I was driving on the interstate highway. While driving at 60 mph towing a fifth wheel RV the front end shuddered for several seconds. Then the drivers side front wheel assembly broke off at the wheel studs. I was able to safely get to the breakdown lane. The drivers side front wheel assembly struck another vehicle traveling the oncoming lane. I was told that the vehicle that was struck was totaled. The police on scene documented the incident. The insurance representative has been notified and approved the repair. The collision repair facility documented. I also have pictures indicating broken front wheel studs.