ON MARCH 13, 2015 DRIVING ON I-95 SOUTH IN A 2006 TOYOTA SIENNA VAN THE CRUISE CONTROL WOULD NOT DISENGAGE WHEN THE BRAKES WERE APPLIED APPROACHING AN EXIT RAMP. THE VEHICLE WOULD NOT SLOWDOWN IN SPITE OF PRESSING THE BRAKE PEDAL AS HARD AS POSSIBLE. MOVING THE CONTROL LEVER FORWARD TO DISENGAGE THE FUNCTION WAS ALSO NOT SUCCESSFUL. THE EXIT RAMP WAS INCLINED SO THE CRUISE CONTROL ACCELERATED THE ENGINE IN AN ATTEMPT TO MAINTAIN OUR SPEED AT 70 MPH. THE VEHICLE WENT THRU A STOP SIGN, BOUNCED OFF THE GUARD RAIL AND CAME TO A SUDDEN STOP WITH THE ENGINE NOT RUNNING. THE IMPACT DESTROYED THE RIGHT SIDE OF THE VEHICLE AND THE STOPPING WAS SO ABRUPT THAT THE CELL PHONE (IN MY SHIRT POCKET)FLEW OUT RIPPING THE POCKET OFF THE SHIRT. NEITHER THE FRONT NOR THE SIDE AIR BAGS WERE DEPLOYED. SKID MARKS MADE BY THE VEHICLE'S RIGHT FRONT TIRE (AND POSSIBLY THE REAR RIGHT TIRE) PRIOR TO AND AFTER HITTING THE GUARD RAIL INDICATE THE BRAKES WERE WORKING ON AT LEAST THIS SIDE. SKID MARKS ATTRIBUTABLE TO THE LEFT HAND TIRES WERE NOT NOTICED. *TR