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STATES**\n\n**SECURITIES AND EXCHANGE COMMISSION**\n\n**WASHINGTON, DC 20549**\n\n \n\n \n\n**FORM 10-Q**\n\n \n\n \n\n**☒**\n\n**QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.**\n\n \n\n**For the quarterly period ended March 31, 2026**\n\n \n\n**or**\n\n \n\n**☐**\n\n**TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.**\n\n \n\n**For the transition period from**            **to**            ****\n\n \n\n**Commission File Number: 001-35068**\n\n \n\n \n\n**TALPHERA, INC.**\n\n**(Exact name of registrant as specified in its charter)**\n\n \n\n \n\n**Delaware**\n\n**41-2193603**\n\n**(State or other jurisdiction of**\n\n**incorporation or organization)**\n\n**(IRS Employer**\n\n**Identification No.)**\n\n \n\n**1850 Gateway Drive, Suite 175**\n\n**San Mateo, CA 94404**\n\n**(650) 216-3500**\n\n**(Address, including zip code, and telephone number, including area code, of registrant**’**s principal executive offices)**\n\n \n\n**Securities registered pursuant to Section 12(b) of the Act:**\n\n \n\n**Title ofEach Class**\n\n**Trading symbol(s)**\n\n**Name of Each Exchange on Which Registered:**\n\n \n \n \n\n**Common Stock, $0.001 par value**\n\n**TLPH**\n\n**The Nasdaq Capital Market**\n\n \n\n \n\nIndicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  ☒    No  ☐\n\n \n\nIndicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes  ☒    No  ☐\n\n \n\nIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.:\n\n \n\nLarge accelerated filer\n\n☐\n\nAccelerated filer\n\n☐\n\n \n \n \n \n\nNon-accelerated filer\n\n☒\n\nSmaller reporting company\n\n☒\n\n \n \n \n \n\nEmerging growth company\n\n☐\n\n \n \n\n \n\nIf an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐\n\n \n\nIndicate by check mark whether the registrant is a shell company (as defined in Exchange Act Rule 12b-2)    Yes  ☐    No  ☒\n\n \n\nAs of May 7, 2026, the number of outstanding shares of the registrant’s common stock was 51,899,648.\n\n \n\n1\n\n \n\n  \n\n \n\n**TALPHERA, INC.**\n\n**QUARTERLY REPORT ON FORM 10-Q FOR THE QUARTER ENDED MARCH 31, 2026**\n\n \n\n**TABLE OF CONTENTS**\n\n \n\n \n \n \n \n\n \n \n \n\n**[Page]** \n\n**PART** **I. FINANCIAL INFORMATION**         \n\n5"}