The contact's company owned a 2014 Ram 5500. The contact stated while driving at 60-65 MPH, he heard an abnormal loud sound coming from the rear of the vehicle. The contact stated the rear wheels detached and flew off, causing the contact to lose control of the vehicle. The stated the vehicle drove off the road, hit a ditch, rolled over three times, and landed on the passenger side. The air bags failed to deploy. There were no warning lights illuminated. The contact sustained bruised ribs, back, and shoulder. The contact was transported to the hospital with the assistance of emergency units. A police report was filed. The vehicle was towed to the contact's company office, where it was totaled. The dealer and the manufacturer were not notified of the failure. The approximate failure mileage was 178,000.