The contact owns a 2006 Mercedes-Benz ML 500. The contact stated that while his wife was driving at an undetermined speed, the vehicle accelerated and crashed into a tree. The brake pedal was applied but it failed to respond. There were no warning lights illuminated. The driver-side air bag was deployed. The contact sustained bruises and injuries to her hands, knees, and shoulder, and medical attention was provided by her primary physician. There was no fire or police report filed. The vehicle was towed to a towing lot. Then towed to another towing lot. The local dealer was not contacted. The vehicle was not diagnosed or repaired. The manufacturer was not notified about the failure. The failure mileage was approximately 125,000. The contact stated that the failure was related to NHTSA Campaign Number: 22V315000 (Service Brakes, Hydraulic). The contact was concerned that he was not notified previously about the do not drive notice.