Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)

Stopped Recommended by DSMB due to lack of accrual

Conditions

• Systemic Lupus Erythematosus

Interventions

• PROCEDURE: Leukapheresis
• PROCEDURE: Non-myeloablative high dose immunosuppressive therapy conditioning (HDIT)
• PROCEDURE: Autologous CD34+HPC transplantation (HSCT)
• PROCEDURE: Plasmapheresis
• DRUG: Rabbit anti-thymocyte globulin
• DRUG: Methylprednisolone
• DRUG: Growth colony stimulating factor (G-CSF)
• DRUG: Corticosteroids
• DRUG: Mycophenolate mofetil
• DRUG: Azathioprine
• DRUG: Intravenous immunoglobulin
• DRUG: Methotrexate
• DRUG: Rituximab
• DRUG: Leflunomide

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)