{"url_path":"/sec/shph/proxy/2026-05-12/000149315226022491","section_key":"body","section_title":"DEFA14A body","topic":"sec","document":{"doc_type":"DEFA14A","doc_date":"2026-05-12","source_url":"https://www.sec.gov/Archives/edgar/data/1757499/0001493152-26-022491-index.html","accession_number":"0001493152-26-022491","cik":"0001757499","ticker":"SHPH","issuer_name":"Shuttle Pharmaceuticals Holdings, Inc.","edgar_url":"https://www.sec.gov/Archives/edgar/data/1757499/0001493152-26-022491-index.html","primary_entity_key":"0001757499","primary_entity_name":"Shuttle Pharmaceuticals Holdings, Inc."},"word_count":669,"has_tables":true,"body_markdown":"DEFA14A\n1\nformdefa14a.htm\nDEFA14A\n\n**UNITED\nSTATES**\n\n**SECURITIES\nAND EXCHANGE COMMISSION**\n\n**Washington,\nD.C. 20549**\n\n**SCHEDULE\n14A**\n\nProxy\nStatement Pursuant to Section 14(a) of\n\nthe\nSecurities Exchange Act of 1934\n\nFiled\nby the Registrant ☒\n\nFiled\nby a Party other than the Registrant ☐\n\nCheck\nthe appropriate box:\n\n☐\nPreliminary\nProxy Statement\n\n☐\n**Confidential,\nfor Use of the Commission Only (as permitted by Rule 14a-6(e)(2))**\n\n☐\nDefinitive\nProxy Statement\n\n☒\nDefinitive\nAdditional Materials\n\n☐\nSoliciting\nMaterial under §240.14a-12\n\n**SHUTTLE\nPHARMACEUTICALS HOLDINGS, INC.**\n\n(Name\nof Registrant as Specified In Its Charter)\n\n(Name\nof Person(s) Filing Proxy Statement, if other than the Registrant)\n\nPayment\nof Filing Fee (Check all boxes that apply):\n\n☒\n**No\nfee required.**\n\n☐\nFee\npaid previously with preliminary material.\n\n☐\nFee\ncomputed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.\n\n**SHUTTLE\nPHARMACEUTICALS HOLDINGS, INC.**\n\n**401\nProfessional Drive, Suite 260**\n\n**Gaithersburg,\nMaryland 20879**\n\n**SUPPLEMENT\nTO**\n\n**NOTICE\nOF ANNUAL MEETING OF STOCKHOLDERS**\n\n**AND\nPROXY STATEMENT DATED APRIL 20, 2026**\n\n**FOR\nANNUAL MEETING OF STOCKHOLDERS**\n\n**TO\nBE HELD ON MAY 21, 2026**\n\nThis\nSupplement provides updated information with respect to the 2026 Annual Meeting of Stockholders (the “**Annual Meeting**”)\nof Shuttle Pharmaceuticals Holdings, Inc., a Delaware corporation, to be held on Thursday, May 21, 2026 at 12:00 p.m. Eastern Time. Unless\nthe context otherwise requires, references to the “Company,” “we,” and “our” refer to Shuttle Pharmaceuticals\nHoldings, Inc.\n\nThe\nCompany previously distributed its Notice of Annual Meeting of Stockholders and Proxy Statement (the “**Notice and Proxy Statement**”)\nfor the Annual Meeting. This Supplement, which describes a recent change in the proposed nominees for election to the Company’s\nBoard of Directors (the “**Board**”), should be read in conjunction with the Notice and Proxy Statement.\n\n**Withdrawal\nof Nominee for Election as Director**\n\nAs\npreviously disclosed by the Company on a Current Report on Form 8-K filed with the Securities and Exchange Commission on May 7, 2026,\nOleh Nabyt, previously a director of the Company, notified the Company of his decision to resign from the Board, effective immediately.\nMr. Nabyt’s decision to resign from the Board was not related to a disagreement with the Company over any of its operations, policies\nor practices. Accordingly, the nomination of Mr. Nabyt for re-election to the Board at the Annual Meeting has been withdrawn.\n\n**In\nlight of Mr. Nabyt’s resignation from the Board and the subsequent withdrawal of his name as a nominee for re-election to the Board,\nProposal No. 1 in the Notice and Proxy Statement now proposes to elect the remaining four director nominees named in the Proxy Statement\nto hold office until the Company’s 2027 Annual Meeting of Stockholders and until their respective successors are elected and qualified.**\n\n**THE\nBOARD RECOMMENDS A VOTE FOR THE ELECTION OF EACH OF THE REMAINING FOUR DIRECTOR NOMINEES**\n\n**Voting\nMatters**\n\nIf\nyou have already voted, you do not need to take any action unless you wish to change your vote. Proxy voting cards already returned by\nstockholders will remain valid and will be voted at the Annual Meeting unless revoked.\n\nIf\nwe receive a proxy instruction from you before the Annual Meeting, your shares will be voted for the directors nominated by the Board\nas instructed by you, except that votes will not be cast for Oleh Nabyt because he has resigned from the Board and is no longer standing\nfor re-election. If you have not yet voted, please complete the Proxy Card or submit your voting instructions, disregarding Mr. Nabyt’s\nname as a nominee for election as director.\n\nNone\nof the other agenda items presented in the Notice and Proxy Statement are affected by this Supplement, and shares represented by proxy\ninstructions returned before the Annual Meeting will be voted with respect to all other matters properly brought before the Annual Meeting\nin accordance with those voting instructions.\n\nInformation\nregarding how to vote your shares, or revoke your proxy or voting instructions, is available in the Proxy Statement.\n\nBy\norder of the Board of Directors,\n\nChristopher\nCooper\n\nInterim\nChief Executive Officer"}