Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and Trastuzumab in Treating Women With Stage III or Stage IV Breast Cancer

NCT00016276 · clinicaltrials.gov ↗

PHASE3

Phase

TERMINATED

Status

396

Enrollment

NIH

Sponsor class

Stopped Administratively complete.

Conditions

Cardiac Toxicity
Inflammatory Breast Cancer
Stage IIIA Breast Cancer
Stage IIIB Breast Cancer
Stage IV Breast Cancer

Interventions

DRUG: dexrazoxane hydrochloride
DRUG: doxorubicin hydrochloride
DRUG: cyclophosphamide
DRUG: paclitaxel
BIOLOGICAL: trastuzumab
PROCEDURE: therapeutic conventional surgery
RADIATION: radiation therapy
DRUG: tamoxifen citrate
OTHER: laboratory biomarker analysis

Sponsor

National Cancer Institute (NCI)