MY WIFE WAS TRAVELING NORTH ON I-395, EXITING OFF AT D STREET WHEN THE RIGHT REAR AXLE BROKE AND THE WHEEL CAME OFF THE VEHICLE. THE 4-RUNNER BOUNCED OFF THE MEDIAN GUARD RAIL, FLIPPED OVER ON ITS RIGHT SIDE THEN RIGHTED ITSELF THEN CAME TO A STOP. MY WIFE SUSTAINED TISSUE DAMAGE, BUT NO BROKEN BONES. THIS VEHICLE HAD NEVER BEEN TAKEN OFF ROAD IN ANY CAPACITY. *AK