Driving on the freeway, cruise control set, a remnant of a large tire was in my lane, I could not avoid hitting it, it caused my car to lose control, drive up on the concrete divider placed by construction crews, came back down to the freeway and hit the back of a semi causing my car to then spin out of control and eventually landing in a ditch. The entire front end of the car was damaged, the car was deemed totaled by the auto repair place. During this incident none of the airbags deployed.