stockholders approved our Say-on-Pay proposal with 91.5% of the votes in favor\n\nof the fiscal year 2024 compensation of our named executive officers. We believe that the 2024 vote approving our Say-on-Pay\n\nproposal once again conveyed our stockholders’ consistent strong support and endorsement of our existing executive\n\ncompensation program and affirmed that our overall executive compensation program is aligned with the interests of our\n\nstockholders. Our Compensation and Human Capital Committee will continue to consider feedback from our stockholders when\n\nmaking future compensation decisions, and will continue to benchmark, against peers, our governance practices and executive\n\ncompensation program.\n\nWe are committed to regular and transparent communication and engagement with our current and future stockholders and reach\n\nout to our largest stockholders at least annually.\n\nII.Compensation Philosophy\n\nWe operate within a complex business environment in a competitive industry, which requires a very strong management team. Our\n\nbusiness model requires our management team to be adept at developing competitive technologies to support multiple customers,\n\nincluding hospitals, all within multiple geographies. Many of our competitors have substantially greater capital resources and larger\n\nsales forces than we do. In addition, the diagnostics industry is characterized by rapid product development and technological\n\nadvances, which require our management team to be adept at managing these key areas of the business.\n\nAs a result, the Compensation and Human Capital Committee believes that it is critical to attract, develop and retain a highly-\n\nqualified management team with the experience, knowledge, expertise and vision capable of not only operating, but also excelling,\n\nin this complex and competitive business environment, including competing against larger competitors and developing and\n\ncommercializing new products, new and improved technologies and new applications for our existing technologies.\n\nOur executive compensation program is intended to help us achieve and foster a goal-oriented, highly-motivated management\n\nteam with a clear understanding of our business objectives and shared corporate values. To this end, the Compensation and\n\nHuman Capital Committee believes that our executive compensation program should provide compensation that:\n\n•attracts and retains the best executive talent;\n\n•appropriately aligns our business objectives and stockholder interests;\n\n•maintains a reasonable balance across types and purposes of compensation;\n\n•motivates our executive officers to achieve our annual and long-term strategic goals and rewards performance based on\n\nthe attainment of such goals;\n\n•appropriately considers risk and reward in the context of our business environment and long-range business plans;\n\n•recognizes individual value and contributions to our success;\n\n•considers, but does not exclusively rely upon, competitive market data; and\n\n•assists with the design and structure of our overall equity compensation practices.\n\n60  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nWe seek to achieve these objectives in a way that is consistent with the long-term interests of our company and those of our\n\nstakeholders, including our stockholders and employees. We structure the annual compensation of our executive officers, including\n\nour NEOs, using three principal elements: base salary, annual cash incentives and long-term compensation opportunities in the\n\nform of equity awards.\n\nOur Compensation and Human Capital Committee believes that our compensation program should align executive interests with\n\nthe drivers of growth and stockholder returns, and support achievement of our primary business goals. The expertise, leadership\n\nand contributions of our executives are critical to our ability to create sustained long-term stockholder value. Consequently, our\n\nCompensation and Human Capital Committee believes the substantial majority of NEO compensation should be at-risk, variable\n\npay to facilitate the successful execution of our business strategy.\n\nIII.Compensation Determination Process\n\nRole of Compensation and Human Capital Committee\n\nThe Compensation and Human Capital Committee discharges the responsibilities of our Board of Directors relating to the\n\ncompensation of our executive officers. The Compensation and Human Capital Committee consists of directors who are\n\n“independent” directors as required by the Nasdaq Rules and Exchange Act Rule 10C-1, and “non-employee directors” for\n\npurposes of Exchange Act Rule 16b-3.\n\nThe Compensation and Human Capital Committee has responsibility for (i) overseeing our compensation and benefits policies\n\ngenerally and (ii) overseeing, evaluating and approving the compensation plans, policies and programs applicable to our Chief\n\nExecutive Officer, as well as our other executive officers, including our other NEOs. In carrying out its responsibilities, the\n\nCompensation and Human Capital Committee evaluates our compensation policies and practices with a focus on the degree to\n\nwhich these policies and practices reflect our executive compensation philosophy, develops recommendations, makes decisions\n\nthat it believes advances our philosophy and reviews the performance of our executive officers when making decisions with respect\n\nto their compensation.\n\nThe Compensation and Human Capital Committee conducts reviews of our compensation policies and programs on at least an\n\nannual basis to ensure that they enhance stockholder value, align pay and performance, and attract and retain top executive talent.\n\nThis includes a review of internal pay equity among the executive team. With the assistance of our independent compensation\n\nconsultant, the Compensation and Human Capital Committee seeks to maintain appropriate base salary, annual bonus and equity\n\ncompensation plans for our executives.\n\nRole of Chief Executive Officer & Management\n\nFor fiscal year 2025, the Compensation and Human Capital Committee considered executive officer compensation including our\n\ncurrent Chief Executive Officer Mr. Hanna, against the Company’s peer group. Our Compensation and Human Capital Committee\n\nreviews recommendations from Mr. Hanna and other data and makes decisions as to total compensation for each executive officer\n\nother than Mr. Hanna, as well as each individual compensation component. The Compensation and Human Capital Committee\n\nmakes the final decisions regarding executive compensation for our Chief Executive Officer. The Compensation and Human\n\nCapital Committee does not delegate any of its functions to others in deciding executive compensation.\n\nUse of Independent Compensation Consultant\n\nOur Compensation and Human Capital Committee is authorized to retain the services of one or more executive compensation\n\nadvisors, as it sees fit, in connection with the establishment of our compensation programs and related policies. Since September\n\n2023, the Compensation and Human Capital Committee has retained Alpine Rewards (“Alpine”) as its independent outside\n\ncompensation consultant to assist with setting executive compensation and the Company’s broader employee equity strategy. The\n\nCompensation and Human Capital Committee has sole authority to retain or replace such independent compensation consultants.\n\nThe Compensation and Human Capital Committee annually evaluates the compensation consultant’s independence and\n\nperformance under the Nasdaq Rules. The Compensation and Human Capital Committee believes that working with an\n\nindependent compensation consultant furthers our objectives to recruit and retain qualified executives, align executive interests\n\nwith those of stockholders and ensure that executive compensation packages will appropriately motivate and reward ongoing\n\nachievement of business goals.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  61\n\nExecutive Compensation\n\nIn 2025, Alpine provided the following services to the Compensation and Human Capital Committee:\n\n•Provided consulting services and key insights on executive compensation based on relevant market data throughout the\n\nprocess of recruiting and hiring our newly-hired NEOs;\n\n•Reviewed and recommended adjustments to our peer group;\n\n•Conducted an extensive executive compensation assessment; and\n\n•Provided other key insights on executive and outside director compensation based on relevant market data.\n\nAlpine did not provide any services to us other than the consulting services to the Compensation and Human Capital Committee.\n\nThe Compensation and Human Capital Committee conducted a review of its relationship with Alpine in 2025 and determined that\n\nAlpine’s work for the Compensation and Human Capital Committee did not raise any conflicts of interest. The Compensation and\n\nHuman Capital Committee determined that Alpine’s work has conformed to the independence factors and guidance provided by the\n\nSEC and The Nasdaq Stock Market LLC.\n\nUse of a Peer Group\n\nWith the assistance and recommendations of Alpine, the Compensation and Human Capital Committee has developed a peer\n\ngroup of companies for use in making compensation decisions as a reference group to provide a broad perspective on competitive\n\npay levels and practices with respect to compensation paid in fiscal year 2025.\n\nWhen selecting appropriate peers, the general criteria used were:\n\n•Industry – US-based companies focused on the discovery, development, and commercialization of clinical diagnostic\n\nsolutions, including genetic testing and sequencing\n\n•Revenues – between $150 million and $850 million\n\n•Market Capitalization – between $400 million and $4 billion\n\nFor compensation decisions for fiscal year 2025, the following public companies were selected as our peer group:\n\n2025 Peer Group\n\n10x Genomics, Inc.*\n\nAdaptive Biotechnologies Corp.\n\nAlphatec Spine, Inc.*\n\nAtriCure, Inc.*\n\nCastle Biosciences, Inc.\n\nCerus Corporation\n\nCytek Biosciences, Inc.*\n\nFulgent Genetics, Inc.\n\nGuardant Health, Inc.\n\niRhythm Technologies, Inc.*\n\nMaravai Lifesciences, Inc.*\n\nNatera, Inc.\n\nMyriad Genetics, Inc.\n\nNeoGenomics, Inc.\n\nPacific Biosciences of California,\n\nInc.\n\nQuanterix Corporation\n\nStandard Bio Tools, Inc.*\n\nTransMedics Group\n\nTwist Bioscience Corporation\n\nVeracyte, Inc.\n\n*New for 2025. Invitae, NanoString Technologies, OraSure Technologies and Renalytix were removed for 2025 from the 2024 peer group of\n\ncompanies.\n\n62  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nThe Compensation and Human Capital Committee does not engage in formal benchmarking against other companies’\n\ncompensation programs or practices to establish our compensation levels or make specific compensation decisions with respect to\n\nour executive officers, including our NEOs. Instead, in making its determinations, the Compensation and Human Capital Committee\n\nreviews information summarizing the compensation paid at a representative group of peer companies, to the extent that the\n\nexecutive positions at these companies are considered comparable to our positions and informative of the competitive\n\nenvironment, as well as more broad-based compensation surveys to gain a general understanding of market compensation levels.\n\nAssessment of Risk\n\nThe Compensation and Human Capital Committee also evaluates and considers the potential risks in our business when designing\n\nand administering our executive compensation program, and discusses these risks with our management to determine whether our\n\ncompensation philosophy and practices encourage excessive risk-taking. We believe our balanced approach to performance\n\nmeasurement and pay delivery works to avoid misaligned incentives for individuals to undertake excessive or inappropriate risk,\n\nand our Compensation and Human Capital Committee has determined that the risks arising from our compensation policies and\n\npractices are not reasonably likely to have a material adverse effect on our company.\n\nIV.Pay Components\n\nOur executive compensation program consists of three primary elements: Base Salaries, Short-Term Incentives, and Long-Term\n\nIncentives:\n\nElement\n\nPerformance\n\nPeriod\n\nObjective\n\nPerformance Measured / Rewarded\n\nBase Salary\n\nAnnual\n\nAttracts, retains, and rewards top\n\ntalent and reflects an NEO’s\n\nresponsibilities, performance, and\n\nrelevant market data\n\n•Provides NEOs with fixed compensation that acts as a vehicle to\n\nmotivate and retain executives\n\n•Rewards executives for key performance and contributions\n\nShort-Term\n\nIncentives\n\nAnnual\n\nRewards achievement of our annual\n\ngoals subject to meeting individual\n\nperformance expectations\n\n•Rewards NEOs for their individual performance and our\n\nperformance over the fiscal year\n\n•Cash bonuses, which are based on our financial and strategic\n\ngoals. The three metrics used for 2025 cash bonuses were:\n\n•Revenues - 40% weighting\n\n•Adjusted EBITDA - 40% weighting\n\n•Cash - 20% weighting\n\nLong-Term\n\nIncentives\n\nLong-Term\n\nAligns the interests of management\n\nand stockholders and serves as an\n\nimportant retention vehicle; supports\n\nthe achievement of strong stock price\n\ngrowth\n\n•Annual equity awards comprising of both RSUs and PRUSs. The\n\nweighting of the awards were 70% RSUs and 30% PRSUs for our\n\nNEOs in 2025. In 2026, this weighting increased to 50% PRSUs\n\nand 50% RSUs for our NEOs.\n\n•PRSUs granted to our NEOs in 2025 and 2026 have a two-year\n\nperformance period with one year of additional time vesting\n\nthereafter, and are based on revenue goals.\n\n•RSUs granted to our NEOs in 2025 and 2026 vest over three years.\n\n•In 2025, we did not grant stock options to our NEOs. This is aligned\n\nwith our strategy of reducing burn rate.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  63\n\nExecutive Compensation\n\nWe are committed to a strong performance orientation in our compensation program and effective corporate governance practices\n\nfor a company at our development stage and industry. As such we routinely review our policies and program design. Some of our\n\nbest practices in governance that we observe include:\n\nWhat We Do\n\nWhat We Don’t Do\n\nü\n\nPay-for-performance based on both financial and non-financial\n\nmetrics\n\nX\n\nProvide excessive severance payments\n\nü\n\nMaintain an Insider Trading Policy\n\nX\n\nUse excise tax gross-ups\n\nü\n\nAlign compensation with stockholder interests\n\nX\n\nUtilize guaranteed bonuses\n\nü\n\nMaintain “Double Trigger” benefits in the case of a change in\n\ncontrol\n\nX\n\nProvide single trigger change-in-control severance payments\n\nü\n\nAnnual compensation review\n\nX\n\nProvide excessive perquisites\n\nü\n\nRecommending annual stockholder advisory vote on NEO\n\ncompensation\n\nX\n\nProvide supplemental executive retirement plans\n\nü\n\nProvide only very limited perquisites to executive\n\nX\n\nProvide special welfare benefits to our executive officers\n\nü\n\nDirector and executive officer stock ownership guidelines\n\nX\n\nPermit the payment of dividends on RSUs or PRSUs prior to\n\nvesting\n\nü\n\nBalanced pay mix of fixed and variable pay\n\nX\n\nPermit cash buyouts of options without stockholder consent\n\nü\n\nMulti-year vesting requirements for restricted stock unit awards\n\nX\n\nPermit option repricings without stockholder consent\n\nü\n\nRobust anti-hedging and pledging policies\n\nü\n\nRetain an independent compensation consultant\n\nü\n\nOnly independent directors serve on our board committees\n\nü\n\nMaintain compensation recovery (“clawback”) policy\n\nü\n\nProvide that equity awards granted under our equity incentive\n\nplans are subject to minimum vesting of at least one year\n\n64  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nTarget Pay Mix\n\nOur target pay mix reflects our philosophy of aligning executive compensation with shareholder interests. A significant portion of\n\nour executives’ compensation is variable, with a majority delivered through long-term incentives. In 2026, we further strengthened\n\nthe alignment between pay and performance by increasing the proportion of Performance Restricted Stock Unit awards.\n\nVariable / At Risk\n\nPay = 91%\n\nVariable / At Risk\n\nPay = 91%\n\nn Fixed Pay\n\nn Variable Pay\n\nn Fixed Pay\n\nn Variable Pay\n\nVariable / At Risk\n\nPay = 80%\n\nVariable / At Risk\n\nPay = 81%\n\nn Fixed Pay\n\nn Variable Pay\n\nn Fixed Pay\n\nn Variable Pay\n\nCareDx Inc.\n\n2026 Proxy Statement  |  65\n\nExecutive Compensation\n\nBase Salary\n\nBase salary is the only fixed component of our executive officers’ total cash compensation and provides competitive pay to attract\n\nand retain our executives. Generally, we use base salary to provide each executive officer with a specified level of cash\n\ncompensation during the year with the expectation that they will perform their responsibilities to the best of their ability and in our\n\nbest interests. Annual salary decisions are made in recognition of competitive data as well as the skills and experience that each\n\nindividual brings to CareDx and the performance contributions each makes.\n\nBase salary changes in 2025 varied by executive due either to merit increases and/or market adjustments. The increases in 2025\n\nwere based on a review of market data from Alpine for similar roles and positions within our compensation peer group and an\n\nassessment of the following factors:\n\n•Peer group data and external market information;\n\n•Individual performance;\n\n•The level of responsibility assumed and the nature and complexity of each NEO’s role;\n\n•The leadership demonstrated to create and promote a day-to-day working environment; and\n\n•The desire to attract, engage and retain NEOs capable of achieving our strategic objectives and the marketability and\n\ncriticality of retention of NEOs.\n\nThe 2025 salary changes were effective April 1, 2025, other than as set forth in footnotes below. The footnotes below describe the\n\nchanges to base salary during fiscal year 2025. Actual amounts of salary paid to our NEOs are described in the “Summary\n\nCompensation Table” below.\n\nNamed Executive Officer*\n\n2025\n\n2024\n\nIncrease\n\nJohn W. Hanna\n\n$700,000\n\n$675,000\n\n4%\n\nKeith Kennedy\n\n$592,250\n\n$575,000\n\n3%\n\nJessica Meng\n\n$489,250\n\n$475,000\n\n3%\n\nJeffrey Novack\n\n$370,000\n\n$340,000\n\n9%\n\nAbhishek Jain(1)\n\n$444,548\n\n$431,600\n\n3%\n\nNathan Smith(2)\n\n$400,000\n\nN/A\n\nN/A\n\n(1)Effective April 1, 2025, Mr. Jain’s annual base salary was increased from $431,600 to $444,548. Mr. Jain’s employment with us was\n\nterminated effective August 6, 2025.\n\n(2)Mr Smith’s employment with us as our Chief Financial Officer commenced effective August 7, 2025. Mr. Smith’s employment with us\n\nterminated effective February 25, 2026. Mr. Kennedy assumed the additional role of Chief Financial Officer effective February 26, 2026.\n\nAnnual Incentives\n\nOur 2025 cash bonus program, adopted pursuant to our Executive Compensation Plan, is designed to provide a financial incentive\n\nto reward key executives for the achievement of annual corporate performance objectives. Under the cash bonus program, each\n\nNEO has an award opportunity expressed as a percentage of their base salary. Payments under the cash bonus program are\n\nbased on pre-established company metrics and departmental goals. Actual performance against these metrics determines the\n\nCompany factor for purposes of calculating payments under the cash bonus program (the “Company Factor”) and determines the\n\nlevel of vesting of the 2025 and 2026 PRSUs. Threshold levels of performance must be met for bonuses to be earned and vesting\n\nto occur. For purposes of our cash bonus program, in 2025, the Company Factor could range from zero to 200%.\n\nFor fiscal year 2025, the cash bonus program was weighted 70% on a Company Factor and 30% on a Departmental Factor.\n\n66  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nFor the Company Factor, the Compensation and Human Capital Committee selected Revenue as the primary financial\n\nperformance measure to be used to determine annual cash bonuses as it is the best indicator of our growth and selected Adjusted\n\nEBITDA and Cash as the second and third measure to determine annual cash bonuses to provide an incentive to manage our cash\n\nexpenditures as we navigated toward profitability. The Company Factor had three metrics: Revenue (weighted at 40%), Adjusted\n\nEBITDA (weighted at 40%), and Cash (weighted at 20%). Adjusted EBITDA is defined as non-GAAP net income (loss) before net\n\ninterest income, income tax expense, depreciation and other (income) expense and excludes the impact of a $6.5 million special\n\ncash payment made to non-executives in lieu of equity grants during the fourth quarter of fiscal year 2025. Cash is defined as cash\n\nand cash equivalents including marketable securities, excluding $88 million of cash used in share repurchases carried out during\n\nfiscal year 2025. For each of these Company metrics, in the first quarter of fiscal year 2025, the Compensation and Human Capital\n\nCommittee established performance thresholds at the following levels: less than 50% (threshold) achievement; 100% (target)\n\nachievement; and 200% or greater achievement (maximum).\n\nThe Departmental Factor was based on departmental goals which were designed to align with the Company’s business priorities\n\nand strategic objectives, focusing on execution against key operational, product, technology, and infrastructure initiatives. Each of\n\nthe Company's 9 departments developed individualized goals. For example, the Commercial department's goals included\n\nlaunching new services and products and expanding our in-network access for patients and the Operations’ department's goals\n\nincluded strengthening tools and processes. The Departmental metrics had the same threshold achievement of 50% and target\n\nachievement of 100% as the Company metrics but the maximum achievement was 125%.\n\nBonus payouts are determined as a percentage of each NEO’s target bonus opportunity, such that threshold performance results in\n\na payment of 50 % of target bonus opportunity; target performance results in 100% of target bonus opportunity and maximum\n\nperformance results in payment of up to 177.5%, with linear interpolation used for achievement between threshold and maximum.\n\nCompany Financial Metrics (2025)\n\nFunding Amount\n\nWeighting\n\n50%\n\n100%\n\n200%\n\nRevenue\n\n40%\n\n$365M\n\n$385M\n\n$400M\n\nAdjusted EBITDA\n\n40%\n\n$28M\n\n$35M\n\n$50M\n\nCash\n\n20%\n\n$261M\n\n$270M\n\n$285M\n\nTherefore, through our cash bonus program, NEOs may earn a significantly higher payout if target performance is exceeded. NEOs\n\nalso bear the risk of a lower payout if target performance is not achieved, and the risk of no payout for below-threshold results.\n\nThe Compensation and Human Capital Committee set the Company metrics, for purposes of the bonuses earned for fiscal year\n\n2025, at 124% based on our 2025 achievements in Revenue, Adjusted EBITDA, and Cash.\n\nCompany Financial Metric Achievement (2025)\n\nWeighting\n\nActual\n\nAchievement (% of\n\nTarget Payout)\n\nRevenue\n\n40%\n\n$380M\n\n88%\n\nAdjusted EBITDA\n\n40%\n\n$32M\n\n123%\n\nCash\n\n20%\n\n$200M\n\n200%\n\nTotal Financial Goals\n\n124%\n\nCareDx Inc.\n\n2026 Proxy Statement  |  67\n\nExecutive Compensation\n\nThe Departmental goal achievement was between 100% and 125%, with the achievement by NEO shown in the table below. The\n\nCompensation and Human Capital Committee elected to award bonuses between 117% and 124% of target to NEOs when\n\nfactoring in this performance.\n\nTo arrive at each NEO’s earned bonus for fiscal year 2025, the Compensation and Human Capital Committee multiplied the NEO’s\n\neligible earnings, by the NEO’s annual target bonus percentage, and then by the Company and Departmental Factor (with 70%\n\nweighted to company and 30% to department).\n\nThe annual incentive cash bonuses paid to our NEOs for 2025 were:\n\nNamed Executive Officer\n\nEligible Earnings for\n\nPurposes of Bonus*\n\n($)\n\n2025 Annual\n\nTarget Bonus\n\n(% of base)\n\n(%)\n\nCompany Factor\n\n(70% Weighting)\n\n(%)\n\nDepartmental\n\nFactor (30%\n\nWeighting)\n\n(%)\n\n2025 Earned\n\nBonus\n\n($)\n\nJohn W. Hanna\n\n694,231\n\n100\n\n124\n\n120\n\n852,515\n\nKeith Kennedy\n\n588,269\n\n60\n\n124\n\n117\n\n430,260\n\nJessica Meng\n\n485,962\n\n60\n\n124\n\n115\n\n353,683\n\nJeffrey Novack\n\n363,077\n\n50\n\n124\n\n108\n\n216,394\n\nAbhishek Jain(1)\n\n441,675\n\n60\n\n124\n\n100\n\n309,526\n\nNathan Smith\n\n156,923\n\n50\n\n124\n\n100\n\n91,643\n\n*Eligible earnings are the actual amounts of salaries that the NEOs received during 2025.\n\n(1)Pursuant to our separation and release agreement with Mr. Jain, dated August 6, 2025, we agreed to pay Mr. Jain his annual bonus for 2025\n\nat the company achievement, payable in accordance with our standard bonus schedule in February 2026. This amount is included in the “Non-\n\nEquity Incentive Plan Compensation” column of the “Summary Compensation Table” below.\n\nLong-Term Incentives\n\nOur focus on long-term value creation results in our executive compensation program having a heavy weighting toward equity\n\ncompensation, which historically included stock options, RSUs and PRSUs and, with respect to fiscal year 2025, includes RSUs\n\nand PRSUs. We rely heavily on equity compensation that vests over a multi-year period to ensure that a significant portion of a\n\nnamed executive officer’s compensation opportunity is related to factors that directly or indirectly influence stockholder value. Our\n\nCompensation and Human Capital Committee believes this serves as a reward for appreciation in our stock price and long-term\n\nvalue creation, and enables us to achieve our retention objectives. Further, equity participation establishes a sense of ownership\n\nand aligns executives’ interests with those of our stockholders.\n\nIn 2025, we provided Mr. Smith initial long-term incentives via a mix of PRSUs and RSUs as a material inducement to agreeing to\n\nenter into employment with the Company. In addition, as a part of the normal annual grant cycle, we provided each of Messrs.\n\nHanna, Jain, Kennedy, Novack, and Ms. Meng long-term incentives in the form of PRSUs and RSUs. Approximately 30% of the\n\nvalue of the equity awards granted to our NEOs during 2025 was in the form of long-term PRSUs (two-year performance period\n\nand overall three-year vesting period) and 70% of the value was in the form of long-term RSUs (three-year vesting period). The\n\nCompensation and Human Capital Committee believes this structure is appropriate for us given our current competitive recruiting\n\nlandscape and focus on retention, our current company size and our current growth trajectory.\n\nIn 2026, we shifted the PRSU/RSU mix to a 50%50% mix to strengthen the alignment of executive compensation to performance.\n\nAs noted above, in “Director Compensation” we also maintain a deferral election program in which our NEOs are eligible to\n\nparticipate. As of December 31, 2025, none of our NEOs held any deferred stock awards.\n\n68  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\n2025 Annual Equity Grants\n\nA summary of (i) our regular, annual cycle grants for fiscal year 2025 for all our NEOs other than Mr. Smith, which were granted on\n\nMarch 23, 2025, and (ii) the new hire grant for Mr. Smith, which was granted in August 2025, is set forth in the table below.\n\nRSUs\n\nPRSUs\n\nNamed Executive Officer(1)\n\n(#)\n\n($)(2)\n\nTarget\n\n(#)\n\nMaximum\n\n(#)\n\nTarget\n\n($)(2)\n\nMaximum\n\n($)(2)\n\nJohn Hanna\n\n200,706\n\n3,935,845\n\n86,017\n\n172,034\n\n1,686,793\n\n3,373,587\n\nKeith Kennedy\n\n77,195\n\n1,513,794\n\n33,083\n\n66,166\n\n648,758\n\n1,297,515\n\nJessica Meng\n\n61,756\n\n1,211,035\n\n26,467\n\n52,934\n\n519,018\n\n1,038,036\n\nJeffrey Novack\n\n23,158\n\n454,128\n\n9,925\n\n19,850\n\n194,629\n\n389,259\n\nAbhishek Jain\n\n55,580\n\n1,089,924\n\n23,820\n\n47,640\n\n467,110\n\n934,220\n\nNathan Smith\n\n42,000\n\n506,940\n\n18,000\n\n36,000\n\n217,260\n\n434,520\n\n(1)This table reflects our regular, annual cycle of grants for fiscal year 2025, which grants were awarded in March 2025 for all NEOs with the\n\nexception of Mr. Smith. Mr. Smith’s employment with the Company commenced in August 2025 and his awards represent his new hire\n\ninducement grants that were awarded in August 2025.\n\n(2)The awards were granted on March 23, 2025. Amounts set forth in this column generally represent the aggregate grant date fair value of the\n\nawards granted to each listed NEO, computed in accordance with FASB ASC Topic 718. These amounts do not represent the actual\n\namounts that may be paid to or realized by the NEOs.\n\n2025 PRSUs\n\nIn early 2025, our Compensation and Human Capital Committee granted PRSUs to our executive officers that include 2025 and\n\n2026 as its performance period. The PRSUs are designed to further reward key executives for the achievement of corporate\n\nperformance objectives. The 2025 PRSUs use Revenue metrics for funding and performance purposes. In determining the metrics\n\nto be used for the PRSUs, the Compensation and Human Capital Committee chose revenue targets tied to our Corporate Long\n\nRange Plan and determined that this was the most important financial measure for our company to focus on for the 2025-2026\n\nperformance period as the best indicator of our growth. For purposes of the PRSUs, the Compensation and Human Capital\n\nCommittee established threshold performance at 50% achievement; target performance at 100% achievement; and maximum\n\nperformance at 200% achievement. The PRSUs are long-term incentives and have a two-year performance period with one year of\n\nadditional vesting. The Company believes that this combination of performance and time-based vesting is appropriate given a new\n\nleadership team and the volatility of the industry.\n\nIn February 2026, the Compensation and Human Capital Committee determined that the performance criteria for the PRSUs were\n\nachieved at 87.5% of target performance levels, resulting in 43.75% of the PRSUs vesting at the end of the first one-year\n\nperformance period on February 1, 2026. The remaining 50% will vest half on February 1, 2027 and half on February 1, 2028\n\nsubject to 2026 revenue performance.\n\nPerformance Year\n\nThreshold (50%)\n\nTarget (100%)\n\nMaximum (200%)\n\nActual\n\nAchievement\n\n% Target PRSUs\n\nAchieved\n\n2025\n\n$365 million\n\n$385 million\n\n$400 million\n\n$379.8 million or\n\n87.5%\n\n44%\n\n2025 RSUs\n\nThe RSUs granted to Messrs. Hanna, Kennedy, Jain, and Novack and Ms. Meng in 2025 vest over three years with one-third\n\nvesting one year from the grant date and the remainder in equal quarterly installments, subject to the executive’s continuing service\n\non each vesting date.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  69\n\nExecutive Compensation\n\nInducement RSUs\n\nIn connection with his appointment as an executive officer, and as provided in his offer letter, Mr. Smith was granted, an award of\n\nRSUs under the 2025 Inducement Equity Incentive Plan that vest over four years in equal annual installments beginning on the\n\none-year anniversary of the date of grant, subject to his continued provision of services to the Company on each vesting date,\n\nexcept on certain qualifying terminations of employment as otherwise provided in his Change of Control and Severance Agreement\n\nas further detailed in “Potential Payments and Benefits upon Termination or Change of Control for Officers”. The size of the\n\ninducement award was determined in consultation with the Company's compensation advisor, Alpine Rewards, considering peer\n\nCFO compensation and the need to build a competitive total compensation package.\n\nPolicies and Practices Related to the Grant of Certain Equity Awards\n\nFollowing the end of each fiscal year, typically in February, the Compensation and Human Capital Committee reviews the\n\nCompany’s results and our NEOs’ performance, and, based on those reviews, grants equity awards to our named executive\n\nofficers. In certain circumstances, including the hiring of an officer, the Compensation and Human Capital Committee may approve\n\ngrants to be effective at other times. The Compensation and Human Capital Committee does not take material nonpublic\n\ninformation into account when determining the timing and terms of equity awards granted to non-employee directors or named\n\nexecutive officers. The Company does not time the disclosure of material nonpublic information for the purpose of affecting the\n\nvalue of executive compensation.\n\n2026 Annual Equity Grants\n\nIn March 2026, the Compensation and Human Capital Committee approved annual equity grants to our executives, including each\n\nof our NEOs, which grants were comprised of 50% RSUs and 50% PRSUs. RSUs vest over a three-year period subject to\n\ncontinued employment through each applicable vesting date, and PRSUs are eligible to become earned and vested over a two-\n\nyear performance period (including the 2026 and 2027 calendar years as the performance years) with one year of additional\n\nvesting of earned PRSUs after the conclusion of such performance period. The PRSUs use revenue as the metric for funding and\n\nvesting, which the Compensation and Human Capital Committee determined to be the most important financial measure for the\n\nCompany to focus on for the 2026-2027 performance period. For purposes of the PRSUs, the Compensation and Human Capital\n\nCommittee established performance thresholds at the following levels: 50% or greater achievement; 100% or greater achievement;\n\nand 200% or greater achievement with linear interpolation between performance achievement level.\n\nOption Grant Timing Disclosure\n\nIn accordance with Item 402(x)(2) of Regulation S-K, we note that we did not grant any stock option awards to our NEOs during our\n\nmost recently completed fiscal year.\n\nEmployment- and Service-related Agreements with our NEOs\n\nThe Company is party to “at will” agreements and Change of Control and Severance Agreements with each of our NEOs. In\n\naddition, in March 2025 we entered into an Amended and Restated Change in Control and Severance Agreement with Mr. Jain\n\nand, in connection with Mr. Jain’s transition from the Company in August 2025, we entered into a Consulting Agreement with him.\n\nFor a summary of the material terms of each NEO’s employment-related agreements, see “Narrative Disclosure to Summary\n\nCompensation Table and Grant of Plan-Based Awards Table” below.\n\nWelfare and Health Benefits\n\nOur NEOs participate in our employee benefit plans on the same terms as all of our other eligible employees.\n\nWe maintain a tax-qualified Code Section 401(k) defined contribution plan in which all of our employees, including our executive\n\nofficers, who satisfy certain eligibility requirements, including requirements relating to age and length of service, are entitled to\n\nparticipate. Employees may contribute their own funds on a pre-tax basis.\n\nThe plan permits us to make matching contributions and we have historically provided employer contributions that match $2 for\n\nevery $1 of eligible employee contributions (“Employer Matching Contributions”), generally limited to a maximum matching\n\ncontribution of $6,000 per year that can be taken into account for this purpose under federal law. On January 1, 2018, we began to\n\nmake contributions to the employee plan.\n\n70  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nIn addition, we provide health care, dental, vision and life insurance, an employee assistance plan and both short-term and long-\n\nterm disability and accidental death and dismemberment benefits to all full-time employees. These benefits are subject to\n\napplicable laws and at benefit levels that we believe are generally consistent with the benefits of companies with which we compete\n\nfor talent.\n\nLimited Perquisites\n\nIn 2025, the Company provided certain limited perquisites to our NEOs, which included electronic allowances and gym allowances.\n\nHedging and Pledging Prohibitions\n\nOur insider trading policy prohibits our directors, officers (including our executive officers), employees and agents, as well as their\n\nimmediate family members, from engaging in short sales of our securities and from engaging in transactions in publicly-traded\n\noptions and other derivative securities with respect to our securities. This prohibition extends to any hedging or similar transactions\n\ndesigned to decrease the risks associated with holding our securities. Our insider trading policy also restricts certain individuals,\n\nincluding our directors and executive officers, from pledging our securities as collateral for loans absent pre-clearance and the\n\nsatisfaction of other conditions.\n\nAccounting and Tax Considerations\n\nThe Company accounts for equity-based compensation paid to employees under FASB ASC Topic 718, which requires the\n\nCompany to estimate and record an expense over the service period of an equity award. Thus, the Company may record an\n\nexpense in one year for awards granted in earlier years. Accounting rules also require the recording of cash compensation as an\n\nexpense at the time the obligation is accrued.\n\nSection 162(m) of the Internal Revenue Code of 1986, as amended, generally disallows public companies a tax deduction for\n\nfederal income tax purposes of compensation in excess of $1 million paid to their chief executive officer, the chief financial officer\n\nand three other most highly-compensated executive officers in any taxable year. In making compensation decisions, the\n\nCompensation and Human Capital Committee considered the potential effects of Section 162(m) on the compensation paid our\n\nexecutive officers who are subject to the deduction limit (the “covered executives”).\n\nTo maintain flexibility in compensating the NEOs in a manner designed to promote varying corporate goals, the Compensation and\n\nHuman Capital Committee has not adopted a policy that all compensation payable to the covered executives must be deductible\n\nfor federal income tax purposes. Accordingly, while the Compensation and Human Capital Committee considers the deductibility of\n\nawards as one factor in determining executive compensation, the Compensation and Human Capital Committee also looks at other\n\nfactors in making its decisions and retains the flexibility to award compensation that it determines to be consistent with the goals of\n\nour executive compensation program even if the awards are not deductible by us for tax purposes.\n\nIn addition to considering the tax consequences, the Compensation and Human Capital Committee considers the accounting\n\nconsequences of its decisions, including the impact of expenses being recognized in connection with equity-based awards, in\n\ndetermining the size and form of different equity-based awards.\n\nCompensation and Human Capital Committee Report\n\nThe Compensation and Human Capital Committee has reviewed and discussed the Compensation Discussion and Analysis\n\nrequired by Item 402(b) of Regulation S-K of the SEC’s rules and regulations with management and, based on such review and\n\ndiscussions, the Compensation and Human Capital Committee recommended to the Board of Directors that the Compensation\n\nDiscussion and Analysis be included in this proxy statement.\n\nThe Compensation and Human Capital Committee:\n\nChristine Cournoyer (Chairwoman)\n\nGeorge W. Bickerstaff, III\n\nCareDx Inc.\n\n2026 Proxy Statement  |  71\n\nExecutive Compensation\n\nSummary Compensation Table\n\nThe following table provides information regarding the compensation awarded to, or earned by, our NEOs during fiscal years 2023,\n\n2024 and 2025.\n\nName and\n\nPrincipal Position\n\nYear\n\nSalary\n\n($)\n\nBonus\n\n($)\n\nStock\n\nAwards\n\n($)(1)\n\nOption\n\nAwards\n\n($)(2)\n\nNon-Equity\n\nIncentive Plan\n\nCompensation\n\n($)(3)\n\nAll Other\n\nCompensation\n\n($)\n\nTotal\n\n($)\n\nJohn W. Hanna\n\nPresident and Chief\n\nExecutive Officer(4)\n\n2025\n\n693,269\n\n—\n\n5,622,638\n\n—\n\n852,515\n\n11,277\n\n(5)\n\n7,179,699\n\n2024\n\n454,327\n\n—\n\n3,999,993\n\n4,001,031\n\n960,577\n\n8,401\n\n9,424,329\n\nKeith Kennedy\n\nChief Operating\n\nOfficer and Chief\n\nFinancial\n\nOfficer(4)(10)\n\n2025\n\n587,606\n\n—\n\n2,162,552\n\n—\n\n430,260\n\n38,813\n\n(6)\n\n3,219,231\n\n2024\n\n148,173\n\n—\n\n2,063,072\n\n2,063,346\n\n204,346\n\n33,278\n\n4,512,215\n\nJessica Meng\n\nChief Commercial\n\nOfficer(4)\n\n2025\n\n485,414\n\n—\n\n1,730,053\n\n—\n\n353,683\n\n10,230\n\n(7)\n\n2,579,380\n\n2024\n\n122,404\n\n—\n\n1,547,312\n\n1,547,504\n\n168,808\n\n6,500\n\n3,392,528\n\nJeffrey Novack\n\nGeneral Counsel\n\nand Secretary(4)\n\n2025\n\n361,923\n\n—\n\n648,758\n\n—\n\n216,394\n\n12,477\n\n(8)\n\n1,239,552\n\n2024\n\n326,923\n\n75,000\n\n592,545\n\n—\n\n272,000\n\n10,376\n\n1,276,844\n\nAbhishek Jain\n\nFormer Chief\n\nFinancial Officer(9)\n\n2025\n\n282,100\n\n—\n\n1,557,034\n\n—\n\n309,526\n\n489,274\n\n(10)\n\n2,637,934\n\n2024\n\n411,169\n\n300,000\n\n1,549,738\n\n—\n\n493,403\n\n8,400\n\n2,762,710\n\n2023\n\n405,000\n\n100,000\n\n1,924,614\n\n481,973\n\n174,300\n\n8,820\n\n3,094,707\n\nNathan Smith\n\nFormer Chief\n\nFinancial\n\nOfficer(4)(10)\n\n2025\n\n141,539\n\n—\n\n724,200\n\n—\n\n91,643\n\n10,577\n\n(11)\n\n967,959\n\n(1)The amounts in this column represent the fair value of the award computed as of the grant date of each stock award in accordance with FASB\n\nASC Topic 718. Our assumptions with respect to the calculation of these values are set forth in Note 2 of the consolidated financial statements\n\nincluded in our Annual Report on Form 10-K for the year ended December 31, 2025 that was filed with the SEC on February 25, 2026. The\n\nvalue of each PRSU was determined based on the probable outcome of the performance condition on the grant date, which was target\n\nperformance. The grant date fair value of the 2025 PRSUs assuming maximum performance is $3,373,587, $1,297,515, $1,038,036,\n\n$389,259, $934,220, and $434,520 for each of John Hanna, Keith Kennedy, Jessica Meng, Jeffrey Novack, Abhishek Jain and Nathan Smith,\n\nrespectively.\n\n(2)No options were granted in 2025.\n\n(3)Represents amounts paid pursuant to our annual cash bonus programs for their performance in 2025 as compared against the performance\n\ngoals set in respect of the 2025 performance period. The amount reported in this column for Messrs. Smith is prorated for the portion of the\n\nyear they provided services to the Company.\n\n(4)In accordance with SEC guidance, compensation information for Messrs. Hanna, Kennedy and Novack, Smith and Ms. Meng, for fiscal years\n\n2023 have not been included in this table because each such NEO was not a named executive officer for fiscal years 2023. Similarly,\n\ncompensation information for Messrs. Smith for fiscal year 2024 has not been included in this table because such NEO was not a named\n\nexecutive officer for fiscal year 2024.\n\n(5)All other compensation for Mr. Hanna for the year ended December 31, 2025 includes: (i) $6,000 in employer matching contributions under our\n\n401(k) plan, (ii) $2,400 in payments in respect of a medical waiver allowance, (iii) $1,917 company paid life insurance premiums and (iv) $960\n\nin payments in respect of other allowances.\n\n72  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\n(6)All other compensation for Mr. Kennedy for the year ended December 31, 2025 includes: (i) $6,000 in employer matching contributions under\n\nour 401(k) plan, (ii) $1,857 in company paid life insurance premiums, (iii) $30,756 for company paid health insurance coverage and (iv) $200 in\n\npayments in respect of other allowances.\n\n(7)All other compensation for Ms. Meng for the year ended December 31, 2025 includes: (i) $6,000 in employer matching contributions under our\n\n401(k) plan, (ii) $1,830 in company paid life insurance premiums and (iii) $2,400 in payments in respect of a medical waiver allowance.\n\n(8)All other compensation for Mr. Novack for the year ended December 31, 2025 includes: (i) $2,300 in payments in respect of a medical waiver\n\nallowance, (ii) $6,000 in employer matching contributions under our 401(k) plan, (iii) $2,137 in company paid life insurance premiums and (iv)\n\n$2,040 in payments in respect of other allowances.\n\n(9)Mr. Jain’s employment with us terminated effective August 6, 2025, and a consulting agreement was subsequently put in place which expired\n\non April 1, 2026, which provides for continued vesting of his outstanding equity awards during the consulting term as consideration for his\n\nservices.\n\n(10)All other compensation for Mr. Jain for the year ended December 31, 2025 includes (i) $482,183 severance payment (equal to 12 months base\n\nsalary) upon the termination of his employment, (ii) $4,482 in employer matching contributions under our 401(k) plan, (iii) $1,109 in company\n\npaid life insurance premiums and (iv) $1,500 in payments in respect of a medical waiver allowance.\n\n(11)Mr. Smith’s employment with the Company commenced on August 7, 2025 and terminated effective February 25, 2026. Mr. Kennedy assumed\n\nthe additional role of Chief Financial Officer effective February 26, 2026.\n\n(12)All other compensation for Mr. Smith for the year ended December 31, 2025 includes (i) $9,716 for Company-paid health insurance coverage\n\n(ii) $668 in respect of life insurance premiums and (i) 192 in payments in respect of other allowances.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  73\n\nExecutive Compensation\n\nGrants of Plan-Based Awards\n\nThe following table presents, for each of the NEOs, information concerning each grant of an equity award made during the fiscal\n\nyear ended December 31, 2025. This information supplements the information about these awards set forth in the Summary\n\nCompensation Table and the Outstanding Equity Awards at Fiscal Year-End Table.\n\nName\n\nGrant Date\n\nNumber of\n\nshares of stock\n\nor units (#)\n\n(RSUs)\n\nNumber of shares of stock or units\n\n(#) (PRSUs)\n\nGrant Date Fair Value of Stock\n\nAwards(1)\n\n(At Target)\n\n(At Maximum)\n\n(At Target)\n\n(At Maximum)\n\nJohn W. Hanna\n\n3/23/2025\n\n200,706\n\n(2)\n\n86,017\n\n172,034\n\n5,622,638\n\n7,309,431\n\nKeith Kennedy\n\n3/23/2025\n\n77,195\n\n(2)\n\n33,083\n\n66,166\n\n2,162,552\n\n2,811,309\n\nJessica Meng\n\n3/23/2025\n\n61,756\n\n(2)\n\n26,467\n\n52,934\n\n1,730,053\n\n2,249,071\n\nJeffrey Novack\n\n3/23/2025\n\n23,158\n\n(2)\n\n9,925\n\n19,850\n\n648,758\n\n843,387\n\nAbhishek Jain\n\n3/23/2025\n\n55,580\n\n(2)\n\n23,820\n\n47,640\n\n1,557,034\n\n2,024,144\n\nNathan Smith\n\n8/7/2025\n\n42,000\n\n(3)\n\n18,000\n\n36,000\n\n724,200\n\n941,460\n\n(1)Amounts reflect the aggregate grant date fair value of the RSUs and PRSUs, determined in accordance with FASB ASC Topic 718. This\n\namount does not reflect the actual economic value realized by the NEO.\n\n(2)Vesting of the RSU is subject to the executive’s continued service on the applicable vesting date with the following schedule: one-third will vest\n\non April 1, 2026 and the remaining two-thirds will vest in equal quarterly installments thereafter on the last day of each of the subsequent eight\n\nquarters.\n\n(3)Mr. Smith’s employment with the Company commenced on August 7, 2025 and terminated effective February 25, 2026. Mr. Smith was granted\n\n42,000 RSUs and 18,000 PRSUs which vested in accordance with the terms of his Change of Control and Severance Agreement as further\n\ndescribed under “Potential Payments and Benefits upon Termination or Change of Control for Officers” below.\n\n74  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nOutstanding Equity Awards at Fiscal Year-End\n\nThe following table presents certain information concerning equity awards held by our NEOs as of December 31, 2025.\n\nOption Awards\n\nStock Awards\n\nName\n\nGrant Date\n\nNumber of\n\nSecurities\n\nUnderlying\n\nUnexercised\n\nOptions\n\n(#) Exercisable\n\nNumber of\n\nSecurities\n\nUnderlying\n\nUnexercised\n\nOptions\n\n(#) Unexercisable\n\nOption\n\nExercise\n\nPrice\n\n($)\n\nOption\n\nExpiration\n\nDate\n\nNumber of\n\nShares or\n\nUnits of\n\nStock\n\n(RSUs) That\n\nHave Not\n\nVested\n\n(#)\n\nMarket\n\nValue of\n\nShares or\n\nUnits of\n\nStock\n\n(RSUs) That\n\nHave Not\n\nVested\n\n($)*\n\nNumber of\n\nUnearned\n\nShares or\n\nUnits of\n\nStock\n\n(PRSUs)\n\nThat Have\n\nNot Vested\n\n(#)\n\nMarket\n\nValue of\n\nUnearned\n\nShares or\n\nUnits of\n\nStock\n\n(PRSUs)\n\nThat Have\n\nNot Vested\n\n($)*\n\nJohn W.\n\nHanna\n\n4/15/2024\n\n(3)(4)\n\n291,961\n\n408,745\n\n8.20\n\n4/15/2034\n\n—\n\n—\n\n—\n\n—\n\n4/15/2024\n\n(3)(5)\n\n—\n\n—\n\n—\n\n—\n\n365,853\n\n6,892,671\n\n—\n\n—\n\n3/25/2025\n\n(2)(6)\n\n—\n\n—\n\n—\n\n—\n\n200,706\n\n3,781,301\n\n—\n\n—\n\n3/25/2025\n\n(2)(8)\n\n—\n\n—\n\n—\n\n—\n\n—\n\n—\n\n86,017\n\n1,620,560\n\nKeith\n\nKennedy\n\n9/12/2024\n\n(3)(4)\n\n31,453\n\n69,198\n\n29.43\n\n9/12/2034\n\n—\n\n—\n\n—\n\n—\n\n9/12/2024\n\n(3)(5)\n\n—\n\n—\n\n—\n\n—\n\n52,575\n\n990,513\n\n—\n\n—\n\n3/25/2025\n\n(2)(6)\n\n—\n\n—\n\n—\n\n—\n\n77,195\n\n1,454,354\n\n—\n\n—\n\n3/25/2025\n\n(2)(8)\n\n—\n\n—\n\n—\n\n—\n\n—\n\n—\n\n33,083\n\n623,284\n\nJessica\n\nMeng\n\n9/12/2024\n\n(3)(4)\n\n23,590\n\n51,898\n\n29.43\n\n9/12/2034\n\n—\n\n—\n\n—\n\n—\n\n9/12/2024\n\n(3)(5)\n\n—\n\n—\n\n—\n\n—\n\n39,432\n\n742,899\n\n—\n\n—\n\n3/25/2025\n\n(2)(6)\n\n—\n\n—\n\n—\n\n—\n\n61,756\n\n1,163,483\n\n—\n\n—\n\n3/25/2025\n\n(3)(8)\n\n—\n\n—\n\n—\n\n—\n\n—\n\n—\n\n26,467\n\n498,638\n\nJeffrey\n\nNovack\n\n4/6/2022\n\n(1)(4)\n\n1,971\n\n179\n\n37.25\n\n4/6/2032\n\n—\n\n—\n\n—\n\n—\n\n8/6/2022\n\n(1)(4)\n\n2,037\n\n348\n\n26.29\n\n8/6/2032\n\n—\n\n—\n\n—\n\n—\n\n4/6/2022\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n1,787\n\n33,667\n\n—\n\n—\n\n11/7/2022\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n2,913\n\n54,881\n\n—\n\n—\n\n4/6/2023\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n3,750\n\n70,650\n\n—\n\n—\n\n7/6/2023\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n5,000\n\n94,200\n\n—\n\n—\n\n2/1/2024\n\n(1)(7)\n\n—\n\n—\n\n—\n\n—\n\n27,804\n\n523,827\n\n—\n\n—\n\n3/25/2025\n\n(2)(6)\n\n—\n\n—\n\n—\n\n—\n\n23,158\n\n436,297\n\n—\n\n—\n\n3/25/2025\n\n(2)(8)\n\n—\n\n—\n\n—\n\n—\n\n—\n\n—\n\n9,925\n\n186,987\n\nCareDx Inc.\n\n2026 Proxy Statement  |  75\n\nExecutive Compensation\n\nOption Awards\n\nStock Awards\n\nName\n\nGrant Date\n\nNumber of\n\nSecurities\n\nUnderlying\n\nUnexercised\n\nOptions\n\n(#) Exercisable\n\nNumber of\n\nSecurities\n\nUnderlying\n\nUnexercised\n\nOptions\n\n(#) Unexercisable\n\nOption\n\nExercise\n\nPrice\n\n($)\n\nOption\n\nExpiration\n\nDate\n\nNumber of\n\nShares or\n\nUnits of\n\nStock\n\n(RSUs) That\n\nHave Not\n\nVested\n\n(#)\n\nMarket\n\nValue of\n\nShares or\n\nUnits of\n\nStock\n\n(RSUs) That\n\nHave Not\n\nVested\n\n($)*\n\nNumber of\n\nUnearned\n\nShares or\n\nUnits of\n\nStock\n\n(PRSUs)\n\nThat Have\n\nNot Vested\n\n(#)\n\nMarket\n\nValue of\n\nUnearned\n\nShares or\n\nUnits of\n\nStock\n\n(PRSUs)\n\nThat Have\n\nNot Vested\n\n($)*\n\nAbhishek\n\nJain\n\n4/18/2022\n\n(1)(4)\n\n2,338\n\n212\n\n32.55\n\n4/18/2032\n\n—\n\n—\n\n—\n\n—\n\n5/6/2022\n\n(1)(4)\n\n917\n\n83\n\n25.78\n\n5/6/2032\n\n—\n\n—\n\n—\n\n—\n\n5/26/2022\n\n(1)(4)\n\n8,958\n\n1,042\n\n24.07\n\n5/26/2032\n\n—\n\n—\n\n—\n\n—\n\n9/7/2022\n\n(1)(4)\n\n—\n\n12,604\n\n18.47\n\n9/7/2032\n\n—\n\n—\n\n—\n\n—\n\n2/1/2023\n\n(1)(4)\n\n—\n\n12,863\n\n15.66\n\n2/1/2033\n\n—\n\n—\n\n—\n\n—\n\n4/18/2022\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n637\n\n12,001\n\n—\n\n—\n\n5/6/2022\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n500\n\n9,420\n\n—\n\n—\n\n5/26/2022\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n3,750\n\n70,650\n\n—\n\n—\n\n9/7/2022\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n5,537\n\n104,317\n\n—\n\n—\n\n2/1/2023\n\n(1)(5)\n\n—\n\n—\n\n—\n\n—\n\n42,550\n\n801,642\n\n—\n\n—\n\n2/1/2024\n\n(1)(7)\n\n—\n\n—\n\n—\n\n—\n\n72,717\n\n1,369,988\n\n—\n\n—\n\n3/25/2025\n\n(2)(6)\n\n—\n\n—\n\n—\n\n—\n\n55,580\n\n1,047,127\n\n—\n\n—\n\n3/25/2025\n\n(2)(8)\n\n—\n\n—\n\n—\n\n—\n\n—\n\n—\n\n23,820\n\n448,769\n\nNathan\n\nSmith\n\n8/7/2025\n\n(2)(9)\n\n—\n\n—\n\n—\n\n—\n\n42,000\n\n791,280\n\n—\n\n—\n\n8/7/2025\n\n(2)(9)\n\n—\n\n—\n\n—\n\n—\n\n—\n\n—\n\n18,000\n\n339,120\n\n*Amounts in this column are calculated by multiplying the number of shares shown as unvested in the prior column by $18.84, the closing price of\n\nour common stock on December 31, 2025, as reported on the Nasdaq Global Market.\n\n(1)Equity award was granted under our 2014 Equity Incentive Plan.\n\n(2)Equity award was granted under our 2024 Equity Incentive Plan.\n\n(3)Equity award was granted under a NASDAQ inducement grant.\n\n(4)25% of the total awards vest upon completion of 1 year of employment with the Company following the vesting commencement and 1/48th of\n\nthe awards will vest each month thereafter, subject to executive’s continued employment on each applicable vesting date.\n\n(5)25% of the RSUs vest on completion of each year of employment with the Company following the vesting commencement date.\n\n(6)33.33% of the shares subject to the award vest on completion of 1 year of employment with the Company following the vesting\n\ncommencement date. An additional 1/8th of the shares subject to the award will vest on completion of each additional quarter of employment\n\nwith the Company.\n\n(7)1/12th of the RSUs vest quarterly subject to executive’s continued employment on each applicable vesting date following the vesting\n\ncommencement date.\n\n(8)PRSUs are earned based on the performance metrics set forth above in the section entitled “2025 PRSUs.” The unearned PRSUs are\n\nincluded assuming the target level of performance. If earned, 50% of the PRSUs will vest on completion of 1 year of employment with the\n\nCompany and an additional 25% of the shares subject to the award will vest on completion of each additional year of employment with the\n\nCompany.\n\n(9)Mr. Smith’s employment with the Company commenced on August 7, 2025 and terminated effective February 25, 2026. Mr. Smith was\n\ngranted 42,000 RSUs and 18,000 PRSUs which vested in accordance with the terms of his Change of Control and Severance Agreement, as\n\nfurther described under “Potential Payments and Benefits upon Termination or Change of Control for Officers” below.\n\n76  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nNarrative Disclosure to Summary Compensation Table and Grant of Plan-\n\nBased Awards Table\n\nEmployment, Separation and Consulting Agreement and Offer Letter Summaries\n\nWe have entered into employment agreements or offer letters with each of the NEOs. These agreements provide for at-will\n\nemployment and generally include the named executive officer’s initial base salary, and an indication of eligibility for an annual\n\ncash incentive award opportunity. We have also entered into separation and change of control agreements with each of our NEOs.\n\nThe terms of these agreements are informed by market data and consultation with our outside compensation consultants, Alpine\n\nRewards.\n\nJohn W. Hanna\n\nIn connection with his appointment as our Chief Executive Officer, we entered into an offer letter with Mr. Hanna dated March 24,\n\n2024. The letter provides for “at-will” employment and sets forth certain agreed upon terms and conditions of employment. During\n\nfiscal year 2024, Mr. Hanna’s annualized base salary $675,000, and included eligibility to receive an annual performance bonus of\n\nup to 100% of base salary (which was pro-rated for 2024).\n\nIn connection with his appointment and the commencement of employment with the Company, on April 15, 2024, Mr. Hanna was\n\ngranted two “inducement grants” (as such term is described in NASDAQ Listing Rule 5635(c)(4)) comprised of (i) an option to\n\npurchase shares of the Company’s common stock, having an approximate grant date fair value of $4,000,000 and (ii) an award of\n\nrestricted stock units, having an approximate grant date fair value of $4,000,000. Mr. Hanna’s inducement equity awards were each\n\ngranted as inducements material to Mr. Hanna agreeing to enter into employment with the Company. Mr. Hanna has also entered\n\ninto a Change of Control and Severance Agreement with us that provides certain severance benefits upon a qualifying termination\n\nof employment as more detailed in “Potential Payments and Benefits upon Termination or Change of Control for Officers” below.\n\nKeith Kennedy\n\nIn connection with his appointment as our Chief Operating Officer, we entered into an offer letter with Mr. Kennedy dated July 27,\n\n2024. The letter provides for “at-will” employment and sets forth certain agreed upon terms and conditions of employment,\n\nincluding his initial annualized base salary of $575,000, and annual performance bonus of up to 60% of his base salary (which was\n\npro-rated for 2024).\n\nIn connection with his appointment, on September 12, 2024, Mr. Kennedy was granted two “inducement grants” (as such term is\n\ndescribed in NASDAQ Listing Rule 5635(c)(4)) comprised of (i) an option to purchase shares of the Company’s common stock,\n\nhaving an approximate grant date fair value of $2,000,000 and (ii) an award of restricted stock units, having an approximate grant\n\ndate fair value of $2,000,000. Mr. Kennedy’s inducement equity awards were each granted as inducements material to Mr.\n\nKennedy agreeing to enter into employment with the Company. Mr. Kennedy also entered into a Change of Control and Severance\n\nAgreement with us that provides certain severance benefits upon a qualifying termination of his employment as more detailed in\n\n“Potential Payments and Benefits upon Termination or Change of Control for Officers” below. Effective February 26, 2026, Mr.\n\nKennedy was appointed as the Company's Chief Financial Officer, in addition to his role as Chief Operating Officer.\n\nJessica Meng\n\nIn connection with her appointment as our Chief Commercial Officer, we entered into an offer letter with Ms. Meng dated August\n\n31, 2024. The letter provides for “at-will” employment and sets forth certain agreed upon terms and conditions of employment,\n\nincluding her initial annualized base salary of $475,000, and annual performance bonus of up to 60% of base salary (which was\n\npro-rated for 2024).\n\nIn connection with appointment, on September 12, 2024, Ms. Meng was granted two “inducement grants” (as such term is\n\ndescribed in NASDAQ Listing Rule 5635(c)(4)) comprised of (i) an option to purchase shares of the Company’s common stock,\n\nhaving an approximate grant date fair value of $1,500,000 and (ii) an award of restricted stock units, having an approximate grant\n\ndate value of $1,500,000. Ms. Meng’s inducement equity awards were each granted as inducements material to Ms. Meng\n\nagreeing to enter into employment with the Company. Ms. Meng entered into a Change of Control and Severance Agreement with\n\nCareDx Inc.\n\n2026 Proxy Statement  |  77\n\nExecutive Compensation\n\nus that provides certain severance benefits upon a qualifying termination of employment as more detailed in “Potential Payments\n\nand Benefits upon Termination or Change of Control for Officers” below.\n\nJeffrey Novack\n\nIn connection with Mr. Novack’s commencement of employment with the Company, we entered into an offer letter with Mr. Novack\n\ndated October 6, 2021. The letter provides for “at-will” employment and sets forth certain agreed upon terms and conditions of\n\nemployment, including his initial annualized base salary of $260,000 and annual performance bonus of up to 20% of base salary.\n\nOn December 1, 2023, the Company entered into a retention bonus agreement with Mr. Novack, which provided for a retention\n\nbonus in an aggregate amount of $100,000. Pursuant to the terms of the retention bonus agreement, 25% of the total retention\n\nbonus was paid in December 2023 and was subject to repayment if Mr. Novack did not remain an employee of the Company\n\nthrough December 1, 2024. The remaining 75% of the retention bonus was paid on the Company’s first payroll date in December\n\n2024.\n\nMr. Novack also entered into a Change of Control and Severance Agreement with us that provides certain severance benefits upon\n\na qualifying termination of his employment as more detailed in “Potential Payments and Benefits upon Termination or Change of\n\nControl for Officers” below.\n\nAbhishek Jain\n\nIn connection with Mr. Jain’s promotion to our Interim Chief Financial Officer, we entered into a promotion letter with Mr. Jain, dated\n\nMay 21, 2022 that entitled Mr. Jain to an annual base salary of $305,000, and target annual performance bonus of up to 35% of his\n\nbase salary. Mr. Jain was appointed as our Chief Financial Officer effective as of September 7, 2022 and in connection with such\n\nappointment entered into a Change of Control and Severance Agreement with us that provides him certain severance benefits\n\nupon a qualifying termination of his employment.\n\nOn December 1, 2023, the Company entered into a retention bonus agreement with Mr. Jain, which provided a retention bonus in\n\nan aggregate amount of $400,000. Pursuant to the terms of the retention bonus agreement, 25% of the total retention bonus was\n\npaid in December 2023 and was subject to repayment if Mr. Jain did not remain an employee of the Company through December\n\n1, 2024. The remaining 75% of the retention bonus was paid on the Company’s first payroll date in December 2024.\n\nOn March 27, 2025, we entered into an Amended and Restated Change of Control and Severance Agreement with Mr. Jain that\n\nprovides for twelve months of severance and continued benefits in the event of a qualifying termination of employment (whether or\n\nnot in the context of a change of control event), in order to better align the terms of Mr. Jain’s severance entitlements with those of\n\nour other executive officers (other than our Chief Executive Officer).\n\nOn August 6, 2025, Mr. Jain’s employment with CareDx terminated. Pursuant to a separation and release agreement dated August\n\n6, 2025, Mr. Jain received (a) a lump-sum cash severance payment equal to twelve months of his base salary in the amount of\n\n$482,183, (b) twelve months of reimbursement of COBRA premiums, provided that such reimbursement will cease on the date that\n\nMr. Jain becomes covered under a similar plan of a new employer, and (c) payment of the 2025 annual bonus in the amount of\n\n$309,526. In addition, effective August 7, 2025, Mr. Jain entered into a Consulting Agreement, as amended in December 2025,\n\nwith a term ending April 1, 2026, under which Mr. Jain agreed to provide transition and advisory services, and his outstanding\n\nequity awards continued to vest during the consulting term, as permitted by the terms of his equity awards.\n\nNathan Smith\n\nIn connection with his appointment as Chief Financial Officer, we entered into an offer letter with Mr. Smith dated May 20, 2025.\n\nThe letter provides for “at-will” employment and sets forth certain agreed upon terms and conditions of employment, including his\n\ninitial annualized base salary of $400,000, and annual performance bonus of up to 50% of base salary (which was pro-rated for\n\n2025).\n\n78  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nIn connection with appointment, on August 7, 2025, Mr. Smith was granted two “inducement grants” (as such term is described in\n\nNASDAQ Listing Rule 5635(c)(4)) comprised of (i) an award of performance restricted stock units, having a grant date fair value of\n\n$217,260 and (ii) an award of restricted stock units, having a grant date value of $506,940. Mr. Smith’s inducement equity awards\n\nwere each granted as inducements material to Mr. Smith agreeing to enter into employment with the Company. Mr. Smith entered\n\ninto a Change of Control and Severance Agreement with us that provides certain severance benefits upon a qualifying termination\n\nof employment as more detailed in “Potential Payments and Benefits upon Termination or Change of Control for Officers” below.\n\nOption Exercises and Stock Vested\n\nThe following table presents, for each of the NEOs, the number of shares of our common stock acquired upon the vesting and\n\nsettlement of RSUs during fiscal year 2025 and the aggregate value realized upon the vesting and settlement of RSUs and upon\n\nthe exercise of stock options during fiscal year 2025 and the aggregate value realized upon the exercise of stock options.\n\nOption Awards\n\nStock Awards\n\nName*\n\nNumber of Shares\n\nAcquired on Vesting\n\n(#)\n\nValue Realized on\n\nExercise\n\n($)\n\nNumber of Shares\n\nAcquired on Vesting\n\n(#)\n\nValue Realized on\n\nVesting\n\n($)\n\nJohn W. Hanna\n\n—\n\n—\n\n121,951\n\n2,336,581\n\nKeith Kennedy\n\n—\n\n—\n\n17,526\n\n237,127\n\nJessica Meng\n\n—\n\n—\n\n13,144\n\n177,838\n\nJeffrey Novack\n\n—\n\n—\n\n38,102\n\n647,184\n\nAbhishek Jain\n\n78,633\n\n71,278\n\n129,048\n\n2,421,777\n\n*Mr. Smith did not hold any option awards or stock awards that vested or settled during fiscal year 2025.\n\nPension Benefits\n\nNo pension benefits were paid to any of our NEOs during fiscal year 2025.\n\nPotential Payments and Benefits upon Termination or Change of Control for Officers\n\nJohn W. Hanna\n\nPursuant to Mr. Hanna’s Change of Control and Severance Agreement, effective March 21, 2024, if within three months prior to, or\n\ntwelve months following a change of control, we or our successor terminate Mr. Hanna’s employment without cause or Mr. Hanna\n\nresigns for good reason, Mr. Hanna will be entitled to (a) a lump sum payment equal to eighteen months of Mr. Hanna’s annual\n\nbase salary (at the greater of the rate in effect immediately prior to the change of control or the rate in effect immediately prior to\n\nthe date of such termination), (b) acceleration of vesting equal to 100% of any unvested equity awards (with any performance\n\ncriteria being deemed achieved at target levels for the relevant performance period(s)), (c) a lump sum payment equal to 150% of\n\nMr. Hanna’s annual bonus (equal to the greater of target bonus in effect for the fiscal year in which the change of control occurs or\n\nthe target bonus in effect for the fiscal year in which the termination occurs) and (d) 18 months of reimbursement of COBRA\n\npremiums, provided, that such reimbursement will cease on the date that Mr. Hanna becomes covered under a similar plan of a\n\nnew employer. Pursuant to the agreement, if we or a successor terminates Mr. Hanna’s employment without cause or he resigns\n\nfor good reason and such termination occurs outside of a change of control event, Mr. Hanna will be entitled to (a) twelve months’\n\nseverance based on Mr. Hanna’s annual base salary, and (b) twelve months of continued benefits, provided, that such\n\nreimbursement will cease on the date that Mr. Hanna becomes covered under a similar plan of a new employer, and (c) if such\n\ntermination occurs prior to the one year anniversary of Mr. Hanna’s start date, the inducement equity awards granted to Mr. Hanna\n\nin connection with the initial appointment will vest pro rata based on the number of days that elapsed since starting employment\n\nwith us.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  79\n\nExecutive Compensation\n\nKeith Kennedy\n\nPursuant to Mr. Kennedy’s Change of Control and Severance Agreement, effective July 27, 2024, if within three months prior to, or\n\ntwelve months following a change of control, we or our successor terminate Mr. Kennedy’s employment without cause or Mr.\n\nKennedy resigns for good reason, Mr. Kennedy will be entitled to (a) a lump sum payment equal to twelve months of Mr. Kennedy’s\n\nannual base salary (at the greater of the rate in effect immediately prior to the change of control or the rate in effect immediately\n\nprior to the date of such termination), (b) acceleration of vesting equal to 100% of any unvested equity awards (with any\n\nperformance criteria being deemed achieved at target levels for the relevant performance period(s)), (c) a lump sum payment equal\n\nto 100% of Mr. Kennedy’s annual bonus (equal to the greater of target bonus in effect for the fiscal year in which the change of\n\ncontrol occurs or the target bonus in effect for the fiscal year in which the termination occurs) and (d) 12 months of reimbursement\n\nof COBRA premiums, provided, that such reimbursement will cease on the date that Mr. Kennedy becomes covered under a\n\nsimilar plan of a new employer. Pursuant to the agreement, if we or a successor terminates Mr. Kennedy’s employment without\n\ncause or he resigns for good reason and such termination occurs outside of a change of control event, Mr. Kennedy will be entitled\n\nto (a) twelve months’ severance based on Mr. Kennedy’s annual base salary, and (b) twelve months of continued benefits,\n\nprovided, that such reimbursement will cease on the date that Mr. Kennedy becomes covered under a similar plan of a new\n\nemployer, and (c) if such termination occurs prior to the one year anniversary of Mr. Kennedy’s start date, the inducement equity\n\nawards granted to Mr. Kennedy in connection with his initial appointment will vest pro rata based on the number of days that\n\nelapsed since starting employment with us.\n\nJessica Meng\n\nPursuant to Ms. Meng’s Change of Control and Severance Agreement, effective August 30, 2024, if within three months prior to, or\n\ntwelve months following a change of control, we or our successor terminate Ms. Meng’s employment without cause or Ms. Meng\n\nresigns for good reason, Ms. Meng will be entitled to (a) lump sum payment equal to twelve months of Ms. Meng’s annual base\n\nsalary (at the greater of the rate in effect immediately prior to the change of control or the rate in effect immediately prior to the date\n\nof such termination), (b) acceleration of vesting equal to 100% of any unvested equity awards (with any performance criteria being\n\ndeemed achieved at target levels for the relevant performance period(s)), (c) a lump sum payment equal to 100% of Ms. Meng’s\n\nannual bonus (equal to the greater of target bonus in effect for the fiscal year in which the change of control occurs or the target\n\nbonus in effect for the fiscal year in which the termination occurs) and (d) 12 months of reimbursement of COBRA premiums,\n\nprovided, that such reimbursement will cease on the date that Ms. Meng becomes covered under a similar plan of a new employer.\n\nPursuant to the agreement, if we or a successor terminates Ms. Meng’s employment without cause or she resigns for good reason\n\nand such termination occurs outside of a change of control event, Ms. Meng will be entitled to (a) twelve months’ severance based\n\non Ms. Meng’s annual base salary, and (b) twelve months of continued benefits, provided, that such reimbursement will cease on\n\nthe date that Ms. Meng becomes covered under a similar plan of a new employer, and (c) if such termination occurs prior to the\n\none year anniversary of Ms. Meng’s start date, the inducement equity awards granted to Ms. Meng in connection with the initial\n\nappointment will vest pro rata based on the number of days that elapsed since starting employment with us.\n\nJeffrey Novack\n\nOn March 28, 2025, we entered into a Change of Control and Severance Agreement with Mr. Novack, in order to better align the\n\nterms of Mr. Novack’s severance entitlements with those of our other executive officers (other than our Chief Executive Officer).\n\nPursuant to the terms of the agreement, if within three months prior to, or twelve months following a change of control, we or our\n\nsuccessor terminate Mr. Novack’s employment without cause or Mr. Novack resigns for good reason, Mr. Novack will be entitled to\n\n(a) twelve months’ severance based on Mr. Novack’s annual base salary, (b) acceleration of vesting equal to 100% of any\n\nunvested equity awards, (c) a lump sum payment equal to Mr. Novack’s annual bonus (equal to the greater of target bonus or the\n\nactual bonus received for performance during the calendar year prior to the year in which the termination occurred) and (d) twelve\n\nmonths of continued benefits, provided, that such reimbursement will cease on the date that Mr. Novack becomes covered under a\n\nsimilar plan of a new employer. Pursuant to the agreement, if we or a successor terminates Mr. Novack’s employment without\n\ncause or he resigns for good reason and such termination occurs outside of a change of control event, Mr. Novack will be entitled\n\nto (a) nine months’ severance based on Mr. Novack’s annual base salary, and (b) nine months of continued benefits, provided, that\n\nsuch reimbursement will cease on the date that Mr. Novack becomes covered under a similar plan of a new employer.\n\n80  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nAbhishek Jain\n\nPursuant to Mr. Jain’s original Change of Control and Severance Agreement, effective September 7, 2022, if within three months\n\nprior to, or twelve months following a change of control, we or our successor terminate Mr. Jain’s employment without cause, Mr.\n\nJain will be entitled to (a) six months’ severance based on Mr. Jain’s annual base salary, (b) acceleration of vesting equal to 100%\n\nof any unvested equity awards, (c) a lump sum payment equal to Mr. Jain’s annual bonus (equal to the greater of target bonus or\n\nthe actual bonus received for performance during the calendar year prior to the year in which the termination occurred) and (d) six\n\nmonths of continued benefits, provided, that such reimbursement will cease on the date that Mr. Jain becomes covered under a\n\nsimilar plan of a new employer. Pursuant to the agreement, if we or a successor terminates Mr. Jain’s employment without cause\n\nand such termination occurs outside of a change of control event, Mr. Jain will be entitled to (a) six months’ severance based on\n\nMr. Jain’s annual base salary, and (b) six months of continued benefits, provided, that such reimbursement will cease on the date\n\nthat Mr. Jain becomes covered under a similar plan of a new employer.\n\nOn March 27, 2025, we entered into an Amended and Restated Change of Control and Severance Agreement with Mr. Jain that\n\nprovides for twelve months of severance and continued benefits in the event of a qualifying termination of employment (whether or\n\nnot in the context of a change of control event), in order to better align the terms of Mr. Jain’s severance entitlements with those of\n\nour other executive officers (other than our Chief Executive Officer).\n\nOn August 6, 2025, Mr. Jain’s employment with CareDx terminated. Per his Amended and Restated Change of Control and\n\nSeverance Agreement Mr. Jain received a lump-sum cash payment in an amount equal to twelve (12) months of his base salary in\n\nthe amount of $482,183. and (b) twelve months of continued benefits, provided, that such reimbursement will cease on the date\n\nthat Mr. Jain becomes covered under a similar plan of a new employer. In addition he received payment of the 2025 annual bonus\n\nin the amount of $309,526.\n\nNathan Smith\n\nPursuant to Mr. Smith’s Change of Control and Severance Agreement, effective May 20, 2025, if within three months prior to, or\n\ntwelve months following a change of control, we or our successor terminate Mr. Smith’s employment without cause or Mr. Smith\n\nresigns for good reason, Mr. Smith will be entitled to (a) lump sum payment equal to twelve months of Mr. Smith’s annual base\n\nsalary (at the greater of the rate in effect immediately prior to the change of control or the rate in effect immediately prior to the date\n\nof such termination), (b) acceleration of vesting equal to 100% of any unvested equity awards (with any performance criteria being\n\ndeemed achieved at target levels for the relevant performance period(s)), (c) a lump sum payment equal to 100% of Mr. Smith’s\n\nannual bonus (equal to the greater of target bonus in effect for the fiscal year in which the change of control occurs or the target\n\nbonus in effect for the fiscal year in which the termination occurs) and (d) 12 months of continued benefits, provided, that such\n\nreimbursement will cease on the date that Mr. Smith becomes covered under a similar plan of a new employer. Pursuant to the\n\nagreement, if we or a successor terminates Mr. Smith’s employment without cause and such termination occurs outside of a\n\nchange of control event, Mr. Smith will be entitled to (a) nine months’ severance based on Mr. Smith’s annual base salary to be\n\npaid periodically in accordance with the Company’s normal payroll policies, and (b) nine months of continued benefits, provided,\n\nthat such reimbursement will cease on the date that Mr. Smith becomes covered under a similar plan of a new employer, and (c) if\n\nsuch termination occurs prior to the one year anniversary of Mr. Smith’s start date, the inducement equity awards granted to Mr.\n\nSmith in connection with the initial appointment will vest pro rata based on the number of days that elapsed since starting\n\nemployment with us.\n\nOn February 25, 2026, Mr. Smith terminated employment with CareDx. Per the Severance Agreement Mr. Smith will receive nine\n\nmonths’ severance based on Mr. Smith’s annual base salary, to be paid periodically in accordance with the Company’s normal\n\npayroll policies, of $300,000, and (b) nine months of continued benefits, provided, that such reimbursement will cease on the date\n\nthat Mr. Smith becomes covered under a similar plan of a new employer. In addition he received payment of the 2025 annual\n\nbonus in the amount of $91,643.\n\nFor purposes of the Change of Control and Severance Agreements with each of our NEOs, “cause” means generally:\n\n•executive’s material failure to perform the executive’s stated duties after a written notice of failure and a cure period of ten\n\ndays;\n\n•executive’s material violation of our policies or any written agreement or covenant with us;\n\nCareDx Inc.\n\n2026 Proxy Statement  |  81\n\nExecutive Compensation\n\n•executive’s conviction of, or entry of a plea of guilty or nolo contendere to, a felony;\n\n•a willful act by executive that constitutes gross misconduct and which is injurious to us;\n\n•executive’s commission of any act of fraud, embezzlement, dishonesty or any other willful misconduct that has caused or\n\nis reasonably expected to result in material injury to us;\n\n•the unauthorized use or disclosure by executive of any of our proprietary information or trade secrets or any other party to\n\nwhom they owe an obligation of nondisclosure as a result of the executive’s relationship with us; or\n\n•executive’s willful failure to cooperate with an investigation by a governmental authority.\n\nGood reason means occurrence of one or more of the following:\n\n•a material reduction in the executive's title, duties, authority, or responsibilities;\n\n•a material reduction in the executive's annual base salary (unless base salaries of all other senior executives are similarly\n\nreduced);\n\n•our failure to obtain assumption of the agreement by any successor;\n\n•a material change in the geographic location of the executive's principal workplace (with relocations of less than thirty\n\nmiles from Brisbane, California not constituting a material change);\n\n•or any other action or inaction by us that constitutes a material breach of the agreement or any other written agreement\n\nbetween us and the executive.\n\nThe following table estimates the amounts payable to our named executive officers in the event that a change of control,\n\ntermination of employment or both occurred on December 31, 2025, or, in the case of Mr. Jain on August 6, 2025, the date of his\n\ntermination of employment. The closing price of our common stock on December 31, 2025, as reported on the Nasdaq Global\n\nMarket, was $18.84 per share. The following table excludes certain benefits, such as accrued vacation, that are available to all\n\nemployees generally. The actual amount of payments and benefits that would be provided can only be determined at the time of a\n\nchange of control and/or the NEOs qualifying separation from the Company:\n\nTermination by the Company Without Cause\n\nOutside of Change of Control Window\n\nTermination by the Company Without Cause\n\nDuring Change of Control Window\n\nName*\n\nCash Payments\n\n($)\n\nContinuation of\n\nBenefits(1)\n\n($)\n\nValue of Equity\n\nAccelerated\n\n($)\n\nCash Payments\n\n($)\n\nContinuation of\n\nBenefits(1)\n\n($)\n\nValue of Equity\n\nAccelerated\n\n($)\n\nJohn W. Hanna\n\n700,000\n\n—\n\n—\n\n2,100,000\n\n—\n\n16,643,579\n\nKeith Kennedy\n\n592,250\n\n45,985\n\n—\n\n947,600\n\n45,985\n\n3,068,151\n\nJessica Meng\n\n489,250\n\n—\n\n—\n\n782,800\n\n—\n\n2,405,020\n\nJeffrey Novack\n\n370,000\n\n—\n\n—\n\n642,000\n\n—\n\n1,400,509\n\nAbhishek Jain*\n\nNathan Smith(2)\n\n*For NEOs other than Mr. Jain, represents the estimated severance payable under each executive’s applicable Change of Control and\n\nSeverance Agreement at the rate in effect on December 31, 2025. For Mr. Jain, it represents the cash severance under his separation and\n\nrelease agreement as of August 6, 2025.\n\n(1)Represents the estimated cost of employer-paid reimbursement of health care coverage for the applicable periods specified in each\n\nexecutive’s Change of Control Agreement (or separation and release agreement). These benefits cease if the executive becomes eligible for\n\ncomparable coverage through a new employer.\n\n(2)The employment of Nathan Smith, Chief Financial Officer was terminated on February 25, 2026. Upon termination of his employment and\n\nunder the Change of Control and Severance Agreement between him and the Company, he was paid (i) a lump-sum cash payment in an\n\namount equal to nine months of his base salary, as in effect immediately prior to the termination date, (ii) payment of bonus in the amount of\n\n$91,643, and (iii) vesting of 5,840 restricted stock units valued at $109,500, representing pro rata vesting during the period of Mr. Smith’s\n\nemployment with the Company through the termination date.\n\n82  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nPay Ratio Disclosure\n\nWe are a leading precision medicine company focused on the discovery, development and commercialization of clinically\n\ndifferentiated, high-value diagnostic solutions for transplant patients and caregivers. We offer testing services, products, and digital\n\nhealthcare solutions along the pre- and post-transplant patient journey, and we are a leading provider of genomics-based\n\ninformation for transplant patients.\n\nAs required by Item 402(u) of Regulation S-K, we are providing the following information about the relationship of the median of the\n\nannual total compensation of all our employees (other than our Chief Executive Officer) and the annual total compensation of John\n\nHanna, our Chief Executive Officer and President (our “CEO”) on October 15, 2025. Neither the Compensation and Human Capital\n\nCommittee nor our management used our CEO pay ratio measure in making compensation decisions. As explained by the SEC\n\nwhen it adopted Item 402(u), the rule was designed to allow stockholders to better understand and assess our compensation\n\npractices and pay ratio disclosures rather than to facilitate a comparison of this information from one company to another.\n\nHowever, the pay ratio rules provide companies with flexibility to select the methodology and assumptions used to identify the\n\nmedian employee, calculate the median employee's compensation and estimate the pay ratio. As a result, our methodology may\n\ndiffer from those used by other companies, which likely will make it difficult to compare pay ratios with other companies, including\n\nthose within our industry.\n\nCEO Pay Ratio for Fiscal Year 2025\n\n•The median of the 2025 annual total compensation of all our employees, excluding our CEO, was $148,417;\n\n•The annualized total compensation of our CEO in 2025 was $7,179,699; and\n\n•The ratio of the annual total compensation of our CEO to the median of the annual total compensation of all our\n\nemployees was 48 to 1. This ratio is a reasonable estimate calculated in a manner consistent with SEC rules.\n\nMethodology\n\nThe methodology, including key assumptions and estimates, used to identify the employee (excluding our Chief Executive Officer)\n\nwith compensation at the median of the annual total compensation of all our employees was based on the following:\n\n•In determining our employee population, we considered the individuals, excluding our Chief Executive Officer, who were\n\nemployed by us and our consolidated subsidiaries as of October 15, 2025, whether employed on a full-time, part-time,\n\nseasonal or temporary basis. As of October 15, 2025, we had 767 employees. As permitted by the de minimis exception\n\ncontained in Item 402(u)(4)(ii) of Regulation S-K, we have excluded our 21 employees in Canada, Egypt, Germany,\n\nHungary, Italy, Saudi Arabia, Serbia, South Africa, Spain, Taiwan and the United Kingdom, leaving us with a population of\n\n746 employees. We did not include any contractors or other non-employee workers in our employee population.\n\n•To identify our median employee, we chose to use total cash and equity compensation as our consistently-applied\n\ncompensation measure, which we calculated as of October 15, 2025. After applying our methodology, our median\n\nemployee was a Software Engineer, based in the U.S.\n\n•For employees paid other than in U.S. dollars, we converted their compensation to U.S. dollars using the applicable\n\nexchange rates in effect on October 15, 2025. For permanent employees hired during 2025, we annualized their total cash\n\nas if they had been employed for the entire measurement period. We did not make any cost-of-living adjustments.\n\nCalculation\n\nUsing the aforementioned methodology, the individual identified as the calculated median employee had actual earnings consisting\n\nof base pay, bonus, company paid health and insurance benefits and 401(k) match for 2025 annual total compensation in the\n\namount of $148,417. Mr. Hanna’s compensation for purposes of the pay ratio disclosure has been adjusted as follows: base salary\n\nannualized and target bonus payout included for a total of $7,179,699.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  83\n\nExecutive Compensation\n\nPay Versus Performance\n\nAs required by Section 953(a) of the Dodd-Frank Act and Item 402(v) of Regulation S-K, we are providing the following information\n\nabout the relationship between executive “compensation actually paid” (the “CAP”) to our principal executive officers (“PEOs”) and\n\nour other NEOs (the “Non-PEO NEOs”) and certain financial performance of the Company. The CAP does not reflect the actual\n\namount of compensation earned, realized or received by the PEOs or Non-PEO NEOs during the applicable fiscal year. The\n\nfollowing table shows the total compensation for our NEOs for the past five fiscal years as set forth in the “Summary Compensation\n\nTable”, the CAP to our PEOs, and on an average basis, our Non-PEO NEOs (in each case, as determined under SEC rules), our\n\nTotal Shareholder Return (“TSR”), the TSR for companies in the Nasdaq Biotech Index, our net income, and our Company-\n\nSelected Measure, Revenue.\n\nValue of Initial\n\nFixed\n\n$100\n\nInvestment Based\n\nOn:\n\nFiscal\n\nYear\n\n(a)\n\nSummary\n\nCompensation\n\nTable (“SCT”)\n\nfor Mr. Hanna\n\n(PEO 1)\n\n(b)(1)\n\nCAP to\n\nMr. Hanna\n\n(PEO 1)\n\n(c)(2)\n\nSummary\n\nCompensation\n\nTable (“SCT”)\n\nfor Mr.\n\nJohnson\n\n(PEO 2)\n\n(d)(1)\n\nCAP to\n\nMr.\n\nJohnson\n\n(PEO 2)\n\n(e)(2)\n\nSCT for\n\nDr. Seeto\n\n(PEO 3)\n\n(f)(1)\n\nCAP to\n\nDr. Seeto\n\n(PEO 3)\n\n(g)(2)\n\nAverage\n\nSCT\n\nfor Non-\n\nPEO NEOs\n\n(j)(3)\n\nAverage\n\nCAP\n\nto Non-\n\nPEO\n\nNEOs\n\n(k)(2)\n\nTSR\n\n(l)(4)\n\nPeer\n\nGroup\n\nTSR\n\n(m)(4)\n\nNet Income\n\n(in\n\nthousands)\n\n(n)\n\nRevenue\n\n(in\n\nthousands)\n\n(o)(5)\n\n2025\n\n$7,179,699\n\n$3,453,094\n\n$—\n\n$—\n\n—\n\n—\n\n$2,128,811\n\n$1,664,869\n\n$26.00\n\n$124.75\n\n($21,354)\n\n$379,805\n\n2024\n\n9,424,329\n\n24,178,001\n\n$2,937,571\n\n$7,443,241\n\n$—\n\n$—\n\n$2,986,074\n\n$3,772,296\n\n$29.55\n\n$93.49\n\n$52,549\n\n$333,785\n\n2023\n\n—\n\n—\n\n3,097,438\n\n1,923,573\n\n$10,551,753\n\n$6,665,898\n\n$4,617,844\n\n$4,412,835\n\n$16.56\n\n$94.03\n\n($190,284)\n\n$280,324\n\n2022\n\n—\n\n—\n\n—\n\n—\n\n$12,786,270\n\n($648,097)\n\n$3,784,612\n\n$118,224\n\n$15.75\n\n$89.90\n\n($76,613)\n\n$321,793\n\n2021\n\n—\n\n—\n\n—\n\n—\n\n$7,090,121\n\n($50,411)\n\n$2,605,699\n\n$140,603\n\n$62.77\n\n$100.02\n\n($30,662)\n\n$296,397\n\n(1)The dollar amounts reported in columns (b), (d), and (f) are the amounts of total compensation reported for Mr. Hanna (our Chief Executive\n\nOfficer and Principal Executive Officer since April 15, 2024), Mr. Johnson (our Principal Executive Officer from November 1, 2023 to April 15,\n\n2024), and Dr. Seeto (Chief Executive Officer and Principal Executive Officer from November 1, 2020 to November 1, 2023) for each\n\ncorresponding year in the “Total” column of the Summary Compensation Table. Refer to the “Summary Compensation Table” on page [71](#i905f78cfb2ec4d6ba9e65cdd610942a5_193) for\n\nadditional information.\n\n(2)The dollar amounts reported in columns (c), (e), (g), (i), and (k) represent the amount of the CAP, as computed in accordance with SEC rules.\n\nThe CAP does not necessarily represent cash and/or equity value transferred to the applicable NEO without restriction, but rather is a value\n\ncalculated under applicable SEC rules. These amounts reflect the total amount of compensation for our NEOs reported in the Summary\n\nCompensation Table with certain adjustments as described in the table below for the most recent fiscal year. We do not have a defined benefit\n\nplan so no adjustment for pension benefits is included. The valuation assumptions and processes used to recalculate fair values did not\n\nmaterially differ from those disclosed at the time of grant.\n\nFiscal\n\nYear\n\nExecutives\n\nSCT\n\n(a)\n\nGrant Date\n\nValue of\n\nNew\n\nAwards\n\n(b)\n\nYear End\n\nValue of\n\nNew Awards\n\n(i)\n\nChange in\n\nValue of\n\nOutstanding\n\nAwards\n\nGranted in\n\nPrior Fiscal\n\nYear\n\n(ii)\n\nChange in\n\nValue of\n\nVested\n\nAwards\n\nGranted in\n\nPrior\n\nFiscal\n\nYears\n\n(iii)\n\nFair Value\n\nof Vested\n\nAwards\n\nGranted\n\nand\n\nVested in\n\nCurrent\n\nFiscal\n\nYear\n\n(iv)\n\nFair\n\nValue at\n\nStart of\n\nFiscal\n\nYear of\n\nAwards\n\nthat\n\nFailed to\n\nMeet\n\nVesting\n\nConditions\n\n(v)\n\nValue of\n\nDividend\n\ns\n\nPaid on\n\nEquity\n\nAwards\n\nnot\n\nReflected\n\nin Fair\n\nValue (vi)\n\nTotal Equity\n\nCAP\n\n(c)=(i)+(ii)+\n\n(iii)+(iv)\n\nCAP\n\n(d)=\n\n(a)-(b)+(c)\n\n2025\n\nPEO 1\n\n$7,179,699\n\n($5,622,638)\n\n$5,199,291\n\n($2,053,392)\n\n($1,249,867)\n\n—\n\n—\n\n—\n\n$1,896,033\n\n$3,453,094\n\nNon-PEO\n\nNEO Avg\n\n$2,128,811\n\n($1,364,519)\n\n$1,345,448\n\n($210,961)\n\n($233,910)\n\n—\n\n—\n\n—\n\n$900,577\n\n$1,664,869\n\n(a)The dollar amounts reported in the Summary Compensation Table for the applicable year.\n\n(b)The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards”\n\ncolumns of the Summary Compensation Table for the applicable year.\n\n84  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\n(c)The recalculated value of equity awards for each applicable year includes the addition (or subtraction, as applicable) of the following:\n\n(d)the year-end fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the\n\napplicable year;\n\n(e)the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of any awards granted in prior\n\nyears that are outstanding and unvested as of the end of the applicable year;\n\n(f)for awards that vest in the applicable year, the change in the fair value as of the vesting date from the beginning of the applicable year;\n\n(g)for awards that failed to meet vesting conditions in the applicable year, the fair value from the end of prior fiscal year.\n\n(h)for awards that failed to meet vesting conditions in the applicable year, the fair value from the end of prior fiscal year;\n\n(i)value of dividend not otherwise captured in the calculation of each Fair Value used to calculate CAP\n\n(j)The CAP does not necessarily represent cash and/or equity value transferred to the applicable NEO without restriction, but rather is a\n\nvalue calculated under applicable SEC rules.\n\n(3)The dollar amounts reported in column (j) are the average amounts of total compensation reported for the Non-PEO NEOs for each\n\ncorresponding year in the “Total” column of the Summary Compensation Table. Refer to our “Summary Compensation Table” on page [71](#i905f78cfb2ec4d6ba9e65cdd610942a5_193) for\n\nadditional information. For each of fiscal years in the table, the Non-PEO NEOs were:\n\n2025\n\n2024\n\n2023\n\n2022\n\n2021\n\nAbhishek Jain\n\nAbhishek Jain\n\nAbhishek Jain\n\nAbhishek Jain\n\nAnkur Dhingra\n\nKeith Kennedy\n\nKeith Kennedy\n\nAbraham Ronai\n\nAlexander Johnson\n\nAlexander Johnson\n\nJessica Meng\n\nJessica Meng\n\nAbraham Ronai\n\nSasha King\n\nJeffrey Novack\n\nJeffrey Novack\n\nAnkur Dhingra\n\nPeter Maag, Ph. D.\n\nNathan Smith\n\nSasha King\n\nMarcel Konrad\n\n(4)TSR is determined based on the value of an initial fixed investment of $100. The TSR peer group consists of the Nasdaq Biotech Index\n\ncompanies. TSR is calculated by dividing (i) the difference between the stock price at the end of each measurement period shown and the\n\nbeginning of the measurement period by (ii) the stock price at the beginning of the measurement period.\n\n(5)We determined Revenue to be the most important financial performance measure used to link Company performance to the CAP to our PEOs\n\nand Non-PEO NEOs in 2025, consistent with the Total Sales targets used for our short-term incentives (annual bonuses) and long-term\n\nincentives (PRSUs). See page [57](#i905f78cfb2ec4d6ba9e65cdd610942a5_172) of our CD&A for additional information.\n\nRelationship Between the CAP and Performance Measures\n\nWe believe the table above shows the alignment between the CAP to the NEOs and the Company’s performance, consistent with\n\nour compensation philosophy as described in our CD&A beginning on page [57](#i905f78cfb2ec4d6ba9e65cdd610942a5_172). The charts below show the relationship between\n\nthe CAP to our PEOs and Non-PEO NEOs and (i) our TSR and the Peer Group TSR; (ii) our net income and (iii) our Company-\n\nSelected Measure, Revenue, during the five most recently completed fiscal years.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  85\n\nExecutive Compensation\n\nChart 1\n\nChart 2\n\n86  |  2026 Proxy Statement\n\nCareDx Inc.\n\nExecutive Compensation\n\nChart 3\n\n2025 Most Important Performance Measures\n\nThe Compensation and Human Capital Committee uses a mix\n\nof performance measures throughout our annual and long-\n\nterm incentive programs to align executive pay with Company\n\nperformance. As required by SEC rules, the performance\n\nmeasures identified as the most important for all of our NEOs’\n\n2025 compensation decisions are listed in the table to the\n\nright. The measures in this table are not ranked.\n\nMost Important Performance Measures\n\nRevenue\n\nAdjusted EBITDA\n\nPipeline\n\nCareDx Inc.\n\n2026 Proxy Statement  |  87\n\nExecutive Compensation\n\nEquity Compensation Plan Information\n\nThe following table provides information as of December 31, 2025 with respect to shares of our common stock that may be issued\n\nunder our existing equity compensation plans.\n\nPlan Category\n\n(a)\n\nNumber of Securities\n\nto be Issued Upon\n\nExercise of\n\nOutstanding Options\n\nand Rights\n\n(b)\n\nWeighted Average\n\nExercise Price of\n\nOutstanding Options\n\nand Rights(1)\n\n(c)\n\nNumber of Securities Remaining\n\nAvailable for Future Issuance Under\n\nEquity Compensation Plans\n\n(Excluding Securities Reflected in\n\nColumn (a))\n\nEquity compensation plans approved by\n\nstockholders(2)\n\n4,675,730\n\n$24.78\n\n3,047,496\n\nEquity compensation plans not approved by\n\nstockholders(3)\n\n1,734,080\n\n$13.12\n\n141,444\n\nTotal:\n\n6,409,810\n\n$20.47\n\n3,188,940\n\n(1)The weighted average exercise price is calculated based solely on outstanding stock options and does not reflect the shares that will be issued\n\nupon the vesting of outstanding awards of RSUs, which have no exercise price.\n\n(2)Includes the following plans: the 2014 Plan and the 2024 Plan.\n\n(3)Consists of shares available for issuance under the CareDx, Inc. 2016 Inducement Equity Incentive Plan, the CareDx, Inc. 2019 Inducement\n\nEquity Incentive Plan, the CareDx Inc. 2025 Inducement Equity Incentive Plan and the inducement grants in connection with the appointments\n\nof Messrs. Hanna and Kennedy and Ms. Meng.\n\n88  |  2026 Proxy Statement\n\nCareDx Inc.\n\nSecurity Ownership of Certain\n\nBeneficial Owners and Management\n\nThe following table sets forth certain information with respect to the beneficial ownership of our common stock as of March 31,\n\n2026 for:\n\n•each of our current directors and nominees for director;\n\n•each of our NEOs;\n\n•all of our current directors and executive officers as a group; and\n\n•each person or group who beneficially owned more than 5% of our common stock.\n\nWe have determined beneficial ownership in accordance with the rules of the SEC and the information is not necessarily indicative\n\nof beneficial ownership for any other purpose. Unless otherwise indicated below, to our knowledge, the persons and entities named\n\nin the table have sole voting and sole investment power with respect to all shares that they beneficially owned, subject to\n\ncommunity property laws where applicable.\n\nWe have based our calculation of the percentage of beneficial ownership on 51,274,651 shares of our common stock outstanding\n\nas of March 31, 2026. We have deemed shares of our common stock subject to stock options that are currently exercisable or\n\nexercisable within 60 days of March 31, 2026, or issuable pursuant to RSUs that are subject to vesting conditions expected to\n\noccur within 60 days of March 31, 2026, to be outstanding and to be beneficially owned by the person holding the warrants, stock\n\noption or RSUs for the purpose of computing the percentage ownership of that person. We did not deem these shares outstanding,\n\nhowever, for the purpose of computing the percentage ownership of any other person.\n\nUnless otherwise indicated, the address of each beneficial owner listed in the table below is c/o CareDx, Inc., 8000 Marina\n\nBoulevard, 4th Floor, Brisbane, California 94005.\n\nName of Beneficial Owner\n\nNumber of Shares\n\nBeneficially Owned\n\nPercentage of Shares\n\nBeneficially Owned\n\n5% Stockholders:\n\nBlackRock, Inc.(1)\n\n4,416,324\n\n8.6%\n\nBaron Capital Group(2)\n\n3,155,180\n\n6.2%\n\nBellevue Group AG.(3)\n\n3,145,546\n\n6.1%\n\nNeil Gagnon(4)\n\n3,054,946\n\n6.0%\n\nState Street Corporation(5)\n\n2,737,752\n\n5.3%\n\nDirectors and Named Executive Officers:\n\nJohn W. Hanna(6)\n\n272,827\n\n*\n\nKeith Kennedy(7)\n\n49,293\n\n*\n\nJessica Meng(8)\n\n39,319\n\n*\n\nJeffrey Novack(9)\n\n50,600\n\n*\n\nCareDx Inc.\n\n2026 Proxy Statement  |  89\n\nSecurity Ownership of Certain Beneficial Owners and Management\n\nName of Beneficial Owner\n\nNumber of Shares\n\nBeneficially Owned\n\nPercentage of Shares\n\nBeneficially Owned\n\nNathan Smith(10)\n\n8,171\n\n*\n\nDirectors and Named Executive Officers:\n\nAbhishek Jain(11)\n\n273,268\n\n*\n\nMichael D. Goldberg(12)\n\n145,358\n\n*\n\nGeorge W. Bickerstaff, III(13)\n\n132,163\n\n*\n\nFred E. Cohen, M.D., D. Phil(14)\n\n143,162\n\n*\n\nChristine M. Cournoyer(15)\n\n37,045\n\n*\n\nSuresh Gunasekaran\n\n—\n\n—\n\nPeter Maag, Ph.D.(16)\n\n296,743\n\n*\n\nR. Bryan Riggsbee(17)\n\n15,674\n\n*\n\nArthur A. Torres(18)\n\n37,132\n\n*\n\nHannah A. Valantine(19)\n\n26,891\n\n*\n\nAll current directors and executive officers as a group (13 persons)(20)\n\n1,246,207\n\n2.4%\n\n*Represents beneficial ownership of less than one percent (1%) of the outstanding shares of our common stock.\n\n(1)Based solely on a Schedule 13G/A filed with the SEC on April 17, 2025, reporting beneficial ownership as of March 31, 2025, BlackRock, Inc.\n\nreported beneficial ownership of 4,416,324 shares of our common stock, including (i) sole voting power over 4,323,315 shares and (ii) sole\n\ndispositive power over 4,416,324 shares. The business address of BlackRock, Inc. is 50 Hudson Yards, New York, NY 10001.\n\n(2)Based solely on a Schedule 13G filed with the SEC on November 14, 2025, reporting beneficial ownership as of September 30, 2025, Baron\n\nCapital Group, Inc., together with BAMCO, Inc., Baron Capital Management, Inc., and Ronald Baron, reported beneficial ownership of\n\n3,155,180 shares of our common stock and shared voting and shared dispositive power over such shares. The business address of the Baron\n\nreporting persons is 767 Fifth Avenue, 49th Floor, New York, NY 10153.\n\n(3)Based solely on a Schedule 13G/A filed with the SEC on November 14, 2024, reporting beneficial ownership as of September 30, 2024,\n\nBellevue Group AG, on behalf of its wholly owned subsidiaries Bellevue Asset Management (UK) Ltd. and Bellevue Asset Management AG,\n\nreported beneficial ownership of 3,145,546 shares of our common stock and shared voting and shared dispositive power over such shares.\n\nThe business addresses of the Bellevue reporting persons are Seestrasse 16, Küsnacht, Switzerland CH‑8700 (Bellevue Group AG and\n\nBellevue Asset Management AG) and 32 London Bridge Street, 24th Floor, London, England SE1 9SG (Bellevue Asset Management (UK)\n\nLtd.).\n\n(4)Based solely on a Schedule 13G/A filed with the SEC on February 12, 2026, reporting beneficial ownership as of December 31, 2025, Mr.\n\nGagnon reported beneficial ownership of 3,054,946 shares of our common stock, including (i) sole voting and dispositive power over 177,878\n\nshares, (ii) shared voting power over 2,551,068 shares, and (iii) shared dispositive power over 2,877,068 shares. The business address of Mr.\n\nGagnon and the affiliated reporting persons is 1370 Avenue of the Americas, 26th Floor, New York, NY 10019.\n\n(5)Based solely on a Schedule 13G filed with the SEC on February 9, 2026, reporting beneficial ownership as of December 31, 2025, State\n\nStreet Corporation. reported beneficial ownership of 2,737,752 shares of our common stock, including (i) sole voting power over 2,737,752\n\nshares and (ii) sole dispositive power over 2,737,752 shares. The business address of State Street Corporation is One Congress Street, Suite\n\n1, Boston, MA 02114.\n\n(6)Represents (i) 54,784 shares of common stock held by Mr. Hanna, (ii) 29,196 shares underlying options to purchase shares of our common\n\nstock that are currently exercisable or will become exercisable within 60 days of March 31, 2026, and (iii) 188,847 shares underlying RSUs\n\nthat are scheduled to vest and settle within 60 days of March 31, 2026.\n\n(7)Represents (i) 19,369 shares of common stock held by Mr. Kennedy and (ii) 4,194 shares underlying options to purchase shares of our\n\ncommon stock that are currently exercisable or will become exercisable within 60 days of March 31, 2026, and (iii) 25,730 shares underlying\n\nRSUs that are scheduled to vest and settle within 60 days of March 31, 2026.\n\n(8)Represents (i) 15,590 shares of common stock held by Ms. Meng, (ii) 3,145 shares underlying options to purchase shares of our common\n\nstock that are currently exercisable or will become exercisable within 60 days of March 31, 2026, and (iii) 20,584 shares underlying RSUs that\n\nare scheduled to vest and settle within 60 days of March 31, 2026.\n\n(9)Represents (i) 33,513 shares of common stock held by Mr. Novack, (ii) 145 shares underlying options to purchase shares of our common\n\nstock that are currently exercisable or will become exercisable within 60 days of March 31, 2026, and (iii) 16,942 shares underlying RSUs that\n\nare scheduled to vest and settle within 60 days of March 31, 2026.\n\n90  |  2026 Proxy Statement\n\nCareDx Inc.\n\nSecurity Ownership of Certain Beneficial Owners and Management\n\n(10)Represents (i) 8,171 shares of common stock held by Mr. Smith. Based solely on the Company’s internal equity records as of March 31, 2026.\n\n(11)Represents (i) 253,824 shares of common stock held by Mr. Jain, (ii) 919 shares underlying options to purchase shares of our common stock\n\nthat are currently exercisable or will become exercisable within 60 days of March 31, 2026, and (iii) 18,525 shares underlying RSUs that are\n\nscheduled to vest and settle within 60 days of March 31, 2026. Based solely on the Company’s internal equity records as of March 31, 2026.\n\n(12)Represents (i) 145,358 shares of common stock held by Mr. Goldberg.\n\n(13)Represents (i) 132,163 shares of common stock held by Mr. Bickerstaff.\n\n(14)Represents (i) 143,162 shares of common stock held by Dr. Cohen.\n\n(15)Represents (i) 37,045 shares of common stock held by Ms. Cournoyer.\n\n(16)Represents (i) 296,743 shares of common stock held by Dr. Maag.\n\n(17)Represents (i) 15,132 shares of common stock held by Mr. Riggsbee and (ii) 542 shares underlying options to purchase shares of our\n\ncommon stock that are currently exercisable or will become exercisable within 60 days of March 31, 2026\n\n(18)Represents (i) 37,132 shares of common stock held by Mr. Torres.\n\n(19)Represents (i) 26,891 shares of common stock held by Dr. Valantine.\n\n(20)Represents (i) 956,882 shares of common stock held by our current directors and executive officers directly, (ii) 37,222 shares underlying\n\noptions to purchase shares of our common stock that are currently exercisable or will become exercisable within 60 days of March 31, 2026,\n\nand (iii) 252,103 shares underlying RSUs that are scheduled to vest and settle within 60 days of March 31, 2026. This excludes shares of\n\ncommon stock held by Messrs. Smith and Jain as they are not current officers as of March 31, 2026.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  91\n\nRelated Party Transactions\n\nSince January 1, 2025, there have not been any transactions or series of transactions, and there is currently no proposed\n\ntransaction, to which we were or are to be a participant in which the amount involved in the transaction or series of transactions\n\nexceeds $120,000, and in which any of our directors, executive officers or persons who we know held more than five percent of\n\nany class of our capital stock, including their immediate family members, had or will have a direct or indirect material interest, other\n\nthan compensation arrangements that are described under “Executive Compensation” above and the indemnification agreements\n\ndescribed below.\n\nIndemnification Agreements\n\nWe have also entered into indemnification agreements with our directors and certain of our executive officers. The indemnification\n\nagreements and the Certificate of Incorporation and Bylaws require us to indemnify our directors and officers to the fullest extent\n\npermitted by Delaware law.\n\nRule 10b5-1 Sales Plans\n\nOur directors and executive officers may adopt written plans, known as Rule 10b5-1 plans, in which they will contract with a broker\n\nto buy or sell shares of our common stock on a periodic basis. Under a Rule 10b5-1 plan, a broker executes trades pursuant to\n\nparameters established by the director or executive officer when entering into the plan, without further direction from them. Rule\n\n10b5-1 plans are subject to certain requirements, including a cooling-off period (the later of 90 days after plan adoption or the next\n\nquarterly earnings release, up to 120 days) before trading may commence, a prohibition on maintaining multiple overlapping plans,\n\nand a limit of one single-trade plan per 12-month period. The director or executive officer may amend a Rule 10b5-1 plan in some\n\ncircumstances and may terminate a plan at any time, subject to the terms of the plan. Our directors and executive officers also may\n\nbuy or sell additional shares outside of a Rule 10b5-1 plan when they are not in possession of material nonpublic information,\n\nsubject to compliance with the terms of our insider trading policy.\n\nPolicies and Procedures for Related Party Transactions\n\nOur Audit and Finance Committee adopted a formal written policy that our Audit and Finance Committee is responsible for\n\nreviewing “related party transactions.” A “related party transaction” is a transaction, arrangement, or relationship in which we\n\n(including any of our subsidiaries) and any “related party” were, are, or will be participants involving an amount that exceeds\n\n$120,000. For purposes of this policy, a related party is defined as a director, nominee for director, executive officer, or greater\n\nthan 5% beneficial owner of our common stock and their immediate family members, any entity in which such person is employed\n\nor is a general partner or principal and any entity where such person has a 5% or greater beneficial ownership interest.\n\nUnder this policy, all related party transactions may be consummated or continued only if approved or ratified by our Audit and\n\nFinance Committee. In determining whether to approve or ratify any such proposal, our Audit and Finance Committee will take into\n\naccount, among other factors it deems appropriate, (a) whether the transaction is on terms no less favorable than terms generally\n\navailable to an unaffiliated third party under the same or similar circumstances, and (b) the extent of the related party’s interest in\n\nthe transaction. The policy grants standing pre-approval of certain transactions, including (1) certain compensation arrangements\n\nof executive officers, (2) certain director compensation arrangements, (3) transactions with another company at which a related\n\nparty’s only relationship is as a non-executive employee, director or beneficial owner of less than 5% of that company’s shares,\n\n(4) transactions where a related party’s interest arises solely from the ownership of our common stock and all holders of our\n\ncommon stock received the same benefit on a pro rata basis, and (5) transactions available to all U.S. employees generally.\n\n92  |  2026 Proxy Statement\n\nCareDx Inc.\n\nOther Matters\n\nDelinquent Section 16(a) Reports\n\nSection 16(a) of the Exchange Act requires that our executive officers and directors, and persons who own more than 10% of our\n\ncommon stock, file reports of ownership and changes of ownership with the SEC. Such directors, executive officers and 10%\n\nstockholders are required by SEC regulation to furnish us with copies of all Section 16(a) forms they file.\n\nSEC regulations require us to identify in this proxy statement anyone who failed to file a timely required report during the most\n\nrecent fiscal year. Based solely upon our review of forms we received, or written representations from reporting persons stating that\n\nthey were not required to file these forms, we believe that during our fiscal year ended December 31, 2025, all Section 16(a) filing\n\nrequirements were satisfied on a timely basis, except that a late Form 4 was filed for Jeffrey Novack on July 14, 2025 due to\n\nadministrative error.\n\nAvailable Information\n\nOur financial statements for our fiscal year ended December 31, 2025 are included in our Annual Report on Form 10-K for the year\n\nended December 31, 2025. This proxy statement and our annual report are posted on the Investors section of our website at\n\ninvestors.caredxinc.com and are available from the SEC at its website at www.sec.gov. You may also obtain a copy of our annual\n\nreport without charge by sending a written request to CareDx, Inc., Attention: Investor Relations, 8000 Marina Boulevard, 4th Floor,\n\nBrisbane, California 94005.\n\nNote About Forward-Looking Statements\n\nThis proxy statement contains forward-looking statements that involve a number of risks and uncertainties. Words such as\n\n“believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” and similar expressions are intended to identify\n\nforward-looking statements. We have based these forward-looking statements largely on our current expectations and projections\n\nabout future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-\n\nterm and long-term business operations and objectives, and financial needs. These forward-looking statements are subject to a\n\nnumber of risks, uncertainties and assumptions, including those described in our Annual Report on Form 10-K for the year ended\n\nDecember 31, 2025. Moreover, we operate in a very competitive and rapidly changing environment. New risks emerge from time to\n\ntime. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the\n\nextent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any\n\nforward-looking statements we may make. In light of these risks, uncertainties and assumptions, the future events and trends\n\ndiscussed in this proxy statement may not occur and actual results could differ materially and adversely from those anticipated or\n\nimplied in the forward-looking statements. We undertake no obligation to revise or publicly release the results of any revision to\n\nthese forward-looking statements, except as required by law. Given these risks and uncertainties, readers are cautioned not to\n\nplace undue reliance on such forward-looking statements.\n\nHouseholding\n\nThe SEC has adopted rules that permit companies and intermediaries to satisfy the delivery requirements for Notice of Internet\n\nAvailability of Proxy Materials (the “Notice”) or other proxy materials with respect to two or more stockholders sharing the same\n\naddress by delivering a single notice or other annual meeting materials addressed to those stockholders. This process, which is\n\ncommonly referred to as householding, potentially provides extra convenience for stockholders and cost savings for companies.\n\nStockholders who participate in householding will continue to be able to access and receive separate proxy cards.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  93\n\nOther Matters\n\nA Notice will be delivered in one single envelope to multiple stockholders sharing an address unless contrary instructions have\n\nbeen received from one or more of the affected stockholders. If, at any time, you no longer wish to participate in householding and\n\nwould prefer to receive a separate Notice or other proxy materials, please notify your broker or call the Company’s Secretary at\n\n(415) 287-2300 or submit a request in writing to our Corporate Secretary, 8000 Marina Boulevard, 4th Floor, Brisbane,\n\nCalifornia 94005. Stockholders who currently receive multiple copies of the Notice or other proxy materials at their address and\n\nwould like to request householding of their communications should contact their broker. In addition, we will promptly deliver, upon\n\nwritten or oral request to the address or telephone number above, a separate copy of the Notice or other proxy materials to a\n\nstockholder at a shared address to which a single copy of the documents was delivered.\n\nCompany Website\n\nWe maintain a website at www.caredx.com. Information contained on, or that can be accessed through, our website is not intended\n\nto be incorporated by reference into this proxy statement, and references to our website address in this proxy statement are\n\ninactive textual references only.\n\nOur Board of Directors does not know of any other matters to be presented at the Annual Meeting. If any additional matters are\n\nproperly presented at the Annual Meeting, the persons named on the enclosed proxy card will have discretion to vote the shares of\n\ncommon stock they represent in accordance with their own judgment on such matters.\n\nIt is important that your shares of common stock be represented at the Annual Meeting, regardless of the number of shares that\n\nyou hold. You are, therefore, urged to vote over the Internet or by telephone as instructed on the proxy card or execute and return,\n\nat your earliest convenience, the proxy card.\n\nThe Board of Directors\n\nBrisbane, California\n\nApril 27, 2026\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-1\n\nAppendix A\n\n2024 Equity Incentive Plan\n\n1.GENERAL.\n\na.Plan Purpose. The Company, by means of the Plan, seeks to secure and retain the services of Employees,\n\nDirectors and Consultants, to provide incentives for such persons to exert maximum efforts for the success of the\n\nCompany and any Affiliate and to promote the creation of long-term value for the stockholders of the Company by\n\nclosely aligning the interests of such individuals with those of such stockholders.\n\nb.Available Awards. The Plan provides for the grant of the following Awards: (i) Incentive Stock Options;\n\n(ii) Nonstatutory Stock Options; (iii) SARs; (iv) Restricted Stock Awards; (v) RSU Awards; and (vi) Other Awards.\n\nc.Effective Date. The Plan will come into existence on the Effective Date.\n\n2.SHARES SUBJECT TO THE PLAN.\n\na.Share Reserve. Subject to adjustment in accordance with Section 2(c) and any adjustments as necessary to\n\nimplement any Capitalization Adjustments, the aggregate number of shares of Common Stock that may be issued\n\npursuant to Awards will not exceed 3,500,000 shares.\n\nb.Aggregate Incentive Stock Option Limit. Notwithstanding anything to the contrary in Section 2(a) and subject to\n\nany adjustments as necessary to implement any Capitalization Adjustments, the aggregate maximum number of\n\nshares of Common Stock that may be issued pursuant to the exercise of Incentive Stock Options is 3,500,000\n\nshares.\n\nc.Share Reserve Operation.\n\n(i)Limit Applies to Common Stock Issued Pursuant to Awards. For clarity, the Share Reserve is a limit on the\n\nnumber of shares of Common Stock that may be issued pursuant to Awards and does not limit the granting of\n\nAwards, except that the Company will keep available at all times the number of shares of Common Stock\n\nreasonably required to satisfy its obligations to issue shares pursuant to such Awards. Shares may be issued in\n\nconnection with a merger or acquisition as permitted by, as applicable, Nasdaq Listing Rule 5635(c), NYSE Listed\n\nCompany Manual Section 303A.08, NYSE American Company Guide Section 711 or other applicable rule, and\n\nsuch issuance will not reduce the number of shares available for issuance under the Plan. For the avoidance of\n\ndoubt, Awards that by their terms settle in cash shall not reduce the Share Reserve.\n\n(ii)Reversion of Previously Issued Shares of Common Stock to Share Reserve. If any Award is forfeited,\n\nexpires, terminates, otherwise lapses or is surrendered pursuant to an Exchange Program or otherwise settled for\n\ncash, in whole or in part, without the delivery of Shares, then the Shares covered by such forfeited, expired,\n\nterminated or lapsed Award or Award surrendered or settled in cash shall be added back to the Share Reserve\n\nand again become available for issuance under the Plan. For the avoidance of doubt, the following will not be\n\nadded back to the Share Reserve or again available for issuance under the Plan: (A) any Shares withheld in\n\nrespect of taxes, (B) any Shares tendered or withheld to pay the exercise price of Options, and (C) any Shares\n\nunderlying an Award of stock-settled SARs.\n\n3.ELIGIBILITY AND LIMITATIONS.\n\na.Eligible Award Recipients. Subject to the terms of the Plan, Employees, Directors and Consultants are eligible to\n\nreceive Awards.\n\nb.Specific Award Limitations.\n\n(i)Limitations on Incentive Stock Option Recipients. Incentive Stock Options may be granted only to Employees\n\nof the Company or a “parent corporation” or “subsidiary corporation” thereof (as such terms are defined in\n\nSections 424(e) and (f) of the Code).\n\nA-2  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\n(ii)Incentive Stock Option $100,000 Limitation. To the extent that the aggregate Fair Market Value (determined at\n\nthe time of grant) of Common Stock with respect to which Incentive Stock Options are exercisable for the first\n\ntime by any Participant during any calendar year (under all plans of the Company and any Affiliates) exceeds\n\n$100,000 (or such other limit established in the Code) or otherwise does not comply with the rules governing\n\nIncentive Stock Options, the Options or portions thereof that exceed such limit (according to the order in which\n\nthey were granted) or otherwise do not comply with such rules will be treated as Nonstatutory Stock Options,\n\nnotwithstanding any contrary provision of the applicable Award Agreement(s).\n\n(iii)Limitations on Incentive Stock Options Granted to Ten Percent Stockholders. A Ten Percent Stockholder\n\nmay not be granted an Incentive Stock Option unless (i) the exercise price of such Option is at least 110% of the\n\nFair Market Value on the date of grant of such Option and (ii) the Option is not exercisable after the expiration of\n\nfive years from the date of grant of such Option.\n\n(iv)Limitations on Nonstatutory Stock Options and SARs. Nonstatutory Stock Options and SARs may not be\n\ngranted to Employees, Directors and Consultants who are providing Continuous Service unless the stock\n\nunderlying such Awards is treated as “service recipient stock” under Section 409A or unless such Awards\n\notherwise comply with the distribution requirements of Section 409A or is not subject to Section 409A.\n\nc.Aggregate Incentive Stock Option Limit. The aggregate maximum number of shares of Common Stock that may\n\nbe issued pursuant to the exercise of Incentive Stock Options is the number of shares specified in Section 2(b).\n\nd.Non-Employee Director Compensation Limit. The aggregate value of all compensation granted or paid, as\n\napplicable, in each case following the Effective Date, to any individual for service as a Non-Employee Director with\n\nrespect to any fiscal year, including Awards granted and cash fees paid by the Company to such Non-Employee\n\nDirector for his or her service as a Non-Employee Director, will not exceed (i) $750,000 in total value or (ii) in the\n\nevent such Non-Employee Director is first appointed or elected to the Board during such fiscal year, $1,500,000 in\n\ntotal value, in each case calculating the value of any equity awards based on the grant date fair value of such equity\n\nawards for financial reporting purposes. For the avoidance of doubt, any Awards granted and cash fees paid to a\n\nNon-Employee Director for his or her service as a Non-Employee Director in respect of any fiscal year shall count\n\nagainst the compensation limits set forth in this Section 3(d) for the fiscal year to which such Awards and fees relate,\n\nregardless of any deferral of such Awards or fees.\n\ne.Minimum Vesting. Notwithstanding the Board’s discretion to determine the vesting schedule applicable to an\n\nAward, all Awards, and all portions of Awards, shall be subject to a vesting schedule that provides that the Award\n\nshall not vest with respect to any of the covered shares of Common Stock prior to the one year anniversary of the\n\ndate of grant of the Award (or the date of commencement of employment or service, in the case of a grant made in\n\nconnection with a Participant’s commencement of employment or service); provided, however, that (i) Awards with\n\nrespect to 5% of the aggregate number of shares subject to the Share Reserve may be granted under the Plan to\n\nany one or more Participants (other than Officers) without respect to such minimum vesting provisions, (ii) vesting of\n\nany Award may accelerate pursuant to Section 6(c)(ii), (iii) Awards that vest on the earlier of the one-year\n\nanniversary of the date on which the Award was granted and the next annual meeting of stockholders (so long as\n\nsuch next annual meeting of stockholders is at least 50 weeks after the immediately preceding year’s annual\n\nmeeting of stockholders) may be granted to Non-Employee Directors without respect to such minimum vesting\n\nprovisions, and (iv) nothing herein shall prohibit the Board from accelerating the vesting of any Award in connection\n\nwith the termination of a Participant’s Continuous Service in exchange for a release of claims.\n\n4.OPTIONS AND STOCK APPRECIATION RIGHTS.\n\nEach Option and SAR will have such terms and conditions as determined by the Board. Each Option will be designated in\n\nwriting as an Incentive Stock Option or Nonstatutory Stock Option at the time of grant; provided, however, that if an Option is\n\nnot so designated or if an Option designated as an Incentive Stock Option fails to qualify as an Incentive Stock Option, then\n\nsuch Option will be a Nonstatutory Stock Option, and the shares purchased upon exercise of each type of Option will be\n\nseparately accounted for. Each SAR will be denominated in shares of Common Stock equivalents. The terms and conditions of\n\nseparate Options and SARs need not be identical; provided, however, that each Award Agreement will conform (through\n\nincorporation of provisions hereof by reference in the Award Agreement or otherwise) to the substance of each of the following\n\nprovisions:\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-3\n\nAppendix A\n\na.Term. Subject to Section 3(b) regarding Ten Percent Stockholders, no Option or SAR will be exercisable after the\n\nexpiration of ten years from the date of grant of such Award or such shorter period specified in the Award\n\nAgreement.\n\nb.Exercise or Strike Price. Subject to Section 3(b) regarding Ten Percent Stockholders, the exercise or strike price of\n\neach Option or SAR will not be less than 100% of the Fair Market Value on the date of grant of such Award.\n\nNotwithstanding the foregoing, an Option or SAR may be granted with an exercise or strike price lower than 100% of\n\nthe Fair Market Value on the date of grant of such Award if such Award is granted pursuant to an assumption of or\n\nsubstitution for another option or stock appreciation right pursuant to a corporate transaction and in a manner\n\nconsistent with the provisions of Sections 409A and, if applicable, 424(a) of the Code.\n\nc.Exercise Procedure and Payment of Exercise Price for Options. In order to exercise an Option, the Participant\n\nmust provide notice of exercise to the Plan Administrator in accordance with the procedures specified in the Award\n\nAgreement or otherwise provided by the Company. The Board has the authority to grant Options that do not permit\n\nall of the following methods of payment (or otherwise restrict the ability to use certain methods) and to grant Options\n\nthat require the consent of the Company to utilize a particular method of payment. The exercise price of an Option\n\nmay be paid, to the extent permitted by Applicable Law and as determined by the Board, by one or more of the\n\nfollowing methods of payment to the extent set forth in the Award Agreement:\n\n(i)by cash or check, bank draft or money order payable to the Company;\n\n(ii)pursuant to a “cashless exercise” program developed under Regulation T as promulgated by the U.S. Federal\n\nReserve Board that, prior to the issuance of the Common Stock subject to the Option, results in either the\n\nreceipt of cash (or check) by the Company or the receipt of irrevocable instructions to pay the exercise price to\n\nthe Company from the sales proceeds;\n\n(iii)by delivery to the Company (either by actual delivery or attestation) of shares of Common Stock that are already\n\nowned by the Participant free and clear of any liens, claims, encumbrances or security interests, with a Fair\n\nMarket Value on the date of exercise that does not exceed the exercise price, provided that (1) at the time of\n\nexercise the Common Stock is publicly traded, (2) any remaining balance of the exercise price not satisfied by\n\nsuch delivery is paid by the Participant in cash or other permitted form of payment, (3) such delivery would not\n\nviolate any Applicable Law or agreement restricting the redemption of the Common Stock, (4) any certificated\n\nshares are endorsed or accompanied by an executed assignment separate from certificate and (5) such shares\n\nhave been held by the Participant for any minimum period necessary to avoid adverse accounting treatment as\n\na result of such delivery;\n\n(iv)if the Option is a Nonstatutory Stock Option, by a “net exercise” arrangement pursuant to which the Company\n\nwill reduce the number of shares of Common Stock issuable upon exercise by the largest whole number of\n\nshares with a Fair Market Value on the date of exercise that does not exceed the exercise price, provided that\n\n(1) such shares used to pay the exercise price will not be exercisable thereafter and (2) any remaining balance\n\nof the exercise price not satisfied by such net exercise is paid by the Participant in cash or other permitted form\n\nof payment; or\n\n(v)in any other form of consideration that may be acceptable to the Board and permissible under Applicable Law.\n\nd.Exercise Procedure and Payment of Appreciation Distribution for SARs. In order to exercise any SAR, the\n\nParticipant must provide notice of exercise to the Plan Administrator in accordance with the Award Agreement. The\n\nappreciation distribution payable to a Participant upon the exercise of a SAR will not be greater than an amount\n\nequal to the excess of (i) the aggregate Fair Market Value on the date of exercise of a number of shares of Common\n\nStock equal to the number of Common Stock equivalents that are vested and being exercised under such SAR, over\n\n(ii) the strike price of such SAR. Such appreciation distribution may be paid to the Participant in the form of Common\n\nStock or cash (or any combination of Common Stock and cash) or in any other form of payment, as determined by\n\nthe Board and specified in the Award Agreement.\n\ne.Transferability. Options and SARs may not be transferred to third-party financial institutions for value. The Board\n\nmay impose such additional limitations on the transferability of an Option or SAR as it determines. In the absence of\n\nany such determination by the Board, the following restrictions on the transferability of Options and SARs will apply,\n\nprovided that, except as explicitly provided herein, neither an Option nor a SAR may be transferred for consideration,\n\nand provided, further, that if an Option is an Incentive Stock Option, such Option may be deemed to be a\n\nNonstatutory Stock Option as a result of such transfer:\n\nA-4  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\n(i)Restrictions on Transfer. An Option or SAR will not be transferable, except by will or by the laws of descent and\n\ndistribution, and will be exercisable during the lifetime of the Participant only by the Participant; provided,\n\nhowever, that the Board may permit transfer of an Option or SAR in a manner that is not prohibited by applicable\n\ntax and securities laws upon the Participant’s request, including to a trust if the Participant is considered to be the\n\nsole beneficial owner of such trust (as determined under Section 671 of the Code and applicable U.S. state law)\n\nwhile such Option or SAR is held in such trust, provided that the Participant and the trustee enter into a transfer\n\nand other agreements required by the Company.\n\n(ii)Domestic Relations Orders. Notwithstanding the foregoing, subject to the execution of transfer documentation\n\nin a format acceptable to the Company and subject to the approval of the Board or a duly authorized Officer, an\n\nOption or SAR may be transferred pursuant to a domestic relations order.\n\nf.Vesting. The Board may impose such restrictions on or conditions to the vesting and/or exercisability of an Option or\n\nSAR as determined by the Board and vesting conditions may include achievement of one or more Performance\n\nGoals. Except as otherwise determined by the Board or provided in the applicable Award Agreement or other written\n\nagreement between a Participant and the Company, vesting of Options and SARs will cease upon termination of the\n\nParticipant’s Continuous Service.\n\ng.Termination of Continuous Service for Cause. Except as otherwise determined by the Board or explicitly provided\n\nin the Award Agreement or other written agreement between a Participant and the Company, if a Participant’s\n\nContinuous Service is terminated for Cause, the Participant’s Options and SARs will terminate and be forfeited\n\nimmediately upon such termination of Continuous Service, and the Participant will be prohibited from exercising any\n\nportion (including any vested portion) of such Awards on and after the date of such termination of Continuous\n\nService and the Participant will have no further right, title or interest in such forfeited Award, the shares of Common\n\nStock subject to the forfeited Award, or any consideration in respect of the forfeited Award. If a Participant is\n\nsuspended pending investigation of whether his or her Continuous Service shall be terminated for Cause, the\n\nParticipant’s rights to exercise an Option or SAR shall be suspended during the investigation period.\n\nh.Post-Termination Exercise Period Following Termination of Continuous Service for Reasons Other than\n\nCause. Subject to Section 4(i), if a Participant’s Continuous Service terminates for any reason other than for Cause,\n\nthe Participant may exercise his or her Option or SAR to the extent vested, but only within the following period of\n\ntime or, if applicable, such other period of time determined by the Board or provided in the Award Agreement or\n\nother written agreement between a Participant and the Company; provided, however, that in no event may such\n\nAward be exercised after the expiration of its maximum term (as set forth in Section 4(a)):\n\n(i)3 months following the date of such termination if such termination is a termination without Cause (other than\n\nany termination due to the Participant’s Disability or death); or\n\n(ii)12 months following the date of such termination if such termination is due to the Participant’s Disability or the\n\nParticipant’s death (or if the Participant’s death occurs following the date of such termination but during the\n\nperiod such Award is otherwise exercisable (as provided in (i) above)).\n\nFollowing the date of such termination, to the extent the Participant does not exercise such Award within the applicable\n\nPost-Termination Exercise Period (or, if earlier, prior to the expiration of the maximum term of such Award), such\n\nunexercised portion of the Award will terminate, and the Participant will have no further right, title or interest in\n\nterminated Award, the shares of Common Stock subject to the terminated Award, or any consideration in respect of\n\nthe terminated Award.\n\ni.Restrictions on Exercise; Extension of Exercisability. A Participant may not exercise an Option or SAR at any\n\ntime that the issuance of shares of Common Stock upon such exercise would violate Applicable Law. Except as\n\notherwise determined by the Board or provided in the Award Agreement or other written agreement between a\n\nParticipant and the Company, if a Participant’s Continuous Service terminates for any reason other than for Cause\n\nand, at any time during the last thirty days of the applicable Post-Termination Exercise Period: (i) the exercise of the\n\nParticipant’s Option or SAR would be prohibited solely because the issuance of shares of Common Stock upon such\n\nexercise would violate Applicable Law, (ii) the immediate sale of any shares of Common Stock issued upon such\n\nexercise would violate the Company’s Trading Policy or (iii) the Board has suspended exercisability under Section\n\n7(b), then the applicable Post-Termination Exercise Period will be extended to the last day of the calendar month\n\nthat commences following the date the Award would otherwise expire, with an additional extension of the exercise\n\nperiod to the last day of the next calendar month to apply if any of the foregoing restrictions apply at any time during\n\nsuch extended exercise period, generally without limitation as to the maximum permitted number of extensions;\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-5\n\nAppendix A\n\nprovided, however, that in no event may such Award be exercised after the expiration of its maximum term (as set\n\nforth in Section 4(a)).\n\nj.Non-Exempt Employees. No Option or SAR, whether or not vested, granted to an Employee who is a non-exempt\n\nemployee for purposes of the Fair Labor Standards Act of 1938, as amended, will be first exercisable for any shares\n\nof Common Stock until at least six months following the date of grant of such Award. Notwithstanding the foregoing,\n\nin accordance with the provisions of the Worker Economic Opportunity Act, any vested portion of such Award may\n\nbe exercised earlier than six months following the date of grant of such Award in the event of (i) such Participant’s\n\ndeath or Disability, (ii) a corporate transaction in which such Award is not assumed, continued or substituted, (iii) a\n\nChange in Control, or (iv) such Participant’s retirement (as such term may be defined in the Award Agreement or\n\nanother applicable agreement between the Employee and the Company or one of its Affiliates or, in the absence of\n\nany such definition, in accordance with the Company’s then current employment policies and guidelines). This\n\nSection 4(j) is intended to operate so that any income derived by a non-exempt employee in connection with the\n\nexercise or vesting of an Option or SAR will be exempt from his or her regular rate of pay.\n\nk.Whole Shares. Options and SARs may be exercised only with respect to whole shares of Common Stock or their\n\nequivalents.\n\nl.Rights as a Stockholder. Dividends and dividend equivalents may not be paid or credited to Options or SARs, and\n\na Participant shall have no rights to dividends, dividend equivalents or distributions or any other rights of a\n\nstockholder with respect to the Shares subject to an Option or SAR until the Participant has given written notice of\n\nthe exercise thereof, has paid in full for such Shares and has satisfied the requirements of Section 4(c) or 4(d), as\n\napplicable.\n\n5.AWARDS OTHER THAN OPTIONS AND STOCK APPRECIATION RIGHTS.\n\na.Restricted Stock Awards and RSU Awards. Each Restricted Stock Award and RSU Award will have such terms\n\nand conditions as determined by the Board; provided, however, that each Restricted Stock Award Agreement and\n\nRSU Award Agreement will conform (through incorporation of the provisions hereof by reference in the Award\n\nAgreement or otherwise) to the substance of each of the following provisions:\n\n(i)Form of Award.\n\n(1)RSAs: To the extent consistent with the Company’s Bylaws, at the Board’s election, shares of Common Stock\n\nsubject to a Restricted Stock Award may be (i) held in book entry form subject to the Company’s instructions\n\nuntil such shares become vested or any other restrictions lapse, or (ii) evidenced by a certificate, which\n\ncertificate will be held in such form and manner as determined by the Board. Unless otherwise determined by\n\nthe Board, a Participant will have voting and other rights as a stockholder of the Company with respect to any\n\nshares subject to a Restricted Stock Award.\n\n(2)RSUs: A RSU Award represents a Participant’s right to be issued on a future date the number of shares of\n\nCommon Stock that is equal to the number of restricted stock units subject to the RSU Award. As a holder of a\n\nRSU Award, a Participant is an unsecured creditor of the Company with respect to the Company’s unfunded\n\nobligation, if any, to issue shares of Common Stock in settlement of such Award and nothing contained in the\n\nPlan or any Award Agreement, and no action taken pursuant to its provisions, will create or be construed to\n\ncreate a trust of any kind or a fiduciary relationship between a Participant and the Company or an Affiliate or\n\nany other person. A Participant will not have voting or any other rights as a stockholder of the Company with\n\nrespect to any RSU Award (unless and until shares are actually issued in settlement of a vested RSU Award).\n\n(ii)Consideration.\n\n(1)RSA: A Restricted Stock Award may be granted in consideration for (A) cash or check, bank draft or money\n\norder payable to the Company, (B) past services to the Company or an Affiliate, or (C) any other form of\n\nconsideration as the Board may determine and permissible under Applicable Law.\n\n(2)RSU: Unless otherwise determined by the Board at the time of grant, a RSU Award will be granted in\n\nconsideration for the Participant’s services to the Company or an Affiliate, such that the Participant will not be\n\nrequired to make any payment to the Company (other than such services) with respect to the grant or vesting\n\nof the RSU Award, or the issuance of any shares of Common Stock pursuant to the RSU Award. If, at the time\n\nof grant, the Board determines that any consideration must be paid by the Participant (in a form other than the\n\nParticipant’s services to the Company or an Affiliate) upon the issuance of any shares of Common Stock in\n\nA-6  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\nsettlement of the RSU Award, such consideration may be paid in any form of consideration as the Board may\n\ndetermine and permissible under Applicable Law.\n\n(iii)Vesting. The Board may impose such restrictions on or conditions to the vesting of a Restricted Stock Award or\n\nRSU Award as determined by the Board, which may include achievement of one or more Performance Goals.\n\nExcept as otherwise determined by the Board or provided in the Award Agreement or other written agreement\n\nbetween a Participant and the Company or an Affiliate, vesting of Restricted Stock Awards and RSU Awards will\n\ncease upon termination of the Participant’s Continuous Service.\n\n(iv)Termination of Continuous Service. Except as otherwise determined by the Board or provided in the Award\n\nAgreement or other written agreement between a Participant and the Company, if a Participant’s Continuous\n\nService terminates for any reason, (i) the Company may receive through a forfeiture condition or a repurchase\n\nright any or all of the shares of Common Stock held by the Participant under his or her Restricted Stock Award\n\nthat have not vested as of the date of such termination as set forth in the Restricted Stock Award Agreement\n\nand (ii) any portion of his or her RSU Award that has not vested will be forfeited upon such termination and the\n\nParticipant will have no further right, title or interest in the RSU Award, the shares of Common Stock issuable\n\npursuant to the RSU Award, or any consideration in respect of the RSU Award; provided, however, that if the\n\nCompany has a contingent contractual obligation to provide for accelerated vesting of a Participant’s Restricted\n\nStock Award or RSU Award after termination of the Participant’s Continuous Service, the unvested portion of\n\nsuch Award subject to potential acceleration shall remain outstanding until the maximum contractual time for\n\ndetermining whether such contingency will occur, and terminate at such time if the contingency has not then\n\noccurred.\n\n(v)Dividends and Dividend Equivalents. Dividends or dividend equivalents may be paid or credited, as\n\napplicable, with respect to any shares of Common Stock subject to a Restricted Stock Award or RSU Award,\n\nsubject to the same restrictions on transferability and forfeitability as the underlying Award with respect to which\n\nsuch dividends or dividend equivalents are granted and subject to such other terms and conditions as\n\ndetermined by the Board and specified in the Award Agreement.\n\n(vi)Settlement of RSU Awards. A RSU Award may be settled by the issuance of shares of Common Stock or cash\n\n(or any combination thereof) or in any other form of payment, as determined by the Board and specified in the\n\nRSU Award Agreement. At the time of grant, the Board may determine to impose such restrictions or conditions\n\nthat delay such delivery to a date following the vesting of the RSU Award in a manner intended to comply with\n\nSection 409A, as applicable.\n\nb.Other Awards. Other Awards may be granted either alone or in addition to Awards provided for under Section 4 and\n\nthe preceding provisions of this Section 5. Subject to the provisions of the Plan, the Board will have sole and\n\ncomplete discretion to determine the persons to whom and the time or times at which such Other Awards will be\n\ngranted, the number of shares of Common Stock (or the cash equivalent thereof) to be granted pursuant to such\n\nOther Awards and all other terms and conditions of such Other Awards (including the form of settlement, which may\n\nbe in the form of Common Stock, cash or other form of payment).\n\n6.ADJUSTMENTS UPON CHANGES IN COMMON STOCK; OTHER CORPORATE EVENTS.\n\na.Capitalization Adjustments. In the event of a Capitalization Adjustment, the Board shall appropriately and\n\nproportionately adjust: (i) the class(es) and maximum number of shares of Common Stock subject to the Plan, (ii) the\n\nclass(es) and maximum number of shares that may be issued pursuant to the exercise of Incentive Stock Options\n\npursuant to Section 2(b), and (iii) the class(es) and number of securities and exercise price, strike price or purchase\n\nprice of Common Stock subject to outstanding Awards. The Board shall make such adjustments, and its\n\ndetermination shall be final, binding and conclusive. Notwithstanding the foregoing, no fractional shares or rights for\n\nfractional shares of Common Stock shall be created in order to implement any Capitalization Adjustment. The Board\n\nshall determine an appropriate equivalent benefit, if any, for any fractional shares or rights to fractional shares that\n\nmight be created by the adjustments referred to in the preceding provisions of this Section.\n\nb.Dissolution or Liquidation. Except as otherwise determined by the Board or provided in the Award Agreement, in\n\nthe event of a dissolution or liquidation of the Company, all outstanding Awards (other than Awards consisting of\n\nvested and outstanding shares of Common Stock not subject to a forfeiture condition or the Company’s right of\n\nrepurchase) will terminate immediately prior to the completion of such dissolution or liquidation, and the shares of\n\nCommon Stock subject to the Company’s repurchase rights or subject to a forfeiture condition may be repurchased\n\nor reacquired by the Company notwithstanding the fact that the holder of such Award is providing Continuous\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-7\n\nAppendix A\n\nService, provided, however, that the Board may determine to cause some or all Awards to become fully vested,\n\nexercisable and/or no longer subject to repurchase or forfeiture (to the extent such Awards have not previously\n\nexpired or terminated) before the dissolution or liquidation is completed but contingent on its completion.\n\nc.Change in Control. All Awards outstanding on the effective date of a Change in Control shall be treated in the\n\nmanner described in the definitive agreement evidencing the Change in Control (or, in the event that the Change in\n\nControl is not effected pursuant to a definitive agreement to which the Company is party, in the manner determined\n\nby the Board, with such determination having final and binding effect on all parties), which agreement or\n\ndetermination need not treat all Awards (or portions thereof) in an identical manner. Unless an Award Agreement\n\nprovides otherwise, without limiting the prior sentence, the treatment specified in the transaction agreement or by the\n\nBoard may include (without limitation) one or more of the following with respect to each outstanding Award:\n\n(i)Awards May Be Assumed. In the event of a Change in Control, any surviving corporation or acquiring\n\ncorporation (or the surviving or acquiring corporation’s parent company) may assume or continue any or all\n\nAwards outstanding under the Plan or may substitute similar awards for Awards outstanding under the Plan\n\n(including but not limited to, awards to acquire the same consideration paid to the stockholders of the Company\n\npursuant to the Change in Control), and any reacquisition or repurchase rights held by the Company in respect\n\nof Common Stock issued pursuant to Awards may be assigned by the Company to the successor of the\n\nCompany (or the successor’s parent company, if any), in connection with such Change in Control. A surviving\n\ncorporation or acquiring corporation (or its parent) may choose to assume or continue only a portion of an Award\n\nor substitute a similar award for only a portion of an Award, or may choose to assume or continue the Awards\n\nheld by some, but not all Participants. The terms of any assumption, continuation or substitution will be set by\n\nthe Board.\n\n(ii)Awards Held by Current Participants. In the event of a Change in Control in which the surviving corporation or\n\nacquiring corporation (or its parent company) does not assume or continue such outstanding Awards or\n\nsubstitute similar awards for such outstanding Awards, then with respect to Awards that have not been\n\nassumed, continued or substituted and that are held by Participants whose Continuous Service has not\n\nterminated prior to the effective time of the Change in Control (referred to as the “Current Participants”), the\n\nvesting of such Awards (and, with respect to Options and Stock Appreciation Rights, the time when such Awards\n\nmay be exercised) will be accelerated in full to a date prior to the effective time of such Change in Control\n\n(contingent upon the effectiveness of the Change in Control) as the Board determines (or, if the Board does not\n\ndetermine such a date, to the date that is five days prior to the effective time of the Change in Control), and such\n\nAwards will terminate if not exercised (if applicable) at or prior to the effective time of the Change in Control, and\n\nany reacquisition or repurchase rights held by the Company with respect to such Awards will lapse (contingent\n\nupon the effectiveness of the Change in Control). With respect to the vesting of Awards with performance-based\n\nvesting that will accelerate upon the occurrence of a Change in Control pursuant to this subsection (ii) and that\n\nhave multiple vesting levels depending on the level of performance, unless otherwise provided in the Award\n\nAgreement, the vesting of such Awards will accelerate at 100% of the target level upon the occurrence of the\n\nChange in Control (or such greater level as determined by the Board). With respect to the vesting of Awards that\n\nwill accelerate upon the occurrence of a Change in Control pursuant to this subsection (ii) and are settled in the\n\nform of a cash payment, such cash payment will be made no later than 30 days following the occurrence of the\n\nChange in Control or such later date as required to comply with Section 409A.\n\n(iii)Awards Held by Persons other than Current Participants. In the event of a Change in Control in which the\n\nsurviving corporation or acquiring corporation (or its parent company) does not assume or continue such\n\noutstanding Awards or substitute similar awards for such outstanding Awards, then with respect to Awards that\n\nhave not been assumed, continued or substituted and that are held by persons other than Current Participants,\n\nsuch Awards will terminate if not exercised (if applicable) prior to the occurrence of the Change in Control;\n\nprovided, however, that any reacquisition or repurchase rights held by the Company with respect to such\n\nAwards will not terminate and may continue to be exercised notwithstanding the Change in Control.\n\n(iv)Payment for Awards in Lieu of Exercise. Notwithstanding the foregoing, in the event an Award will terminate if\n\nnot exercised prior to the effective time of a Change in Control, the Board may provide, in its sole discretion, that\n\nthe holder of such Award may not exercise such Award but will receive a payment, in such form as may be\n\ndetermined by the Board, equal in value, at the effective time, to the excess, if any, of (1) the value of the\n\nproperty the Participant would have received upon the exercise of the Award (including, at the discretion of the\n\nBoard, any unvested portion of such Award), over (2) any exercise price payable by such holder in connection\n\nwith such exercise; for clarity, an Award may be cancelled without payment of any consideration if the value of\n\nsuch property is equal to or less than the exercise price.\n\nA-8  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\nd.Appointment of Stockholder Representative. As a condition to the receipt of an Award under this Plan, a\n\nParticipant will be deemed to have agreed that the Award will be subject to the terms of any agreement governing a\n\nChange in Control involving the Company, including, without limitation, a provision for the appointment of a\n\nstockholder representative that is authorized to act on the Participant’s behalf with respect to any escrow,\n\nindemnities and any contingent consideration.\n\ne.No Restriction on Right to Undertake Transactions. The grant of any Award under the Plan and the issuance of\n\nshares pursuant to any Award does not affect or restrict in any way the right or power of the Company or the\n\nstockholders of the Company to make or authorize any adjustment, recapitalization, reorganization or other change\n\nin the Company’s capital structure or its business, any merger or consolidation of the Company, any issue of stock or\n\nof options, rights or options to purchase stock or of bonds, debentures, preferred or prior preference stocks whose\n\nrights are superior to or affect the Common Stock or the rights thereof or which are convertible into or exchangeable\n\nfor Common Stock, or the dissolution or liquidation of the Company, or any sale or transfer of all or any part of its\n\nassets or business, or any other corporate act or proceeding, whether of a similar character or otherwise.\n\n7.ADMINISTRATION.\n\na.Administration by Board. The Board will administer the Plan unless and until the Board delegates administration of\n\nthe Plan to a Committee or Committees, as provided in subsection (c) below.\n\nb.Powers of Board. The Board will have the power, subject to, and within the limitations of, the express provisions of\n\nthe Plan:\n\n(i)To determine from time to time: (1) which of the persons eligible under the Plan will be granted Awards;\n\n(2) when and how each Award will be granted; (3) what type or combination of types of Award will be granted;\n\n(4) the provisions of each Award granted (which need not be identical), including the time or times when a\n\nperson will be permitted to receive an issuance of Common Stock or other payment pursuant to an Award (and\n\nwhether and to what degree any applicable Performance Goals have been attained); (5) the number of shares\n\nof Common Stock or cash equivalent with respect to which an Award will be granted to each such person;\n\n(6) the Fair Market Value applicable to an Award; and (7) the terms of any Award with performance-based\n\nvesting that is not valued in whole or in part by reference to, or otherwise based on, the Common Stock,\n\nincluding the amount of cash payment or other property that may be earned and the timing of payment.\n\n(ii)To construe and interpret the Plan and Awards granted under it, and to establish, amend and revoke rules and\n\nregulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or\n\ninconsistency in the Plan or in any Award Agreement, in a manner and to the extent it deems necessary or\n\nexpedient to make the Plan or Award fully effective.\n\n(iii)To settle all controversies regarding the Plan and Awards granted under it.\n\n(iv)To accelerate the time at which an Award may first be exercised or the time during which an Award or any part\n\nthereof will vest, notwithstanding the provisions in the Award Agreement stating the time at which it may first be\n\nexercised or the time during which it will vest.\n\n(v)To prohibit the exercise of any Option, SAR or other exercisable Award during a period of up to 30 days prior to\n\nthe consummation of any pending stock dividend, stock split, combination or exchange of shares, merger,\n\nconsolidation or other distribution (other than normal cash dividends) of Company assets to stockholders, or\n\nany other change affecting the shares of Common Stock or the share price of the Common Stock including any\n\nChange in Control, for reasons of administrative convenience or in connection with any other event pursuant to\n\nwhich the Board determines prohibition of exercise is necessary or reasonable.\n\n(vi)To suspend or terminate the Plan at any time. Suspension or termination of the Plan will not Materially Impair\n\nrights and obligations under any Award granted while the Plan is in effect except with the written consent of the\n\naffected Participant.\n\n(vii)To amend the Plan in any respect the Board deems necessary or advisable; provided, however, that\n\nstockholder approval will be required for any amendment to the extent required by Applicable Law. Except as\n\nprovided above, rights under any Award granted before amendment of the Plan will not be Materially Impaired\n\nby any amendment of the Plan unless (1) the Company requests the consent of the affected Participant, and\n\n(2) such Participant consents in writing.\n\n(viii)To submit any amendment to the Plan for stockholder approval.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-9\n\nAppendix A\n\n(ix)To institute and determine the terms and conditions of an Exchange Program; provided that the Board shall not\n\nimplement an Exchange Program without stockholder approval.\n\n(x)To approve forms of Award Agreements for use under the Plan and to amend the terms of any one or more\n\nAwards, including, but not limited to, amendments to provide terms more favorable to the Participant than\n\npreviously provided in the Award Agreement, subject to any specified limits in the Plan that are not subject to\n\nBoard discretion; provided however, that, (1) the Board shall not, without stockholder approval, reduce the\n\nexercise or strike price of an Option or SAR (other than in connection with a Capitalization Adjustment) and, at\n\nany time when the exercise or strike price of an Option or SAR is above the Fair Market Value of a share of\n\nCommon Stock, the Board shall not, without stockholder approval, cancel and re-grant or exchange such\n\nOption or SAR for a new Award with a lower (or no) purchase price or for cash, and (2) a Participant’s rights\n\nunder any Award will not be Materially Impaired by any such amendment unless (A) the Company requests the\n\nconsent of the affected Participant, and (B) such Participant consents in writing.\n\n(xi)Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to\n\npromote the best interests of the Company and that are not in conflict with the provisions of the Plan or Awards.\n\n(xii)To adopt such procedures and sub-plans as are necessary or appropriate to permit and facilitate participation\n\nin the Plan by, or take advantage of specific tax treatment for Awards granted to, Employees, Directors or\n\nConsultants who are non-U.S. nationals or employed outside the United States (provided that Board approval\n\nwill not be necessary for immaterial modifications to the Plan or any Award Agreement to ensure or facilitate\n\ncompliance with the laws of the relevant non-U.S. jurisdiction).\n\nc.Delegation to Committee.\n\n(i)General. The Board may delegate some or all of the administration of the Plan to a Committee or Committees. If\n\nadministration of the Plan is delegated to a Committee, the Committee will have, in connection with the\n\nadministration of the Plan, the powers theretofore possessed by the Board that have been delegated to the\n\nCommittee, including the power to delegate to another Committee or a subcommittee of the Committee any of\n\nthe administrative powers the Committee is authorized to exercise (and references in this Plan to the Board will\n\nthereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the\n\nprovisions of the Plan, as may be adopted from time to time by the Board. Each Committee may retain the\n\nauthority to concurrently administer the Plan with the Committee or subcommittee to which it has delegated its\n\nauthority hereunder and may, at any time, revest in such Committee some or all of the powers previously\n\ndelegated. The Board will retain the authority to concurrently administer the Plan with any Committee and may,\n\nat any time, revest in the Board some or all of the powers previously delegated.\n\n(ii)Rule 16b-3 Compliance. To the extent an Award is intended to qualify for the exemption from Section 16(b) of\n\nthe Exchange Act that is available under Rule 16b-3 of the Exchange Act, the Award will be granted by the\n\nBoard or a Committee that consists solely of two or more Non-Employee Directors, as determined under\n\nRule 16b-3(b)(3) of the Exchange Act, and, thereafter, any action establishing or modifying the terms of the\n\nAward will be approved by the Board or a Committee meeting such requirements to the extent necessary for\n\nsuch exemption to remain available.\n\nd.Effect of Board’s Decision. All determinations, interpretations and constructions made by the Board or any\n\nCommittee in good faith will not be subject to review by any person and will be final, binding and conclusive on all\n\npersons.\n\ne.Delegation to an Officer. The Board or any Committee may delegate to one or more Officers the authority to do\n\none or both of the following (i) designate Employees who are not Officers to be recipients of Options and SARs (and,\n\nto the extent permitted by Applicable Law, other types of Awards) and, to the extent permitted by Applicable Law, the\n\nterms thereof, and (ii) determine the number of shares of Common Stock to be subject to such Awards granted to\n\nsuch Employees; provided, however, that the resolutions or charter adopted by the Board or any Committee\n\nevidencing such delegation will specify the total number of shares of Common Stock that may be subject to the\n\nAwards granted by such Officer and that such Officer may not grant an Award to himself or herself. Any such Awards\n\nwill be granted on the applicable form of Award Agreement most recently approved for use by the Board or the\n\nCommittee, unless otherwise provided in the resolutions approving the delegation of authority. Notwithstanding\n\nanything to the contrary herein, neither the Board nor any Committee may delegate to an Officer who is acting solely\n\nin the capacity of an Officer (and not also as a Director) the authority to determine the Fair Market Value.\n\nA-10  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\n8.TAX WITHHOLDING\n\na.Withholding Authorization. As a condition to acceptance of any Award under the Plan, a Participant authorizes\n\nwithholding from payroll and any other amounts payable to such Participant, and otherwise agrees to make\n\nadequate provision for (including), any sums required to satisfy any U.S. and/or non-U.S. federal, state, or local tax\n\nor social insurance contribution withholding obligations of the Company or an Affiliate, if any, which arise in\n\nconnection with the exercise, vesting or settlement of such Award, as applicable. Accordingly, a Participant may not\n\nbe able to exercise an Award even though the Award is vested, and the Company shall have no obligation to issue\n\nshares of Common Stock subject to an Award, unless and until such obligations are satisfied.\n\nb.Satisfaction of Withholding Obligation. To the extent permitted by the terms of an Award Agreement, the\n\nCompany may, in its sole discretion, satisfy any U.S. and/or non-U.S. federal, state or local tax or social insurance\n\nwithholding obligation relating to an Award by any of the following means or by a combination of such means:\n\n(i) causing the Participant to tender a cash payment; (ii) withholding shares of Common Stock from the shares of\n\nCommon Stock issued or otherwise issuable to the Participant in connection with the Award; (iii) withholding cash\n\nfrom an Award settled in cash; (iv) withholding payment from any amounts otherwise payable to the Participant;\n\n(v) by allowing a Participant to effectuate a “cashless exercise” pursuant to a program developed under Regulation T\n\nas promulgated by the U.S. Federal Reserve Board or (vi) by such other method as may be set forth in the Award\n\nAgreement.\n\nc.No Obligation to Notify or Minimize Taxes; No Liability to Claims. Except as required by Applicable Law, the\n\nCompany has no duty or obligation to any Participant to advise such holder as to the time or manner of exercising\n\nsuch Award. Furthermore, the Company has no duty or obligation to warn or otherwise advise such holder of a\n\npending termination or expiration of an Award or a possible period in which the Award may not be exercised. The\n\nCompany has no duty or obligation to minimize the tax consequences of an Award to the holder of such Award and\n\nwill not be liable to any holder of an Award for any adverse tax consequences to such holder in connection with an\n\nAward. As a condition to accepting an Award under the Plan, each Participant (i) agrees not to make any claim\n\nagainst the Company, or any of its Officers, Directors, Employees or Affiliates related to tax liabilities arising from\n\nsuch Award or other Company compensation and (ii) acknowledges that such Participant was advised to consult\n\nwith his or her own personal tax, financial and other legal advisors regarding the tax consequences of the Award and\n\nhas either done so or knowingly and voluntarily declined to do so. Additionally, each Participant acknowledges any\n\nOption or SAR granted under the Plan is exempt from Section 409A only if the exercise or strike price is at least\n\nequal to the “fair market value” of the Common Stock on the date of grant as determined by the Internal Revenue\n\nService and there is no other impermissible deferral of compensation associated with the Award. Additionally, as a\n\ncondition to accepting an Option or SAR granted under the Plan, each Participant agrees not to make any claim\n\nagainst the Company, or any of its Officers, Directors, Employees or Affiliates in the event that the U.S. Internal\n\nRevenue Service asserts that such exercise price or strike price is less than the “fair market value” of the Common\n\nStock on the date of grant as subsequently determined by the U.S. Internal Revenue Service.\n\nd.Withholding Indemnification. As a condition to accepting an Award under the Plan, in the event that the amount of\n\nthe Company’s and/or its Affiliate’s withholding obligation in connection with such Award was greater than the\n\namount actually withheld by the Company and/or its Affiliates, each Participant agrees to indemnify and hold the\n\nCompany and/or its Affiliates harmless from any failure by the Company and/or its Affiliates to withhold the proper\n\namount.\n\n9.MISCELLANEOUS.\n\na.Source of Shares; Fractional Shares. The stock issuable under the Plan will be shares of authorized but unissued\n\nor reacquired Common Stock, including shares repurchased by the Company on the open market or otherwise. No\n\nfractional shares of Common Stock will be issued or delivered pursuant to this Plan or any Award. The Board may\n\ndetermine whether cash, other Awards or other securities or property will be issued or paid in lieu of such fractional\n\nshares or whether such fractional shares or any rights thereto will be forfeited or otherwise eliminated.\n\nb.Use of Proceeds from Sales of Common Stock. Proceeds from the sale of shares of Common Stock pursuant to\n\nAwards will constitute general funds of the Company.\n\nc.Corporate Action Constituting Grant of Awards. Corporate action constituting a grant by the Company of an\n\nAward to any Participant will be deemed completed as of the date of such corporate action, unless otherwise\n\ndetermined by the Board, regardless of when the instrument, certificate, or letter evidencing the Award is\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-11\n\nAppendix A\n\ncommunicated to, or actually received or accepted by, the Participant. In the event that the corporate records (e.g.,\n\nBoard consents, resolutions or minutes) documenting the corporate action approving the grant contain terms (e.g.,\n\nexercise price, vesting schedule or number of shares) that are inconsistent with those in the Award Agreement or\n\nrelated grant documents as a result of a clerical error in the Award Agreement or related grant documents, the\n\ncorporate records will control and the Participant will have no legally binding right to the incorrect term in the Award\n\nAgreement or related grant documents.\n\nd.Stockholder Rights. No Participant will be deemed to be the holder of, or to have any of the rights of a holder with\n\nrespect to, any shares of Common Stock subject to such Award unless and until (i) such Participant has satisfied all\n\nrequirements for exercise of the Award pursuant to its terms, if applicable, and (ii) the issuance of the Common\n\nStock subject to such Award is reflected in the records of the Company.\n\ne.No Employment or Other Service Rights. Nothing in the Plan, any Award Agreement or any other instrument\n\nexecuted thereunder or in connection with any Award granted pursuant thereto will confer upon any Participant any\n\nright to continue to serve the Company or an Affiliate in the capacity in effect at the time the Award was granted or\n\naffect the right of the Company or an Affiliate to terminate at will and without regard to any future vesting opportunity\n\nthat a Participant may have with respect to any Award (i) the employment of an Employee with or without notice and\n\nwith or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultant’s agreement with the\n\nCompany or an Affiliate or (iii) the service of a Director pursuant to the Bylaws of the Company or an Affiliate, and\n\nany applicable provisions of the corporate law of the U.S. state or non-U.S. jurisdiction in which the Company or the\n\nAffiliate is incorporated, as the case may be. Further, nothing in the Plan, any Award Agreement or any other\n\ninstrument executed thereunder or in connection with any Award will constitute any promise or commitment by the\n\nCompany or an Affiliate regarding the fact or nature of future positions, future work assignments, future\n\ncompensation or any other term or condition of employment or service or confer any right or benefit under the Award\n\nor the Plan unless such right or benefit has specifically accrued under the terms of the Award Agreement and/or\n\nPlan.\n\nf.Change in Time Commitment. In the event a Participant’s regular level of time commitment in the performance of\n\nhis or her services for the Company and any Affiliates is reduced (for example, and without limitation, if the\n\nParticipant is an Employee of the Company and the Employee has a change in status from a full-time Employee to a\n\npart-time Employee or takes an extended leave of absence) after the date of grant of any Award to the Participant,\n\nthe Board may determine, to the extent permitted by Applicable Law and without the affected Participant’s consent,\n\nto (i) make a corresponding reduction in the number of shares or cash amount subject to any portion of such Award\n\nthat is scheduled to vest or become payable after the date of such change in time commitment, and (ii) in lieu of or in\n\ncombination with such a reduction, extend the vesting or payment schedule applicable to such Award. In the event of\n\nany such reduction, the Participant will have no right with respect to any portion of the Award that is so reduced or\n\nextended.\n\ng.Execution of Additional Documents. As a condition to accepting an Award under the Plan, the Participant agrees\n\nto execute any additional documents or instruments necessary or desirable, as determined in the Plan\n\nAdministrator’s sole discretion, to carry out the purposes or intent of the Award, or facilitate compliance with\n\nsecurities and/or other regulatory requirements, in each case at the Plan Administrator’s request.\n\nh.Electronic Delivery and Participation. Any reference herein or in an Award Agreement to a “written” agreement or\n\ndocument will include any agreement or document delivered electronically, filed publicly at www.sec.gov (or any\n\nsuccessor website thereto) or posted on the Company’s intranet (or other shared electronic medium controlled by\n\nthe Company to which the Participant has access). By accepting any Award the Participant consents to receive\n\ndocuments by electronic delivery and to participate in the Plan through any on-line electronic system established and\n\nmaintained by the Plan Administrator or another third party selected by the Plan Administrator. The form of delivery\n\nof any Common Stock (e.g., a stock certificate or electronic entry evidencing such shares) shall be determined by\n\nthe Company.\n\ni.Clawback/Recovery. All Awards granted under the Plan will be subject to recoupment in accordance with any\n\nclawback policy that the Company is required to adopt pursuant to the listing standards of any national\n\nsecurities exchange or association on which the Company’s securities are listed or as is otherwise required by\n\nthe Dodd-Frank Wall Street Reform and Consumer Protection Act or other Applicable Law and any clawback\n\npolicy that the Company otherwise adopts, to the extent applicable and permissible under Applicable Law. In\n\naddition, the Board may impose such other clawback, recovery or recoupment provisions in an Award\n\nAgreement as the Board determines necessary or appropriate, including but not limited to a reacquisition right\n\nA-12  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\nin respect of previously acquired shares of Common Stock or other cash or property upon the occurrence of\n\nCause. No recovery of compensation under such a clawback policy will be an event giving rise to a\n\nParticipant’s right to voluntarily terminate employment upon a “resignation for good reason,” or for a\n\n“constructive termination” or any similar term under any plan of or agreement with the Company or any of its\n\nAffiliates.\n\nj.Securities Law Compliance. A Participant will not be issued any shares in respect of an Award unless either (i) the\n\nshares are registered under the Securities Act; or (ii) the Company has determined that such issuance would be\n\nexempt from the registration requirements of the Securities Act. Each Award also must comply with other Applicable\n\nLaw governing the Award, and a Participant will not receive such shares if the Company determines that such\n\nreceipt would not be in material compliance with Applicable Law.\n\nk.Transfer or Assignment of Awards; Issued Shares. Except as otherwise determined by the Board or expressly\n\nprovided in the Plan or the form of Award Agreement, Awards granted under the Plan may not be transferred or\n\nassigned by the Participant. After the vested shares subject to an Award have been issued, or in the case of\n\nRestricted Stock Awards and similar awards, after the issued shares have vested, the holder of such shares is free\n\nto assign, hypothecate, donate, encumber or otherwise dispose of any interest in such shares provided that any\n\nsuch actions are in compliance with the provisions herein, the terms of the Trading Policy and Applicable Law.\n\nl.Effect on Other Employee Benefit Plans. The value of any Award granted under the Plan, as determined upon\n\ngrant, vesting or settlement, shall not be included as compensation, earnings, salaries, or other similar terms used\n\nwhen calculating any Participant’s benefits under any employee benefit plan sponsored by the Company or any\n\nAffiliate, except as such plan otherwise expressly provides. The Company expressly reserves its rights to amend,\n\nmodify, or terminate any of the Company’s or any Affiliate’s employee benefit plans.\n\nm.Deferrals. To the extent permitted by Applicable Law, the Board, in its sole discretion, may determine that the\n\ndelivery of Common Stock or the payment of cash, upon the exercise, vesting or settlement of all or a portion of any\n\nAward may be deferred and may establish programs and procedures for deferral elections to be made by\n\nParticipants. Deferrals will be made in accordance with the requirements of Section 409A.\n\nn.Section 409A. Unless otherwise expressly provided for in an Award Agreement, the Plan and Award Agreements\n\nwill be interpreted to the greatest extent possible in a manner that makes the Plan and the Awards granted\n\nhereunder exempt from Section 409A, and, to the extent not so exempt, in compliance with the requirements of\n\nSection 409A. If the Board determines that any Award granted hereunder is not exempt from and is therefore subject\n\nto Section 409A, the Award Agreement evidencing such Award will incorporate the terms and conditions necessary\n\nto avoid the consequences specified in Section 409A(a)(1) of the Code, and to the extent an Award Agreement is\n\nsilent on terms necessary for compliance, such terms are hereby incorporated by reference into the Award\n\nAgreement. Notwithstanding anything to the contrary in this Plan (and unless the Award Agreement specifically\n\nprovides otherwise), if the shares of Common Stock are publicly traded, and if a Participant holding an Award that\n\nconstitutes “deferred compensation” under Section 409A is a “specified employee” for purposes of Section 409A, no\n\ndistribution or payment of any amount that is due because of a “separation from service” (as defined in Section 409A\n\nwithout regard to alternative definitions thereunder) will be issued or paid before the date that is six months and one\n\nday following the date of such Participant’s “separation from service” or, if earlier, the date of the Participant’s death,\n\nunless such distribution or payment can be made in a manner that complies with Section 409A, and any amounts so\n\ndeferred will be paid in a lump sum on the day after such six month period elapses, with the balance paid thereafter\n\non the original schedule.\n\no.Choice of Law. This Plan and any controversy arising out of or relating to this Plan shall be governed by, and\n\nconstrued in accordance with, the internal laws of the State of Delaware, without regard to conflict of law principles\n\nthat would result in any application of any law other than the law of the State of Delaware.\n\np.Data Privacy. As a condition of receipt of any Award, each Participant explicitly and unambiguously acknowledges\n\nthat the Company and its Affiliates will process certain personal information about the Participant in accordance with\n\nthe provisions of the Company’s privacy notice, a copy of which can be obtained by the Participant by contacting his\n\nor her local human resources representative. Such personal information may include, but is not limited to, the\n\nParticipant’s name, home address, email address and telephone number, date of birth, social security or insurance\n\nnumber, passport number or other identification number, salary, nationality, job title, any shares or directorships held\n\nin the Company, and details of all Awards or any other entitlement to shares of Common Stock awarded, canceled,\n\nexercised, vested, unvested or outstanding in Participant’s favor (“Data”), for the exclusive purpose of implementing,\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-13\n\nAppendix A\n\nadministering and managing the Plan. In certain jurisdictions, the Participant’s consent is required in order for the\n\nparties to process Participant’s personal information for the purpose of implementing, administering and managing\n\nParticipant’s participation in the Plan pursuant to and in accordance with his or her Award Agreement. Where such\n\nconsent is required and without limiting any other specific consent provided by the Participant, including in any\n\nconsent provided in a separate document, the Participant explicitly and unambiguously consents to the collection,\n\nuse and transfer, in electronic or other form, of the Participant’s personal data as described herein and any other\n\napplicable Award grant materials by and among, as applicable, the Company or any of its Affiliates for the exclusive\n\npurpose of implementing, administering and managing the Participant’s participation in the Plan. The Participant\n\nunderstands that Data will be transferred to a stock plan service provider as may be selected by the Company from\n\ntime-to-time (the “Designated Broker”), which is assisting the Company with the implementation, administration and\n\nmanagement of the Plan. The Participant understands that the recipients of the Data may be located in the United\n\nStates or elsewhere, and that the recipient’s country of operation may have different data privacy laws and\n\nprotections than the Participant’s country. The Participant understands that if he or she resides outside the United\n\nStates, he or she may request a list with the names and addresses of any potential recipients of the Data by\n\ncontacting his or her local human resources representative. The Participant authorizes (where such authorization is\n\nrequired) the Company, the Designated Broker and any other possible recipients which may assist the Company\n\n(presently or in the future) with implementing, administering and managing the Plan to receive, possess, use, retain\n\nand transfer the Data, in electronic or other form, for the sole purpose of implementing, administering and managing\n\nhis or her participation in the Plan. The Participant understands that Data will be held only as long as is necessary to\n\nimplement, administer and manage his or her participation in the Plan. The Participant understands that if he or she\n\nresides outside the United States, he or she may, at any time, view Data, request additional information about the\n\nstorage and processing of Data, require any necessary amendments to Data or, where applicable, refuse or\n\nwithdraw the consents herein, in any case without cost, by contacting in writing his or her local human resources\n\nrepresentative. Further, the Participant understands that where his or her consent is required by applicable law, he\n\nor she is providing the consents on a purely voluntary basis. If the Participant does not consent, or if the Participant\n\nlater seeks to revoke his or her consent, his or her status as an Employee, Consultant or Director and career with the\n\nCompany and its Affiliates will not be adversely affected; the only adverse consequence of refusing or withdrawing\n\nthe Participant’s consent is that the Company would not be able to grant Awards to the Participant or administer or\n\nmaintain such Awards. Therefore, the Participant understands that refusing or withdrawing his or her consent may\n\naffect the Participant’s ability to participate in the Plan. For more information on the consequences of the\n\nParticipant’s refusal to consent or withdrawal of consent, the Participant understands that he or she may contact his\n\nor her local human resources representative.\n\n10.COMPLIANCE WITH LAW.\n\nThe Company will seek to obtain from each regulatory commission or agency, as may be deemed necessary, having\n\njurisdiction over the Plan such authority as may be required to grant Awards and to issue and sell shares of Common Stock\n\nupon exercise or vesting of the Awards; provided, however, that this undertaking will not require the Company to register under\n\nthe Securities Act the Plan, any Award or any Common Stock issued or issuable pursuant to any such Award. If, after\n\nreasonable efforts and at a reasonable cost, the Company is unable to obtain from any such regulatory commission or agency\n\nthe authority that counsel for the Company deems necessary or advisable for the lawful issuance and sale of Common Stock\n\nunder the Plan, the Company will be relieved from any liability for failure to issue and sell Common Stock upon exercise or\n\nvesting of such Awards unless and until such authority is obtained. A Participant is not eligible for the grant of an Award or the\n\nsubsequent issuance of Common Stock pursuant to the Award if such grant or issuance would be in violation of any Applicable\n\nLaw.\n\n11.SEVERABILITY.\n\nIf all or any part of the Plan or any Award Agreement is declared by any court or governmental authority to be unlawful or\n\ninvalid, such unlawfulness or invalidity shall not invalidate any portion of the Plan or such Award Agreement not declared to be\n\nunlawful or invalid. Any Section of the Plan or any Award Agreement (or part of such a Section) so declared to be unlawful or\n\ninvalid shall, if possible, be construed in a manner which will give effect to the terms of such Section or part of a Section to the\n\nfullest extent possible while remaining lawful and valid.\n\nA-14  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\n12.TERMINATION OF THE PLAN.\n\nThe Board may suspend or terminate the Plan at any time. No Incentive Stock Options may be granted after the tenth\n\nanniversary of the Effective Date. No Awards may be granted under the Plan while the Plan is suspended or after it is\n\nterminated.\n\n13.DEFINITIONS.\n\nAs used in the Plan, the following definitions apply to the capitalized terms indicated below:\n\n(a)“Affiliate” means, at the time of determination, any “parent” or “subsidiary” of the Company as such terms are\n\ndefined in Rule 405 promulgated under the Securities Act. The Board may determine the time or times at which\n\n“parent” or “subsidiary” status is determined within the foregoing definition.\n\n(b)“Applicable Law” means the Code and any applicable U.S. or non-U.S. securities, federal, state, material local or\n\nmunicipal or other law, statute, constitution, principle of common law, resolution, ordinance, code, edict, decree, rule,\n\nlisting rule, regulation, judicial decision, ruling or requirement issued, enacted, adopted, promulgated, implemented\n\nor otherwise put into effect by or under the authority of any Governmental Body (including under the authority of any\n\napplicable self-regulating organization such as The Nasdaq Stock Market LLC, the New York Stock Exchange or the\n\nFinancial Industry Regulatory Authority, Inc.).\n\n(c)“Award” means any right to receive Common Stock, cash or other property granted under the Plan (including an\n\nIncentive Stock Option, a Nonstatutory Stock Option, a Restricted Stock Award, a RSU Award, a SAR or any Other\n\nAward).\n\n(d)“Award Agreement” means a written agreement between the Company and a Participant evidencing the terms and\n\nconditions of an Award. The Award Agreement generally consists of the Grant Notice and the agreement containing\n\nthe written summary of the general terms and conditions applicable to the Award and which is provided to a\n\nParticipant along with the Grant Notice.\n\n(e)“Board” means the board of directors of the Company (or its designee). Any decision or determination made by the\n\nBoard shall be a decision or determination that is made in the sole discretion of the Board (or its designee), and such\n\ndecision or determination shall be final and binding on all Participants.\n\n(f)“Capitalization Adjustment” means any change that is made in, or other events that occur with respect to, the\n\nCommon Stock subject to the Plan or subject to any Award after the Effective Date without the receipt of\n\nconsideration by the Company through merger, consolidation, reorganization, recapitalization, reincorporation, stock\n\ndividend, dividend in property other than cash, large nonrecurring cash dividend, stock split, reverse stock split,\n\nliquidating dividend, combination of shares, exchange of shares, change in corporate structure or any similar equity\n\nrestructuring transaction, as that term is used in Statement of Financial Accounting Standards Board Accounting\n\nStandards Codification Topic 718 (or any successor thereto). Notwithstanding the foregoing, the conversion of any\n\nconvertible securities of the Company will not be treated as a Capitalization Adjustment.\n\n(g)“Cause” has the meaning ascribed to such term in any written agreement between the Participant and the Company\n\ndefining such term and, in the absence of such agreement, such term means, with respect to a Participant, the\n\noccurrence of any of the following events: (i) the Participant’s theft, dishonesty, willful misconduct, breach of fiduciary\n\nduty for personal profit, or intentional falsification of any Company or Affiliate documents or records; (ii) the\n\nParticipant’s material failure to abide by the Company’s Code of Conduct or other policies (including, without\n\nlimitation, policies relating to confidentiality and reasonable workplace conduct and policies of any Affiliate, as\n\napplicable); (iii) the Participant’s unauthorized use, misappropriation, destruction or diversion of any tangible or\n\nintangible asset or corporate opportunity of the Company or any of its Affiliates (including, without limitation, the\n\nParticipant’s improper use or disclosure of Company or Affiliate confidential or proprietary information); (iv) any\n\nintentional act by the Participant which has a material detrimental effect on the Company’s or its Affiliate’s reputation\n\nor business; (v) the Participant’s repeated failure or inability to perform any reasonable assigned duties after written\n\nnotice from the Company (or its Affiliate, as applicable) of, and a reasonable opportunity to cure, such failure or\n\ninability; (vi) any material breach by the Participant of any employment or service agreement between the Participant\n\nand the Company (or its Affiliate, as applicable), which breach is not cured pursuant to the terms of such agreement;\n\nor (vii) the Participant’s conviction (including any plea of guilty or nolo contendere) of any criminal act involving fraud,\n\ndishonesty, misappropriation or moral turpitude, or which impairs the Participant’s ability to perform his or her duties\n\nwith the Company (or its Affiliate, as applicable). The determination that a termination of the Participant’s Continuous\n\nService is either for Cause or without Cause will be made by the Board with respect to Participants who are\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-15\n\nAppendix A\n\nexecutive officers of the Company or members of the Board and by the Company’s Chief Executive Officer or his or\n\nher designee with respect to all other Participants. Any determination by the Company that the Continuous Service\n\nof a Participant was terminated with or without Cause for the purposes of outstanding Awards held by such\n\nParticipant will have no effect upon any determination of the rights or obligations of the Company or such Participant\n\nfor any other purpose.\n\n(h)“Change in Control” means the occurrence, in a single transaction or in a series of related transactions, of any one\n\nor more of the following events; provided, however, to the extent necessary to avoid adverse personal income tax\n\nconsequences to the Participant in connection with an Award, also constitutes a Section 409A Change in Control:\n\n(i)any Exchange Act Person becomes the Owner, directly or indirectly, of securities of the Company representing\n\nmore than 50% of the combined voting power of the Company’s then outstanding securities other than by virtue\n\nof a merger, consolidation or similar transaction. Notwithstanding the foregoing, a Change in Control shall not be\n\ndeemed to occur (A) on account of the acquisition of securities of the Company directly from the Company,\n\n(B) on account of the acquisition of securities of the Company by an investor, any affiliate thereof or any other\n\nExchange Act Person that acquires the Company’s securities in a transaction or series of related transactions\n\nthe primary purpose of which is to obtain financing for the Company through the issuance of equity securities, or\n\n(C) solely because the level of Ownership held by any Exchange Act Person (the “Subject Person”) exceeds\n\nthe designated percentage threshold of the outstanding voting securities as a result of a repurchase or other\n\nacquisition of voting securities by the Company reducing the number of shares outstanding, provided that if a\n\nChange in Control would occur (but for the operation of this sentence) as a result of the acquisition of voting\n\nsecurities by the Company, and after such share acquisition, the Subject Person becomes the Owner of any\n\nadditional voting securities that, assuming the repurchase or other acquisition had not occurred, increases the\n\npercentage of the then outstanding voting securities Owned by the Subject Person over the designated\n\npercentage threshold, then a Change in Control shall be deemed to occur;\n\n(ii)there is consummated a merger, consolidation or similar transaction involving (directly or indirectly) the\n\nCompany and, immediately after the consummation of such merger, consolidation or similar transaction, the\n\nstockholders of the Company immediately prior thereto do not Own, directly or indirectly, either (A) outstanding\n\nvoting securities representing more than 50% of the combined outstanding voting power of the surviving Entity in\n\nsuch merger, consolidation or similar transaction or (B) more than 50% of the combined outstanding voting\n\npower of the parent of the surviving Entity in such merger, consolidation or similar transaction, in each case in\n\nsubstantially the same proportions as their Ownership of the outstanding voting securities of the Company\n\nimmediately prior to such transaction;\n\n(iii)the stockholders of the Company approve or the Board approves a plan of complete dissolution or liquidation of\n\nthe Company, or a complete dissolution or liquidation of the Company shall otherwise occur, except for a\n\nliquidation into a parent corporation;\n\n(iv)there is consummated a sale, lease, exclusive license or other disposition of all or substantially all of the\n\nconsolidated assets of the Company and its Subsidiaries, other than a sale, lease, license or other disposition of\n\nall or substantially all of the consolidated assets of the Company and its Subsidiaries to an Entity, at least 50%\n\nof the combined voting power of the voting securities of which are Owned by stockholders of the Company in\n\nsubstantially the same proportions as their Ownership of the outstanding voting securities of the Company\n\nimmediately prior to such sale, lease, license or other disposition; or\n\n(v)during any period of 12 consecutive months, individuals who, on the date the Plan is adopted by the Board, are\n\nmembers of the Board (the “Incumbent Board”) cease for any reason to constitute at least a majority of the\n\nmembers of the Board; provided, however, that if the appointment or election (or nomination for election) of any\n\nnew Board member was approved or recommended by a majority vote of the members of the Incumbent Board\n\nthen still in office, such new member shall, for purposes of this Plan, be considered as a member of the\n\nIncumbent Board and that no individual initially elected or nominated as a member of the Board as a result of an\n\nactual or threatened election contest with respect to the election or removal of directors or other actual or\n\nthreatened solicitation of proxies or consents by or on behalf of any person other than the Board (a “Proxy\n\nContest”), including by reason of any agreement intended to avoid or settle any Proxy Contest, shall be\n\nconsidered to be a member of the Incumbent Board.\n\nNotwithstanding the foregoing or any other provision of this Plan, (A) the term Change in Control shall not include a\n\nsale of assets, merger or other transaction effected exclusively for the purpose of changing the domicile of the\n\nCompany, and (B) the definition of Change in Control (or any analogous term) in an individual written agreement\n\nA-16  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\nbetween the Company or any Affiliate and the Participant shall supersede the foregoing definition with respect to\n\nAwards subject to such agreement; provided, however, that if no definition of Change in Control or any analogous term\n\nis set forth in such an individual written agreement, the foregoing definition shall apply.\n\n(i)“Code” means the U.S. Internal Revenue Code of 1986, as amended, including any applicable regulations and\n\nguidance thereunder.\n\n(j)“Committee” means the Compensation Committee and any other committee of one or more Directors to whom\n\nauthority has been delegated by the Board or Compensation Committee in accordance with the Plan.\n\n(k)“Common Stock” means the common stock, par value $0.001 per share, of the Company.\n\n(l)“Company” means CareDx, Inc., a Delaware corporation, and any successor corporation thereto.\n\n(m)“Compensation Committee” means the Compensation Committee of the Board.\n\n(n)“Consultant” means any person, including an advisor, who is (i) engaged by the Company or an Affiliate to render\n\nconsulting or advisory services and is compensated for such services, or (ii) serving as a member of the board of\n\ndirectors of an Affiliate and is compensated for such services. However, service solely as a Director, or payment of a\n\nfee for such service, will not cause a Director to be considered a “Consultant” for purposes of the Plan.\n\nNotwithstanding the foregoing, a person is treated as a Consultant under this Plan only if a Registration Statement\n\non Form S-8 under the Securities Act is available to register either the offer or the sale of the Company’s securities\n\nto such person.\n\n(o)“Continuous Service” means that the Participant’s service with the Company or an Affiliate, whether as an\n\nEmployee, Director or Consultant, is not interrupted or terminated. A change in the capacity in which the Participant\n\nrenders service to the Company or an Affiliate as an Employee, Director or Consultant or a change in the Entity for\n\nwhich the Participant renders such service, provided that there is no interruption or termination of the Participant’s\n\nservice with the Company or an Affiliate, will not terminate a Participant’s Continuous Service; provided, however,\n\nthat if the Entity for which a Participant is rendering services ceases to qualify as an Affiliate, as determined by the\n\nBoard, such Participant’s Continuous Service will be considered to have terminated on the date such Entity ceases\n\nto qualify as an Affiliate. For example, a change in status from an Employee of the Company to a Consultant of an\n\nAffiliate or to a Director will not constitute an interruption of Continuous Service. To the extent permitted by law, the\n\nBoard or the chief executive officer of the Company, in that party’s sole discretion, may determine whether\n\nContinuous Service will be considered interrupted in the case of (i) any leave of absence approved by the Board or\n\nchief executive officer, including sick leave, military leave or any other personal leave, or (ii) transfers between the\n\nCompany, an Affiliate, or their successors. Notwithstanding the foregoing, a leave of absence will be treated as\n\nContinuous Service for purposes of vesting in an Award only to such extent as may be provided in the Company’s\n\nleave of absence policy, in the written terms of any leave of absence agreement or policy applicable to the\n\nParticipant, or as otherwise required by law. In addition, to the extent required for exemption from or compliance with\n\nSection 409A, the determination of whether there has been a termination of Continuous Service will be made, and\n\nsuch term will be construed, in a manner that is consistent with the definition of “separation from service” as defined\n\nunder U.S. Treasury Regulation Section 1.409A-1(h) (without regard to any alternative definition thereunder).\n\n(p)“determine” or “determined” means as determined by the Board or the Committee (or its designee) in its sole\n\ndiscretion.\n\n(q)“Director” means a member of the Board.\n\n(r)“Disability” means, with respect to a Participant, such Participant is unable to engage in any substantial gainful\n\nactivity after accounting for reasonable accommodations (if applicable and required by Applicable Law) by reason of\n\nany medically determinable physical or mental impairment which can be expected to result in death or which has\n\nlasted or can be expected to last for a continuous period of not less than 12 months, as provided in Section 22(e)(3)\n\nof the Code, and will be determined by the Board on the basis of such medical evidence as the Board deems\n\nwarranted under the circumstances.\n\n(s)“Effective Date” means the date on which the Company’s stockholders approve the adoption of the Plan.\n\n(t)“Employee” means any person employed by the Company or an Affiliate. However, service solely as a Director, or\n\npayment of a fee for such services, will not cause a Director to be considered an “Employee” for purposes of the\n\nPlan.\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-17\n\nAppendix A\n\n(u)“Employer” means the Company or the Affiliate that employs the Participant.\n\n(v)“Entity” means a corporation, partnership, limited liability company or other entity.\n\n(w)“Exchange Act” means the U.S. Securities Exchange Act of 1934, as amended, and the rules and regulations\n\npromulgated thereunder.\n\n(x)“Exchange Act Person” means any natural person, Entity or “group” (within the meaning of Section 13(d) or 14(d)\n\nof the Exchange Act), except that “Exchange Act Person” will not include (i) the Company or any Subsidiary of the\n\nCompany, (ii) any employee benefit plan of the Company or any Subsidiary of the Company or any trustee or other\n\nfiduciary holding securities under an employee benefit plan of the Company or any Subsidiary of the Company,\n\n(iii) an underwriter temporarily holding securities pursuant to a registered public offering of such securities, (iv) an\n\nEntity Owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their\n\nOwnership of stock of the Company; or (v) any natural person, Entity or “group” (within the meaning of Section 13(d)\n\nor 14(d) of the Exchange Act) that, as of the Effective Date, is the Owner, directly or indirectly, of securities of the\n\nCompany representing more than 50% of the combined voting power of the Company’s then outstanding securities.\n\n(y)“Exchange Program” means a program subject to stockholder approval as set forth in Section 7(b)(ix) under which\n\n(i) outstanding Awards are surrendered or cancelled in exchange for awards of the same type (which may have\n\nhigher or lower exercise prices and different terms), awards of a different type, and/or cash, (ii) Participants would\n\nhave the opportunity to transfer any outstanding Awards to a financial institution or other person or entity selected by\n\nthe Board or the Committee, and/or (iii) the exercise price of an outstanding Award is increased or reduced. The\n\nBoard or the Committee will determine the terms and conditions of any Exchange Program in its sole discretion.\n\n(z)“Fair Market Value” means, as of any date, unless otherwise determined by the Board, the value of the Common\n\nStock (as determined on a per share or aggregate basis, as applicable) determined as follows:\n\n(i)if the Common Stock is listed on any established stock exchange or traded on any established market, the Fair\n\nMarket Value will be the closing sales price for such stock as quoted on such exchange or market (or the\n\nexchange or market with the greatest volume of trading in the Common Stock) on the date of determination, as\n\nreported in a source the Board deems reliable;\n\n(ii)if there is no closing sales price for the Common Stock on the date of determination, then the Fair Market Value\n\nwill be the closing selling price on the last preceding date for which such quotation exists; or\n\n(iii)in the absence of such markets for the Common Stock, or if otherwise determined by the Board, the Fair Market\n\nValue will be determined by the Board in good faith and in a manner that complies with Sections 409A and 422\n\nof the Code.\n\n(aa)“Governmental Body” means any: (a) nation, state, commonwealth, province, territory, county, municipality,\n\ndistrict or other jurisdiction of any nature; (b) U.S. or non-U.S. federal, state, local, municipal, or other\n\ngovernment; (c) governmental or regulatory body, or quasi-governmental body of any nature (including any\n\ngovernmental division, department, administrative agency or bureau, commission, authority, instrumentality,\n\nofficial, ministry, fund, foundation, center, organization, unit, body or Entity and any court or other tribunal, and for\n\nthe avoidance of doubt, any tax authority) or other body exercising similar powers or authority; or (d) self-\n\nregulatory organization (including The Nasdaq Stock Market LLC, the New York Stock Exchange, and the\n\nFinancial Industry Regulatory Authority, Inc.).\n\n(bb)“Grant Notice” means the notice provided to a Participant that he or she has been granted an Award under the\n\nPlan and which includes the name of the Participant, the type of Award, the date of grant of the Award, number of\n\nshares of Common Stock subject to the Award or potential cash payment right, (if any), the vesting schedule for\n\nthe Award (if any) and other key terms applicable to the Award.\n\n(cc) “Incentive Stock Option” means an option granted pursuant to Section 4 of the Plan that is intended to be, and\n\nqualifies as, an “incentive stock option” within the meaning of Section 422 of the Code.\n\n(dd)“Materially Impair” means any amendment to the terms of the Award that materially adversely affects the\n\nParticipant’s rights under the Award. A Participant’s rights under an Award will not be deemed to have been\n\nMaterially Impaired by any such amendment if the Board, in its sole discretion, determines that the amendment,\n\ntaken as a whole, does not materially impair the Participant’s rights. For example, the following types of\n\namendments to the terms of an Award do not Materially Impair the Participant’s rights under the Award:\n\n(i) imposition of reasonable restrictions on the minimum number of shares subject to an Option that may be\n\nA-18  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\nexercised; (ii) to maintain the qualified status of the Award as an Incentive Stock Option under Section 422 of the\n\nCode; (iii) to change the terms of an Incentive Stock Option in a manner that disqualifies, impairs or otherwise\n\naffects the qualified status of the Award as an Incentive Stock Option under Section 422 of the Code; (iv) to\n\nclarify the manner of exemption from, or to bring the Award into compliance with or qualify it for an exemption\n\nfrom, Section 409A; or (v) to comply with other Applicable Laws.\n\n(ee)“Non-Employee Director” means a Director who either (i) is not a current employee or officer of the Company or\n\nan Affiliate, does not receive compensation, either directly or indirectly, from the Company or an Affiliate for\n\nservices rendered as a consultant or in any capacity other than as a Director (except for an amount as to which\n\ndisclosure would not be required under Item 404(a) of Regulation S-K promulgated pursuant to the Securities Act\n\n(“Regulation S-K”)), does not possess an interest in any other transaction for which disclosure would be required\n\nunder Item 404(a) of Regulation S-K, and is not engaged in a business relationship for which disclosure would be\n\nrequired pursuant to Item 404(b) of Regulation S-K; or (ii) is otherwise considered a “non-employee director” for\n\npurposes of Rule 16b-3.\n\n(ff)“Nonstatutory Stock Option” means any option granted pursuant to Section 4 of the Plan that does not qualify\n\nas an Incentive Stock Option.\n\n(gg)“Officer” means a person who is an officer of the Company within the meaning of Section 16 of the Exchange\n\nAct.\n\n(hh)“Option” means an Incentive Stock Option or a Nonstatutory Stock Option to purchase shares of Common\n\nStock granted pursuant to the Plan.\n\n(ii)“Other Award” means an award valued in whole or in part by reference to, or otherwise based on, Common\n\nStock, including the appreciation in value thereof (e.g., options or stock rights with an exercise price or strike\n\nprice less than 100% of the Fair Market Value at the time of grant) that is not an Incentive Stock Option,\n\nNonstatutory Stock Option, SAR, Restricted Stock Award or RSU Award.\n\n(jj)“Other Award Agreement” means a written agreement between the Company and a holder of an Other Award\n\nevidencing the terms and conditions of an Other Award grant. Each Other Award Agreement will be subject to the\n\nterms and conditions of the Plan.\n\n(kk)“Own,” “Owned,” “Owner,” “Ownership” means that a person or Entity will be deemed to “Own,” to have\n\n“Owned,” to be the “Owner” of or to have acquired “Ownership” of securities if such person or Entity, directly or\n\nindirectly, through any contract, arrangement, understanding, relationship or otherwise, has or shares voting\n\npower, which includes the power to vote or to direct the voting, with respect to such securities.\n\n(ll)“Participant” means an Employee, Director or Consultant to whom an Award is granted pursuant to the Plan or,\n\nif applicable, such other person who holds an outstanding Award.\n\n(mm)“Performance Criteria” means the one or more criteria that the Board will select for purposes of establishing the\n\nPerformance Goals for a Performance Period. The Performance Criteria that will be used to establish such\n\nPerformance Goals may include (but is not limited to) any one of, or combination of, the following as determined\n\nby the Board: earnings (including earnings per share and net earnings); earnings before interest, taxes and\n\ndepreciation; earnings before interest, taxes, depreciation and amortization; total stockholder return; return on\n\nequity or average stockholder’s equity; return on assets, investment, or capital employed; stock price; margin\n\n(including gross margin); income (before or after taxes); operating income; operating income after taxes; pre-tax\n\nprofit; operating cash flow; sales or revenue targets; increases in revenue or product revenue; expenses and cost\n\nreduction goals; improvement in or attainment of working capital levels; economic value added (or an equivalent\n\nmetric); market share; cash flow; cash flow per share; share price performance; debt reduction; customer\n\nsatisfaction; stockholders’ equity; capital expenditures; debt levels; operating profit or net operating profit;\n\nworkforce diversity; growth of net income or operating income; billings; pre-clinical development related\n\ncompound goals; financing; regulatory milestones, including approval of a compound; stockholder liquidity;\n\ncorporate governance and compliance; product commercialization; intellectual property; personnel matters;\n\nprogress of internal research or clinical programs; progress of partnered programs; partner satisfaction; budget\n\nmanagement; clinical achievements; completing phases of a clinical study (including the treatment phase);\n\nannouncing or presenting preliminary or final data from clinical studies; in each case, whether on particular\n\ntimelines or generally; timely completion of clinical trials; submission of INDs and NDAs and other regulatory\n\nachievements; partner or collaborator achievements; internal controls, including those related to the Sarbanes-\n\nOxley Act of 2002; research progress, including the development of programs; investor relations, analysts and\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-19\n\nAppendix A\n\ncommunication; manufacturing achievements (including obtaining particular yields from manufacturing runs and\n\nother measurable objectives related to process development activities); strategic partnerships or transactions\n\n(including in-licensing and out-licensing of intellectual property; establishing relationships with commercial entities\n\nwith respect to the marketing, distribution and sale of the Company’s products (including with group purchasing\n\norganizations, distributors and other vendors)); supply chain achievements (including establishing relationships\n\nwith manufacturers or suppliers of active pharmaceutical ingredients and other component materials and\n\nmanufacturers of the Company’s products); co-development, co-marketing, profit sharing, joint venture or other\n\nsimilar arrangements; individual performance goals; corporate development and planning goals; and other\n\nmeasures of performance selected by the Board.\n\n(nn)“Performance Goals” means, for a Performance Period, the one or more goals established by the Board for the\n\nPerformance Period based upon the Performance Criteria. Performance Goals may be based on a Company-\n\nwide basis, with respect to one or more business units, divisions, Affiliates, or business segments, and in either\n\nabsolute terms or relative to the performance of one or more comparable companies or the performance of one\n\nor more relevant indices. Unless specified otherwise by the Board (i) in the Award Agreement at the time the\n\nAward is granted or (ii) in such other document setting forth the Performance Goals at the time the Performance\n\nGoals are established, the Board will appropriately make adjustments in the method of calculating the attainment\n\nof Performance Goals for a Performance Period as follows: (1) to exclude restructuring and/or other nonrecurring\n\ncharges; (2) to exclude exchange rate effects; (3) to exclude the effects of changes to generally accepted\n\naccounting principles; (4) to exclude the effects of any statutory adjustments to corporate tax rates; (5) to exclude\n\nthe effects of items that are “unusual” in nature or occur “infrequently” as determined under generally accepted\n\naccounting principles; (6) to exclude the dilutive effects of acquisitions or joint ventures; (7) to assume that any\n\nbusiness divested by the Company achieved performance objectives at targeted levels during the balance of a\n\nPerformance Period following such divestiture; (8) to exclude the effect of any change in the outstanding shares\n\nof Common Stock of the Company by reason of any stock dividend or split, stock repurchase, reorganization,\n\nrecapitalization, merger, consolidation, spin-off, combination or exchange of shares or other similar corporate\n\nchange, or any distributions to common stockholders other than regular cash dividends; (9) to exclude the effects\n\nof stock based compensation and the award of bonuses under the Company’s bonus plans; (10) to exclude costs\n\nincurred in connection with potential acquisitions or divestitures that are required to be expensed under generally\n\naccepted accounting principles; and (11) to exclude the goodwill and intangible asset impairment charges that\n\nare required to be recorded under generally accepted accounting principles. In addition, the Board retains the\n\ndiscretion to reduce or eliminate the compensation or economic benefit due upon attainment of Performance\n\nGoals and to define the manner of calculating the Performance Criteria it selects to use for such Performance\n\nPeriod. Partial achievement of the specified criteria may result in the payment or vesting corresponding to the\n\ndegree of achievement as specified in the Award Agreement.\n\n(oo)“Performance Period” means the period of time selected by the Board over which the attainment of one or more\n\nPerformance Goals will be measured for the purpose of determining a Participant’s right to vesting or exercise of\n\nan Award. Performance Periods may be of varying and overlapping duration, at the sole discretion of the Board.\n\n(pp) “Plan” means this CareDx, Inc. 2024 Equity Incentive Plan, as amended from time to time.\n\n(qq)“Plan Administrator” means the person, persons, and/or third-party administrator designated by the Company to\n\nadminister the day-to-day operations of the Plan and the Company’s other equity incentive programs.\n\n(rr)“Post-Termination Exercise Period” means the period following termination of a Participant’s Continuous\n\nService within which an Option or SAR is exercisable, as specified in Section 4(h).\n\n(ss)“Restricted Stock Award” or “RSA” means an Award of shares of Common Stock granted pursuant to the terms\n\nand conditions of Section 5(a).\n\n(tt)“Restricted Stock Award Agreement” means a written agreement between the Company and a holder of a\n\nRestricted Stock Award evidencing the terms and conditions of a Restricted Stock Award grant. The Restricted\n\nStock Award Agreement includes the Grant Notice for the Restricted Stock Award and the agreement containing\n\nthe written summary of the general terms and conditions applicable to the Restricted Stock Award and which is\n\nprovided to a Participant along with the Grant Notice. Each Restricted Stock Award Agreement will be subject to\n\nthe terms and conditions of the Plan.\n\n(uu)“RSU Award” or “RSU” means an Award of restricted stock units representing the right to receive an issuance of\n\nshares of Common Stock which is granted pursuant to the terms and conditions of Section 5(a).\n\nA-20  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix A\n\n(vv)“RSU Award Agreement” means a written agreement between the Company and a holder of a RSU Award\n\nevidencing the terms and conditions of a RSU Award. The RSU Award Agreement includes the Grant Notice for\n\nthe RSU Award and the agreement containing the written summary of the general terms and conditions\n\napplicable to the RSU Award and which is provided to a Participant along with the Grant Notice. Each RSU\n\nAward Agreement will be subject to the terms and conditions of the Plan.\n\n(ww)“Rule 16b-3” means Rule 16b-3 promulgated under the Exchange Act or any successor to Rule 16b-3, as in\n\neffect from time to time.\n\n(xx)“Rule 405” means Rule 405 promulgated under the Securities Act.\n\n(yy)“Section 409A” means Section 409A of the Code and the regulations and other guidance thereunder.\n\n(zz)“Section 409A Change in Control” means a change in the ownership or effective control of the Company, or in\n\nthe ownership of a substantial portion of the Company’s assets, as provided in Section 409A(a)(2)(A)(v) of the\n\nCode and Treasury Regulations Section 1.409A-3(i)(5) (without regard to any alternative definition thereunder).\n\n(aaa)“Securities Act” means the U.S. Securities Act of 1933, as amended.\n\n(bbb)“Share” means a share of Common Stock, as adjusted in accordance with Section 6 of the Plan.\n\n(ccc)“Share Reserve” means the number of shares available for issuance under the Plan as set forth in Section 2(a).\n\n(ddd)“Stock Appreciation Right” or “SAR” means a right to receive the appreciation on Common Stock that is\n\ngranted pursuant to the terms and conditions of Section 4.\n\n(eee)“Subsidiary” means, with respect to the Company, (i) any corporation of which more than 50% of the outstanding\n\nCommon Stock having ordinary voting power to elect a majority of the board of directors of such corporation\n\n(irrespective of whether, at the time, stock of any other class or classes of such corporation will have or might\n\nhave voting power by reason of the happening of any contingency) is at the time, directly or indirectly, Owned by\n\nthe Company, and (ii) any partnership, limited liability company or other entity in which the Company has a direct\n\nor indirect interest (whether in the form of voting or participation in profits or capital contribution) of more\n\nthan 50%.\n\n(fff)“Ten Percent Stockholder” means a person who Owns (or is deemed to Own pursuant to Section 424(d) of the\n\nCode) stock possessing more than 10% of the total combined voting power of all classes of stock of the\n\nCompany or any Affiliate.\n\n(ggg)“Trading Policy” means the Company’s policy permitting certain individuals to sell Company shares only during\n\ncertain “window” periods and/or otherwise restricts the ability of certain individuals to transfer or encumber\n\nCompany shares, as in effect from time to time.\n\nAmendment No. 1 to the CareDx, Inc. 2024 Equity Incentive Plan (April 23, 2025)\n\nThis Amendment No 1. (this “Amendment”) to the CareDx, Inc. 2024 Equity Incentive Plan (the “Plan”) was\n\nadopted by the Board of Directors (the “Board”) of CareDx, Inc. (the “Company”), and following the Board’s approval of this\n\nAmendment as of the date first written above, will be effective as of the date on which this Amendment is approved by the\n\nstockholders of the Company (the “Amendment Effective Date”).\n\nWHEREAS, the Company maintains the Plan, and pursuant to Section 7(b) of the Plan, the Board is authorized to\n\namend the Plan;\n\nWHEREAS, the Board desires to amend the Plan to increase the number of shares of the Company’s Common\n\nStock reserved and available for issuance thereunder; and\n\nWHEREAS, following approval by the Board, this Amendment will become effective as of and contingent upon\n\napproval by the Company’s stockholders and if, for any reason, the Company’s stockholders fail to approve this\n\nAmendment, this Amendment shall be void ab initio and the existing Plan shall continue in full force and effect.\n\nNOW, THEREFORE, the Plan is hereby amended as follows, subject to and effective upon the Amendment\n\nEffective Date:\n\nCareDx Inc.\n\n2026 Proxy Statement  |  A-21\n\nAppendix A\n\n1.Capitalized Terms. Capitalized terms that are not defined in this Amendment shall have the meanings ascribed\n\nthereto in the Plan.\n\n2.Amendments to the Plan.\n\ni.Section 2(a) of the Plan is hereby amended in its entirety to read as follows:\n\n“(a) Share Reserve. Subject to adjustment in accordance with Section 2(c) and\n\nany adjustments as necessary to implement any Capitalization Adjustments, the\n\naggregate number of shares of Common Stock that may be issued pursuant to\n\nAwards will not exceed 5,100,000 shares.”\n\nii.Section 2(b) of the Plan is hereby amended in its entirety to read as follows:\n\n“(b) Aggregate Incentive Stock Option Limit. Notwithstanding anything to the\n\ncontrary in Section 2(a) and subject to any adjustments as necessary to implement\n\nany Capitalization Adjustments, the aggregate maximum number of shares of\n\nCommon Stock that may be issued pursuant to the exercise of Incentive Stock\n\nOptions is 5,100,000 shares.”\n\n3.Ratification and Confirmation. Except as specifically amended by this Amendment, the Plan is hereby ratified and\n\nconfirmed in all respects and remains valid and in full force and effect.\n\n4.Choice of Law. This Amendment shall be governed by and construed in accordance with the laws of the State of\n\nDelaware, without reference to the principles of conflicts of laws thereof.\n\n5.Headings. Section headings are for convenience only and shall not be considered a part of this Amendment.\n\n*      *      *\n\nAdopted by the Board of Directors (contingent on approval by the Stockholders) on April 24, 2024 and\n\nApproved by the Stockholders on June 13, 2024\n\nAs Amended by Amendment No. 1 on June 12, 2025\n\nB-1  |  2026 Proxy Statement\n\nCareDx Inc.\n\nAppendix B\n\nAmendment No. 2 to the CareDx, Inc. 2024 Equity Incentive Plan\n\nApril 21, 2026\n\nThis Amendment No 2. (this “Amendment”) to the CareDx, Inc. 2024 Equity Incentive Plan (the “Plan”) was\n\nadopted by the Board of Directors (the “Board”) of CareDx, Inc. (the “Company”), and following the Board’s approval of this\n\nAmendment as of the date first written above, will be effective as of the date on which this Amendment is approved by the\n\nstockholders of the Company (the “Amendment Effective Date”).\n\nWHEREAS, the Company maintains the Plan, and pursuant to Section 7(b) of the Plan, the Board is authorized to\n\namend the Plan;\n\nWHEREAS, the Board desires to amend the Plan to increase the number of shares of the Company’s Common\n\nStock reserved and available for issuance thereunder; and\n\nWHEREAS, following approval by the Board, this Amendment will become effective as of and contingent upon\n\napproval by the Company’s stockholders and if, for any reason, the Company’s stockholders fail to approve this\n\nAmendment, this Amendment shall be void ab initio and the existing Plan shall continue in full force and effect.\n\nNOW, THEREFORE, the Plan is hereby amended as follows, subject to and effective upon the Amendment\n\nEffective Date:\n\n1.Capitalized Terms. Capitalized terms that are not defined in this Amendment shall have the meanings ascribed\n\nthereto in the Plan.\n\n2.Amendments to the Plan.\n\ni.Section 2(a) of the Plan is hereby amended in its entirety to read as follows:\n\n“(a) Share Reserve. Subject to adjustment in accordance with Section 2(c) and\n\nany adjustments as necessary to implement any Capitalization Adjustments, the\n\naggregate number of shares of Common Stock that may be issued pursuant to\n\nAwards will not exceed 6,700,000 shares.”\n\nii.Section 2(b) of the Plan is hereby amended in its entirety to read as follows:\n\n“(b) Aggregate Incentive Stock Option Limit. Notwithstanding anything to the\n\ncontrary in Section 2(a) and subject to any adjustments as necessary to implement\n\nany Capitalization Adjustments, the aggregate maximum number of shares of\n\nCommon Stock that may be issued pursuant to the exercise of Incentive Stock\n\nOptions is 6,700,000 shares.”\n\n3.Ratification and Confirmation. Except as specifically amended by this Amendment, the Plan is hereby ratified and\n\nconfirmed in all respects and remains valid and in full force and effect.\n\n4.Choice of Law. This Amendment shall be governed by and construed in accordance with the laws of the State of\n\nDelaware, without reference to the principles of conflicts of laws thereof.\n\n5.Headings. Section headings are for convenience only and shall not be considered a part of this Amendment.\n\nAdopted by the Board of Directors (contingent on approval by the Stockholders) on April 21, 2026\n\n                                                                                                        Approved by the Stockholders on"}