The Department of the Treasury's Office of Foreign Assets Control (OFAC) is amending the Transnational Criminal Organizations Sanctions Regulations and reissuing them in their entirety to further implement a July 24, 2011 Executive order and a March 15, 2019 Executive order related to transnational criminal organizations. This final rule replaces the regulations that were published in abbreviated form on January 12, 2012 and amended on July 23, 2019, and includes additional interpretive guidance, definitions, general licenses, and other regulatory provisions that will provide further guidance to the public. Due to the number of regulatory sections being updated or added, OFAC is amending and reissuing the Transnational Criminal Organizations Sanctions Regulations in their entirety.