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EXCHANGE COMMISSION**\n\n**Washington,\nD.C. 20549**\n\n \n\n**FORM\n20-F**\n\n \n\n(Mark\none)\n\n \n\n☐\nREGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934\n\n \n\nOR\n\n \n\n☒\nANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934\n\n \n\nFor\nthe fiscal year ended December 31, 2025\n\n \n\nOR\n\n \n\n☐\nTRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934\n\n \n\nOR\n\n \n\n☐\nSHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934\n\n \n\nDate\nof event requiring this shell company report:\n\n \n\nFor\nthe transition period from __________ to ____________\n\n \n\nCommission\nfile number: 001-42288\n\n \n\n**Cuprina\nHoldings (Cayman) Limited**\n\n(Exact\nname of the Registrant as specified in its charter)\n\n \n\nN/A\n\n(Translation\nof registrant’s name into English)\n\n \n\nCayman\nIslands\n\n(Jurisdiction\nof incorporation or organization)\n\n \n\nc/o\nBlk 1090\n\nLower\nDelta Road #06-08\n\nSingapore\n169201\n\n(Address\nof principal executive offices)\n\n \n\nDavid\nQuek Yong Qi, Chief Executive Officer\n\n \n\nTel:\n+65 8512 7275\n\n \n\nEmail:\ngeneral@cuprina.com.sg\n\n \n\nBlk\n1090\n\nLower\nDelta Road #06-08\n\nSingapore\n169201\n\n(Name,\nTelephone, E-mail and Address of Company Contact Person)\n\n \n\nSecurities\nregistered or to be registered pursuant to Section 12(b) of the Act:\n\n \n\n**Title\nof each class**\n** **\n**Trading\nsymbol(s)**\n** **\n**Name\nof each exchange on which registered**\n\nClass\nA Ordinary shares, par value US$0.001 per share\n \nCUPR\n \nThe\nNasdaq Capital Market, LLC\n\n \n\nSecurities\nregistered or to be registered pursuant to Section 12(g) of the Act:\n\n \n\nWarrants,\neach to purchase one ordinary share\n\nTitle\nof Class\n\n \n\nSecurities\nfor which there is a reporting obligation pursuant to Section 15(d) of the Act:\n\n \n\nNone\n\n \n\nThe\nregistrant had 7,365,000 Class A ordinary shares issued and outstanding as of April 27, 2026.\n\n \n\nIndicate\nby check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.\n\n \n\n☐\nYes ☒ No\n\n \n\nIf\nthis report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section\n13 or 15(d) of the Securities Exchange Act of 1934.\n\n \n\n ☐\nYes ☒ No\n\n \n\nIndicate\nby check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange\nAct of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)\nhas been subject to such filing requirements for the past 90 days.\n\n \n\n☒\nYes ☐ No\n\n \n\nIndicate\nby check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule\n405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant\nwas required to submit such files).\n\n \n\n☒\nYes ☐ No\n\n \n\nIndicate\nby check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or an emerging growth\ncompany. See definition of “large accelerated filer,” “accelerated filer,” and “emerging growth company”\nin Rule 12b-2 of the Exchange Act.\n\n \n\n☐\nLarge Accelerated filer\n☐\nAccelerated filer\n☒\nNon-accelerated filer\n\n \n \n☒\nEmerging growth company\n\n \n\nIf\nan emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant\nhas elected not to use the extended transition period for complying with any new or revised financial accounting standards† provided\npursuant to Section 13(a) of the Exchange Act. ☐\n\n \n\n†\nThe\nterm “new or revised financial accounting standard” refers to any update issued by the Financial Accounting Standards\nBoard to its Accounting Standards Codification after April 5, 2012.\n\n \n\nIndicate\nby check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness\nof its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered\npublic accounting firm that prepared or issued its audit report. ☐\n\n \n\nIndicate\nby check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:\n\n \n\n☒\nU.S. GAAP\n\n☐\nInternational Financial Reporting\n\nStandards\nas issued by the International\n\nAccounting\nStandards Board\n\n☐\nOther\n\n \n\nIf\n“Other” has been checked in response to the previous question, indicate by check mark which financial statement item the\nregistrant has elected to follow.\n\n \n\n☐"}